Full list of technical support documents (TSDs)

All the technical support documents produced by the Nice DSU. The TSDs have the aim of providing further information about how to implement the approaches described in the current Guide to the Methods of Technology Appraisal (2022).


One-page technical support document (TSD) summaries that have been produced so far.

One-page summaries

TSD 21: Flexible methods for survival analysis (PDF, 5.7MB)

TSD 20: Multivariate meta-analysis of summary data for combining treatment effects on correlated outcomes and evaluating surrogate endpoints (PDF, 1.2MB)

TSD 19: Partitioned survival analysis as a decision modelling tool (PDF, 529KB)

TSD 18: Methods for population-adjusted indirect comparisons in submissions to NICE (PDF, 1.5MB)

TSD 17: The use of observational data to inform estimates of treatment effectiveness in technology appraisal: Methods for comparative individual patient data (PDF, 604KB)

TSD 16: Adjusting survival time estimates in the presence of treatment switching (PDF, 450KB)

TSD 15: Cost-effectiveness modelling using patient-level simulation (PDF, 494KB)

TSD 14: Survival analysis for economic evaluations alongside clinical trials – extrapolation with patient-level data (PDF, 395KB)

TSD 13: Identifying and reviewing evidence to inform the conceptualisation and population of cost-effectiveness models (PDF, 376KB)

TSD 12: The use of health state utility values in decision models (PDF, 164KB)

TSD 11: Alternatives to EQ-5D for generating health state utility values (PDF, 157KB)

TSD 10: The use of mapping methods to estimate health state utility values (PDF, 144KB)

TSD 9: The identification, review and synthesis of health state utility values from the literature (PDF, 304KB)

TSD 8: An introduction to the measurement and valuation of health for NICE submissions (PDF, 136KB)

TSD 7: Evidence synthesis of treatment efficacy in decision making: a reviewer’s checklist (PDF, 147KB)

TSD 6: Embedding evidence synthesis in probabilistic cost effectiveness analysis: Software choices (PDF, 122KB)

TSD 5: Evidence synthesis in the baseline natural history model (PDF, 178KB)

TSD 4: Inconsistency in networks of evidence based on randomised controlled trials (PDF, 429KB)

TSD 3: Heterogeneity: subgroups, meta-regression, bias and bias-adjustment (PDF, 492KB)

TSD 2: A general linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials (PDF, 1.6MB)

TSD 1: Introduction to evidence synthesis for decision making (PDF, 106KB)

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