Professor Nils P Krone
MD, FRCPCH
School of Medicine and Population Health
Professor of Paediatric Endocrinology
Honorary Consultant Paediatric Endocrinologist
+44 114 271 7508
Full contact details
School of Medicine and Population Health
Room 16, The Damer Street Building
Sheffield Children's Hospital
Western Bank
Sheffield
S10 2TH
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I graduated from the Ludwig-Maximilian’s University, Munich, Germany, where I was also awarded my MD for studies into the genotype-phenotype correlation in congenital adrenal hyperplasia. I have trained in General Paediatrics and Paediatric Endocrinology at the University Children’s Hospital, Munich and University of Kiel Children’s Hospital, Germany (1999-2006). I have been working at the University of Birmingham as Wellcome Trust Clinician Scientist and Senior Clinical Lecturer (2006-2015).
I was appointed at the University of Sheffield in 2015 and work as Honorary Consultant Paediatric Endocrinologist at Sheffield Children’s Hospital, where I lead the adrenal and disorders/ differences of sex development (DSD) clinical service.
Current PhD Opportunities:
- Research interests
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My main clinical and basic research interests are inborn errors of steroid hormone biosynthesis and steroid hormone metabolism in health and disease. This is closely interlinked with my main clinical interests into inborn errors of steroidogenesis, congenital adrenal hyperplasia (CAH), disorders/ differences of sex development (DSD), and PCOS.
Ongoing work of my group explores the systemic consequences of disrupted steroid hormone synthesis and action on whole organism employing zebrafish as a model organism in translational steroid hormone research. This research is based at the Bateson Centre.
The main focus of my clinical research program is on CAH. I led on several projects to establish the evidence basis on the current health status in children and young people with congenital adrenal hyperplasia in the UK as well as standardisation of healthcare provision.
In addition, I work on a program to improve health care deliver for children and young people with DSD .
Current projects
- Understanding the systemic consequences to disrupted steroidogenesis.
- Long-term pathophysiology of glucocorticoid deficiency
- Health status of children and young persons with congenital adrenal hyperplasia (CAH-UK).
- Improving biomarkers for therapy monitoring in CAH.
- Current practice of CAH healthcare delivery in the UK.
- Publications
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- Teaching interests
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I deliver undergraduate teaching as well as postgraduate medical training and education. I teach on the MBChB course in phase 1, 2 and 3 and I am Endocrinology Phase 1 Teaching Lead.
I am module lead for the MED6100 module on the Clinical Research MSc course.
I am Deputy Director Clinical Academic Training, Sheffield Medical School and South Yorkshire and Humber Deanery. Furthermore, I am Academic training lead for paediatric clinical academic posts, University of Sheffield.
- Professional activities and memberships
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Editorship
- Associate Editor: Frontiers Genomic Endocrinology since 2014
- Editorial Board: Journal of Clinical Endocrinology & Metabolism (2013-2019)
- Editorial Board: International Journal Endocrinology since 2015
- Editorial Board: Endocrine Connections, 2012-2015
National committees (selected)
- Chair of the Adrenal/ CAH Special Interest Groups of The British Society of Paediatric Endocrinology and Diabetes (since 2021, Founding Chair)
- Member, Clinical guideline development "Diagnosis of disorders of sexual development (DSD); Member of Joint Society for Endocrinology/ BSPED DSD taskforce (2009-2011); revision of guidance in 2015, 2021
- Member of the Society for Endocrinology Program Organising Committee (2016-2020)
- Chair of the Disorders of Sex Development Special Interest Groups of The British Society of Paediatric Endocrinology and Diabetes (BSPED DSD SIG) (2014-2020); Founding Member of the BSPED DSD SIG 2011-2013)
International Activities (selected)
- Chair of the European Society for Paediatric Endocrinology (ESPE) program organising committee and ESPE Council Member (since 2019)
- Member of the European Society for Paediatric Endocrinology (ESPE) program organising committee (POC) (2013-2019)
- UK Representative to Management Committees for COST Action DSDnet (2013-2018)
- Member of the I-DSD/CAH Registry (http://www.i-cah.org/) Scientific Panel (since 2018)