Professor Christopher Newman
MA, PhD, FRCP
Department of Infection, Immunity and Cardiovascular Disease
Professor of Clinical Cardiology
Honorary Consultant Cardiologist
Dean of the Medical School
C.Newman@sheffield.ac.uk
+44 114 215 9529
+44 114 215 9529
+44 114 271 3194
(CRF Office)
+44 114 222 8714
(PA - Laura Haslam)
The Medical School
Full contact details
Professor Christopher Newman
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact – iicd-operational@sheffield.ac.uk
I joined the University in 1995 following an MRC Clinician Scientist Fellowship spent at the National Institute for Medical Research and Royal Postgraduate Medical School (1989-1992) and University of Cambridge (1992-1995).
I was appointed as Director of the Clinical Research Facility in 2004, a joint initiative between the University and Sheffield Teaching Hospitals NHS Foundation Trust.
The NIHR Sheffield CRF has units both at the Royal Hallamshire Hospital and Northern General Hospital.
- Research interests
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My main research interest is in non-viral gene delivery, particularly the use of high frequency ultrasound to promote plasmid-mediated vascular gene delivery.
I also have interests in site specific targeting of gene therapy vectors, the vascular biology of pulmonary hypertension, the pathophysiology of sudden death in young diabetics, new approaches to the analysis of gene expression in acute coronary syndromes and links between the pathobiology of osteoporosis and cardiovascular disease.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.. J Exp Med, 209(11), 1919-1935. View this article in WRRO
- Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.. Pulm Circ, 2(1), 21-27. View this article in WRRO
- Rate-dependent measures of repolarization predict inducibility of ventricular arrhythmias.. Europace, 12(4), 553-560.
- P-selectin dependent targeting to inflamed endothelium of recombinant P-selectin glycoprotein ligand-1 immunoglobulin chimera-coated poly[N-(2-hydroxypropyl) methacrylamide]-DNA polyplexes in vivo visualised by intravital microscopy.. J Gene Med, 11(4), 326-334.
- Effects of sumatriptan and eletriptan on diseased epicardial coronary arteries.. Eur J Clin Pharmacol, 61(10), 733-742.
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.. Gene Ther, 12(14), 1154-1157.
- VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection.. J Gene Med, 7(3), 375-385.
- Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
All publications
Journal articles
- A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nature Communications, 10(1). View this article in WRRO
- Type I collagen degradation during tissue repair: Comparison of mechanisms following fracture and acute coronary syndromes. Bone, 69, 1-5.
- Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.. J Exp Med, 209(11), 1919-1935. View this article in WRRO
- Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.. Pulm Circ, 2(1), 21-27. View this article in WRRO
- Heart drugs that affect bone. Trends in Endocrinology & Metabolism, 23(4), 163-168.
- Cardiovascular disease and bone. Archives of Biochemistry and Biophysics, 503(1), 78-83.
- Rate-dependent measures of repolarization predict inducibility of ventricular arrhythmias.. Europace, 12(4), 553-560.
- P-selectin dependent targeting to inflamed endothelium of recombinant P-selectin glycoprotein ligand-1 immunoglobulin chimera-coated poly[N-(2-hydroxypropyl) methacrylamide]-DNA polyplexes in vivo visualised by intravital microscopy.. J Gene Med, 11(4), 326-334.
- Evidence of a Role for Osteoprotegerin in the Pathogenesis of Pulmonary Arterial Hypertension. The American Journal of Pathology, 172(1), 256-264.
- The effects of ultrasound on polymer-mediated gene transfer in vitro. INTERNATIONAL JOURNAL OF CARDIOLOGY, 122, 49-50.
- Gene therapy progress and prospects: ultrasound for gene transfer.. Gene Ther, 14(6), 465-475.
- Targeting drug-eluting stents to lesions at high risk of restenosis: a flawed approach?. Heart, 93, 251-252.
- Effects of sumatriptan and eletriptan on diseased epicardial coronary arteries.. Eur J Clin Pharmacol, 61(10), 733-742.
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.. Gene Ther, 12(14), 1154-1157.
- VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection.. J Gene Med, 7(3), 375-385.
- Influence of Autonomic Neuropathy on QTc Interval Lengthening During Hypoglycemia in Type 1 Diabetes. Diabetes, 53(6), 1535-1542.
- Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
- Nonviral gene delivery: techniques and implications for molecular medicine. Expert Reviews in Molecular Medicine, 5(22), 1-15.
- Preventing saphenous vein graft failure: does gene therapy have a role?. The Annals of Thoracic Surgery, 76(3), 959-966.
- National audit of myocardial infarction project. Journal of Clinical Excellence, 4(4), 375.
- Mechanisms of Abnormal Cardiac Repolarization During Insulin-Induced Hypoglycemia. Diabetes, 52(6), 1469-1474.
- Drug eluting stents: maximising benefit and minimising cost.. Heart, 89(2), 127-131.
- Intercellular Trafficking of Vp22 Fusion Proteins to Enhance the Effects of Vascular Gene Delivery. Clinical Science, 103(s47), 14P-14P.
- National service framework for coronary heart disease: audit of English hospitals. BMJ, 324(7339), 709-709.
- Clinical experience of amiodarone-induced thyrotoxicosis over a 3-year period: role of colour-flow Doppler sonography.. Clin Endocrinol (Oxf), 56(1), 33-38.
- Ultrasound gene therapy: on the road from concept to reality.. Echocardiography, 18(4), 339-347.
- Microbubble-enhanced ultrasound for vascular gene delivery.. Gene Ther, 7(23), 2023-2027.
- Small stent, small vessel is not equivalent to standard stent, standard vessel.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Effects of arterial taper upon in-stent restenosis in very small coronary vessels.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 117I-117I.
- Are we achieving intended dimensions in stenting very small coronary arteries?. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
- Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro.. Circulation, 99(20), 2617-2620.
- Efficient extraction of RNA from vascular tissue.. Methods Mol Med, 30, 39-46.
- Intravascular stents: a new technique for tissue processing for histology, immunohistochemistry, and transmission electron microscopy.. Heart, 80(5), 509-516.
- Overlapping stents: No alteration in neointima formation.. CIRCULATION, 98(17), 189-189.
- Apoptosis and cell proliferation after porcine coronary angioplasty.. Circulation, 98(16), 1657-1665.
- Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 68S-68S.
- Assessment of the safety and efficacy of supersaturated oxygen solution: A novel method of reducing myocardial ischaemia in PTCA.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 100S-100S.
- 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
- Apoptosis and Cell Proliferation Following Porcine Angioplasty. Journal of the American College of Cardiology, 31(2), 22A-22A.
- Phosporylcholine Coated Stents: Angiographic and Morphometric Assessment in Porcine Coronary Arteries. Journal of the American College of Cardiology, 31(2), 414A-414A.
- Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
- Amiodarone and the thyroid: a practical guide to the management of thyroid dysfunction induced by amiodarone therapy.. Heart, 79(2), 121-127.
- The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
- Trifluoromethanesulfonic Acid, an Efficient Catalyst for the Hetero Diels-Alder Reaction and an Improved Synthesis of Mefrosol.. Tetrahedron Letters, 38(14), 2569-2572.
- The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty.. Circ Res, 80(4), 520-531.
- In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
- Osteopontin Is Not a Marker for Proliferating Human Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 15, 2010-2018.
- Processing of the Small GTP-Binding Protein SpYPT1P in Schizosaccharomyces pombe and in Mammalian COS Cells. Biochemical and Biophysical Research Communications, 192(3), 983-990.
- Capsaicin induced afferent denervation and receptor-linked responses to CGRP in the rat. Regulatory Peptides, 44(1), 61-69.
- A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Biochem J, 291 ( Pt 2), 349-353.
- Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants. Journal of Biological Chemistry, 268, 24467-24474.
- Inhibition in the rat of nitric oxide synthesis in vivo does not attenuate the hypotensive action of acetylcholine, ATP or bradykinin. Experimental Physiology, 77, 285-292.
- Post-translational processing of Schizosaccharomyces pombe YPT proteins. Journal of Biological Chemistry, 267, 11329-11336.
- Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol, 66, 1070-1076.
- Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L- but not N-acetyl-D-cysteine. Br J Pharmacol, 99, 825-829.
- Cardiac catheterization as an outpatient procedure. BMJ, 298, 1310.
- Enalapril for severe heart failure in infancy. Arch Dis Child, 64, 219-223.
- The importance of bradykinin and histamine in the skin response to antigen. Br J Clin Pharmacol, 26, 803-805.
Conference proceedings papers
- Tumour necrosis factor-related apoptosis-inducing ligand is a novel therapeutic target in pulmonary arterial hypertension. The Lancet, Vol. 381 (pp S47-S47)
- 03 Tissue Trail Drives Pulmonary Vascular Remodeling and its Inhibition Reverses Experimental Pulmonary Arterial Hypertension. Heart, Vol. 98(Suppl 3) (pp A1.3-A1)
- TYPE I COLLAGEN DEGRADATION DURING TISSUE REPAIR: COMPARISON OF MECHANISMS FOLLOWING FRACTURE AND MYOCARDIAL INFARCTION. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S580-S581)
- Type I collagen degradation during tissue repair: Comparison of mechanisms following fracture and myocardial infarction. Bone, Vol. 50 (pp S119-S119)
- Osteoprotegerin Blockade Prevents And Reverses Experimental Pulmonary Arterial Hypertension. D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
- S69 Serum osteoprotegerin predicts mortality in a prospective study on incident cases of pulmonary arterial hypertension. Thorax, Vol. 66(Suppl 4) (pp A34-A34)
- T6 TRAIL is a potential novel therapeutic target in pulmonary arterial hypertension. Thorax, Vol. 66(Suppl 4) (pp A3-A3)
- Beneficial Effects Of Inhibiting Trail In Monocrotaline-Induced Experimental Pulmonary Hypertension. B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
- S151 TRAIL deficiency is protective in experimental pulmonary arterial hypertension. Thorax, Vol. 65(Suppl 4) (pp A68-A68)
- TRAIL EXPRESSION IS INCREASED IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A8-A8)
- OSTEOPROTEGERIN/TUMOUR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND PATHWAY: A POTENTIAL BIOMARKER FOR PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A58-A59)
- OSTEOPROTEGERIN EXPRESSION IS INCREASED PRIOR TO HAEMODYNAMIC ALTERATIONS IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A9-A9)
- REGULATION OF EXPRESSION AND FUNCTION OF OSTEOPROTEGERIN IN PULMONARY ARTERY SMOOTH MUSCLE CELLS IN VITRO. THORAX, Vol. 64 (pp A9-A9)
- OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
- Investigating Cardiac Autonomic Neuropathy and Sudden Death. The Effect of Neuropathy on Abnormal Cardiac Repolarisation during Sympatho-Adrenal Activation in Type 1 Diabetes. DIABETES, Vol. 58 (pp A170-A170)
- THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
- A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
- A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
- Osteoprotegerin is up-regulated by BMP-R2 RNA-interference and induces proliferation and migration of human pulmonary artery smooth cells in vitro. Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
- The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98)
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
- Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
- Modulation of non-viral vascular gene delivery by VP22-mediated intercellular protein transport. ATHEROSCLEROSIS, Vol. 169(1) (pp 200-201)
- Enhancing the effective efficiency of non-viral vascular gene transfer by intercellular trafficking of VP22 fusion proteins. HEART, Vol. 89 (pp A16-A16)
- Highly efficient bystander effect and intercellular trafficking of VP22-tghymidine kinase fusion proteins following non-viral transfection in vascular cells. CIRCULATION, Vol. 106(19) (pp 269-269)
- Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H)
- Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H)
- Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUROPEAN HEART JOURNAL, Vol. 22 (pp 3-3)
- Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
- High frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
- Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
- Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.. J Exp Med, 209(11), 1919-1935. View this article in WRRO
- Teaching activities
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I organise and deliver teaching within modules of the undergraduate medical student curriculum. I teach on courses related to the ethics and governance of clinical research.