Dr Gordon Sloan
MBChB, PhD
School of Medicine and Population Health
NIHR Clinical Lecturer in Diabetes and Endocrinology
Full contact details
School of Medicine and Population Health
Room FU32, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I am a clinical scientist, with a specialist interest in the field of neurological complications of diabetes mellitus.
I completed my undergraduate training at the University of Sheffield in 2011. During this training I completed an intercalated BMedSci where I developed an interest in research. I then undertook clinical training in South Yorkshire, and commenced specialist training in Diabetes and Endocrinology in 2015. I commenced a Clinical Research Fellowship at Sheffield Teaching Hospitals NHS Foundation Trust in 2017 and defended my PhD in 2022, which was entitled ‘Central Biomarkers of Painful Diabetic Peripheral Neuropathy’. Since 2022 I have been a NIHR Academic Clinical Lecturer working in the Division of Clinical Medicine.
- Research interests
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My research interests lie in developing a greater understanding of the mechanisms which underlie Diabetic Peripheral Neuropathy. In particular, I have utilized neuroimaging techniques to determine the cerebral alterations which differentiate Painful- compared with Painless-Diabetic Peripheral Neuropathy.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study. Diabetologia, 67(1), 190-198. View this article in WRRO
- Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study. Diabetes, 72(7), 1028-1034.
- Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy. Diabetes Care, 46(4), 777-785.
- Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
- The Treatment of Painful Diabetic Neuropathy. Current Diabetes Reviews, 18(5).
- Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nature Reviews Endocrinology, 17(7), 400-420.
- Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy. Diabetologia, 64(6), 1412-1421. View this article in WRRO
- Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study. Diabetes, 69(8), 1804-1814.
- Painful and Painless Diabetic Neuropathies: What Is the Difference?. Current Diabetes Reports, 19. View this article in WRRO
- A new look at painful diabetic neuropathy. Diabetes Research and Clinical Practice, 144, 177-191. View this article in WRRO
All publications
Journal articles
- Beyond pain relief: the effects of chronic opioid use on brain structure and function in diabetic neuropathy—a multimodal neuroimaging study. Diabetologia. View this article in WRRO
- 154-OR: Combined Point-of-Care Devices, DPN-Check and Sudoscan, Diagnose Early DPN and Predict Diabetic Foot Ulceration. Diabetes, 74(Supplement_1).
- 105-OR: ADA Presidents' Select Abstract: Enhanced Dopamine and Opioid Receptor Target Engagement Predicts Neuropathic Pain Treatment Response—A Resting-State fMRI Study in Painful Diabetic Neuropathy. Diabetes, 74(Supplement_1).
- Vascular and nerve biomarkers in thigh skin biopsies differentiate painful from painless diabetic peripheral neuropathy. Frontiers in Pain Research, 5. View this article in WRRO
- Sheffield One‐Stop Service: A potential model to improve the screening uptake of diabetic peripheral neuropathy and other microvascular complications of diabetes. Journal of Diabetes Investigation, 15(10), 1355-1362. View this article in WRRO
- Increased Thalamocortical Functional Connectivity on Discontinuation of Treatment in Painful Diabetic Peripheral Neuropathy. Diabetes, 73(9), 1486-1494.
- 11-OR: Combined DPNCheck and SUDOSCAN as a Screening Tool for DPN—The Sheffield Prospective Study. Diabetes, 73(Supplement_1).
- Reduced Thalamic γ-Aminobutyric Acid (GABA) in Painless but Not Painful Diabetic Peripheral Neuropathy. Diabetes, 73(8), 1317-1324.
- Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study. Diabetologia, 67(1), 190-198. View this article in WRRO
- 489-P: Abnormal Combined Point-of-Care-Device DPN-Check and SUDOSCAN Results Predict All-Cause Mortality in People with Diabetes. Diabetes, 72(Supplement_1).
- 478-P: Brain Volume Changes after Long-Term Opioid Treatment in Painful Diabetic Peripheral Neuropathy. Diabetes, 72(Supplement_1).
- 477-P: Thalamic Mitochondrial and Neuronal Function Is Preserved in Painful Diabetic Peripheral Neuropathy—A Multimodal Magnetic Resonance Imaging Study. Diabetes, 72(Supplement_1).
- 104-OR: Identifying Painful Diabetic Neuropathy Subtypes from Resting-State Functional Magnetic Resonance Brain Imaging—A Novel Unsupervised Machine Learning Approach. Diabetes, 72(Supplement_1).
- Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study. Diabetes, 72(7), 1028-1034.
- Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy. Diabetes Care, 46(4), 777-785.
- Who really benefits from drug combinations and long titrations for pain? – Authors' reply. The Lancet, 401(10372), 192-193. View this article in WRRO
- Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy: a magnetic resonance spectroscopy study. Frontiers in Pain Research, 3. View this article in WRRO
- Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. Health Technology Assessment, 26(39). View this article in WRRO
- Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
- 85-OR: Thalamic H1-MRS Metabolite Parameters Are Related to Mood Disorders in Type 1 Diabetes. Diabetes, 71(Supplement_1).
- 84-OR: Responders to Neuropathic Pain Treatment Have Greater Target Engagement of Opioid Receptor Systems: A Resting State Functional Magnetic Resonance Imaging Study in Painful Diabetic Neuropathy. Diabetes, 71(Supplement_1).
- 457-P: Increase in Functional Connectivity of the Thalamus to the Primary Somatosensory Cortex and Insular Cortex after Withdrawal of Neuropathic Pain Medication: A Potential Biomarker of Painful-DPN. Diabetes, 71(Supplement_1).
- 455-P: Artificial Intelligence Approach to Treatment Classification in Painful Diabetic Neuropathy. Diabetes, 71(Supplement_1).
- The Treatment of Painful Diabetic Neuropathy. Current Diabetes Reviews, 18(5).
- Involvement of the central nervous system in diabetic distal symmetrical polyneuropathy. Journal of Xiangya Medicine, 6. View this article in WRRO
- 422-P: Intrinsic Brain Connectivity in Chronic Painful Diabetic Neuropathy: A Resting-State fMRI Study. Diabetes, 70(Supplement_1).
- 210-OR: Cerebral Morphometric Alterations in Painless and Painful Diabetic Peripheral Neuropathy. Diabetes, 70(Supplement_1).
- 423-P: Altered Microvascular Perfusion of the Pain-Processing Areas of the Brain during the Experience of Spontaneous Neuropathic Pain. Diabetes, 70(Supplement_1).
- Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nature Reviews Endocrinology, 17(7), 400-420.
- Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy. Diabetologia, 64(6), 1412-1421. View this article in WRRO
- Authors’ Reply to Eerdekens et al. “Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs”. Drugs, 80(11), 1141-1143.
- 129-OR: Abnormal Mitochondrial Activity in Pain Processing Regions of the Brain in Painful Diabetic Peripheral Neuropathy. Diabetes, 69(Supplement_1).
- 533-P: Predicting Treatment Response in Painful Diabetic Neuropathy Using Magnetic Resonance Brain Imaging. Diabetes, 69(Supplement_1).
- Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study. Diabetes, 69(8), 1804-1814.
- Diabetic Polyneuropathy – Advances in Diagnosis and Intervention Strategies. European Endocrinology, 16(1), 15-15.
- Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs. Drugs, 80(4), 363-384.
- New perspective in diabetic neuropathy: From the periphery to the brain, a call for early detection, and precision medicine. Frontiers in Endocrinology, 10. View this article in WRRO
- 326-OR: A Novel Machine Learning Analysis of Brain Multimodal Magnetic Resonance Imaging Classifies Painful Diabetic Neuropathic Pain Severity with High Accuracy. Diabetes, 68(Supplement_1).
- Painful and Painless Diabetic Neuropathies: What Is the Difference?. Current Diabetes Reports, 19. View this article in WRRO
- A new look at painful diabetic neuropathy. Diabetes Research and Clinical Practice, 144, 177-191. View this article in WRRO
- Prolonged diabetic ketoacidosis associated with canagliflozin. Endocrinology, Diabetes & Metabolism Case Reports, 2018.
- A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. Endocrinology, Diabetes & Metabolism Case Reports, 2017.
- Radioactive Iodine Therapy in Benign Thyroid Disease - results from implementing 2007 RCP Guidelines. Endocrine Abstracts.
Book chapters
- Diabetic Foot Complications and Challenges, Management of Diabetic Complications (pp. 301-318). Springer Nature Singapore
- Clinical Features of Diabetes Neuropathies, Contemporary Diabetes (pp. 37-49). Springer International Publishing
- Diabetic Neuropathy (pp. 89-103). Wiley
Conference proceedings
- Real-world evaluation of OpSite topical dressing in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 40
- A novel data driven machine learning approach to identify painful diabetic neuropathy subtypes from resting-state functional magnetic resonance brain imaging. DIABETIC MEDICINE, Vol. 40
- Abnormal combined diabetic peripheral neuropathy (DPN)-check and SUDOSCAN results predict all-cause mortality in people with diabetes: The Sheffield prospective study. DIABETIC MEDICINE, Vol. 40
- Preservation of thalamic mitochondrial and neuronal function in painful diabetic peripheral neuropathy: A multi-modal magnetic resonance imaging study. DIABETIC MEDICINE, Vol. 40
- Abnormal combined DPN-check and Sudoscan results predict all-cause mortality in people with diabetes: the Sheffield prospective study. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S469-S469)
- Cerebral dopamine receptor engagement and treatment response: a resting-state functional magnetic resonance imaging study in painful diabetic neuropathy. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S469-S469)
- Preservation of thalamic mitochondrial and neuronal function in Painful-Diabetic Peripheral Neuropathy: a multi-modal cerebral imaging study. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S106-S106)
- Increased functional connectivity of the thalamus to the primary somatosensory cortex and insular cortex following treatment withdrawal: A potential biomarker of painful-diabetic peripheral neuropathy. DIABETIC MEDICINE, Vol. 39
- Better target engagement of opioid receptor systems in responders to neuropathic pain treatment: A resting-state functional magnetic resonance imaging study in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 39
- Mood disorders are related to thalamic H1-MRS metabolite parameters in type 1 diabetes. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S380-S381)
- Better target engagement of opioid receptor systems in responders to neuropathic pain treatment: a neurotransmitter-enriched functional connectivity mapping study. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S99-S99)
- Increased functional connectivity of the Thalamus and primary Somatosensory cortex and insular cortex following treatment withdrawal: a potential biomarker of painful-DPN. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S99-S99)
- Identification of painful diabetic neuropathy subtypes from functional connectivity resting state MRI patterns: a novel data driven machine learning approach. DIABETOLOGIA, Vol. 65(SUPPL 1) (pp S380-S380)
- Pain processing areas of the brain demonstrate altered microvascular perfusion during spontaneous neuropathic pain. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 34-34)
- Morphometric abnormalities of the brain in diabetic peripheral neuropathy. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 33-34)
- A novel, multimodal magnetic resonance imaging and a machine learning approach to classifying sensory phenotypes in painful DPN. DIABETOLOGIA, Vol. 64(SUPPL 1) (pp 316-317)
- Morphometric abnormalities in the brain in painless and painful diabetic peripheral neuropathy. DIABETIC MEDICINE, Vol. 38
- Microvascular perfusion of the processing of the brain is altered during the experience of spontaneous neuropathic pain in diabetes. DIABETIC MEDICINE, Vol. 38
- Abnormal somatosensory cortex functional connectivity in painful diabetic neuropathy: Clues to the pathogenesis of different sensory clinical phenotypes of neuropathic pain: A novel, multimodal magnetic resonance imaging study. DIABETIC MEDICINE, Vol. 38
- Basic and clinical science posters: New insulins, technology, therapies and treatment. Diabetic Medicine, Vol. 37(S1) (pp 56-56)
- The prevalence of incidental haematological conditions in patients with extremely low HbA1c levels (<20mmol/mol) identified through routine diabetes testing. DIABETIC MEDICINE, Vol. 37 (pp 141-141)
- Predicting treatment response using magnetic resonance imaging in painful diabetic neuropathy. DIABETIC MEDICINE, Vol. 37 (pp 7-7)
- Altered mitochondrial activity in the thalamus and somatosensory cortex in painful diabetic peripheral neuropathy. DIABETOLOGIA, Vol. 63(SUPPL 1) (pp S92-S92)
- Low haemoglobin A1c (HbA1c) result: lessons learnt in clinical practice. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 189 (pp 78-79)
- Central brain mechanisms that predict treatment response in painful diabetic neuropathy. DIABETOLOGIA, Vol. 62 (pp S15-S16)
- Central pain signature for painful diabetic neuropathy (DN) derived from magnetic resonance imaging. DIABETOLOGIA, Vol. 62 (pp S17-S17)
- Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study. Diabetologia, 67(1), 190-198. View this article in WRRO
- Professional activities and memberships
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Clinical Academic Trainee Representative: University of Sheffield Clinical Academic Working Group
Youth Committee Co-Ordinator: Diabetic Neuropathy Study Group (NEUROdiab)
Treasurer: Young Diabetologist and Endocrinologist Forum
Committee member: International Association for the Study of Pain, Neuropathic Pain Specialist Interest Group Subcommittee