BEADS trial – Behavioural Activation therapy for Depression after Stroke
BEADS (Behavioural Activation therapy for Depression after Stroke) is a pilot randomised controlled trial to assess the feasibility of a study to investigate the clinical and cost-effectiveness of behavioural activation (BA) therapy for people with post-stroke depression.
Our key objectives are to assess the feasibility of proceeding to a definitive trial, and the feasibility of delivering BA to people with post-stroke depression. To address this, the study also incorporates qualitative research with participants, carers and therapists and an economic evaluation. The primary clinical outcome measure is the PHQ-9 (Patient Health Questionnaire 9) at six months after randomisation.
The study is being led by Shirley Thomas from the Division of Rehabilitation and Ageing at the University of Nottingham and the trial is being coordinated from the Sheffield Clinical Trials Research Unit. It is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (ref: 13/14/01).
This work builds on the success of a previous study led by the Chief Investigator: CALM (Communication and Low Mood) which was funded by the Stroke Association to test BA for people with aphasia, and showed a positive impact on mood at six months.
The trial opened in May 2015 and aims to recruit 72 people with post-stroke depression across three centres (Derby, Mansfield and Sheffield) over 12 months. Participants will be randomised to receive BA or usual care for four months.
Update: BEADS has now finished recruiting and we are currently completing follow up for recruited participants.
Study staff
| Name | Role | Site | Contact |
|---|---|---|---|
| Shirley Thomas | Chief Investigator | Division of Rehabilitation & Ageing University of Nottingham |
shirley.thomas@nottingham.ac.uk +44 115 846 7484 |
| Gemma Hackney | Trial Manager (maternity cover) | Clinical Trials Research Unit (CTRU) The University of Sheffield |
g.hackney@sheffield.ac.uk +44 114 222 4320 |
| Zoe Furniss | Trials Support Officer | Clinical Trials Research Unit (CTRU) The University of Sheffield |
z.furniss@sheffield.ac.uk +44 114 225 9122 |
| Stephen Walters | Senior Statistician | Clinical Trials Research Unit (CTRU) The University of Sheffield |
s.j.walters@sheffield.ac.uk +44 114 272 4095 |
| Laura Mandefield | Statistician | Clinical Trials Research Unit (CTRU) The University of Sheffield |
l.mandefield@sheffield.ac.uk +44 114 22 20750 |
| Nick Latimer | Health Economist | Clinical Trials Research Unit (CTRU) The University of Sheffield |
n.latimer@sheffield.ac.uk +44 114 272 4095 |
| Tim Chater | Data Manager | Clinical Trials Research Unit (CTRU) The University of Sheffield |
t.chater@sheffield.ac.uk +44 114 22 20876 |
| Saleema Rex | Data Analyst | Clinical Trials Research Unit (CTRU) The University of Sheffield |
s.rex@sheffield.ac.uk +44 114 22 20737 |
| Cindy Cooper | CTRU Director | Clinical Trials Research Unit (CTRU) The University of Sheffield |
c.l.cooper@sheffield.ac.uk +44 114 22 20749 |
| Professor Patrick Callaghan | Co-Investigator | University of Nottingham | patrick.callaghan@nottingham.ac.uk |
| Professor Avril Drummond | Chief Investigator (maternity cover) | University of Nottingham | avril.drummond@nottingham.ac.uk |
| Associate Professor Timothy England | Co-Investigator | University of Nottingham | timothy.england@nottingham.ac.uk |
| Professor Nadina Lincoln | Co-Investigator | University of Nottingham | nadina.lincoln@nottingham.ac.uk |
| Dr Roshan das Nair | Co-Investigator | Nottingham University Hospitals NHS Trust | roshan.nair@nottingham.ac.uk |
| Dr Rebecca Palmer | Co-Investigator | University of Sheffield | r.l.palmer@sheffield.ac.uk |
Links
Download
- BEADS Newsletter (June 2016) (PDF, 407KB)