Chloe
Thomas
School of Medicine and Population Health
Research Fellow
c.thomas@sheffield.ac.uk
+44 114 222 0785
+44 114 222 0785
+44 114 222 0749
(Fax)
Regent Court (ScHARR)
Full contact details
Chloe Thomas
Regent Court (ScHARR)
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
-
I joined HEDS in January 2014 as an assistant modeller studying part-time for the HEDM MSc. This was a change of direction following a 13 year career in biomedical research. I completed a BSc in Genetics in 1999 and followed this with a PhD in 2003, both from the University of Sheffield, before working at the University of Nice, France and the department of Biomedical Science at the University of Sheffield.
Within HEDS I specialise in public health-related modelling projects, focussing particularly upon modelling of diabetes and cardiovascular disease prevention, and development of return on investment tools. I have worked closely with Public Health England (PHE), NHS England and NICE for a series of projects modelling the return on investment of the NHS Diabetes Prevention Programme, based upon adaptation of the School for Public Health Research Diabetes Prevention Model. More recently, I worked with PHE to develop a cardiovascular disease prevention return on investment tool. I am also part of the team working on the Sheffield bowel cancer screening model, which informs decisions about the UK bowel cancer screening programme.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Cost-effectiveness and equity impact of complex primary care interventions for disadvantaged populations. BJGP Open. View this article in WRRO
- Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project. BMJ Public Health, 3(1). View this article in WRRO
- Cost-effectiveness of one-off upper abdominal CT screening as an add-on to lung cancer screening in England. British Journal of Cancer, 133(2), 239-247. View this article in WRRO
- The feasibility and acceptability of an app-based intervention with brief behavioural support (APPROACH) to promote brisk walking in people diagnosed with breast, prostate and colorectal cancer in the UK. Cancer Medicine, 13(6). View this article in WRRO
- The health, cost and equity impacts of restrictions on the advertisement of high fat, salt and sugar products across the transport for London network: a health economic modelling study. International Journal of Behavioral Nutrition and Physical Activity, 19. View this article in WRRO
- Modelling cost-effective strategies for minimising socioeconomic inequalities in colorectal cancer screening outcomes in England. Preventive Medicine, 162. View this article in WRRO
- Modelling the impact of the coronavirus pandemic on bowel cancer screening outcomes in England: a decision analysis to prepare for future screening disruption. Preventive Medicine, 160. View this article in WRRO
- The costs and benefits of risk-stratification for colorectal cancer screening based on phenotypic and genetic risk: a health economic analysis. Cancer Prevention Research, 14(8), 811-822.
- Should colorectal cancer screening start at different ages for men and women? Cost‐effectiveness analysis for a resource‐constrained service. Cancer Reports, 4(4). View this article in WRRO
- The impact of including costs and outcomes of dementia in a health economic model to evaluate lifestyle interventions to prevent diabetes and cardiovascular disease. Medical Decision Making, 40(7), 912-923. View this article in WRRO
- What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation. BMJ Open, 10(9). View this article in WRRO
- External validation of a colorectal cancer model against screening trial long term follow-up data. Value in Health, 22(10), 1154-1161. View this article in WRRO
- Assessing the Potential Return on Investment of the Proposed UK NHS Diabetes Prevention Programme in Different Population Subgroups: An Economic Evaluation. BMJ Open, 7. View this article in WRRO
- Cost-effectiveness of population-based, community, workplace and individual policies for diabetes prevention in the UK.. Diabetic Medicine, 34(8), 1136-1144. View this article in WRRO
- The impact of Type 2 diabetes prevention programmes based on risk-identification and lifestyle intervention intensity strategies: a cost-effectiveness analysis.. Diabetic Medicine, 34(5), 632-640. View this article in WRRO
All publications
Journal articles
- Small area estimates of co-occurring health risk factors: A test of two synthetic population methodologies to estimate small-area prevalence of smoking, harmful alcohol consumption and obesity in England. Social Science & Medicine, 410, 119896-119896.
- EE4 HEALTH AND ECONOMIC IMPACT OF SALT AND ALCOHOL REDUCTION STRATEGIES FOR HYPERTENSION AND CARDIOVASCULAR DISEASE PREVENTION IN GHANA. Value in Health, 29(6), S62-S62.
- Equity impact and cost-effectiveness of a community health worker breast cancer educational programme in rural South Africa: a modelling study. BMJ Open, 16(4), e114908-e114908.
- Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group.. Pharmacoeconomics.
- EE383 Economic Evaluation of Second-Generation Colon Capsule Endoscopy for Investigation of the Colon Through Direct Visualization. Value in Health, 28(12), S180-S181.
- MSR68 Demonstrating the Importance of Modeling Rapid Cancer Progression in Screening Evaluations. Value in Health, 28(12), S506-S506.
- Wastewater-based epidemiology for local tobacco and nicotine use with small-area estimations. European Journal of Public Health, 35(Supplement_4).
- Application of the socio-ecological model to understand the drivers of excessive alcohol and salt consumption: a qualitative study in Ghana. BMJ Open, 15(10), e100490-e100490.
- Cost-effectiveness and equity impact of complex primary care interventions for disadvantaged populations. BJGP Open. View this article in WRRO
- Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project. BMJ Public Health, 3(1). View this article in WRRO
- Assessing the value for money, from a policy maker perspective, of 24 randomised controlled trial designs for an online weight maintenance guided self-help intervention: an expected value of sample information analysis. International Journal of Obesity, 49(8), 1598-1607. View this article in WRRO
- Cost-effectiveness of one-off upper abdominal CT screening as an add-on to lung cancer screening in England. British Journal of Cancer, 133(2), 239-247. View this article in WRRO
- Public health economic modelling in evaluations of salt and/or alcohol policies: a systematic scoping review. BMC Public Health, 25(1). View this article in WRRO
- Home urine dipstick screening for bladder and kidney cancer in high-risk populations in England: a microsimulation study of long-term impact and cost-effectiveness. PharmacoEconomics, 43(4), 441-452. View this article in WRRO
- A systematic review of public health interventions to address breast cancer inequalities in low- and middle-income countries. Systematic Reviews, 13(1). View this article in WRRO
- Understanding the preferences and considerations of the public towards risk‐stratified screening for colorectal cancer: Insights from think‐aloud interviews based on a discrete choice experiment. Health Expectations, 27(4). View this article in WRRO
- Development of the Microsimulation Model in Cancers of Bladder and Kidney (MiMiC-BlaKy). HEDS Discussion Paper Series(24.03). View this article in WRRO
- The feasibility and acceptability of an app-based intervention with brief behavioural support (APPROACH) to promote brisk walking in people diagnosed with breast, prostate and colorectal cancer in the UK. Cancer Medicine, 13(6). View this article in WRRO
- Cross-model validation of public health microsimulation models; comparing two models on estimated effects of a weight management intervention. BMC Public Health, 24. View this article in WRRO
- SA18 Public Health Economic Modelling in Evaluations of Salt and Alcohol Policies: A Scoping Review. Value in Health, 26(12), S544-S544.
- A discrete choice experiment to understand public preferences and priorities for risk-stratified bowel cancer screening programmes in the UK. Preventive Medicine, 177(107786). View this article in WRRO
- Implementation of risk stratification within bowel cancer screening: a community jury study exploring public acceptability and communication needs. BMC Public Health, 23(1). View this article in WRRO
- Dietary approaches to the management of type 2 diabetes (DIAMOND) in primary care: a protocol for a cluster randomised trial. Contemporary Clinical Trials, 129. View this article in WRRO
- Effectiveness and cost-effectiveness of referral to a commercial open group behavioural weight management programme in adults with overweight and obesity: 5-year follow-up of the WRAP randomised controlled trial. The Lancet Public Health, 7(10), e866-e875. View this article in WRRO
- The health, cost and equity impacts of restrictions on the advertisement of high fat, salt and sugar products across the transport for London network: a health economic modelling study. International Journal of Behavioral Nutrition and Physical Activity, 19. View this article in WRRO
- Estimating the impact of changes in weight and BMI on EQ-5D-3L : a longitudinal analysis of a behavioural group-based weight loss intervention. Quality of Life Research, 31(11), 3283-3292. View this article in WRRO
- Modelling cost-effective strategies for minimising socioeconomic inequalities in colorectal cancer screening outcomes in England. Preventive Medicine, 162. View this article in WRRO
- A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening. Health Expectations, 25(4), 1789-1806.
- Modelling the impact of the coronavirus pandemic on bowel cancer screening outcomes in England: a decision analysis to prepare for future screening disruption. Preventive Medicine, 160. View this article in WRRO
- A comparison of the World Health Organisation's HEAT model results using a non-linear physical activity dose response function with results from the existing tool. Wellcome Open Research, 7. View this article in WRRO
- An app with brief behavioural support to promote physical activity after a cancer diagnosis (APPROACH) : study protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 8(1), 74-74. View this article in WRRO
- Using health economic modelling to inform the design and development of an intervention : estimating the justifiable cost of weight loss maintenance in the UK. BMC Public Health, 22(1). View this article in WRRO
- Calibrating natural history of cancer models in the presence in the presence of data incompatibility; problems and solutions. PharmacoEconomics, 40(4), 359-366. View this article in WRRO
- A comparison of the World Health Organisation's HEAT model results using a non-linear physical activity dose response function with results from the existing tool [under peer review]. Wellcome Open Research, 7(2022). View this article in WRRO
- Development of a web-based, guided self-help, acceptance and commitment therapy-based intervention for weight loss maintenance: evidence-, theory-, and person-based approach.. Jmir Formative Research, 6(1). View this article in WRRO
- Exploring structural uncertainty and impact of health state utility values on lifetime outcomes in diabetes economic simulation models : findings from the Ninth Mount Hood Diabetes Quality-of-Life Challenge. Medical Decision Making, 42(5), 599-611. View this article in WRRO
- Optimizing the design of a repeated fecal immunochemical test bowel cancer screening programme with a limited endoscopy capacity from a health economic perspective. Value in Health, 25(6), 954-964. View this article in WRRO
- The costs and benefits of risk-stratification for colorectal cancer screening based on phenotypic and genetic risk: a health economic analysis. Cancer Prevention Research, 14(8), 811-822.
- The price of precision: trade-offs between usability and validity in the World Health Organization Health Economic Assessment Tool for walking and cycling. Public Health, 194, 263-269. View this article in WRRO
- Electronic clinical decision support tool for assessing stomach symptoms in primary care (ECASS): a feasibility study. BMJ Open, 11(3).
- Should colorectal cancer screening start at different ages for men and women? Cost‐effectiveness analysis for a resource‐constrained service. Cancer Reports, 4(4). View this article in WRRO
- Schizophrenia treatment with second-generation antipsychotics : a multi-country comparison of the costs of cardiovascular and metabolic adverse events and weight gain. Neuropsychiatric Disease and Treatment, 17, 125-137. View this article in WRRO
- The impact of including costs and outcomes of dementia in a health economic model to evaluate lifestyle interventions to prevent diabetes and cardiovascular disease. Medical Decision Making, 40(7), 912-923. View this article in WRRO
- What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation. BMJ Open, 10(9). View this article in WRRO
- External validation of a colorectal cancer model against screening trial long term follow-up data. Value in Health, 22(10), 1154-1161. View this article in WRRO
- Assessing the Potential Return on Investment of the Proposed UK NHS Diabetes Prevention Programme in Different Population Subgroups: An Economic Evaluation. BMJ Open, 7. View this article in WRRO
- Cost-effectiveness of population-based, community, workplace and individual policies for diabetes prevention in the UK.. Diabetic Medicine, 34(8), 1136-1144. View this article in WRRO
- Screening for glucose intolerance and development of a lifestyle education programme for prevention of Type 2 diabetes in a population with intellectual disabilities. Programme Grants for Applied Research, 5(11). View this article in WRRO
- The impact of Type 2 diabetes prevention programmes based on risk-identification and lifestyle intervention intensity strategies: a cost-effectiveness analysis.. Diabetic Medicine, 34(5), 632-640. View this article in WRRO
- Estimating the cost-effectiveness of brief interventions for heavy drinking in primary health care across Europe. European Journal of Public Health, 27(2), 345-351. View this article in WRRO
- The cost-effectiveness of an updated theory-based online health behavior intervention for new university students: U@Uni2. Journal of Public Health & Epidemiology, 8(10), 191-203. View this article in WRRO
- Retracted: Impact of Type 2 diabetes prevention programmes based on risk identification and lifestyle intervention intensity strategies: a cost‐effectiveness analysis. Diabetic Medicine, 33(8), 1155-1163.
- A theory-based online health behaviour intervention for new university students (U@Uni: LifeGuide): Results from a repeat randomized controlled trial. Trials, 16(1).
- The cost-effectiveness of a theory-based online health behaviour intervention for new university students: an economic evaluation. Annals of Surgical Innovation and Research, 14. View this article in WRRO
- Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.. Dev Biol, 385(1), 107-121.
- Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous. Current Biology.
- The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila. Developmental Dynamics, 192(4).
- JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30. Developmental Biology, 331(2), 250-260.
- Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.. Mech Dev, 121(6), 507-518.
- Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes.. Genetics, 165(4), 1915-1928.
- Erratum: Mutations in the sterol sensing domain of patched suggest a role for vesicular trafficking in Smoothened regulation (current biology (2001) 11:8 (608-613)). Current Biology, 11(14), 1153.
- Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.. Curr Biol, 11(8), 608-613.
- PillCam COLON 2 for investigation of the colon through direct visualisation: systematic review and economic evaluation. Health Technology Assessment, 1-164. View this article in WRRO
- Correction: Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group. PharmacoEconomics.
- Lung Cancer Screening in a Population from Northeast Italy Exposed to Both Asbestos and Smoking: A Cost-Effectiveness Analysis. Journal of Clinical Medicine, 15(8), 3136-3136.
- An app-based behavioural support intervention promoting physical activity (APPROACH) in patients diagnosed with breast, prostate or colorectal cancer: a study protocol for a randomised controlled trial (Preprint). JMIR Research Protocols.
Conference proceedings
- HEALTH AND ECONOMIC IMPACT OF SALT AND ALCOHOL REDUCTION STRATEGIES FOR HYPERTENSION AND CARDIOVASCULAR DISEASE PREVENTION IN GHANA. VALUE IN HEALTH, Vol. 29(6) (pp S62-S62)
- DEMONSTRATING THE IMPORTANCE OF MODELING RAPID CANCER PROGRESSION IN SCREENING EVALUATIONS. VALUE IN HEALTH, Vol. 28(12)
- ECONOMIC EVALUATION OF SECOND-GENERATION COLON CAPSULE ENDOSCOPY FOR INVESTIGATION OF THE COLON THROUGH DIRECT VISUALIZATION. VALUE IN HEALTH, Vol. 28(12)
- PUBLIC HEALTH ECONOMIC MODELLING IN EVALUATIONS OF SALT AND ALCOHOL POLICIES: A SCOPING REVIEW. VALUE IN HEALTH, Vol. 26(12) (pp S544-S544)
- Promoting physical activity via a smartphone application in people living with breast, prostate or colorectal cancer: study protocol for a randomised pilot trial (APPROACH). Psycho-Oncology, Vol. 31(S2) (pp 20-20). Online, 28 April 2022 - 28 April 2022. View this article in WRRO
- Validation of the SPHR Diabetes Prevention Model. Value in Health, Vol. 17(7) (pp A556-A556)
- Layering Interventions for Type-2 Diabetes Prevention Using The Sphr Diabetes Model. Value in Health, Vol. 17(7) (pp A347-A347)
Reports
- Development of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies View this article in WRRO
- ECASS health economic feasibility study View this article in WRRO
- Optimising Bowel Cancer Screening Phase 1: Optimising the cost effectiveness of repeated FIT screening and screening strategies combining bowel scope and FIT screening View this article in WRRO
- SPHR Diabetes Prevention Model: Detailed Description of Model Background, Methods, Assumptions and Parameters View this article in WRRO
Software, code or databases
- SPHR Obesity and Diabetes Prevention Model Version 6.2.
- Sheffield Type 2 Diabetes Treatment Model version 4.0: with the GLoW Trial health economic analysis implemented..
- Sheffield Type 2 Diabetes Treatment Model version 3: with the Embedding RCT health economic analyses implemented.
Presentations
- Evaluating the potential impact of FAIRSTEPS primary care interventions on health inequity and cost-effectiveness.. Society of Academic Primary Care Conference.
Other
- Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Supplementary Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Supplementary Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Data from The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk: A Health Economic Analysis.
- Evaluation of Cancer screening and awareness programme in Leeds: Initial report.
- Evaluation of Cancer screening and awareness programme in Leeds: Interim report.
- DIAMOND: Dietary Approaches to the Management of Type 2 Diabetes Cluster Randomised Trial. Health Economics Modelling Analysis Plan..
Preprints
- Diabetes testing, care cascade and the burden of undiagnosed diabetes in Kenya. Evidence from the Kenya STEPwise Survey, openRxiv.
- An App-Based Behavioral Support Intervention Promoting Physical Activity (APPROACH) in Patients Diagnosed With Breast, Prostate, or Colorectal Cancer: Protocol for a Randomized Controlled Trial (Preprint), JMIR Publications Inc..
- Assessing the value for money, from a policy maker prospective, of 24 randomised controlled trial designs for an online weight maintenance guided self-help intervention: An expected value of sample information analysis., Springer Science and Business Media LLC.
- Dietary Approaches to the Management of Type 2 Diabetes (DIAMOND) in Primary Care: A Protocol for a Cluster Randomised Trial, Elsevier BV.
- An App With Brief Behavioural Support to Promote Physical Activity After a Cancer Diagnosis (APPROACH): Study Protocol for a Pilot Randomised Controlled Trial, Springer Science and Business Media LLC.
- Development of a Web-Based, Guided Self-help, Acceptance and Commitment Therapy–Based Intervention for Weight Loss Maintenance: Evidence-, Theory-, and Person-Based Approach (Preprint), JMIR Publications Inc..
- Calibration and Validation of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies. View this article in WRRO
- Cost-effectiveness and equity impact of complex primary care interventions for disadvantaged populations. BJGP Open. View this article in WRRO