Dr Ruth Payne

All publications

Journal articles

• Mentzer AJ, O’Connor D, Bibi S, Chelysheva I, Clutterbuck EA, Demissie T, Dinesh T, Edwards NJ, Felle S, Feng S , Flaxman AL et al (2023) Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection. Nature Medicine, 29(1), 147-157.
• Stuart ASV, Shaw RH, Liu X, Greenland M, Aley PK, Andrews NJ, Cameron JC, Charlton S, Clutterbuck EA, Collins AM , Darton T et al (2021) Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial. The Lancet.
• Swanson PA, Padilla M, Hoyland W, McGlinchey K, Fields PA, Bibi S, Faust SN, McDermott AB, Lambe T, Pollard AJ , Durham NM et al (2021) AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire.. Science Translational Medicine. View this article in WRRO
• Zaric M, Marini A, Nielsen CM, Gupta G, Mekhaiel D, Pham TP, Elias SC, Taylor IJ, de Graaf H, Payne RO , Li Y et al (2021) Poor CD4+ T cell immunogenicity limits humoral immunity to P. falciparum transmission-blocking candidate Pfs25 in humans. Frontiers in Immunology, 12.
• de Graaf H, Payne RO, Taylor I, Miura K, Long CA, Elias SC, Zaric M, Minassian AM, Silk SE, Li L , Poulton ID et al (2021) Safety and immunogenicity of ChAd63/MVA Pfs25-IMX313 in a phase I first-in-human trial. Frontiers in Immunology, 12, 694759-694759.
• Fernandes H (2021) Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance. Annals of Nutrition and Metabolism, 77(4), 197-203.
• Minassian AM, Silk SE, Barrett JR, Nielsen CM, Miura K, Diouf A, Loos C, Fallon JK, Michell AR, White MT , Edwards NJ et al (2021) Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination. Med. View this article in WRRO
• Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE , Bibi S et al (2021) Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. The Lancet, 397(10277), 881-891. View this article in WRRO
• Milne K, Ivens A, Reid AJ, Lotkowska ME, O'Toole A, Sankaranarayanan G, Munoz Sandoval D, Nahrendorf W, Regnault C, Edwards NJ , Silk SE et al (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10.
• Nielsen CM, Ogbe A, Pedroza-Pacheco I, Doeleman SE, Chen Y, Silk SE, Barrett JR, Elias SC, Miura K, Diouf A , Bardelli M et al (2021) Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors. Cell Reports Medicine, 2(3).
• Lynch HF, Darton TC, Levy J, McCormick F, Ogbogu U, Payne RO, Roth AE, Shah AJ, Smiley T & Largent EA (2021) Promoting ethical payment in human infection challenge studies. The American Journal of Bioethics. View this article in WRRO
• Abaleke E, Abbas M, Abbasi S, Abbott A, Abdelaziz A, Abdelbadiee S, Abdelfattah M, Abdul B, Abdul Rasheed A, Abdul-Kadir R , Abdulmumeen A et al (2021) Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10274), 605-612.
• Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE , Bibi S et al (2020) Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 397(10269), 99-111. View this article in WRRO
• Labbé GM, Miura K, Silk SE, Gu W, Moon JE, Jin J, Payne RO, Fay MP, Dutta S, Long CA & Draper SJ (2019) Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL. Malaria Journal, 18(1). View this article in WRRO
• Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE , Jamwal A et al (2019) Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies. Cell, 178(1), 216-228. View this article in WRRO
• Rawlinson TA, Barber NM, Mohring F, Cho JS, Kosaisavee V, Gérard SF, Alanine DGW, Labbé GM, Elias SC, Silk SE , Quinkert D et al (2019) Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody. Nature Microbiology. View this article in WRRO
• Jin J, Tarrant RD, Bolam EJ, Angell-Manning P, Soegaard M, Pattinson DJ, Dulal P, Silk SE, Marshall JM, Dabbs RA , Nugent FL et al (2018) Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells. npj Vaccines, 3(1). View this article in WRRO
• Rampling T, Ewer KJ, Bowyer G, Edwards NJ, Wright D, Sridhar S, Payne R, Powlson J, Bliss C, Venkatraman N , Poulton ID et al (2018) Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP. npj Vaccines, 3(1). View this article in WRRO
• Coughlan L, Sridhar S, Payne R, Edmans M, Milicic A, Venkatraman N, Lugonja B, Clifton L, Qi C, Folegatti PM , Lawrie AM et al (2018) Corrigendum to “Heterologous Two-dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-lasting Cellular Immunity to Influenza Virus A in Healthy Adults” [EBioMedicine 29 (2018) 146–154]. EBioMedicine, 31, 321-321.
• Coughlan L, Sridhar S, Payne R, Edmans M, Milicic A, Venkatraman N, Lugonja B, Clifton L, Qi C, Folegatti PM , Lawrie AM et al (2018) Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults. EBioMedicine, 29, 146-154. View this article in WRRO
• Payne RO, Silk SE, Elias SC, Miura K, Diouf A, Galaway F, de Graaf H, Brendish NJ, Poulton ID, Griffiths OJ , Edwards NJ et al (2017) Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions. JCI insight, 2(21). View this article in WRRO
• Payne RO, Silk SE, Elias SC, Milne KH, Rawlinson TA, Llewellyn D, Shakri AR, Jin J, Labbé GM, Edwards NJ , Poulton ID et al (2017) Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies. JCI insight, 2(12). View this article in WRRO
• Payne RO, Griffin PM, McCarthy JS & Draper SJ (2017) Plasmodium vivax Controlled Human Malaria Infection – Progress and Prospects. Trends in parasitology, 33(2), 141-150. View this article in WRRO
• Rampling T, Ewer KJ, Bowyer G, Bliss CM, Edwards NJ, Wright D, Payne RO, Venkatraman N, de Barra E, Snudden CM , Poulton ID et al (2016) Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP. The Journal of infectious diseases, 214(5), 772-781. View this article in WRRO
• Payne RO, Milne KH, Elias SC, Edwards NJ, Douglas AD, Brown RE, Silk SE, Biswas S, Miura K, Roberts R , Rampling TW et al (2016) Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01. The Journal of infectious diseases, 213(11), 1743-1751. View this article in WRRO
• Ewer K, Rampling T, Venkatraman N, Bowyer G, Wright D, Lambe T, Imoukhuede EB, Payne R, Fehling SK, Strecker T , Biedenkopf N et al (2016) A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA. The New England journal of medicine, 374, 1635-1646.
• Payne R, Forde D, Vedio A, Cope A, Pratt G & Tunbridge A (2013) ‘It's just a virus’ – viral illness in older people: prevention and management. Reviews in Clinical Gerontology, 23(2), 131-141.
• Payne R, Darton TC & Greig JM (2009) Systematic telephone triage of possible ‘Swine’ influenza leads to potentially serious misdiagnosis of infectious diseases. Journal of Infection, 59(5), 371-372.
• Salkeld J, Themistocleous Y, Barrett JR, Mitton CH, Rawlinson TA, Payne RO, Hou MM, Khozoee B, Edwards NJ, Nielsen CM , Sandoval DM et al () Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics. Frontiers in Immunology, 13.
• Payne R () Commentary on 'Payment in challenge studies: ethics, attitudes and a new payment for risk model'. Journal of Medical Ethics.
• Fernandez Lynch H, Darton TC, Levy J, McCormick F, Ogbogu U, Payne RO, Roth AE, Shah AJ, Smiley T & Largent EA () Plumbing the Depths of Ethical Payment for Research Participation. The American Journal of Bioethics, 1-4.

Preprints

• Nielsen CM, Barrett JR, Davis CL, Fallon JK, Goh C, Michell AR, Griffin CL, Kwok A, Loos C, Darko S , Laboune F et al () Delayed Booster Dosing Improves Human Antigen-Specific IG and B Cell Responses to the RH5.1/AS01 _B Malaria Vaccine.
• Nielsen CM, Barrett JR, Davis CL, Fallon JK, Goh C, Michell AR, Griffin CL, Kwok A, Loos C, Darko S , Laboune F et al () Delayed Booster Dosing Modulates Human Antigen-Specific Ig and B Cell Responses to the RH5.1/AS01 _B Malaria Vaccine.
• Lynch HF, Darton T, Largent E, Levy J, McCormick F, Ogbogu U, Payne R, Roth AE, Jefferson Shah A & Smiley T () Ethical Payment to Participants in Human Infection Challenge Studies, with a Focus on SARS-CoV-2: Report and Recommendations.