Current trials and studies

Completed trials and studies

To view all our finished projects, take a look at:

Completed trials and studies

A 

AWARE-IBD  

Working with patients to redesign hospital services for people with gut conditions like Crohn's Disease and Ulcerative Colitis (together known as Inflammatory Bowel Disease or IBD).

• Chief investigator: Professor Alan Lobo, Sheffield Teaching Hospitals
• Funding body: The Health Foundation
• Status: Analysis

View project summary

B

BASIS

Bracing Adolescent Idiopathic Scolio-SIS:

Comparing night-time bracing with full-time bracing in children and young people with adolescent idiopathic scoliosis.

• Chief investigator: Mr. Ashley Cole, Sheffield Children’s NHS Foundation Trust
• Funding body: Health Technology Assessment
• Status: Recruitment

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C

CONTACT-GAD

A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder

• Chief investigator: Rebecca Gould, University College London
• Funding body: NIHR
• Status: Recruitment

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D

DAFNEplus

Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes

• Chief investigator: Professor Simon Heller, Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffield
• Funding body: NIHR Programme Grant for Applied Research
• Status: Follow-up

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DENIM

Delivering Effective Non-Invasive ventilation in Motor neuron disease:

The DENIM clinical trial focuses on improving Non-Invasive Ventilation (NIV) support for people living with Motor Neuron Disease (MND).

• Chief investigator: Esther Hobson, University of Sheffield
• Funding body: National Institute for Health and Care Research
• Status: Recruitment

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DETECT-CRC

Early DETECTion of ColoRectal Cancer in Yorkshire (DETECT-CRC):

A feasibility study using pharmacies to help with active case finding of colorectal cancer in socio-economically deprived areas.

• Chief investigator: Matthew Kurien, University of Sheffield
• Funding body: Yorkshire Cancer Research
• Status: Recruitment

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E

EXPERTS-ALS

EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis

• Chief investigators: Professor Christopher McDermott, University of Sheffield and Professor Martin Turner, University of Oxford
• Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
• Status: Recruitment

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F

FIRST

Flexor Injury Rehabilitation Splint Trial:

A pragmatic multi-centre randomised control trial (RCT) comparing splints following repair of finger flexor tendons.

• Chief investigator: Emma Bamford, Hand Therapist, Extended Scope Practitioner, Pulvertaft Hand Centre, Derby
• Funding body: National Institute for Health Research, Health Technology Assessment
• Status: Follow-up

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H

Healthy weight management - grant development work

We plan to apply for research funding in January 2024. This work will inform the application. 

• Chief investigator: TBC
• Status: Recruitment

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HELP Fertility?

What is the clinical and cost-effectiveness of hysteroscopic removal of submucosal fibroids and polyps in women presenting with infertility and recurrent miscarriage?

• Chief investigator: Mostafa Metwally, Sheffield Teaching Hospitals
• Funding body: National Institute for Health Research, Health Technology Assessment
• Status: Analysis

View project summary

I

Improving time-critical assessments in Emergency Departments - grant development work

Developing a programme on improving early identification of emergency department patients who need time-critical treatment.

• Chief investigator: Steve Goodacre, University of Sheffield
• Funding body: NIHR Programme Development Grants
• Status: Set-up

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M

MEErKAT

MEsenteric Excision and Kono-S Anastomosis Trial (MEErKAT):

This is a randomised control trial trying to find out which options are best for people having surgery for their Crohn's disease. We are testing whether a type of bowel connection (an anastomosis) called the 'Kono-S technique, or if the amount of mesentery removed during surgery can prevent people's Crohn's disease coming back.

• Chief investigator: Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
• Status: Recruitment

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MIND

MedIcal studeNt mental health stuDy

• Chief investigator: Elena Sheldon, University of Sheffield
• Funding body: British Medical Association
• Status: Reporting

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MissionEB

Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (EB).

• Chief investigator: Dr Anna Martinez, Great Ormond Street Hospital
• Funding body: The Efficacy and Mechanism Evaluation (EME) Programme, NHS England and Cure EB
• Status: Reporting

View project summary

O

OptiCALS

A programme to develop and evaluate a complex intervention to improve nutritional management for people with Amyotrophic Lateral Sclerosis (ALS)

• Chief investigator: Professor Christopher McDermott, Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffield
• Funding body: National Institute for Health Research
• Status: Recruitment

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ORION

RadiO fRequency ablatION for haemorrhoids

• Chief investigator: Professor Steven Brown, Sheffield Teaching Hospitals
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Follow-up

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P

PRAISE

Pain Relief After Instrumented Spinal surgEry trial

• Chief investigator: Professor Matthew Wilson, University of Sheffield
• Funding body: NIHR Health Technology Assessment (HTA)

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PRAMS

Perinatal Redesign for Accessing Mental Health Services

• Chief investigator: Kelly Mackenzie
• Funding body: NIHR Three Schools Mental Health Programme
• Status: Set-up

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S

STAR MS

Autologous stem cell transplantation versus alemtuzumab or ocrelizumab in relapsing-remitting multiple sclerosis

• Chief investigator: Professor John Snowden, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: EME Programme
• Status: Recruitment

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STOP-OHSS

Shaping and Trialling Outpatient Protocols for Ovarian HyperStimulation Syndrome

• Chief investigator: Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment
• Status: Reporting

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StratCare-2

Evaluating the clinical and cost effectiveness of stratified care for depression

• Chief investigator: Professor Jaime Delgadillo, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment
• Status: Recruiting

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T

TRICEPS

TRanscutaneous lImb reCovEry Post-Stroke

• Chief investigator: Professor Arshad Majid, University of Sheffield
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
• Status: Recruitment

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