Professor Lynda Wyld

Department of Oncology and Metabolism

Professor of Surgical Oncology

l.wyld@sheffield.ac.uk
+44 114 215 9066

Full contact details

Professor Lynda Wyld
Department of Oncology and Metabolism
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

Undergraduate Education: University of Sheffield Medical School, graduated in 1990.
PhD: University of Sheffield, 1990.
Surgical Training: Basic surgical training in Leeds.
Higher Surgical Training in Sheffield, Nottingham and Manchester.
Appointed Consultant and Senior Lecturer 2002 at the University of Sheffield.

Current post:  Professor of Surgical Oncology at University of Sheffield, Honorary Consultant Breast Surgeon, the Jasmine Breast Centre, Doncaster

Research interests

Chief Investigator (jointly with Malcolm Reed) for the Age Gap multicentre trial to establish optimal care pathways for older women with breast cancer.

The study is looking at cancer outcomes relative to treatment selection and how this is influenced by patient variation in health and fitness. The study is also undertaking detailed review of quality of life in older women and is developing a validating a series of decision tools for breast cancer treatment choices in older women in collaboration with experts at the University of Cardiff.

The study group is also undertaking modelling of cancer outcomes in this age group in collaboration with the team at SCHARR. Via a longstanding collaboration with experts at Sheffield Hallam University a number of qualitative and mixed methods studies are ongoing looking at various aspects of breast cancer and familial breast cancer risks.

Current projects

  • Breast cancer in older women: cancer outcomes, risk prediction model development and validation, decision support, quality of life, outcome modelling
  • Psychosocial outcomes for women with familial high breast cancer risk
  • Epigenetic modifiers of the BRCA gene promotor in collaboration with Professor Angie Cox
Publications

Journal articles

Chapters

Conference proceedings papers

  • Battisti NML, Herbert E, Bradburn M, Morgan J, Wyld L & Ring A (2020) 190P Impact of chemotherapy for early stage breast cancer on quality of life in older adults: Results from 2811 women enrolled in the Bridging the Age Gap study. Annals of Oncology, Vol. 31 (pp S318-S319) RIS download Bibtex download
  • Hynes C, Mitchell C & Wyld L (2020) Cancer treatment decisions for people living with dementia : experiences of family carers. British Journal of General Practice, Vol. 70(Suppl 1). London, UK, 12 March 2020 - 12 March 2020. View this article in WRRO RIS download Bibtex download
  • Battisti NML, Ring A, Bradburn M & Wyld L (2020) Abstract P2-14-08: Use of systemic therapy for early stage breast cancer in older adults: Results from the Bridging the Age Gap study. Poster Session Abstracts RIS download Bibtex download
  • Khurram DSA, Jones DA, Hughes DD, Wyld PL, Kotnis DN & Fernando DM (2019) Sarcomas of the head and neck - a 10-year review from a specialist centre. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 128(1) (pp e54-e54), 23 June 2018 - 28 June 2018. View this article in WRRO RIS download Bibtex download
  • Burton M, Lifford KJ, Wyld L, Armitage F, Collins K, Reed M, Brain K, Edwards A & Team AGT (2019) Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomized trial. FUTURE ONCOLOGY, Vol. 15(7S) (pp 14-14) RIS download Bibtex download
  • Wyld L & Team AGTM (2019) Updates on the 'Bridging The Age Gap' (BTAG) Study. FUTURE ONCOLOGY, Vol. 15(7S) (pp 10-10) RIS download Bibtex download
  • Athanasiou I, Reed MW, Shrestha A, Cheung K-L, Audisio R, Collins K & Wyld L (2019) Abstract P2-14-06: Withdrawn. Poster Session Abstracts RIS download Bibtex download
  • Rubio IT, Wyld L, Kovacs T, Leidenius M, Kolacinska A, Marotti L, Bianca S, Cardoso MJ, Biganzoli L & Audisio R (2019) Variability in breast cancer surgery training across Europe : an ESSO-EUSOMA international survey. European Journal of Surgical Oncology, Vol. 45(2) (pp e17-e18). Budapest, Hungary, 10 October 2018 - 12 October 2018. View this article in WRRO RIS download Bibtex download
  • MacInnes E, Erskine S, Collins K, Hughes J, Wilkinson J, Cook J, Walters S & Wyld L (2018) Experiences of women and partners of women at increased familial breast cancer risk: A qualitative study of the impact upon partnerships. European Journal of Surgical Oncology, Vol. 44(6) (pp 904-905) RIS download Bibtex download
  • Shrestha A, Martin C, Collins K, Burton M, Chater T, Pemberton K, Ward S, Holmes G, Walters S, Cheung KL , Audisio R et al (2018) Preference for quality of life versus length of life in older women making treatment decisions in early breast cancer. European Journal of Surgical Oncology, Vol. 44(6) (pp 871-871) RIS download Bibtex download
  • MacInnes E, Erksine S, Collins K, Hughes J, Wilkinson J, Cook J, Walters S & Wyld L (2018) Views and experiences of MRI breast screening in women at increased familial breast cancer risk. European Journal of Surgical Oncology, Vol. 44(6) (pp 905-906), 18 June 2018 - 19 June 2018. View this article in WRRO RIS download Bibtex download
  • Shrestha A, Martin C, Burton M, Collins K, Holmes G, Ward S, Audisio R, Chater T, Pemberton K, Robinson T , Cheung KL et al (2018) Comparison of quality of life of older women treated with surgery or primary endocrine therapy for early breast cancer: propensity score matched analysis of a large prospective multicentre cohort study. European Journal of Cancer, Vol. 92 (pp S3-S4) RIS download Bibtex download
  • Shrestha A, Martin C, Burton M, Collins K, Holmes G, Ward S, Audisio R, Chater T, Pemberton K, Robinson T , Cheung KL et al (2018) Comparison of quality of life of older women treated with surgery or primary endocrine therapy for early breast cancer: propensity score matched analysis of a large prospective multicentre cohort study. EUROPEAN JOURNAL OF CANCER, Vol. 92 (pp S3-S4) RIS download Bibtex download
  • Shrestha A, Martin C, Collins K, Burton M, Audisio R, Chater T, Pemberton K, Cheung K, Ward S, Walters S , Malcolm R et al (2018) Quality of life of elderly women with early breast cancer following surgery. European Journal of Surgical Oncology, Vol. 44 (pp S4-S4) RIS download Bibtex download
  • Shrestha A, Martin C, Collins K, Burton M, Audisio R, Chater T, Pemberton K, Cheung K, Ward S, Walters S , Malcolm R et al (2017) 1017. Quality of life of elderly women with early breast cancer following surgery. European Journal of Surgical Oncology, Vol. 43(11) (pp 2204-2205) RIS download Bibtex download
  • Collins KA, Burton M, Lifford KJ, Reed MWR, Armitage F, Wyld L & Team BTAG (2017) Bridging the Age Gap in Breast Cancer (BTAG) trial update. FUTURE ONCOLOGY, Vol. 13(8) (pp 14-14) RIS download Bibtex download
  • Shrestha A, Martin C, Collins K & Wyld L (2017) Quality of life versus length of life in cancer patients: literature review. EUROPEAN JOURNAL OF CANCER, Vol. 72 (pp S165-S165) RIS download Bibtex download
  • Zaman O, Ward S, Collins K, Cheung K-L, Robinson T, Audisio R, Bortolami O, Martin C, Reed M & Wyld L (2016) Impact of dementia on treatment of older patients with breast cancer. An interim analysis of the bridging the age gap in Breast Cancer Study. European Journal of Surgical Oncology (EJSO), Vol. 42(11) (pp S232-S233) RIS download Bibtex download
  • Zaman O, Richards P, Ward S, Bortolami O, Collins K, Cheung KL, Robinson T, Audisio R, Reed M & Wyld L (2016) 83. Risk factors for surgical morbidity in older women with breast cancer: An interim analysis of the Bridging the Age Gap in Breast Cancer Study. European Journal of Surgical Oncology (EJSO), Vol. 42(9) (pp S100-S101) RIS download Bibtex download
  • Richards P, Ward S, Morgan J, Francis M, Collins K, Burton M, Nettleship A, Lifford K, Reed M & Wyld L (2015) Bridging The Age Gap in Breast Cancer - improving treatment decisions for older women using routine data. EUROPEAN JOURNAL OF CANCER CARE, Vol. 24 (pp 62-62) RIS download Bibtex download
  • Morgan J, Richards P, Ward S, Lawrence G, Francis M, Collins K, Reed M & Wyld L (2015) The effect of dementia on the treatment of older women with breast cancer in England. FUTURE ONCOLOGY, Vol. 11(4) (pp 13-13) RIS download Bibtex download
  • Richards P, Ward S, Morgan J, Francis M, Lawrence G & Wyld L (2015) Age, and not comorbidity, is associated with adjuvant chemotherapy use in older breast cancer patients in England. FUTURE ONCOLOGY, Vol. 11(4) (pp 20-21) RIS download Bibtex download
  • Drake TM, Kanthou C, Ritchie JE & Wyld L (2015) Activation of the Endoplasmic Reticulum Stress Pathwaymay Enhance the Radiosensitivity of Human Colorectal Cancer Cells in Vitro. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 6-6) RIS download Bibtex download
  • Daniels SL, Brock IW, Connley D, Cross SS, Wyld L & Cox A (2014) Hypermethylation of the BCRA1 promoter in blood DNA is associated with triple negative phenotype breast cancer. BRITISH JOURNAL OF SURGERY, Vol. 101 (pp 40-41) RIS download Bibtex download
  • Collins KA, Burton M, Caldon L, Lifford K, Brain K, Wyld L & Reed MWR (2014) The information and decision support needs of older women (> 75 yrs) facing treatment choices for their breast cancer: A qualitative study. EUROPEAN JOURNAL OF CANCER, Vol. 50 (pp S125-S125) RIS download Bibtex download
  • Rafia R, Ward SE, Scope A & Wyld L (2013) EVALUATING THE COST EFFECTIVENESS OF GENE EXPRESSION PROFILING AND IMMUNOHISTOCHEMISTRY TESTS. VALUE IN HEALTH, Vol. 16(7) (pp A413-A413) RIS download Bibtex download
  • Walker H, Collins K, Morgan JL, Sandhu S, Cox V, Reed MW & Wyld L (2013) Information needs of older women considering breast screening attendance: A mixed methods study. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S342-S342) RIS download Bibtex download
  • Vicini E, Van der Vorst JR, Montroni I, Fontein DBY, Mieog JSD, Partelli S, Polom K, Malyshev NA, Mordant P & Wyld L (2013) Training in cancer surgery across Europe: The trainees perspective. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S6-S6) RIS download Bibtex download
  • Ritchie J, Wyld L & Bryant HE (2013) UPR Activation via glucose deprivation and depletion of GRP78 protein (using siRNA) do not alter radiosensitivity in the human breast cancer cell line MCF7. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S425-S425) RIS download Bibtex download
  • Salawu A, Ul-Hassan A, Woll P, Wyld L, Fernando M, Reed MWR & Sisley K (2012) Identification of soft tissue sarcoma subtypes using microarray-based comparative genomic hybridization. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol. 30 (pp S61-S61) RIS download Bibtex download
  • Wyld L, Collins K, Winslow M, Reed M, Robinson T, Walters S, Madan J, Green T & Cocker H (2010) The views of older women regarding mammographic screening: a qualitative and quantitative study. EJC SUPPLEMENTS, Vol. 8(3) (pp 242-242) RIS download Bibtex download
  • Husain L, Collins K, Wyld L & Reed M (2007) Factors that affect counselling and treatment decision making in older women (> 70 years) with breast cancer: a qualitative study. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, Vol. 64 (pp S31-S31) RIS download Bibtex download
  • Scriven P, Cross SS, Stephenson YL, Balasubramanian SP, Reed MWR, Brown NJ & Wyld L (2005) Glucose-regulated protein 78 (Grp78) is highly expressed in the majority of human breast cancers. JOURNAL OF PATHOLOGY, Vol. 207 (pp 26-26) RIS download Bibtex download
  • Scriven P, Cross SS, Stephenson YL, Bury JP, Ackroyd R, Stoddard CJ, Wyman A, Brown NJ, Reed MWR & Wyld L (2005) Glucose-regulated protein 78 (Grp78) is highly expressed in carcinoma of the oesophagus, more frequently in adenocarcinoma than squamous cell carcinoma. JOURNAL OF PATHOLOGY, Vol. 207 (pp 49-49) RIS download Bibtex download
  • Safdar G, Peart S, Chatterjee S, Cook J, Alam N & Wyld L (2005) Prophylactic mastectomy: indications and outcome. BRITISH JOURNAL OF SURGERY, Vol. 92 (pp 145-146) RIS download Bibtex download
  • Wyld L, Kumar ID, Brown H & Reed MWR (2004) Stage and treatment variation with age in postmenopausal women with breast cancer. BRITISH JOURNAL OF SURGERY, Vol. 91(9) (pp 1230-1230) RIS download Bibtex download
  • Balasubramanian SP, Kumar ID, Wyld L & Reed MWR (2004) What happens to abstracts presented at the ASGBI?. BRITISH JOURNAL OF SURGERY, Vol. 91 (pp 19-19) RIS download Bibtex download

Posters

  • Harnan S, Cooper K, Meng Y, Ward S, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson I & Lorenz E Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review. RIS download Bibtex download
Research group

PhD/MD Students

  • Ms Jenna Morgan
  • Ms Emma McInnes
  • Ms Charlene Martin
Teaching interests
  • Undergraduate teaching of breast diseases at the University of Sheffield.
  • Chair of the Education and Training Committee of the European Society of Surgical Oncology (ESSO).
  • Chair of the European Union of Medical Specialists (UEMS) Surgical Oncology exam board.
  • Secretary of the UEMS breast examination board.
Professional activities
  • Professor of Surgical Oncology
  • Honorary Consultant Surgeon, The Jasmine Breast Centre, Doncaster
  • President of the British Association for Surgical Oncology
  • Board Member of the European Society of Mastology (EUSOMA) 2015-2019.