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ABOUT

About

Building tissues and organs require cells to perform dynamic processes involving changes in their mechanical properties. Recent advances in the study of cellular processes regulating growth development, adhesion, and migration, show a significant transition towards interdisciplinary research at the interface of cell biology, physics and engineering. The aim of the school ’’Mechanobiology of polarized cells’’ is to focus on how intrinsic physical properties of cells and environment govern cellular behaviour. In particular, the series of lectures will provide an extraordinary number of new insights into the specific relation between environmental sensing and signal transduction, membrane tension and cellular properties/activities like cell volume, endocytosis or signalling as well as force generation and tissue formation. A few talks will decipher more technical aspects presenting recent advances in methods to measure cell stiffness and single-molecule mechanics.

FIND OUT MORE

Registration and payment deadline

2 March 2018

REGISTER NOW!



Abstract submission deadline

2 March 2018

SUBMIT NOW!

SPEAKERS

Speakers

Cecile Perrault

University of Sheffield, UK

Christophe Lamaze

Insitut Curie, Paris, France

Christophe Leterrier

Aix-Marseille University, France

Elizabeth Smythe

University of Sheffield, UK

Ewa Paluch

UCL, UK

Guillaume Salbreux

The Francis Crick Institute, London, UK

Henriëtte Lanz

MIMETAS, The Netherlands

Jochen Guck

BIOTEC, Dresden, Germany

Jorge Alegre-Cebollada

CNIC, Madrid, Spain

Kai Erdmann

University of Sheffield, UK

Kevin Chalut

University of Cambridge, UK

Maria Montoya Sánchez

CNIC, Madrid, Spain

Miguel Ángel del Pozo Barriuso

CNIC, Madrid, Spain

Pere Roca-Cusachs Soulere

IBEC, Barcelona, Spain

Pietro Cicuta

University of Cambridge, UK

Torsten Müller

JPK Instruments, Berlin, Germany

Ulrich Schwarz

University of Heidelberg, Germany

PROGRAM

Program

*Please note that program is subject to change.

Day 1 - 8 April 2018

15:00          ARRIVAL/REGISTRATION OPENS

19:30          DINNER

Day 2 - 9 April 2018

7:45            BREAKFAST

9:00            KAI ERDMANN: Life sciences at the intersection of cell biology and physics

10:00          PERE ROCA-CUSACHS: Role and mechanism of rigidity sensing

11:00          COFFEE BREAK

11:30          ULRICH SCHWARZ: Modelling cell spreading on micropatterned substrates

12:30          LUNCH

14:00          MIGUEL ÁNGEL DEL POZO: Cell mechanoadaptation and tissue stiffening in health and disease

15:00          CECILE PERRAULT: Flow-mechanotransduction and its role in cardiovascular disease

16:00          COFFEE BREAK

16:30          HENRIËTTE LANZ: High throughput microfluidic tissue models 

17:30          NETWORKING/FREE TIME

19:30          DINNER

Day 3 - 10 April 2018

7:45            BREAKFAST

9:00            TORSTEN MÜLLER: Optical tweezers combined with Atomic Force Microscopy - Investigating cell reactions to mechanical and biochemical stimuli    

10:00          JORGE ALEGRE-CEBOLLADA: Latest advances in protein mechanics by single-molecule methods

11:00          COFFEE BREAK

11:30          PIETRO CICUTA: Mechanical coupling in tissues with motile cilia: fluid dynamics and physics

12:30          LUNCH

13:45          ITN-BIOPOL FELLOWS presentations

16:15          COFFEE BREAK

16:30          POSTER SESSION I

18:00          Small group discussion rounds on mechanobiology topics

19:30          DINNER

Day 4 - 11 April 2018

7:45            BREAKFAST

9:00            CHRISTOPHE LAMAZE: Caveolae and nanodomains: Role in signalling and cancer mechanotransduction

10:00          ELIZABETH SMYTHE: How do endocytic nano domains regulate intracellular trafficking?

11:00          COFFEE BREAK

11:30          JOCHEN GUCK: Methods to measure cell stiffness - past, present and future

12:30          LUNCH

14:00          EXCURSION/FREE TIME

19:30          DINNER

Day 5 - 12 April 2018

7:45            BREAKFAST

9:00            KEVIN CHALUT: Mechanics and transitions in cell fate choice

10:00          MARIA MONTOYA SÁNCHEZ: Engineering mechanically relevant cell-based assays for drug screening

11:00          COFFEE BREAK

11:30          GUILLAUME SALBREUX: Epithelial flows and folds

12:30          LUNCH

13:45          ITN-BIOPOL FELLOWS presentations

15:45          External talk

16:15          COFFEE BREAK

16:30          POSTER SESSION II

18:00          Small group discussion rounds on mechanobiology topics

19:30          DINNER

Day 6 - 13 April 2018

7:45            BREAKFAST

9:00            EWA PALUCH: Cell morphogenesis across scales: from molecular processes to cell-scale mechanics

10:00          CHRISTOPHE LETERRIER: The neuronal cytoskeleton revealed by cellular imaging

11:00          COFFEE BREAK AND NETWORKING

12:30          LUNCH

15:00          DEPARTURE

REGISTRATION

Registration 

Registration and payment deadline

2 MARCH 2018

Register and pay online by credit/debit card via The University of Sheffield’s Online Store. You will receive an email confirmation of your payment (once the credit/debit card payment has been successfully processed).

ONLINE REGISTRATION AND PAYMENT

fee summer school

 Registration includes:

  • full access to course materials
  • accommodation (single room with own bathroom/toilet: towels, shampoo, soap, shower gel and hair-dryer are provided)
  • three meals a day (breakfast, lunch, dinner)

Special requirements will need to be arranged separately (email us).




Abstract submission deadline:

2 MARCH 2018

Every applicant can submit an abstract. There is a limit of 40 posters to be presented during two poster sessions (20 posters/session). In case the limit of attendees will be exceeded, abstracts will be selected based on relevance and scientific excellence.

Abstracts are limited to 200-250 words (excluding title and author information). We recommend posters A0 size in portait orientation.

ABSTRACT SUBMISSION

CONTACT US

Contact

General enquires:

Dr Agnieszka Skowronek

biopol.summerschool@sheffield.ac.uk

tel.: +44 (0)114 222 2364


Summer school organizers:

Dr Kai Erdmann

k.erdmann@sheffield.ac.uk

tel.: +44 (0)114 222 4698



Dr Agnieszka Skowronek

a.skowronek@sheffield.ac.uk

tel.: +44 (0)114 222 2364

ABOUT LES HOUCHES

Les Houches

Les Houches is a village located in Chamonix valley, in the French Alps. Established in 1951, the Physics School is situated at 1150 m above sea level in natural surroundings, with breathtaking views on the Mont-Blanc mountain range. Les Houches Physics School is funded by Université Grenoble Alpes, Grenoble-INP, ENS Lyon, CNRS and CEA.

Ecole de Physique des Houches, Côte des Chavants, F-74310 Les Houches, France.

Click here to learn more about the school, including practical information on travel, stay, facilities, etc…


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