Completed trials and studies
An alphabetical list of all completed trials and studies undertaken by the Clinical Trials Research Unit.
A
ACCESS (Methods project)
A collaborative study between CTUs and other researchers to identify the activities needed to improve representation of under-served groups in trials and understand their implementation.
- Chief investigator: Katie Biggs, University of Sheffield
- Funding body: NIHR
ACE (Methods project)
Adaptive designs CONSORT Extension
- Chief investigator: Dr. Munya Dimairo, University of Sheffield
- Funding body: National Institute for Health Research CTU Funding
ACUTE
(Use, Treatment Effect and Economics) feasibility study: A pilot randomised controlled trial of prehospital CPAP for acute respiratory failure.
- Chief investigator: Gordon Fuller, University of Sheffield
- Funding body: Health Technology Assessment
ASPECT
Alleviating Specific Phobias Experienced by Children Trial
- Chief investigator: Professor Barry Wright, Leeds and York Partnership NHS Foundation Trust
- Funding body: Health Technology Assessment
ASTIClite
Autologous Stem Cell Transplantation In refractory Crohn’s Disease – Low-Intensity Therapy Evaluation
- Chief investigator: Professor James Lindsay, Bart's Health NHS Trust
- Funding body: Efficacy and Mechanism Evaluation (EME) Programme
B
BEADS
BEhavioural Activation therapy for Depression after Stroke
- Chief investigator: Shirley Thomas, Division of Rehabilitation & Ageing, University of Nottingham
- Funding body: Health Technology Assessment
Big CACTUS
A study to assess the clinical and cost-effectiveness of aphasia computer treatment versus usual stimulation or attention control long-term post-stroke (CACTUS)
- Chief investigator: Dr Rebecca Palmer, Rehabilitation and Assistive Technology (RAT) group, ScHARR
- Funding body: Health Technology Assessment
Booster Trial
A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods
- Chief investigator: Professor Liddy Goyder, Public Health, ScHARR
- Funding body: Health Technology Assessment
BRAINS (Methods project)
Benefit-risk is a methodology used to simultaneously evaluate multiple aspects of a treatment, ie the effectiveness on the primary health outcome, safety and cost.
- Chief investigator: Professor Steven Julious, University of Sheffield
- Funding body: Medical Research Council
C
CACTUS
Computerised assisted language therapy pilot study
- Chief investigator: Dr Rebecca Palmer, Sheffield Teaching Hospitals
- Funding body: Research for Patient Benefit
CFHealthHub Data Observatory
- Chief investigator: Dr Martin Wildman, Sheffield Teaching Hospitals
- Funding body: NIHR Programme Grant for Applied Research
CFHealthHub Data Observatory summary
CFHealthHub RCT
Development and evaluation of an intervention to support adherence to treatment in adults with Cystic Fibrosis
- Chief investigator: Dr Martin Wildman, Sheffield Teaching Hospitals
- Funding body: NIHR Programme Grant for Applied Research
CoSMoS
CBT Software for the treatment of depression in people with MS
- Chief investigator: Dr Cindy Cooper, CTRU
- Funding body: MS Society Symptom Relief Research Initiative
D
DAVROS
Development and validation of risk-adjusted outcomes for systems of emergency medical care
- Chief investigator: Prof Steve Goodacre, MCRU Emergency & Immediate Care, ScHARR
- Funding body: Medical Research Council
DIAMOND (Methods project)
Development of generalisable methodology for n-of-1 trials delivery for very low volume treatments.
- Chief investigator: Liv Hawksworth, Research Assistant, Sheffield Clinical Trials Research Unit)
- Funding body: NIHR CTU Support Funding
DiPALS
A Randomised Controlled Trial Evaluating NeuRx/4 Diaphragm Pacing in Patients with Respiratory Muscle Weakness Due to Motor Neurone Disease
- Chief investigator: Dr Chris McDermott, Sheffield Institute of Translational Neuroscience
- Funding body: NIHR Health Technology Assessment
DiPEP
Diagnosis of Pulmonary Embolism in Pregnancy
- Chief investigator: Prof Steve Goodacre, University of Sheffield
- Funding body: Health Technology Assessment
E
ENACT (Methods project)
EcoNomics of Adaptive Clinical Trials
- Chief investigator: Laura Flight, University of Sheffield
- Funding body: NIHR CTU Support Funding (2019 call)
The Endometrial Scratch Trial
The Endometrial Scratch Trial
- Chief investigator: Mostafa Metwally, Sheffield Teaching Hospital
- Funding body: Health Technology Assessment
Equality, Diversity and Inclusion (EDI) in early phase trials (Methods project)
- Chief investigator: Mostafa Metwally, Sheffield Teaching Hospital
- Funding body: Health Technology Assessment
E-SEE
Enhancing Social-Emotional Health and Wellbeing in the Early Years: A Community-based Randomised Controlled Trial (and Economic) Evaluation of the Incredible Years Infant and Toddler (0-2) Parenting Programmes
- Chief investigator: Dr Tracey Bywater, Institute for Effective Education, University of York
- Funding body: National Institute for Health Research
H
HubBLe
Haemorrhoidal Artery Ligation (HAL) versus Rubber Band Ligation (RBL) for haemorrhoids
- Chief investigator: Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust
- Funding body: Health Technology Assessment
Hydro-DMD
Hydrotherapy for Duchenne Muscular Dystrophy (DMD): a pilot and feasibility randomised controlled trial in children
- Chief investigator: Dr Peter Baxter, Sheffield Children's NHS Foundation Trust
- Funding body: Health Technology Assessment
I
I-Socialise
Investigating SOcial Competence and Isolation in children with Autism taking part in LEGO-based therapy clubs In School Environments
- Chief investigator: Prof Barry Wright, University of York
- Funding body: NIHR Public Health Research Programme
J
JtD: Journeying Through Dementia
- Chief investigator: Professor Gail Mountain, University of Bradford
- Funding body: Health Technology Assessment
L
Learning from COVID-19 Efficient Trial Adaptations (Methods project)
- Chief investigator: Robin Chatters, University of Sheffield
- Funding body: NIHR CTU Support Funding
Lifestyle Matters
- Chief investigator: Professor Gail Mountain, ScHARR, The University of Sheffield
- Funding body: Medical Research Council
M
MAGIC
Melatonin for Anxiety prior to General anaesthesia In Children
- Chief investigator: Professor Chris Deery, School of Clinical Dentistry
- Funding body: Health Technology Assessment
MERIDIAN
Magnetic Resonance Imaging to Enhance the Diagnosis of Fetal Development Brain Abnormalities In Utero
- Chief investigator: Professor Paul Griffiths, Academic Unit of Radiology, The University of Sheffield
- Funding body: NIHR Health Technology Assessment
MG
(3MG - Magnesium sulphate for treatment of severe acute asthma).
- Chief investigator: Professor Steve Goodacre, MCRU Emergency & Immediate Care
- Funding body: Health Technology Assessment
O
OPTION-DM
Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus trial
- Chief investigator: Professor Solomon Tesfaye, Sheffield Teaching Hospitals
- Funding body: NIHR Health Technology Assessment
P
PANDA (Methods project)
A Practical Adaptive and Novel Designs Toolkit (PANDA)
- Chief investigator: Prof Steve Goodacre, University of Sheffield
- Funding body: NIHR Health Technology Assessment
PHEWS
(Pre-Hospital Early Warning scores for Sepsis) Accuracy, impact and cost-effectiveness of pre-hospital clinical early warning scores for adults with suspected sepsis
- Chief investigator: Prof Steve Goodacre, University of Sheffield
- Funding body: NIHR Health Technology Assessment
PITSTOP
PIlonidal sinus Treatment: STudying the OPtions
- Chief investigator: Professor Steven Brown, Sheffield Teaching Hospitals
- Funding body: NIHR Health Technology Assessment
PLEASANT
Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term
- Chief investigator: Prof Steven Julious, ScHARR, The University of Sheffield
- Funding body: NIHR Health Technology Assessment
PLINY
(Putting Life in Years): Evaluation of the Comparative Effectiveness and Cost Effectiveness of an Intervention to Promote Mental Wellbeing in Community Living Older People
- Chief investigator: Prof Gail Mountain, Health Services Research, ScHARR
- Funding body: NIHR Public Health Research Programme
PoPSTER
Patient preferences and current Practice for adults with STERoid-resistant ulcerative colitis
- Chief investigator: Professor Alan Lobo, Sheffield Teaching Hospitals NHS Foundation Trust
- Funding body: NIHR Health Technology Assessment
PRACTICE
Pulmonary Rehabilitation and ACTIvity after COPD Exacerbations
- Chief investigator: Dr Rodney Hughes, Sheffield Teaching Hospitals NHS Foundation Trust
- Funding body: Health Technology Assessment
PRIEST
Pandemic Respiratory Infection Emergency System Triage
- Chief investigator: Professor Steve Goodacre, University of Sheffield
- Funding body: NIHR Health Technology Assessment
R
REEACT
The randomised evaluation of the effectiveness and acceptability of computerised therapy.
- Chief investigator: Dr Simon Gilbody, University of York
- Funding body: Health Technology Assessment
REPOSE
The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 Diabetes
- Chief investigator: Professor Simon Heller, School of Medicine, The University of Sheffield
- Funding body: Health Technology Assessment
S
SABRE
Hypertonic Saline in Acute Bronchiolitis: A Randomised Controlled Trial and Economic Evaluation
- Chief investigator: Kelechi Ugonna, Sheffield Children's Hospital
- Funding body: Health Technology Assessment
STEPWISE
STructured Education for People WIth SchizophrEnia
- Chief investigator: Professor Richard Holt, University of Southampton
- Funding body: Health Technology Assessment
T
TABUL
(The role of ultrasound compared to biopsy of tempural arteries in the diagnosis and treatment of giant cell arteritis)
- Chief investigator: Dr Raashid Luqmani, University of Oxford
- Funding body: Health Technology Assessment
V
VTEAM
Venous Thromboembolism Assessment Model Study: The cost-effectiveness of venous thromboembolism risk assessment tools for hospital inpatients
- Chief investigator: Prof Steve Goodacre, University of Sheffield
- Funding body: NIHR Health Technology Assessment