Three new grants to support nucleic acid and DNA repair studies

Flapped DNAThree new grants have recently been awarded to staff in our Chemical Biology research cluster, who are working on nucleic acid chemistry and the secrets of DNA replication and repair.

Dr David Williams has been awarded a Marie Curie Incoming Fellowship, to bring an international researcher to work in Sheffield on the detection and characterisation of O6-alkylguanine adducts in DNA. Understanding alkylation damage of DNA is important because alkylated DNA is mutagenic if not repaired, leading to diseases such as cancer.

Professor Jane Grasby, Dr Tim Craggs, Professor Jon Waltho and Dr David Finger have been awarded £480,000 from the BBSRC to study the conformational properties of two-way junction DNAs.

In this project, the researchers intend to characterise the dynamic properties of the junction DNAs that are formed during DNA replication and as a result of DNA damage. They will investigate whether the conformational flexibility of these DNAs is what marks them out for processing by DNA repair enzymes.

Finally, Dr David Williams has been awarded a collaborative £500,000 Multidisciplinary Grant from Cancer Research UK and the Engineering and Physical Sciences Research Council. He'll work with Professor Nick Williams, plus Dr Andy Povey, Professor Perdita Barran and Professor Geoff Margison at the University of Manchester on the identification and nucleotide resolution mapping of alkyl adducts in human DNA.

Chemical Biology