Professor Nils P Krone

MD, FRCPCH

Department of Oncology and Metabolism

Professor of Paediatric Endocrinology

Honorary Consultant Paediatric Endocrinologist

STAFF Nils Krone
n.krone@sheffield.ac.uk
+44 114 271 7508

Full contact details

Professor Nils P Krone
Department of Oncology and Metabolism
Room 16, The Damer Street Building
Sheffield Children's Hospital
Western Bank
Sheffield
S10 2TH
Profile

I graduated from the Ludwig-Maximilian’s University, Munich, Germany, where I was also awarded my MD for studies into the genotype-phenotype correlation in congenital adrenal hyperplasia.  I have trained in General Paediatrics and Paediatric Endocrinology at the University Children’s Hospital, Munich and University of Kiel Children’s Hospital, Germany (1999-2006). I have been working at the University of Birmingham as Wellcome Trust Clinician Scientist and Senior Clinical Lecturer (2006-2015).

I was appointed at the University of Sheffield in 2015 and work as Honorary Consultant Paediatric Endocrinologist at Sheffield Children’s Hospital, where I leads the adrenal and disorders/ differences of sex development (DSD) clinical service.

Research interests

My main clinical and basic research interests are inborn errors of steroid hormone biosynthesis and steroid hormone metabolism in health and disease. This is closely interlinked with my main clinical interests into inborn errors of steroidogenesis, congenital adrenal hyperplasia (CAH), disorders of sex development (DSD), and PCOS.

Ongoing work of my group explores the systemic consequences of disrupted steroid hormone synthesis and action on whole organism employing zebrafish as a model organism in translational steroid hormone research. This research is based at the Bateson Centre.

The main focus of my clinical research program is on CAH. I led on a multicentre, 14 tertiary paediatric endocrine centres in the UK, NIHR RD TRC funded project to establish the evidence basis on the current health status in children and young people with congenital adrenal hyperplasia in the UK.

In addition, I work on a program to improve health care deliver for children and young people with adrenal conditions and DSD .


Current projects

  • Understanding the systemic consequences to disrupted steroidogenesis.
  • Long-term pathophysiology of glucocorticoid deficiency
  • Health status of children and young persons with congenital adrenal hyperplasia (CAH-UK).
  • Improving biomarkers for therapy monitoring in CAH.
  • Current practice of CAH healthcare delivery in the UK.
Publications

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Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Hebenstreit D, Ahmed F, Springer A, Krall C, Krone N, Birkebaek N, Milenkovic T, Koehler B, Flueck C, Krone R , Balsamo A et al (2019) Contemporary surgical approach in CAH 46XX-Results from the I-DSD/I-CAH Registries. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 96-97) RIS download Bibtex download
  • Ali S, Daniel E, Bryce J, Ikiroma A, Lewsey J, Ross R, Krone R, Acerini C, Krone N, Das U , Tomlinson J et al (2019) Development Of An International Benchmark For Sick Day Episodes As A Core Clinical Outcome In People With Congenital Adrenal Hyperplasia. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 209-210) RIS download Bibtex download
  • Bacila I-A, Blankenstein O, Neumann U, Claahsen-van der Grinten HL, Krone R, Acerini C, Bachega TSS, Miranda MC, Mendonca B, Birkebaek NH , Cools M et al (2019) Global Practice of Glucocorticoid and Mineralocorticoid Treatment in Children and Adults with Congenital Adrenal Hyperplasia - Insights from the I-CAH Registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 132-133) RIS download Bibtex download
  • Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) Investigating the roles of androgens in male reproductive development, maintenance and function by characterisation of androgen and cortisol deficient 11 beta-hydroxylase mutant zebrafish lines. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 50-50) RIS download Bibtex download
  • Bacila I-A, Mahdi S, Acerini CL, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M, Cheetham T , Kyriako A et al (2019) Health status of children with Congenital Adrenal Hyperplasia due to 21-hydroxylase deficiency in the United Kingdom: results of a multi-centre cohort study. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 129-130) RIS download Bibtex download
  • Bacila I-A, Adaway J, Hawley J, Mahdi S, Acerini CL, Krone R, Patel L, Alvi S, Randell T, Gevers E , Dattani M et al (2019) Development of novel non-invasive strategies for monitoring of treatment control in patients with congenital adrenal hyperplasia. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 107-107) RIS download Bibtex download
  • Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) The P450 side-chain cleavage isozyme cyp11a2 facilitates interrenal and gonadal steroid hormone biosynthesis in developing and adult zebrafish. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 66-67) RIS download Bibtex download
  • Hughes LA, Bounford KM, Webb EA, Cole T, Krone NP, Fews G & Allen S (2018) Improved diagnosis and management of patients with Disorders of Sex Development (DSDs) Using Next Generation Sequencing. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 26 (pp 202-203) RIS download Bibtex download
  • Aji A, Colyer S, Burn S, Dimitri P, Wright N, Krone N & Elder C (2018) The relationship of baseline, incremental and peak cortisol following a Short Synacthen Test - single-centre analysis of three years' data. Hormone Research in Paediatrics, Vol. 90(Suppl 1) (pp 128-129), 27 September 2018 - 29 September 2018. View this article in WRRO RIS download Bibtex download
  • Burn S, Colyer S, Dimitri P, Wright N, Krone N & Elder C (2018) Borderline peak plasma cortisol following Synacthen stimulation - single-centre analysis of three years' data. Endocrine Abstracts, Vol. 90(S1) (pp 146-146), 27 September 2018 - 29 September 2018. View this article in WRRO RIS download Bibtex download
  • De Ridder J, Bashamboo A, De Baere E, Krone N, Mitchell R, Rajpert-De Meyts E, Tobias E, Looijenga L, Achermann J, Werner R , Ahmed F et al (2018) SDgeneMatch, A New Tool to Aid the Identification of the Genetic Causes of DSD. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 540-540) RIS download Bibtex download
  • Mohamed Z, Allen S, Bounford KM, Idkowiak J, Godber C, Chandran H, McCarthy L, Cole T, Kirk J & Krone N (2018) Revisiting the Diagnosis: Next Generation Sequencing (NGS) Identifies Concurrence of PAIS in a Previously Reported Case of Klinefelter Syndrome (47,XXY) with Hypospadias. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 562-563) RIS download Bibtex download
  • Li N, Weger M, Griffin A, Eachus H, Cunliffe VT & Krone N (2018) Glucocorticoid Deficiency Causes Differentially Dysregulated Oxidative Stress Depending on the Steroidogenic Defects. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 71-72) RIS download Bibtex download
  • Oakes JA, Liz N, Wistow B, Storbeck K-H, Cunliffe VT & Krone N (2018) The Roles of Steroids in Gonadal Development and Maintenance - Insights from a Zebrafish Model of Androgen and Cortisol Deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 53-53) RIS download Bibtex download
  • Daniel E, Sandrk M, Blankenstein O, Neumann U, Claahsen-Van der Grinten H, Van der Linde A, Darendeliler F, Pyrazoglu S, Mendonca BB, Bachega TSS , Miranda MC et al (2017) DEFINING THE DOSE, TYPE AND TIMING OF GLUCOCORTICOID AND MINERALOCORTICOID REPLACEMENT IN 256 CHILDREN AND ADULTS WITH CONGENITAL ADRENAL HYPERPLASIA (CAH) IN THE I-CAH REGISTRY. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 358-358) View this article in WRRO RIS download Bibtex download
  • Lucas-Herald AK, Kyriakou A, Bryce J, Rodie M, Acerini C, Arlt W, Audi L, Balsamo A, Baronico F, Bertelloni S , Brooke A et al (2017) THE PREVALENCE OF ADULTS WITH DSD CONDITIONS AT RISK OF HYPOGONADISM IN THE INTERNATIONAL DISORDERS OF SEX DEVELOPMENT REGISTRY. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 557-558) RIS download Bibtex download
  • Guven A, Guran T & Krone N (2017) 17-HYDROXYLASE DEFICIENCY: RARE CAUSE OF DELAYED PUBERTY. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 255-256) RIS download Bibtex download
  • Van Der Linde A, Neumann U, Bryce J, Ahmed SF, Kourime M, Krone N, Ross RJ, Claahsen-Van Der Grinten H & Blankenstein O (2017) MANAGEMENT OF FLUDROCORTISONE AND SALT THERAPY IN 0-3 YEAR OLD CHILDREN WITH CONGENITAL ADRENAL HYPERPLASIA (CAH) - PRELIMINARY ANALYSIS. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 251-252) RIS download Bibtex download
  • Nikolaos N, Nasiri M, Gathercole LL, Parajes S, Krone NP, Valsamakis G, Mastorakos G & Tomlinson JW (2014) Androgen Receptor Activation Stimulates Hepatic Lipid Accumulation in Human Hepatocytes. ENDOCRINE REVIEWS, Vol. 35(3) RIS download Bibtex download
  • Krone N (2011) Phenotypic Variability and Uncommon Forms of Congenital Adrenal Hyperplasia. JOURNAL OF MEDICAL GENETICS, Vol. 48 (pp S29-S29) RIS download Bibtex download
  • Idkowiak J, O'Riordan S, Malunowicz EM, Collins F, Kerstens M, Reisch N, Szarras-Czapnik M, Maiter D, Sillink M, Dattani M , Shackleton CHL et al (2010) Pubertal Presentation in Congenital Adrenal Hyperplasia Due to P450 Oxidoreductase Deficiency.. ENDOCRINE REVIEWS, Vol. 31(3) RIS download Bibtex download
  • Reisch N, Dhir V, Berry AA, Krone N, Taylor AE, Nogueira EF, Malunowicz EM, Hindmarsh PC, Wudy SA, Taylor NF , Stewart PM et al (2010) Evidence for the Existence and Significance of an Alternative Pathway towards Androgen Synthesis in the Human Fetal Adrenal.. ENDOCRINE REVIEWS, Vol. 31(3) RIS download Bibtex download
  • Taylor AE, Biehl M, Hahner S, Libe R, Hughes BA, Stiekema H, Schneider P, Smith DJ, Krone N, Porfiri E , Opocher G et al (2010) Urinary Steroid Profiling as a High-Throughput Screening Tool for the Detection of Malignancy in Patients with Adrenal Tumors.. ENDOCRINE REVIEWS, Vol. 31(3) RIS download Bibtex download
  • Idkowiak J, Mohamed Z, Allen S, Chandran H, McCarthy L, Kirk J, Cole T & Krone N () Pitfalls in the diagnosis of an infant with 46,XX DSD with Congenital Adrenal Hyperplasia due to Cytochrome P450 Oxidoreductase deficiency - the value of simultaneous genetic analysis to the diagnosis in DSD. Endocrine Abstracts RIS download Bibtex download
  • Mannion P, Elhassan Y, Smith K, Webster R, Saraff V, Barrett T, Shaw N, Krone N, Dias R, Kershaw M , Kirk J et al () Mass spectrometry-based assessment of childhood androgen excess in 487 consecutive patients. Endocrine Abstracts RIS download Bibtex download
  • Webb EA, Saraff V, Hughes L, Allen S, Cole T, Dattani MT, Hughes IA, Kirk JMW, Fews G & Krone NP () The role of a next generation sequencing panel in the diagnostic pathway in disorders of sex development. Endocrine Abstracts RIS download Bibtex download
Teaching interests

I deliver undergraduate teaching as well as  postgraduate medical training and education. I teach on the MBChB course in phase 1, 2 and 3 and I am Endocrinology Phase 1 Teaching Lead. 

I am Course Director for the MSc programme in Clinical Endocrinology and Diabetes and module lead for the MED6100 module on the Clinical Research MSc course.

I am Deputy Director Clinical Academic Training, Sheffield Medical School & South Yorkshire and Humber Deanery. Furthermore, I am Academic training lead for paediatric clinical academic posts, University of Sheffield.

Professional activities

Editorship

National committees (selected)

International Activities (selected)