Current trials and studies

Completed trials and studies

To view all our finished projects, take a look at:

Completed trials and studies

A 

AWARE-IBD  

Working with patients to redesign hospital services for people with gut conditions like Crohn's Disease and Ulcerative Colitis (together known as Inflammatory Bowel Disease or IBD). 

• Chief investigator: Prof Alan Lobo, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: The Health Foundation
• Status: Analysis

AWARE-IBD Website

B

BASIS

Bracing Adolescent Idiopathic Scolio-SIS:

Comparing night-time bracing with full-time bracing in children and young people with adolescent idiopathic scoliosis.

• Chief investigator: Ashley Cole, Sheffield Children’s NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Recruitment

BASIS Website

C

CONTACT-GAD

A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder

• Chief investigator: Prof Rebecca Gould, University College London
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Recruitment

CONTACT-GAD Website

D

DAFNEplus

Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes

• Chief investigator: Prof Simon Heller, Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffield
• Funding body: NIHR Programme Grants for Applied Research (PGfAR)
• Status: Follow-up

DAFNEplus Website

DENIM

Delivering Effective Non-Invasive ventilation in Motor neuron disease:

The DENIM clinical trial focuses on improving Non-Invasive Ventilation (NIV) support for people living with Motor Neuron Disease (MND).

• Chief investigator: Dr Esther Hobson, University of Sheffield
• Funding body: NIHR Health and Social Care Delivery Research (HSDR) Programme
• Status: Recruitment

DENIM Website

DETECT-CRC

Early DETECTion of ColoRectal Cancer in Yorkshire (DETECT-CRC):

A feasibility study using pharmacies to help with active case finding of colorectal cancer in socio-economically deprived areas.

• Chief investigators: Dr Matthew Kurien, University of Sheffield, and Prof Dan Hind, University of Leeds
• Funding body: Yorkshire Cancer Research
• Status: Recruitment

DETECT-CRC Website

E

EXPERTS-ALS

EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis

• Chief investigators: Prof Christopher McDermott, University of Sheffield and Prof Martin Turner, University of Oxford
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
• Status: Recruitment

EXPERTS-ALS Website

F

FIRST

Flexor Injury Rehabilitation Splint Trial:

A pragmatic multi-centre randomised control trial (RCT) comparing splints following repair of finger flexor tendons.

• Chief investigator: Emma Bamford, Hand Therapist, Extended Scope Practitioner, Pulvertaft Hand Centre, Derby
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Follow-up

FIRST Website

H

Healthy weight management - grant development work

We plan to apply for research funding in January 2024. This work will inform the application. 

• Chief investigator: TBC
• Status: Recruitment

Healthy Weight Management (grant development work) Website

HELP Fertility?

What is the clinical and cost-effectiveness of hysteroscopic removal of submucosal fibroids and polyps in women presenting with infertility and recurrent miscarriage?

• Chief investigator: Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Analysis

HELP Fertility? Website

I

Improving time-critical assessments in Emergency Departments - grant development work

Developing a programme on improving early identification of emergency department patients who need time-critical treatment.

• Chief investigator: Prof Steve Goodacre, University of Sheffield
• Funding body: NIHR Programme Development Grants (PDG)
• Status: Set-up

Emergency Departments (grant development work) Website

M

MAP

Metformin and Psychosis Weight Prevention Trial (MAP)

Comparing metformin plus usual care with placebo plus usual care for preventing antipsychotic-induced weight gain in people experiencing their first episode of psychosis.

• Chief investigator: Dr Paul French, Pennine Care NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Set-up

MEErKAT

MEsenteric Excision and Kono-S Anastomosis Trial (MEErKAT):

This is a randomised control trial trying to find out which options are best for people having surgery for their Crohn's disease. We are testing whether a type of bowel connection (an anastomosis) called the 'Kono-S technique, or if the amount of mesentery removed during surgery can prevent people's Crohn's disease coming back.

• Chief investigator: Prof Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
• Status: Recruitment

MEErKAT Website

MIND

MedIcal studeNt mental health stuDy

• Chief investigator: Elena Sheldon, University of Sheffield
• Funding body: British Medical Association
• Status: Reporting

MIND Website

MissionEB

Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (EB).

• Chief investigator: Dr Anna Martinez, Great Ormond Street Hospital for Children NHS Foundation Trust
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme, NHS England and Cure EB
• Status: Reporting

MissionEB Website

O

OptiCALS

A programme to develop and evaluate a complex intervention to improve nutritional management for people with Amyotrophic Lateral Sclerosis (ALS)

• Chief investigator: Prof Christopher McDermott, University of Sheffield
• Funding body: NIHR Programme Grants for Applied Research (PGfAR)
• Status: Recruitment

OptiCALSWebsite

ORION

RadiO fRequency ablatION for haemorrhoids

• Chief investigator: Prof Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Follow-up

ORION Website

P

PRAISE

Pain Relief After Instrumented Spinal surgEry trial

• Chief investigator: ProfMatthew Wilson, University of Sheffield
• Funding body: NIHR Health Technology Assessment (HTA)

PRAISE Website

PRAMS

Perinatal Redesign for Accessing Mental Health Services

• Chief investigator: Dr Kelly Mackenzie
• Funding body: NIHR Three Schools Mental Health Programme
• Status: Set-up

PRAMS Website

PUMA

Person-centred Use of Music in residents living with dementia and Associated changes in behaviour in care homes (PUMA)

To determine if incorporating personalised music into care plans using the FITS (Focussed Intervention Training and Support) model reduces distress compared to standard practice without a systematic music intervention.

• Chief investigator: Prof Dan Hind, University of Leeds
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Set-up

S

STAR MS

Autologous stem cell transplantation versus alemtuzumab or ocrelizumab in relapsing-remitting multiple sclerosis

• Chief investigator: Prof John Snowden, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
• Status: Recruitment

STAR MS Website

STOP-OHSS

Shaping and Trialling Outpatient Protocols for Ovarian HyperStimulation Syndrome

• Chief investigator: Mostafa Metwally, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Reporting

STOP-OHSS Website

StratCare-2

Evaluating the clinical and cost effectiveness of stratified care for depression

• Chief investigator: Prof Jaime Delgadillo, Sheffield Teaching Hospitals NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Recruiting

StratCare-2 Website

T

TOTs

Treatment of Toddlers Fractures: Observation Or Immobilisation (TOTs)

To determine whether treating a toddler’s fracture without a cast is an appropriate alternative to immobilisation in terms of pain, convenience for the child and family, and value for money to the NHS.

• Chief investigator: Nicolas Nicolau, Sheffield Children’s NHS Foundation Trust
• Funding body: NIHR Health Technology Assessment (HTA)
• Status: Set-up

TRICEPS

TRanscutaneous lImb reCovEry Post-Stroke

• Chief investigator: Prof Arshad Majid, University of Sheffield
• Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
• Status: Recruitment

TRICEPS Website