Professor Michael J Cork

BSc MB PhD FRCP

Department of Infection, Immunity and Cardiovascular Disease

Professor of Dermatology

M.J.Cork@sheffield.ac.uk
+44 114 215 9520

Full contact details

Professor Michael J Cork
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I joined the University of Sheffield in 1991 as a lecturer in dermatology whilst continuing as a practising dermatologist for the NHS in Sheffield. I had previously been a Registrar in Dermatology at the Royal Hallamshire Hospital, Sheffield, and before that a Registrar in Respiratory General Medicine at Leeds General Infirmary.

I have been closely involved with research in many areas of dermatology; including Atopic Eczema(dermatitis), Psoriasis, Vitiligo and the Genetics of Skin Disease. My major current research work is aimed at identifying gene–environment interactions in the development of atopic dermatitis leading to skin barrier breakdown and the understanding of how topical agents interact with the skin barrier; using this information to enhance the treatment of atopic dermatitis.

I am currently Head of Sheffield Dermatology Research in the Department of Infection, Immunity & Cardiovascular Disease at the University of Sheffield Medical School and am Honorary Consultant Dermatologist to both Sheffield Children´s Hospital NHS Foundation Trust and to Sheffield Teaching Hospitals NHS Foundation Trust; my time is evenly split between the University and the NHS.

Research interests

My research interests are inflammatory skin disorders including: atopic dermatitis (atopic eczema), psoriasis, alopecia areata and vitiligo. The group which includes both clinical and non-clinical staff has identified genetic variants associated with all of these diseases.

Internationally, Sheffield Dermatology Research is one of the leading groups translating basic dermatological science into new treatments for the clinic. Examples include `Skin Protease Inhibitors´ and `Vitamin A Metabolic Pathway Inhibitors´. In 2001, with help from The Wellcome Trust, the group formed a `spin-out´ company called `Molecular SkinCare´, with the aim of developing these treatments.

Another major focus of the group is the effect of topical pharmaceuticals, cosmetics and oils on the structure and function of the skin barrier. Research in this area comprises investigation of the skin barrier defect associated with skin disorders such as atopic dermatitis, how skin barrier defects develop and how to treat or repair the skin barrier defect. This includes the determination of the effect of topical agents/products on the skin of volunteers visiting our clinical diagnostic `skin laboratory´, where we can measure specific properties of the skin barrier, non-invasively, using an array of specialised equipment. These results are then correlated with variants in the genes that determine the structure and function of the skin barrier.

Research conducted by Sheffield Dermatology Research is at the interface between the clinic, academia and industry. Work has been funded by charities, including: The Wellcome Trust, British Skin Foundation and Psoriasis Association; also by the Kuwait Ministry of Health; and by pharmaceutical/cosmetics companies; including Astellas, Johnson & Johnson and Stiefel-GSK.

Publications

Journal articles

Chapters

  • Danby SG & Cork MJ (2018) pH in Atopic Dermatitis, pH of the Skin: Issues and Challenges (pp. 95-107). S. Karger AG RIS download Bibtex download
  • Danby S, Bedwell C & Cork MJ (2014) Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders RIS download Bibtex download
  • Cork MJ & Danby SG (2012) Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley RIS download Bibtex download
  • Cork MJ & Danby S (2011) The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd.. RIS download Bibtex download
  • Cork MJ, Moustafa M, Danby S, Vasilopoulos Y, Tazi-Ahnini R, Ward SJ, Hadgraft J, Lane ME, Guy R & MacGowan A (2009) Skin Barrier Dysfunction in Atopic Dermatitis, Basic and Clinical Dermatology (pp. 211-240). Informa Healthcare RIS download Bibtex download
  • Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane M, Moustafa M, Guy R, MacGowan A, Tazi-Ahnini R & Ward SJ (2009) Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc.. RIS download Bibtex download

Conference proceedings papers

  • Cork MJ, Eichenfield LF, Blauvelt A, Rosmarin D, Hussain I, Davis JD, Li M, Zhang Q, Gadkari A, Eckert L , Kamal MA et al (2019) 605 Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis. Journal of Investigative Dermatology, Vol. 139(5) (pp s104-s104), 8 May 2019 - 11 May 2019. View this article in WRRO RIS download Bibtex download
  • Cork MJ, Eichenfield LF, Blauvelt A, Rosmarin D, Hussain I, Davis JD, Li M, Zhang Q, Gadkari A, Eckert L , Kamal MA et al (2019) Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 139(5) (pp S104-S104) RIS download Bibtex download
  • de Bruin-Weller M, Eckert L, Simpson EL, Cork MJ, Ardeleanu M, Chen Z, Shumel B, Rossi AB, Graham NMH, Pirozzi G & Gadkari A (2019) Clinically meaningful responses in moderate-to-severe atopic dermatitis patients treated with Dupilumab. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 17 (pp 116-116) RIS download Bibtex download
  • Chittock J, Brown K, Cork MJ & Danby SG (2018) Quantification of natural moisturizing factors at the skin surface using a portable infrared spectrometer device: a pilot, calibration model. BRITISH JOURNAL OF DERMATOLOGY, Vol. 179(1) (pp E35-E36) View this article in WRRO RIS download Bibtex download
  • Cork MJ, Thaci D, Davis JD, Zhang Q, Akinlade B, Graham NMH, Pirozzi G & Bansal A (2017) An open-label phase IIa trial assessing the pharmacokinetics, safety and efficacy of dupilumab in a paediatric population with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 155-155) RIS download Bibtex download
  • Cork MJ, Thaci D, Davis JD, Zhang Q, Akinlade B, Graham NMH, Pirozzi G & Bansal A (2017) An open-label phase IIa trial assessing the pharmacokinetics, safety and efficacy of dupilumab in a paediatric population with moderate-to-severe atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 67-68) RIS download Bibtex download
  • Simpson EL, Bieber T, Guttman-Yassky E, Beck LA, Blauvelt A, Cork MJ, Silverberg JI, Deleuran M, Kataoka Y, Lacour J-P , Kingo K et al (2017) Dupilumab in moderate-to-severe atopic dermatitis: results from two randomized phase 3 trials (SOLO 1 & 2). JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Vol. 15 (pp 79-79) RIS download Bibtex download
  • Byers RA, Maiti R, Danby SG, Pang EJ, Mitchell B, Carré MJ, Lewis R, Cork MJ & Matcher SJ (2017) Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography. Proceedings of SPIE, Vol. 10037 View this article in WRRO RIS download Bibtex download
  • Danby S, Wan H, Chittock J, Brown K, Wigley A & Cork M (2016) Characterisation of the skin barrier defect in atopic dermatitis using in vivo ATR-FTIR spectroscopy. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 136(9) (pp S182-S182) RIS download Bibtex download
  • Cooke A, Cork M, Victor S, Campbell M, Danby S, Chittock J & Lavender T (2015) A pilot, assessor-blinded, randomized controlled trial of topical oils for neonatal skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 173 (pp 153-153) RIS download Bibtex download
  • Danby S, Brown K, Higgs-Bayliss T, Chittock J & Cork M (2014) The effect of a complex emollient cream containing 5% urea, ceramide 3 and lactic acid, compared with a simple emollient, on the skin barrier in older people with dry skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 171 (pp 57-58) RIS download Bibtex download
  • Chalmers JR, Simpson EL, Chen YY, Cork MJ, Brown SJ, Thomas KS, Williams HC & Grp BEEPS (2014) Feasibility study of Barrier Enhancement For Eczema Prevention (BEEP). BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E8-E9) RIS download Bibtex download
  • Chalmers JR, Thomas KS, Montgomery A, Sach T, Boyle RJ, Ridd MJ, Simpson EL, Cork MJ, Brown SJ, Lawton S , Thornton J et al (2014) A protocol for a randomized controlled trial to determine whether application of emollient from birth can prevent eczema in high-risk children (BEEP Trial). BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E32-E32) RIS download Bibtex download
  • Higgs-Bayliss T, Brown K, Chittock J, Cork MJ & Danby SG (2014) Noninvasive assessment of the lipid structure and water holding properties of the stratum corneum in vivo by ATR-FTIR using a fibre optic probe in patients with atopic dermatitis and healthy controls. BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E29-E29) RIS download Bibtex download
  • Shareef MS, Albenali L, Cork MJ & Clark SM (2013) A difficult case of atopic eczema: useful learning points. BRITISH JOURNAL OF DERMATOLOGY, Vol. 169 (pp 120-120) RIS download Bibtex download
  • Danby S, Chittock J, Martin KM, Cork MJ & Tierney NK (2013) Chymotrypsin-like protease activity in the stratum corneum is increased in atopic dermatitis and upon washing with soap. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 68(4) (pp AB172-AB172) RIS download Bibtex download
  • Cork MJ (2012) Skin barrier breakdown in atopic dermatitis: the effect of topical products. INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 34(4) (pp 363-364) RIS download Bibtex download
  • Albenali L, Danby S, Moustafa M, Chittock J, Kennedy K, Shackley F & Cork MJ (2012) Vitamin D supplementation improves atopic dermatitis and atopic dermatitis complicated by eczema herpeticum. BRITISH JOURNAL OF DERMATOLOGY, Vol. 167 (pp 127-127) RIS download Bibtex download
  • Danby S, Al Enezi T, Chittock J, Kennedy K, Sultan A & Cork M (2011) A randomized comparison of aqueous cream and Oilatum (R) Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 44-45) RIS download Bibtex download
  • Danby S, Al Enezi T, Chittock J, Kennedy K, Sultan A & Cork M (2011) A randomized comparison of aqueous cream and Oilatum (R) Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 115-115) RIS download Bibtex download
  • Moustafa M, Holden C, Athavale P, Cork M, Messenger A & Gawkrodger DJ (2009) Patch testing is a useful investigation in children with eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 125-125) RIS download Bibtex download
  • Danby S, Moustafa M, MacGowan AL, Ward SJ & Cork MJ (2009) Skin protease inhibitors: a new treatment for atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 30-31) RIS download Bibtex download
  • Al Enezi T, Sultan A, Chittock J, Moustafa M, Danby S & Cork MJ (2009) Breakdown of the skin barrier induced by aqueous cream: implications for the management of atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 115-116) RIS download Bibtex download
  • Danby S, Moustafa M, MacGowan AL, Ward SJ & Cork MJ (2009) Skin protease inhibitors: A new treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 60(3) (pp AB67-AB67) RIS download Bibtex download
  • Carr J, Akram M, Sultan A, Hunter L, Moustafa M, Messenger AG, Fenton P & Cork MJ (2008) Contamination of emollient creams and ointments with Staphylococcus aureus in children with atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 159 (pp 114-114) RIS download Bibtex download
  • Harcastle NJ, MacGowan AL, Henderson JK, Cork MJ & Ward SJ (2008) Vitamin A metabolic pathway inhibition: a new therapeutic approach to treating psoriasis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 159 (pp 118-118) RIS download Bibtex download
  • Cork MJ, Varghese J, Hadcraft J, Lane M, Ferguson A, Moustafa M, Guy RH & Ward S (2007) Differences in the effect of topical corticosteroids and calcineurin inhibitors on the skin barrier - Implications for therapy. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 127 (pp S45-S45) RIS download Bibtex download
  • Kemp EH, McDonagh AJG, Wengraf DA, Messenger AG, Gawkodger DJ, Cork MJ & Tazi-Ahnini R (2007) Severe alopecia areata is associated with a functional polymorphism in the PTPN22 gene. IMMUNOLOGY, Vol. 120 (pp 70-70) RIS download Bibtex download
  • Cork M, Robinson D, Vasilopoulos Y & Ferguson A (2007) The effects of topical corticosteroids and pimecrolimus skin barrier function, gene expression, and topical drug penetration in atopic eczema and unaffected controls. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 56(2) (pp AB69-AB69) RIS download Bibtex download
  • Simon M, Tazi-Ahnini R, Jonca N, Cork MJ & Serre G (2006) Reduced and abnormal proteolysis of corneodesmosomal proteins in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 126 (pp 116-116) RIS download Bibtex download
  • Lovewell TRJ, Cork MJ, Wengraf DA, Messenger AG, McDonagh AJG & Tazi-Ahnini R (2006) A study on the effect of genetic variants of the autoimmune regulator (AIRE) promoter, on AIRE activity and downstream Aire-regulated genes. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 250-250) RIS download Bibtex download
  • Vasilopoulos Y, Cork MJ, Sagoo GS, Ward SJ, Duff GW & Tazi-Ahnini R (2006) A synonymous single nucleotide polymorphism in human cystatin A, a candidate gene in the PSORS5 locus, confers susceptibility to psoriasis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 235-235) RIS download Bibtex download
  • Cork M, Robinson D, Vasilopoulos Y & Ferguson A (2006) Interaction of topical corticosteroids and pimecrolimus with the skin barrier: Implications for efficacy and safety of treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 54(3) (pp AB3-AB3) RIS download Bibtex download
  • Cork MJ, Robinson D, Vasilopoulos Y, Ferguson A, Moustafa M, Tazi-Ahnini R & Ward SJ (2005) Skin barrier damage: Cause or consequence of atopic dermatitis?. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125(3) (pp 605-605) RIS download Bibtex download
  • Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, Tazi-Ahnini R & Ward SJ (2005) Treatment of atopic dermatitis from a skin barrier perspective. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125(3) (pp 611-611) RIS download Bibtex download
  • Cork M (2005) Skin barrier damage: Cause or consequence of atopic dermatitis?. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 52(3) (pp P9-P9) RIS download Bibtex download
  • Cork MJ, Timmins J, Holden C, Carr J, Berry V, Tazi-Ahnini R & Ward SJ (2004) An audit of adverse drug reactions to aqueous cream in children with atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 151 (pp 57-58) RIS download Bibtex download
  • Simon M, Tazi-Ahnini R, Cork MJ & Serre G (2003) Abnormal proteolysis of corneodesmosin in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 121(6) (pp 1568-1568) RIS download Bibtex download
  • Tazi-Ahnini R, Vasilopoulos Y, Henderson JK, Murphy R, Williams H, Ward SJ, Duff GW & Cork MJ (2003) Role of variants within genes regulating the skin barrier in the pathogenesis of atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 149 (pp 4-4) RIS download Bibtex download
  • Wengraf DA, McDonagh AJG, Cork MJ, Gawkrodger D, Messenger AG & Tazi-Ahnini R (2003) Genetic analysis of the autoimmune regulator (aire) gene: potential role of aire in susceptibility to alopecia universalis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 849-850) RIS download Bibtex download
  • McDonagh AJG, Messenger AG, Birch MP, Cork MJ & Tazi-Ahnini R (2003) Alopecia areata: age at onset, atopy & disease associations. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 866-867) RIS download Bibtex download
  • Price VH, Moshell AN, Stenn KS, Duvic M, Goldsmith LA, Cork MJ, Happle R & Kalabokes V (1999) Third International Research Workshop on Alopecia Areata: Introduction. Journal of Investigative Dermatology Symposium Proceedings, Vol. 4(3) (pp 199) RIS download Bibtex download
  • CORK M (1996) The role of in atopic eczema: treatment strategies. Journal of the European Academy of Dermatology and Venereology, Vol. 7 (pp S31-S37) RIS download Bibtex download
  • Cork MJ, Tarlow JK, Clay FE, Crane A, Blakemore AIF, McDonagh AJG, Messenger AG & Duff GW (1995) An Allele of the Interleukin-1 Receptor Antagonist as a Genetic Severity Factor in Alopecia Areata. Journal of Investigative Dermatology, Vol. 104(5) (pp 15-16) RIS download Bibtex download

Reports

  • Danby SG, Ewence A, Rumsby P, Cork MJ, Williams HC, Rockett L & Davey HMSAUIII-PP (2011) A systematic review of skin irritation and tap water RIS download Bibtex download
Teaching interests

My teaching interests within The University include medical undergraduate lecturing and in-clinic training plus postgraduate researcher training and mentoring. I also lecture to related courses at other universities, such as the MSc in Dermatology at Cardiff and at major international and national conferences in the field of dermatology. In addition I undertake a large number of atopic eczema related educational presentations at local, national and international level to a wide range of audiences including; pharmacists, general practitioners, hospital nurses, community nurses, midwives, paediatricians, practice nurses and patient support charities (e.g. National Eczema Society, Skin Care Campaign and Psoriasis Association).

Education of Children with Skin Diseases:

I have developed a special interest in `translating´ the complex pathophysiology of skin disease into cartoons and language that can be understood by a child of six. I presented these to the National Eczema Society and the Skin Care Campaign. I have written papers for these charities describing the content of the lectures, for example Cork et al 2000; 2002 "Skin Wars". I use the cartoons in my clinics to teach children and their parent about skin diseases. The medical students that sit-in during my clinics, suggested I incorporated the "Skin Wars" cartoons into their lectures because they made dermatology exciting. The "Skin Wars" cartoons have been disseminated to many other dermatology departments. I have assigned all commercial profits from use of the "Skin Wars" cartoons to the National Eczema Society. The "Skin Wars" teaching approach was cited as being an innovative approach to education by the judges in the Hospital Doctor Dermatology Team of the Year Awards, which our paediatric dermatology team won in 2001. This teaching method was also highlighted in the National Eczema Society Health Care Professionals Award 2004.

Professional activities
  • Member of the National Institute of Clinical Excellence (NICE) clinical guideline development group for the treatment of Atopic Eczema in children.
  • Advisor, Lecturer and developer of educational materials for the National Eczema Society, Skin Care Campaign, Psoriasis Association and Allergy UK.
  • Wellcome Trust Translational Grants Reviewer & Expert Panel member.
  • Grant Reviewer, British Skin Foundation, Psoriasis Association and Wellcome Trust.
  • Fellow of the Royal College of Physicians, London and Edinburgh.
  • Member of British Association of Dermatologists.
  • Member of European Academy of Dermatology and Venereology.
  • Member of British Society for Investigative Dermatology.
  • Member of European Society for Dermatological Research.
  • Member of British Society for Paediatric Dermatology.
  • Member of Dowling Dermatology Society.
  • Professional Member of the National Eczema Society.
  • Member of The Council (board) of the Psoriasis Association.
  • South Yorkshire Biotech Enterprise Network (SYBEN): York Pharma – Biotech company of the year, 2006.
  • Yorkshire Forward Bioscience Yorkshire Annual Awards: Molecular Skin Care: Recognised for Outstanding Achievements in Bioscience. Awarded to the company who has made the greatest advances in Yorkshire in 2005.
  • Leader of the team awarded ‘Health Care Professional Team of the Year’ by the National Eczema Society in 2004.
  • Leader of the team awarded ‘Hospital Doctor Dermatology Team of the Year’ 2001.
Enquiries

For Teaching & Academic Supervisory Enquiries, Post-Graduate and Undergraduate (i.e. PATs) please email:
Susan Clary & cc to Prof. Michael J. Cork
For Research Enquiries (including Pharmacological, Cosmetic & Academic) please email: Les Hunter & cc to Prof. Michael J. Cork
For Children’s Clinical NHS Enquiries please email: Elaine Cox & cc to Prof. Michael J. Cork
For Adult Clinical NHS Enquiries please email: Lucy Lowe & cc to Prof. Michael J. Cork