Dr Enrico Dall'Ara

PhD

Department of Oncology and Metabolism

Senior Lecturer

e.dallara@sheffield.ac.uk
+44 114 215 9079

Full contact details

Dr Enrico Dall'Ara
Department of Oncology and Metabolism
DU19
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - om-operationalteam@sheffield.ac.uk

I hold a PhD in Biomechanics from the Vienna University of Technology and a Master degree in Mechanical Engineering from the University of Bologna, and I joined the University of Sheffield in 2013 as Marie Curie Fellow at the Department of Mechanical Engineering.

In 2015 I was appointed as Lecturer in Musculoskeletal Multiscale Imaging at the Department of Oncology and Metabolism. I have been Senior Lecturer since 2019 and part of the Insigneo Institute for in silico Medicine since 2013.

Research interests

My research interests are related to better understanding the properties of musculoskeletal tissues across the space and time scales, by using imaging, experimental and computational methods.  In particular, the main goal of my research is to develop and validate subject-specific computational models for the prediction of bone strength, bone remodelling and risk of fracture in healthy subjects and in patients with musculoskeletal diseases, applied to both preclinical and clinical studies.

Research projects:

  • Validation of Finite Element models for bone at different dimensional levels
  • Development and validation of multiscale models for predicting bone remodelling over time
  • Preclinical assessment of osteoarthritis with longitudinal microCT
  • Development of Finite Element models to study the outcomes of spine fixation
  • Prediction of fracture risk for patients with vertebral metastases with QCT based computational models
  • Investigation of the effect of bone metastatic lesions on bone strength
  • Investigation of the mechanical properties of subchondral bone from OA patients
  • Optimisation of Digital Volume Correlation techniques for measuring deformation in heterogeneous biomaterials
Publications

Show: Featured publications All publications

Journal articles

Chapters

Conference proceedings papers

  • Zysset PK, Maquer G, Lu Y, Dall'Ara E, Chevalier Y, Krause M, Yang L, Eastell R & Lippuner K (2016) HOW DOES THE INITIAL SLOPE OF THE VARIOGRAM, THE TEXTURAL BASIS OF THE TRABECULAR BONE SCORE, PREDICT VERTEBRAL STRENGTH?. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp S105-S105) RIS download Bibtex download

All publications

Journal articles

Chapters

Conference proceedings papers

Reports

  • Carusi A (2015) In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative. RIS download Bibtex download

Software / Code

Datasets

Other

Research group

Team

  • Dr Sara Oliviero (PDRA)
  • Dr Marco Palanca (MCSA PD fellow)
  • Dr Vee Cheung (PDRA)
  • Dr Bryant Roberts (PDRA)
  • Mr Samuel Lapworth (PhD student, 1st sup.)
  • Mr Marco Sensale (PhD student, ANSYS, 1st sup.)
  • Will Griffith (Software Developer)
  • Ms Saira Frage-O'Reilly (PhD student, 1st sup.)
  • Mr Will Henson (PhD student, 2nd sup.)
  • Ms Stamatina Moraiti (PhD student, 2nd sup.)
  • Mr Corey Miller (PhD student, QUT, 3rd sup.)
Grants
  • 2020-2024; Inksson B (PI), Pinna C, Dall'Ara E, Fairclough JPA, Moebus G, Hounslow MJ, Cumming D, Reeves-McLaren N; “An X-ray Micro-Computed Tomography Facility with in-situ/in operando testing”: EPSRC ; £1412k
  • 2019-2026; Narracott AJ (PI), Fenner JW, Gunn JP, Clayton RH, Mazza C, Reilly G, Lawford PV, Wild JM, Hose DR, Marzo A, Villa-Uriol MC, Li X, Guo L, Dall'Ara E, Bhattacharya P, Walker DC, Watton P; “Centre for New Methods in Computational Diagnostics and Personalised Therapy (SANO)”: Horizon2020; €2897k
  • 2019-2021; Dall’Ara E (PI), Palanca M; “Comprehensive experimental and computational mechanical characterization of metastatic vertebrae (METASPINE)”: Horizon2020, Marie Curie Intra-European Fellowship; €213k
  • 2019-2021; Mazza’ C (PI), Dall’Ara E, Li X, Battacharia P, Kadirkamanathan V, McCloskey E; “Frontier Engineering: Progression Grant in Modelling complex and partially identified engineering problems. Application to the musculoskeletal system (MULTISIM2)”: Progression Grant EPSRC; £758k
  • 2019-2020; Dall’Ara E (PI); “Equipment for Mouse gait lab”: EPSRC ECR Capital Enhancement Programme 2018
  • 2018-2022; Reilly G (PI), Mazza’ C, Lacroix D, Claeyssen F, Guo L, Dall’Ara E; “SPINe: Numerical and Experimental Repair strategies”: Horizon2020 European program, Initial Training Network; £476k
  • 2017-2020; Dall’Ara E (PI), Bellantuono I, Viceconti M; “In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies”: National Centre for replacement, refinement and reduction of animal use in research; £353k
  • 2017-2019; Bellantuono I (PI), Dall’Ara E; “Targeting mechanisms of ageing to maintain musculoskeletal health”: Biological and Biotechnological Sciences Research Council; £261k
  • 2017-2019; Dall’Ara E (PI); “Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation”: Engineering and Physical Sciences Research Council; £101k
  • 2015-2016; Dall’Ara E (PI); “Multiscale characterization of osteoarthritic subchondral bone: combination of microCT, elastic registration and microindentation”: Royal Society research grant; £15k
  • 2016-2019; Dall’Ara E (PI), Hose R, Lawford P; “Assessment of bone growth in preclinical studies with Kalman filtering”: EPSRC PhD scholarship; £65k
  • 2015-2018; Dall’Ara E (PI), Viceconti M; “Prediction of the risk of vertebral fracture in patients with metastatic lesions as a tool for more effective patients’ management”: Sheffield Hospitals Charity; £65k
  • 2013-2015; Dall’Ara E (Fellow), Viceconti M; “Methodologically and Accurate modelling of bone”: FP7, Marie Curie Intra-European Fellowship; €222k
Teaching interests

I teach in the Computational Biomechanics of the Musculoskeletal System (MEC457).

I give invited lectures in different modules in engineering.

Professional activities
  • Council member for the European Society of Biomechanics since 2018
  • Executive Board of the Italian Chapter of the European Society of Biomechanics since 2018
  • President of the UK chapter of the Virtual Physiological Human Institute since 2018
  • Editorial Board member of the Journal of Mechanical Behaviour of Biomedical Materials since 2019
  • Member of IFMRS Huble Methods Committee
  • Member of the ESB since 2008, BRS since 2014, ECTS since 2015 and ORS since 2017.
  • Reviewer for the major journals of biomechanics and bone research.