Dr Nicola Green
PhD FRMS
Bioengineering
Department of Materials Science and Engineering
Senior Lecturer in Bioengineering
Course Director for Bioengineering
+44 114 222 3932
Full contact details
Bioengineering
North Campus
Broad Lane
Sheffield
S3 7HQ
- Profile
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Nicola is a Senior Lecturer in Bioengineering. She obtained her first degree from the University of Nottingham and her PhD from the University of Kent. She has worked as a Research Fellow at the University of Nottingham, in the Laboratory of Biophysics and Surface Analysis, and as a Senior Scientist in a Nottingham University biomedical spin-off company.
She joined the department in 2006 as a postdoctoral researcher, before taking charge of the Kroto Imaging Facility as Experimental Officer in 2010. She was appointed as Lecturer in Bioengineering in 2019 and Senior Lecturer in 2022.
- Qualifications
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1998 PhD – Biotechnology, University of Kent
1992 – BSc Hons Biochemistry and Genetics, Nottingham University
- Research interests
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Nicola’s interdisciplinary research focuses biomaterials and tissue engineering. Her portfolio can be divided into three key areas
Biohybrid scaffolds for tissue engineering: Scaffolds which incorporate biological components into synthetic scaffolds combine benefits from both and have significant clinical potential. This research seeks to optimise the composition and manufacture of these scaffolds to create tuneable scaffolds with enhanced cellular responses and reduced immunogenicity.
Improved in vitro models: The development and use of in vitro 3D models for improved drug discovery and to more reliably model disease progression including cancer invasion and metastasis, wound healing, and the musculoskeletal system.
Imaging of biomaterials and tissues: Development and application of non-invasive imagine techniques to better characterise biomaterials and the cellular response.
- Publications
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Journal articles
- Porous biomaterials for tissue engineering: a review. Journal of Materials Chemistry B.
- Electrospun fiber alignment guides osteogenesis and matrix organization differentially in two different osteogenic cell types. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
- In vitro low-fluence photodynamic therapy parameter screening using 3D tumor spheroids shows that fractionated light treatments enhance phototoxicity. ACS Biomaterials Science & Engineering. View this article in WRRO
- Identifying and mapping chemical bonding within phenolic resin using Secondary Electron Hyperspectral Imaging. Polymer Chemistry. View this article in WRRO
- Characterizing cross‐linking within polymeric biomaterials in the SEM by secondary electron hyperspectral imaging. Macromolecular Rapid Communications, 41(3). View this article in WRRO
- Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging. Chemical Communications. View this article in WRRO
- Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis. APL Bioengineering. View this article in WRRO
- Measurement of friction-induced changes in pig aorta fibre organization by non-invasive imaging as a model for detecting the tissue response to endovascular catheters. Biotribology, 12, 24-32. View this article in WRRO
- Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles.. Chemical Communications, 53, 12672-12675. View this article in WRRO
- A new mode of contrast in biological second harmonic generation microscopy. Scientific Reports, 7. View this article in WRRO
- Oxygen Mapping of Melanoma Spheroids using Small Molecule Platinum Probe and Phosphorescence Lifetime Imaging Microscopy.. Scientific Reports, 7. View this article in WRRO
- Poly(n-butyl Methacrylate) with Primary Amine End Groups for Supporting Cell Adhesion and Proliferation of Renal Epithelial Cells. International Journal of Polymeric Materials and Polymeric Biomaterials. View this article in WRRO
- Second Harmonic Generation microscopy reveals collagen fibres are more organised in the cervix of postmenopausal women. Reproductive Biology and Endocrinology, 14. View this article in WRRO
- Creating a model of diseased artery damage and failure from healthy porcine aorta. Journal of the Mechanical Behavior of Biomedical Materials, 60, 378-393. View this article in WRRO
- Production and Characterization of a Novel,
Electrospun, Tri-Layer Polycaprolactone Membrane
for the Segregated Co-Culture of Bone and Soft Tissue. Polymers, 8(6), 221-229. View this article in WRRO
- Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. Applied Spectroscopy Reviews, 51(4), 243-257. View this article in WRRO
- Developing repair materials for stress urinary incontinence to withstand dynamic distension. PLoS One, 11(3). View this article in WRRO
- Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials, 54, 159-172. View this article in WRRO
- Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6, 7974-7987. View this article in WRRO
- Rocking Media Over Ex Vivo Corneas Improves This Model and Allows the Study of the Effect of Proinflammatory Cytokines on Wound Healing. Investigative Ophthalmology & Visual Science, 56(3), 1553-1561. View this article in WRRO
- Characterisation of the Physical Composition and Microbial Community Structure of Biofilms within a Model Full-Scale Drinking Water Distribution System. PLOS ONE, 10(2), e0115824-e0115824. View this article in WRRO
- Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa. International Journal of Experimental Pathology, 95(3), 216-228. View this article in WRRO
- Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA.. Angew Chem Int Ed Engl, 53(13), 3367-3371. View this article in WRRO
- Monitoring fibrous scaffold guidance of three-dimensional collagen organisation using minimally-invasive second harmonic generation.. PLoS One, 9(2), e89761. View this article in WRRO
- NF-κB is activated in oesophageal fibroblasts in response to a paracrine signal generated by acid-exposed primary oesophageal squamous cells.. Int J Exp Pathol, 92(5), 345-356. View this article in WRRO
- The development and characterization of an organotypic tissue-engineered human esophageal mucosal model.. Tissue Eng Part A, 16(3), 1053-1064. View this article in WRRO
- The glycosylation of recombinant human interferon-gamma in Chinese hamster ovary cells..
Chapters
- Fluorescence Microscopy, Optical Techniques in Regenerative Medicine (pp. 29-59).
- Fluorescence Microscopy In Morgan S, Rose FR & Matcher SJ (Ed.), Optical Techniques in Regenerative Medicine (pp. 29-59). Boca Raton: Taylor & Francis.
Conference proceedings papers
- Enhanced Collagen Production from Human Dermal Fibroblasts on Poly(glycerol sebacate)-methacrylate Scaffolds. 2018 11th Biomedical Engineering International Conference (BMEiCON), 21 November 2018 - 24 November 2018. View this article in WRRO
- The Use of Second-Harmonic-Generation (SHG) to Assess the Impact of Menopause on the Orientation of Collagen Fibres in the Human Cervix.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 214A-214A)
- Collagen and Mineral Deposition by MLO-A5 Late-Stage Osteoblasts, is Guided by the Fibre Alignment of Electrospun Scaffolds. Proceedings of the 22nd Congress of the European Society of Biomechanics, 10 July 2016 - 13 July 2016.
- Optical measurement of oxygen concentration in melanoma spheroid and skin engineered models. European Cells and Materials (ECM), Vol. Collection 5 (pp 8-8)
- Highly Porous Particles for Cell Recruitment and Delivery in Bone Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 21 (pp S287-S288)
- Barrett's Metaplasia: Exploiting a Tissue-engineered Model to Understand the Response of the Oesophageal Squamous Mucosa to Bile and Acid Exposure. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Visualising and quantifying the matrix of drinking water biofilms. IWA Biofilms 2011. Shanghai, China, 27 October 2011 - 30 October 2011.
- Invasive behaviour of the OE33 oesophageal adenocarcinoma cell line is dependent on co-operation with fibroblasts.. JOURNAL OF PATHOLOGY, Vol. 222 (pp S43-S43)
- Taurochenodeoxycholic acid activates NF-KB in oesophageal squamous cells without accompanying loss in cell viability. Journal of Pathology, Vol. 220(S1) (pp S11-S11)
- Porous biomaterials for tissue engineering: a review. Journal of Materials Chemistry B.
- Research group
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PhD students
Main Supervisor
- Jeerawan Thanarak
- Meghna Suvarna
Co-supervisor
- Samuel Higginbotham
- Tugba Cebe
- Alice Hann
- Boyang Liu
- Abigail Smith
- Mina Aleemardani
- Jonathan Hinchliffe
- Caitlin Jackson
- Grants
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- Multi-materials additive manufacturing for musculoskeletal applications (principal investigator, Royal Society International Exchanges, £12,000)
- Reversing skin contraction in paediatric burns patients (co-investigator, Sheffield Hospitals Charity, £426,288)
- Transforming metalorganic frameworks promoted bone regeneration through secondary electron hyperspectral imaging (co-investigator, Newton Mobility Grant, £11,930)
- Teaching interests
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Nicola contributes to learning and teaching within the Department of Materials Science and Engineering and the Faculty of Engineering. She teaches on a number of modules based on her research interests which are taken by both Bioengineering in Interdisciplinary Engineering, and Materials Science and Engineering students.
- Teaching activities
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- Biology and Chemistry of Living Systems II (MAT2530)
- Bioimaging (MAT408/6311, Module lead) - fourth year/MSc module.
She also is module lead for BIE103 and BIE201, two courses taken by Bioengineering students which demonstrate the breadth of the Bioengineering field and introduce students to key technical, practical and professional skills within Bioengineering.