Professor Philippe Clézardin

BSc, MSc, PhD, DSc

Department of Oncology and Metabolism

Professor of Bone Oncology

Philippe Clezardin
p.clezardin@sheffield.ac.uk
+44 114 222 9242

Full contact details

Professor Philippe Clézardin
Department of Oncology and Metabolism
EU28, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I was awarded my PhD from the University of Lyon, France, in 1984 after which I joined the Medical Research Council / Scottish National Blood Transfusion Centre in Edinburgh as a post-doctoral research associate for 2 years. I was appointed in 1987 as Research Scientist (Lecturer) at INSERM (National Institute for Health and Medical Research), Lyon, France. In 1990 I undertook a one-year sabbatical as visiting scientist at the Ottawa General Hospital (Ottawa, Canada). In 1991 I was appointed Senior Research Scientist (Senior Lecturer) and in 1993 Research Director 2nd class (Reader) at INSERM. In 2005 I was appointed Research Director 1st Class (Professor) and became head of the INSERM Research Unit UMR_S664 entitled: “Mechanisms and Treatments of Bone Metastases” (2005-2010) and then Director of the Federative Research Institute “IFR62” entitled: “Cancer, Nutrition and Metabolism” (14 laboratories, circa: 500 people; 2007-2010). From 2011, I am head of the INSERM Research Unit UMR_S1033 entitled: “Pathophysiology, Diagnosis and Treatments of Bone Diseases” (http://www.lyos.fr). I have recently joined the Department of Oncology & Metabolism at the University of Sheffield as a Professor of Bone Oncology.

Research interests

My main research interest is the understanding of molecular mechanisms that govern breast cancer cell colonisation of the bone marrow, with the goal of developing novel biomarkers to identify patients at high risk for developing bone metastasis.

Current projects:

ROBO. Role of axon guidance, roundabout (ROBO) transmembrane receptors in breast cancer bone metastasis formation.

LOXs. Role of lysyl oxidases in early onset of breast cancer bone metastasis formation.

AMG161. Anti-tumour effect of a human anti-RANKL monoclonal antibody on early-stage bone colonisation of human RANK-expressing breast cancer cells

MicroRNAs. Role of breast cancer stem cell-derived microRNAs, and their mRNA/protein targets in controlling bone metastasis formation.

Publications

Journal articles

Chapters

Conference proceedings papers

  • Das S, Gabrion A, Six I, Boudot C, Kamel S, Clezardin P, Brazier M & Mentaverri R (2019) Abstract 2859: Targeting the calcium sensing receptor in breast cancer cells diminishes colonization and migratory response in a trabecular bone explant model, and reduces osteolytic lesions in vivo. Tumor Biology RIS download Bibtex download
  • Das S, Gabrion A, Six I, Boudot C, Kamel S, Clezardin P, Brazier M & Mentaverri R (2019) Abstract 2859: Targeting the calcium sensing receptor in breast cancer cells diminishes colonization and migratory response in a trabecular bone explant model, and reduces osteolytic lesions in vivo. Tumor Biology RIS download Bibtex download
  • Vargas G, Bouchet M, Kan C, Benetollo C, Croset M, Mazel M, Cayrefourcq L, Vacher S, Pantano F, Driouch K , Bieche I et al (2018) ERRa in primary breast tumours promotes tumour cell dissemination to bone by regulating RANK. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 33 (pp 72-72) RIS download Bibtex download
  • Sousa S, Gineyts E, Geraci S, Croset M & Clézardin P (2018) Abstract 29: RANK-RANKL signaling inhibition delays early breast cancer bone metastasis formation. Tumor Biology RIS download Bibtex download
  • Croset M, Pantano F, Kan C, Bonnelye E, Descotes F, Alix-Panabières C, Lecellier C, Bachelier R, Allioli N, Hong SS , Bartkowiak K et al (2018) Abstract 486: MicroRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis-associated genes. Molecular and Cellular Biology / Genetics RIS download Bibtex download
  • Pantano F, Croset M, Driouch K, Iuliani M, Fioramonti M, Santini D, Tonini G, Bednarz-Knoll N, Pantel K & Clezardin P (2016) Integrin a5 is an independent prognosis factor and a potential therapeutic target for breast cancer bone metastasis. ANNALS OF ONCOLOGY, Vol. 27 RIS download Bibtex download
  • Gineyts E, Bonnet N, Bertholon C, Pagnon-Minot A, Borel O, Hartmann D, Chapurlat RD, Ferrari S, Garnero P, Clezardin P & Rousseau J-C (2016) ELISA MEASUREMENT OF CIRCULATING PERIOSTIN IN ANIMAL MODELS OF BONE LOSS OR BONE FORMATION AND IDENTIFICATION OF CIRCULATING AND TISSUE-SPECIFIC ASSOCIATED FORMS OF PERIOSTIN. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp S207-S207) RIS download Bibtex download
  • Mathevet P, Magaud L & Clézardin P (2016) Abstract P6-13-19: Adding zoledronic acid to neo-adjuvant chemotherapy may improve the efficiency of chemotherapy in locally advanced breast cancer: Results from the prospective randomized study NEOZOL. Poster Session Abstracts RIS download Bibtex download
  • Reynaud C, Ferreras L & Clezardin P (2014) THE HIF-1 TARGET LYSYL OXIDASE PROMOTES SURVIVAL AND OUTGROWTH OF COLON CANCER CELLS IN THE BONE MARROW ENABLING BONE METASTASIS FORMATION. ANTICANCER RESEARCH, Vol. 34(10) (pp 6134-6134) RIS download Bibtex download
  • Sahay D, Leblanc R, Ribeiro J, Clézardin P & Peyruchaud O (2014) Abstract 1448: Disseminated tumor cell formation promoted by lysophosphatidic acid (LPA) involves ZEB1/miR21-dependent activation pathway. Molecular and Cellular Biology RIS download Bibtex download
  • Clement-Demange L, Eckel B, Gonin V, Goehrig D, Diaz-Latoud C & Clezardin PAR (2014) Roundabout receptors mediate breast cancer bone metastasis formation and progression.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S65-S66) RIS download Bibtex download
  • Pantano F, Croset M, Driouch K, Bonnelye E, Iuliani M, Fioramonti M, Santini D, Tonini G & Clezardin PAR (2014) Integrin Alpha5beta1 is a Potential Therapeutic Target to Treat Experimental Breast Cancer Bone Metastasis.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S65-S65) RIS download Bibtex download
  • Bouchet M, Fradet A, Delliaux C, Bouazza L, Pantano F, Leroy X, Bellahcene A, Castonovo V, Clezardin PAR, Duterque-Coquillaud M & Bonnelye E (2014) ERRalpha, a pro-Bone metastatic factor : Implication in metastatic Niche and prostate Cancer Stem Cells phenotype.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S13-S13) RIS download Bibtex download
  • Pantano F, Croset M, Driouch K, Santini D, Tonini G & Clézardin P (2013) Abstract P5-04-13: Antibody-based therapy targeting integrin a5 is an effective strategy to treat experimental breast cancer bone metastasis. Poster Session Abstracts RIS download Bibtex download
  • Brevet M, Confavreux CB, Pialat J-B, Devouassoux-Shisheboran M, Isaac S, Rousseau J-C, Bringuier P-P, Clezardin P, Thivolet-Bejui F & Girard N (2013) MUTATIONAL PROFILING OF SYNCHRONOUS BONE METASTASES FROM LUNG ADENOCARCINOMA: FEASIBILITY AND RESULTS IN A PROSPECTIVE COHORT OF 46 PATIENTS (POUMOS STUDY). JOURNAL OF THORACIC ONCOLOGY, Vol. 8 (pp S796-S796) RIS download Bibtex download
  • Croset M, Goehrig D, Ansieau S, Puisieux A & Clezardin PAR (2013) Ectopic expression of twist-1 in breast cancer cells promotes bone metastasis formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28 RIS download Bibtex download
  • Fradet A, Bellahcene A, Castronovo V, Clezardin PAR & Bonnelye E (2013) Function of ERRa in Mediating Mixed Metastatic Bone Lesion from Prostate Cancer Cells: Implication of Endothelin 1 and Wnt/periostin pathway. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28 RIS download Bibtex download
  • Clezardin P (2011) PATHOPHYSIOLOGY OF TUMORAL BONE DISEASE. OSTEOPOROSIS INTERNATIONAL, Vol. 22 (pp 6-7) RIS download Bibtex download
  • Croset M, Bachelier R, Allioli N, Song S-S, Agami R & Clezardin P (2011) Targeting breast cancer osteomimetic genes by microRNAs-30 decreases the formation of metastatic osteolytic lesions in mice. BULLETIN DU CANCER, Vol. 98 (pp S29-S30) RIS download Bibtex download
  • Diaz-Latoud C, Gonin V, Eckel B, Bachelier R, Deux B, Bonnelye E & Clezardin P (2011) Role of axon guidance receptor Robo-1 in training and development of bone metastases of breast cancer. BULLETIN DU CANCER, Vol. 98 (pp S27-S28) RIS download Bibtex download
  • Reynaud C, Pez F, Dayan F, Clezardin P, Sommer P & Pouyssegur J (2011) The HIF-1-inducible Lysyl Oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell. BULLETIN DU CANCER, Vol. 98 (pp S9-S10) RIS download Bibtex download
  • Fradet A, Sorel H, Deux B, Clezardin P & Bonnelye E (2010) A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer. BONE, Vol. 47 (pp S289-S289) RIS download Bibtex download
  • Gonin V, Bachelier R, Deux B, Contie S, Bonnelye E, Rabbitts P, Wu J & Clezardin P (2010) Involvement of the SLIT2/ROBO1 Pathway in Breast Cancer Bone Metastasis. BONE, Vol. 47 (pp S273-S273) RIS download Bibtex download
  • Benzaid I, Monkkonen H, Stresing V, Bonnelye E, Green J, Monkkonen J, Touraine J & Clezardin P (2010) Zoledronic acid-induced IPP/Apppl (phosphoantigen) accumulation in human breast cancer cells correlates with Vgamma9Vdelta2 T cell-mediated cancer cell death in vitro and in vivo. BONE, Vol. 47 (pp S266-S267) RIS download Bibtex download
  • Lowik CWG, Contie S, Voorzanger-Rousselot N, Litvin J, Clezardin P & Garnero P (2010) Periostin as a circulating marker for breast cancer bone metastases. BONE, Vol. 47 (pp S328-S329) RIS download Bibtex download
  • Stresing V, Deux B, Mathevet P, Ebetino FH & Clezardin P (2010) Frequent intermittent low-dose therapy accentuates the antitumour activity of the bisphosphonate risedronate in vivo. BONE, Vol. 47 (pp S322-S322) RIS download Bibtex download
  • Bachelier R, Gonin V, Goehrig D, Deux B, Van der Pluijm G & Clezardin P (2010) The combined targeting of VEGF-A and VEGF receptors inhibits breast cancer bone metastases in mice. BONE, Vol. 47 (pp S322-S323) RIS download Bibtex download
  • David M, Wannecq E, Jansen S, Deux B, Ribeiro J, Serre C-M, Grès S, Bendriss-Vermare N, Bollen M, Saulnier-Blache J-S , Clézardin P et al (2010) Abstract 2368: Autotaxin/Enpp2 controls of bone metastasis formation through osteoclast function. Tumor Biology RIS download Bibtex download
  • Ricci E, Bourrelly E, Mege LF, Martin X, Clezardin P & Colombel M (2010) 674 EXPRESSION OF INTEGRIN ALPHA 2 AND ALPHA 6 AND C-MET IN PRIMARY PROSTATE CARCONIMA: IMPACT ON BONE METASTASIS FREE SURVIVAL. European Urology Supplements, Vol. 9(2) (pp 221-221) RIS download Bibtex download
  • Voorzanger-Rousselot N, Goehrig D, Clezardin P, Facon T & Garnero P (2008) Platelets Contribute to Circulating Levels of Dickkopf-1 (Dkk-1): Clinical Implications in Multiple Myeloma.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S297-S297) RIS download Bibtex download
  • Monkkonen H, Benzaid I, Stresing V, Green J, Monkkonen J, Touraine JL & Clezardin P (2008) Zoledronic acid-induced IPP accumulation in cancer cells strongly correlates with gammadelta T-Cell mediated cancer cell death. Bone, Vol. 42 (pp S102-S103) RIS download Bibtex download
  • David M, Deux B, Serre CM, Bendriss-Vermare N, Caux C, Saulnier-Blache JS, Clezardin P & Peyruchaud O (2008) Autotaxin controls the metastatic progression of breast cancer cells. BULLETIN DU CANCER, Vol. 95 (pp S91-S92) RIS download Bibtex download
  • Clezardin P (2008) New physiopathological pathways of bone metastases. CALCIFIED TISSUE INTERNATIONAL, Vol. 82 (pp S24-S24) RIS download Bibtex download
  • Bachelier R, Gonin V, Goehrig D, Deux B & Clézardin P (2008) P56. Targeting VEGF and its receptors in the treatment of breast cancer bone metastases. Cancer Treatment Reviews, Vol. 34 (pp 41-41) RIS download Bibtex download
  • Monkkonen H, Benzaid I, Stresing V, Green J, Monkkonen J, Touraine J-L & Clezardin P (2008) P49. Zoledronic acid-induced IPP accumulation in cancer cells strongly correlates with γδ T-cell mediated cancer cell death. Cancer Treatment Reviews, Vol. 34 (pp 37-37) RIS download Bibtex download
  • Daubiné F, Fournier P, Ebetino H & Clezardin P (2008) P57. Manipulating the bone mineral affinity of bisphosphonates to directly target cancer cells in the bone marrow. Cancer Treatment Reviews, Vol. 34 (pp 42-42) RIS download Bibtex download
  • David M, Wannecq E, Grès S, Deux B, Serre CM, Bendriss-Vermare N, Caux C, Saulnier-Blache J-S, Clézardin P & Peyruchaud O (2008) P20. Autotaxin promotes metastasis dissemination of breast cancer cells. Cancer Treatment Reviews, Vol. 34 (pp 20-21) RIS download Bibtex download
  • Clezardin P (2008) Cathepsin K inhibitors for treating cancer-induced bone disease. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 25 (pp 15-15) RIS download Bibtex download
  • Ottewell PD, Deux B, Monkkonen H, Cross SS, Coleman RE, Clezardin P & Holen I (2007) Differential effects of doxorubicin and zoledronic acid on intra-osseous vs extra-osseous breast tumour growth in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 106 (pp S39-S39) RIS download Bibtex download
  • Body JJ, Coleman R, Clezardin P, Ripamonti C, Rizzoli R & Aapro M (2007) 1302 POSTER Updated International Society of Geriatric Oncology (SIOG) recommendations for the use of bisphosphonates in elderly cancer patients with bone metastases. European Journal of Cancer Supplements, Vol. 5(4) (pp 174-174) RIS download Bibtex download
  • Ottewell PD, Deux B, Monkkonen H, Coleman RE, Clezardin P & Holen I (2007) Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1111) RIS download Bibtex download
  • Boucharaba A, Menaa F, Clezardin P & Peyruchaud O (2007) Role of lysophosphatidic acid (LPA) and LPA1 receptor in the treatment of bone metastases in breast cancer. BULLETIN DU CANCER, Vol. 94(6) (pp 560-561) RIS download Bibtex download
  • Buijs J, Henriquez N, van Overveld P, van der Horsy G, Que I, Schwaninger R, Rentsch C, ten Dijke P, Cleton A, Lidereau R , Bachelier R et al (2007) Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. BONE, Vol. 40(6) (pp S145-S145) RIS download Bibtex download
  • Saltel F, Chabadel A, Zhao Y, Lafage-Proust M, Clezardin P, Jurdic P & Bonnelye E (2006) Transmigration, a new property of mature osteoclasts.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S161-S161) RIS download Bibtex download
  • Guglielmi J, Daubiné F, Gasser J, Green J & Clézardin P (2006) Continuous or repeated intermittent low-dose therapy with zoledronic acid induces a sustained inhibition of tumor cell trafficking to bone in vivo. Bone, Vol. 38(3) (pp 44-45) RIS download Bibtex download
  • Fournier P, Daubiné F, Lundy MW, Ebetino FH & Clézardin P (2006) The direct antitumor activity of bisphosphonates in vivo depends on their bone mineral affinity. Bone, Vol. 38(3) (pp 45-45) RIS download Bibtex download
  • Le Gall C, Guglielmi J, Gasser J, Zimmermann J & Clézardin P (2006) A cathepsin k inhibitor (alone or in combination with zoledronic acid) inhibits the progression of breast cancer bone metastases. Bone, Vol. 38(3) (pp 55-56) RIS download Bibtex download
  • (2006) Dickkopf-1 (Dkk-1) is involved in the development of breast cancer osteolytic lesions. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S27-S27) RIS download Bibtex download
  • (2006) Transcriptome analysis reveals an osteomimetic phenotype for human bone metastatic breast cancer cells. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S85-S86) RIS download Bibtex download
  • Clezardin P & Ctement-Lacroix P (2006) Prevention of breast cancer bone metastasis by an integrin alpha V beta 3 antagonist. CANCER TREATMENT REVIEWS, Vol. 32 (pp S18-S18) RIS download Bibtex download
  • Le Gall C, Gasser J, Bonnelye E, Zimmermann J & Clezardin P (2006) A cathepsin K inhibitor inhibits the progression of breast cancer bone metastases. CANCER TREATMENT REVIEWS, Vol. 32 (pp S16-S16) RIS download Bibtex download
  • Bachelier R, Gonin V, Goehrig D, Confavreux C & Clezardin P (2006) Effects of thrombospondin-1 overexpression and VEGF silencing on bone metastasis formation. CANCER TREATMENT REVIEWS, Vol. 32 (pp S41-S41) RIS download Bibtex download
  • Voorzanger-Rousselot N, Goehrig D, Clezardin P & Garnero P (2006) Serum levels of Dickkopf-1 (Dkk-1) are increased in women with breast cancer and bone metastases. CANCER TREATMENT REVIEWS, Vol. 32 (pp S38-S38) RIS download Bibtex download
  • Boucharaba A, Clezardin P & Peyruchaud O (2006) The type 1 lysophosphatidic acid receptor is a pivotal factor for early and late events for bone metastasis formation in breast cancer. CANCER TREATMENT REVIEWS, Vol. 32 (pp S30-S30) RIS download Bibtex download
  • Daubine F, Fournier P, Boucher P & Clezardin P (2006) Integrin alpha V beta 3 confers tumor cells a higher sensitivity to the pro-apoptotic effect of the aminobisphosphonate zoledronate in vitro. CANCER TREATMENT REVIEWS, Vol. 32 (pp S45-S46) RIS download Bibtex download
  • Fournier PG, Ebetino FH, Castronovo V & Clezardin P (2005) Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. BONE, Vol. 36 (pp S219-S219) RIS download Bibtex download
  • Fournier PG, Ebetino FH, Castronovo V & Clezardin P (2005) Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S23-S24) RIS download Bibtex download
  • Guglielmi J, Pecheur I, Pujuguet P, Minet D, Baron R, Clement-Lacroix P & Clezardin P (2005) A novel integrin antagonist: Evaluation in bone growth tumor models. CANCER TREATMENT REVIEWS, Vol. 31 (pp S16-S16) RIS download Bibtex download
  • Zhao Y, Fournier P, Serre CM, Boucharaba A, Guglielmi J, Peyruchaud O & Clezardin P (2005) Integrin alpha v beta 3 is critical for human breast cancer bone metastasis. CANCER TREATMENT REVIEWS, Vol. 31 (pp S26-S26) RIS download Bibtex download
  • Boucharaba A, Serre C, Blache JS, Bordet J, Clezardin P & Peyruchaud O (2005) LPA: A new local factor acting on breast cancer bone metastasis. CANCER TREATMENT REVIEWS, Vol. 31 (pp S27-S27) RIS download Bibtex download
  • Fournier PGJ, Ebetino FH, Lundy MW & Clezardin P (2005) Use of analogs of risedronate to elucidate antitumor mechanisms of bisphosphonates in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S36-S37) RIS download Bibtex download
  • Fournier P, Ebetino FH, Bellahcene A, Castronovo V & Clezardin P (2005) Antibody to rank ligand - Overview of RANK ligand. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P23-P24) RIS download Bibtex download
  • Fournier P, Ebetino FH, Bellahcene A, Castronovo V & Clezardin P (2005) Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P24-P24) RIS download Bibtex download
  • Zhao Y, Boucharaba A, Fournier P & Clezardin P (2005) Integrin alpha V beta 3 is critical for human breast cancer bone metastasis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P16-P17) RIS download Bibtex download
  • Jackson A, Pujuguet P, Clement-Lacroix P, Baron R, Clezardin P & Garcia T (2005) Genome profiling aiming at identifying "bone metastasis signatures". JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P36-P36) RIS download Bibtex download
  • Bellahcene A, Bachelier R, Detry C, Clezardin P & Castronovo V (2005) Transcriptome analysis reveals an osteomimetic phenotype for human breast cancer cells that selectively target the skeleton. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P32-P32) RIS download Bibtex download
  • Fournier PG, Lundy MW, Ebetino RH & Clezardin P (2004) Use of bisphosphonate analogs of risedronate to elucidate antitumor mechanisms of bisphosphonates in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S25-S25) RIS download Bibtex download
  • Boucharaba A, Serre C, Blache JS, Bordet J, Guglielmi J, Clezardin P & Peyruchaud O (2004) Lysophosphatidic acid: A new link between breast cancer and bone metastasis.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S25-S25) RIS download Bibtex download
  • Guglielmi J, Pecheur I, Pujuguet P, Minet D, Baron R, Clement-Lacroix P & Clezardin P (2004) A nonpeptide integrin avb3 antagonist inhibits bone metastasis formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S66-S66) RIS download Bibtex download
  • Fournier P, Serre CM, Colombel M, Ebetino FH & Clezardin P (2004) The bisphosphonate risedronate inhibits angiogenesis and tumor growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1599-1599) RIS download Bibtex download
  • Clezardin P (2004) Cell adhesion and bone metastasis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1561-1562) RIS download Bibtex download
  • Lundy MW, Ebetino FH & Clezardin P (2004) NE-10790, a phosphonocarboxylate analogue of the bisphosphonate risedronate, exhibits direct antitumor activity in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1033-1033) RIS download Bibtex download
  • Fournier PG, Lundy MW, Ebetino FH & Clezardin P (2004) NE-10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF THE BISPHOSPHONATE RISEDRONATE, EXHIBITS DIRECT ANTITUMOR ACTIVITY IN IN VIVO. CALCIFIED TISSUE INTERNATIONAL, Vol. 74 (pp S43-S44) RIS download Bibtex download
  • Fournier PG, Lundy MW, Ebetino FH & Clezardin P (2004) NE-10790, a phosphonocarboxylate analogue of the bisphosphonate risedronate, exhibits direct antitumor activity in vivo. BONE, Vol. 34 (pp S56-S57) RIS download Bibtex download
  • Fournier P, Boissier S, Serre C, Colombel M, Ebetino FH & Clezardin PAR (2003) The bisphosphonate risedronate inhibits angiogenesis and tumor growth in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S113-S113) RIS download Bibtex download
  • Colombel MC, Fournier P, Bouvier R & Clezardin P (2003) Androgens repress the expression of thrombospondin-1, an inhibitor of angiogenesis, in the rat prostate and in hormone-responsive human prostate cancer. JOURNAL OF UROLOGY, Vol. 169(4) (pp 84-84) RIS download Bibtex download
  • Boissier S, Colombel M, Delmas P, Cabon F & Clezardin P (2002) Zoledronic acid inhibits in vivo experimental angiogenesis. BONE, Vol. 30(3) (pp 38S-38S) RIS download Bibtex download
  • Pecheur I, Peyruchaud O, Fournier P, Sarre CM, Bourre F, Delmas PD, Kieffer N & Clezardin P (2002) Integrin alpha v beta 3 plays an essential role in the homing of tumor cells in bone.. BONE, Vol. 30(3) (pp 43S-43S) RIS download Bibtex download
  • Fournier P, Peyruchaud O, Frappart L, Serre CM, Boissier S, Delmas P & Clezardin P (2002) Effects of bisphosphonates zoledronic acid and risedronate on the growth of a human breast carcinoma cell line in vivo. BONE, Vol. 30(3) (pp 40S-40S) RIS download Bibtex download
  • Pecheur L, David M, Schaffer-Reckinger S, Delmas PD, Kieffer N & Clezardin PAR (2000) Ectopic expression of integrin alpha v beta 3 confers tumor cells a high propensity to metastasize to bone.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 15 (pp S177-S177) RIS download Bibtex download
  • Voland C, Kehrel B, Grahe H, Amiral J, Lawler J & Clezardin P (1997) Identification of specific sequences within thrombospondin-1 involved in the formation of irreversible platelet macroaggregates. THROMBOSIS AND HAEMOSTASIS (pp P1385-P1385) RIS download Bibtex download
  • Merle B, Choi HU, Amiral J, Rosenberg L, Lawler J, Delmas PD & Clezardin P (1996) Decorin inhibits cell adhesion by binding to a specific cell adhesive site of thrombospondin.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 11 (pp M460-M460) RIS download Bibtex download
  • Boissier S, Lozano S, Cuzin B, Delmas PD & Clezardin P (1996) Bisphosphonates inhibit tumor cell attachment to unmineralized and mineralized bone extracellular matrices.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 11 (pp P229-P229) RIS download Bibtex download
  • CLEZARDIN P, LOZANO S, LAWLER J, SILVERSTEIN R, LECERF J & DELMAS P (1995) MOLECULAR MECHANISMS OF ATTACHMENT OF CD36-TRANSFECTED CELLS TO THROMBOSPONDIN-1. MOLECULAR BIOLOGY OF THE CELL, Vol. 6 (pp 267-267) RIS download Bibtex download
  • CLEZARDIN P, DROUIN J, KAPLAN C, HANSS M, KEHREL B, SERRE CM, MORELKOPP MC & DELMAS P (1993) MECHANISMS OF PLATELET-OSTEOSARCOMA CELL-INTERACTIONS. THROMBOSIS AND HAEMOSTASIS, Vol. 69(6) (pp 573-573) RIS download Bibtex download
  • CLEZARDIN P, FRAPPART L, CLERGET M, PECHOUX C & DELMAS PD (1993) EXPRESSION OF THROMBOSPONDIN (TSP1) AND ITS RECEPTORS (CD36, CD51) IN NORMAL, HYPERPLASTIC AND NEOPLASTIC HUMAN BREAST. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 159-159) RIS download Bibtex download
  • FRAPPART L, CLEZARDIN P, DANTE R, SERRE CM, CLERGET M & PECHOUX C (1993) ORIGIN AND ROLE OF THROMBOSPONDIN IN THE EARLY DEVELOPMENT OF THE HUMAN MAMMARY-GLAND. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 160-160) RIS download Bibtex download
  • HOTT M, CLEZARDIN P & MARIE PJ (1992) THROMBOSPONDIN INDUCES THE PROLIFERATION OF RAT CALVARIA OSTEOBLASTIC CELLS. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 7 (pp S213-S213) RIS download Bibtex download
  • ABBADIA Z, CLEZARDIN P, SERRE C, MAILLARD C & DELMAS PD (1992) THROMBOSPONDIN MEDIATES PROLIFERATION OF HUMAN OSTEOBLASTIC CELLS INDUCED BY THROMBIN. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 7 (pp S223-S223) RIS download Bibtex download
  • DROUIN J, MCLEISH W, SUTHERLAND M & CLEZARDIN P (1991) PSEUDO-GRAY PLATELET SYNDROME - MULTIPLE PLATELET ABNORMALITIES AND NORMAL HEMOSTASIS. THROMBOSIS AND HAEMOSTASIS, Vol. 65(6) (pp 1105-1105) RIS download Bibtex download
  • CLEZARDIN P, SERRE CM, TRZECIAK MC, DELMAS P & DROUIN J (1991) THROMBOSPONDIN BINDS TO THE SURFACE OF HUMAN OSTEOSARCOMA CELLS AND MEDIATES PLATELET-OSTEOSARCOMA CELL-INTERACTION. THROMBOSIS AND HAEMOSTASIS, Vol. 65(6) (pp 1055-1055) RIS download Bibtex download
  • CLEZARDIN P, ALFARO E, GRANGE J, DESGRANGES C, KAPLAN C, DELMAS P & DECHAVANNE M (1991) THROMBOSPONDIN BINDING BY HUMAN OSTEOSARCOMA CELLS - RELATIONSHIP TO PLATELET-AGGREGATING ACTIVITY OF OSTEOSARCOMA CELLS. PLATELET IMMUNOLOGY : FUNDAMENTAL AND CLINICAL ASPECTS, Vol. 206 (pp 195-207) RIS download Bibtex download
  • CLEZARDIN P, MALAVAL L, DELMAS PD & KAPLAN C (1989) A POLYCLONAL ANTIBODY TO OSTEONECTIN INHIBITS COLLAGEN-INDUCED PLATELET-AGGREGATION AND CELL-SURFACE EXPRESSION OF ENDOGENOUS THROMBOSPONDIN. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 195-195) RIS download Bibtex download
  • CLEZARDIN P, JOUISHOMME H, CHAVASSIEUX P & MARIE PJ (1989) THROMBOSPONDIN AND CELL-ADHESION. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 592-592) RIS download Bibtex download
  • CLEZARDIN P, MALAVAL L, DELMAS PD & KAPLAN C (1989) OSTEONECTIN DEFICIENCY IN PLATELETS ISOLATED FROM A PATIENT WITH THE GRAY PLATELET SYNDROME. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 420-420) RIS download Bibtex download
  • MCGREGOR J, CATIMEL B, PARAMENTIER S, CLEZARDIN P, DECHAVANNE M & LEUNG L (1988) RAPID PURIFICATION AND PARTIAL CHARACTERIZATION OF HUMAN-PLATELET GLYCOPROTEIN IIIB. CLINICAL RESEARCH, Vol. 36(3) (pp A567-A567) RIS download Bibtex download
  • CLEZARDIN P & MCGREGOR JL (1987) STRUCTURAL AND FUNCTIONAL COMPARISON OF THROMBOSPONDIN FROM PLATELETS, ENDOTHELIAL-CELLS AND FIBROBLASTS. THROMBOSIS AND HAEMOSTASIS, Vol. 58(1) (pp 278-278) RIS download Bibtex download
  • Clezardin P & McGregor JL (1987) STRUCTURAL AND FUNCTIONAL COMPARISON OF THROMBOSPONDIN FROM PLATELETS, ENDOTHELIAL CELLS AND FIBROBLASTS. XIth International Congress on Thrombosis and Haemostasis, 6 July 1987 - 10 July 1987. RIS download Bibtex download
  • CLEZARDIN P & DAWES J (1986) STRUCTURAL AND IMMUNOLOGICAL COMPARISON OF THROMBOSPONDIN FROM PLATELETS AND COLOSTRUM. THROMBOSIS RESEARCH (pp 55-55) RIS download Bibtex download
  • ROBERT F, MCGREGOR JL, CLEZARDIN P, SAYEGH A, DECHAVANNE M & CHATAING B (1985) STUDY ON THE RELEASE OF THROMBOSPONDINE DURING PLATELET CONSERVATION - DOSAGE BY MEANS OF THE ELISA METHOD, WITH A MONOCLONAL-ANTIBODY. NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, Vol. 27(2) (pp 117-117) RIS download Bibtex download
  • CLEZARDIN P, MCGREGOR JL, LYON M, BOUKERCHE H, DECHAVANNE M & HUPPERT J (1985) CHARACTERIZATION OF MONOCLONAL-ANTIBODIES WHICH AFFECT HUMAN-PLATELET THROMBOSPONDIN HEMAGGLUTINATION ACTIVITY. THROMBOSIS AND HAEMOSTASIS, Vol. 54(1) (pp 249-249) RIS download Bibtex download
  • BOUKERCHE H, MCGREGOR JL, MCGREGOR L, CLEZARDIN P, DECHAVANNE M, CLEMETSON KJ & BROCHIER J (1985) CHARACTERIZATION OF AN ANTI-THROMBOSPONDIN MURINE MONOCLONAL-ANTIBODY (P8) THAT INHIBITS HUMAN-BLOOD PLATELET FUNCTIONS. THROMBOSIS AND HAEMOSTASIS, Vol. 54(1) (pp 218-218) RIS download Bibtex download
  • MCGREGOR JL, SICARD B, CLEZARDIN P, JAMES E, CLEMETSON KJ & DECHAVANNE M (1984) MEMBRANEOUS PROTEINS AND GLYCOPROTEINS OF ENDOTHELIAL-CELLS FROM UMBILICAL CORDS. NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, Vol. 26(6) (pp 417-417) RIS download Bibtex download
  • Clezardin P, McGregor L, McGregor JL, Clemetson KJ & Dechavanne M (1983) Effect of Thrombospondin on Platelet ADP-Induced Aggregation and 125I-Fibrinogen Binding. European Heart Journal, Vol. 4(suppl B) (pp 5-5) RIS download Bibtex download
  • CLEZARDIN P, MCGREGOR JL, DECHAVANNE M & CLEMETSON KJ (1983) PLATELET MEMBRANE GLYCOPROTEIN ABNORMALITIES IN PATIENTS WITH MYELOPROLIFERATIVE DISORDERS, ACUTE-LEUKEMIA AND SECONDARY THROMBOCYTOSIS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 218-218) RIS download Bibtex download
  • BENDOUMA M, MCGREGOR JL, CLEZARDIN P, DECHAVANNE M, AGUERCIF M & CLEMETSON KJ (1983) PROTEINS AND GLYCOPROTEINS OF NEONATAL PLATELETS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 213-213) RIS download Bibtex download
  • CLEZARDIN P, MCGREGOR JL, MANACH M, DECHAVANNE M & CLEMETSON KJ (1983) PURIFICATION OF THROMBOSPONDIN, FIBRONECTIN AND FIBRINOGEN BY FAST PROTEIN LIQUID-CHROMATOGRAPHY. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 16-16) RIS download Bibtex download
  • MCGREGOR JL, SICARD B, JAMES E, CLEZARDIN P, DECHAVANNE M & CLEMETSON KJ (1983) MEMBRANE-PROTEINS AND GLYCOPROTEINS OF ENDOTHELIAL-CELLS ISOLATED FROM HUMAN UMBILICAL CORDS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 396-396) RIS download Bibtex download
  • MCGREGOR JL, CLEZARDIN P, JAMES E, MCGREGOR L, DECHAVANNE M & CLEMETSON KJ (1983) IDENTIFICATION AND CHARACTERIZATION OF FRAGMENTS OF MAJOR MEMBRANE-GLYCOPROTEINS REMAINING ON PLATELETS AFTER CHYMOTRYPSIN TREATMENT. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 187-187) RIS download Bibtex download
  • Clezardin P, McGregor JL, Clemetson KJ, Dechavanne M & Lüscher EF (1981) Further Characterization Of Platelet Membrane Glycoproteins. Oral Presentations, 13 July 1981 - 17 July 1981. RIS download Bibtex download
  • McGregor JL, Clemetson KJ, James E, Clezardin P, Dechavanne M & Lüscher EF (1981) Tryptic Peptide Maps Of The Major Human Blood Platelet Membrane Glycoproteins, Ia, IIa, IIb, IIIa, IIIb and IIIc. Oral Presentations, 13 July 1981 - 17 July 1981. RIS download Bibtex download
  • CLEZARDIN P, MCGREGOR JL, CLEMETSON KJ, DECHAVANNE M & LUSCHER EF (1981) FURTHER CHARACTERIZATION OF PLATELET MEMBRANE-GLYCOPROTEINS. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 108-108) RIS download Bibtex download
  • MCGREGOR JL, CLEMETSON KJ, JAMES E, CLEZARDIN P, DECHAVANNE M & LUSCHER EF (1981) TRYPTIC PEPTIDE MAPS OF THE MAJOR HUMAN-BLOOD PLATELET MEMBRANE-GLYCOPROTEINS, IIA, IIA, IIB, IIIA, IIIB AND IIIC. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 22-22) RIS download Bibtex download
  • MCGREGOR JL, CLEMETSON KJ, JAMES E, CAPITANIO A, DECHAVANNE M & LUSCHER EF (1981) ADDITIONAL GLYCOPROTEIN DEFECTS IN GLANZMANN THROMBASTHENIA PLATELETS. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 22-22) RIS download Bibtex download
Teaching interests

I have supervised a total of 18 PhD students (16 as main supervisor and 2 as co-supervisor) and 9 postdocs.

I am currently module leader of the UE « Metastasis, Migration and EMT » for the Master in Oncology at the University Claude Bernard Lyon-1, Lyon, France.

Professional activities

I am/was engaged, as academic partner or coordinator, in several research projects/programmes funded by the French National Agency for Cancer (INCa) and INSERM, as well as European projects within the framework of FP6 and FP7, and H2020 research programmes [MetaBre (partner; 2004-2007), PROMET (partner; 2006-2010), BONE-NET (coordinator; 2011-2014), miROMeS (coordinator; 2016-2017)]. In this respect, I received a European Star Award (Paris, France, 2015) as coordinator of the Marie Curie ITN project BONE-NET.

Board of Directors member of the Laboratory of Excellence « DEVweCAN » funded by the French National Research Agency (ANR) (2011-present).

President of the Cancer & Bone Society (CABS; 2009-2010).

Board of Directors member of national and international learned societies (2004-2018) [CABS, International Bone and Mineral Society (IBMS), ARTP (French Prostate Cancer Society), and GEMO ((French Study Group of Bone Metastasis)].

Member of American Association for Cancer Research (AACR), American Society for Bone and Mineral Research (ASBMR), Cancer & Bone Society (CABS), and GEMO.