Publications
Peer reviewed publications containing work performed by the Skeletal Analysis Laboratories team.
2022
2021
- The role of static bone histomorphometry in diagnosing renal osteodystrophy (Bone)
- Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease (Bone)
- Subchondral Bone Microarchitectural and Mineral Properties and Expression of Key Degradative Proteinases by Chondrocytes in Human Hip Osteoarthritis (Biomedicines)
- MicroFE models of porcine vertebrae with induced bone focal lesions: Validation of predicted displacements with digital volume correlation (J Mech Behav Biomed Mater)
- Positive interactions of mechanical loading and PTH treatments on spatio-temporal bone remodelling (Acta Biomater)
- The Role of the Loading Condition in Predictions of Bone Adaptation in a Mouse Tibial Loading Model (Front Bioeng Biotechnol)
- A novel approach to evaluate the effects of artificial bone focal lesion on the three-dimensional strain distributions within the vertebral body (PLoS One)
- Subchondral bone microarchitecture and mineral density in human osteoarthritis and osteoporosis: A regional and compartmental analysis (J Orthop Res)
- Non-invasive prediction of the mouse tibia mechanical properties from microCT images: comparison between different finite element models (Biomech Model Mechanobiol)
- Damage tolerance and toughness of elderly human femora (Acta Biomater)
- Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications (J Mech Behav Biomed Mater)
- Investigation of Aurora Kinase A as a Potential Biomarker of Radiation in Non-Small Cell Lung Cancer (J Thorac Oncol)
- Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial (Lancet Rheum)
2020
- Characterization of a composite polylactic acid-hydroxyapatite 3D-printing filament for bone-regeneration (Biomed Phys Eng Exp)
- The relationship between bone regulatory markers and bone turnover in renal osteodystrophy (Bone)
- Regional Nanoindentation Properties in Different Locations on the Mouse Tibia From C57BL/6 and Balb/C Female Mice (Front Bioeng Biotechnol).
- Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation (Materials Basel).
- Development of Subject Specific Finite Element Models of the Mouse Knee Joint for Preclinical Applications (Front Bioeng Biotechnol).
- Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications (J Mech Behav Biomed Mater).
- PTH(1-34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse (Nature).
- Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study (Acta Biomater).
- A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint. (Sci Rep).
2019
- A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions. (Biomech Model Mechanobiol).
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia. (PLoS One).
- A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones. (PLoS One).
- Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models. (J Mech Behav Biomed Mater).
- The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains. (Bone).
- Analysis of Bone Architecture in Rodents Using Micro-Computed Tomography. (Methods Mol Biol).
- From bed to bench: How in silico medicine can help ageing research. (Mech Ageing Dev).
2018
- Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy. (JASN).
- An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion. (JBMR Plus).
- Variability in strain distribution in the mice tibia loading model: A preliminary study using digital volume correlation. (Med Eng Phys).
- Comparison of HR-pQCT- and microCT-based finite element models for the estimation of the mechanical properties of the calcaneus trabecular bone. (Biomech Model Mechanobiol).
- Validation of finite element models of the mouse tibia using digital volume correlation. (J Mech Behav Biomed Mater).
- Validation of calcaneus trabecular microstructure measurements by HR-pQCT. (Bone).
2017
- Effect of integration time on the morphometric, densitometric and mechanical properties of the mouse tibia. (J Biomech).
- Longitudinal effects of Parathyroid Hormone treatment on morphological, densitometric and mechanical properties of mouse tibia. (J Mech Behav Biomed Mater).
2016
- The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. (J Clin Invest).
- Development of a protocol to quantify local bone adaptation over space and time: Quantification of reproducibility. (J Biomech).
2015
- Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation. (J Biomech).
- Three-dimensional local measurements of bone strain and displacement: comparison of three digital volume correlation approaches. (J Biomech Eng. 2015)
- The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. (Nature. 2015).
- Lack of prolidase causes a bone phenotype both in human and in mouse. (Bone. 2015).
2014
- Direct fracture resistance testing of bone in children using the RPI instrument. (Ann Med and Surg).
- About the inevitable compromise between spatial resolution and accuracy of strain measurement for bone tissue: a 3D zero-strain study. (J Biomech. 2014)
- Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models. (J Bone Miner Res. 2014)
2013
- Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. (PLoS One).
- The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading. (J Bone Miner Res. 2013)
- Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. (PLoS One. 2013).
2012
- A Soluble bone morphogenetic protein type 1A receptor increases bone mass and bone strength (PNAS 2012).
- Bone healing response to a synthetic calcium sulfate/β-tricalcium phosphate graft material in a sheep vertebral body defect model. (Journal of Biomedical Materials Research 2012).
- Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. (PLoS Genet 2012).
- Inhibitor Rcan2 Have an Isolated Defect of Osteoblast Function. (Endocrinology 2012).
- Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway. (Leukemia 2012).
- Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. (PLoS Genet 2012).
- A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. (J Bone Miner Res 2012).
2009 – 11
- Differential expression of microRNA processing machinery in Urothelial Carcinoma (BJU International)
- A tissue-engineered approach to augmentation of the urinary bladder (Int J Surgery)
- Hypermethylation of CpG islands and shores around specific microRNAs and mirtrons is associated with the phenotype and presence of bladder cancer (Clin Cancer Res)
- LOXL2-mediated matrix remodelling in metastasis and mammary gland involution (Cancer Res 2011).
- Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts (PNAS 2010).
- Inhibiting activin-A signalling stimulates bone formation and prevents cancer induced bone destruction in vivo. (J Bone Miner Res 2010).
- Cancer-induced bone loss and associated pain-related behaviour is reduced by risedronate but not its phosphocarboxylate analog NE-10790. (Int J Cancer 2009).
- Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. (J Bone Miner Res 2009).
Before 2008
- Decellularization and sterilization of porcine urinary bladder matrix for tissue engineering in the lower urinary tract (Regen Med, 2008)
- Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Inhibit Osteoclast Activation and Increase Trabecular Bone Area in a Xenogeneic Murine Model of Myeloma. (Blood, 2008).
- RAP-011, a soluble activin receptor type IIA IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone disease in multiple myeloma. (Clin Exp Metastasis).
- Geranylgeranyl transferase type II inhibition prevents myeloma bone disease. (Biochem Biophys Res Commun 2008).
- An Osteoprotegerin-like Peptidomimetic Inhibits Osteoclastic Bone Resorption and Osteolytic Bone Disease in Myeloma. (Cancer Res 2007).
- A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer. (Leukemia 2007).
- Targeting the IGF-1R using picropodophyllin (PPP) in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival. (Int J Cancer 2007).
- Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone. (Cancer Res 2007).
- Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma. (Cancer Res 2009).
- Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model. (Clin Exp Metastasis 2006).
- Mutations in VAPB are not associated with sporadic ALS. (Neurology 2007).