Sue Harnan
Population Health, School of Medicine and Population Health
Senior Research Fellow
+44 114 222 0869
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
-
I graduated from the University of Sheffield in 1996 with a BSc in Physiology and went on to graduate with an MSc in Science, Culture and Communication at the University of Bath in 2002. I worked in the charitable sector as a systematic reviewer at Penny Brohn Cancer Care for two years before joining ScHARR in 2009.
My primary interest is in Health Technology Assessment, and I have been a member of ScHARR’s Technology Assessment Group (ScHARR-TAG), which conducts assessments for the National Institute for Health and Care Excellence (NICE), since 2009. I have worked on and led systematic reviews and technology appraisals on a wide range of topics as part of this programme of work, and have special interest and expertise in diagnostic and prognostic topics.
I also plan and conduct reviews as part of ScHARR’s Knowledge Exchange partnerships, with industry, public health and charitable funders.
- Research interests
-
- Health technology assessment
- Systematic review methodologies including
- Diagnostic reviews
- Rapid reviews
- Review of reviews
- Review techniques for network meta analyses
- Non-RCT reviews
- Systematic review of psychometric properties of outcome measures
- Health and wellbeing benefits of the natural environment
Recent and current projects
Recent and current NICE projects
- Quantitative faecal immunochemical tests to guide referral in primary care for people with a change in bowel habit or abdominal pain [DAP50] (Diagnostic Assessment Report for NICE) (2020- ongoing; project lead)
- Volanesorsen for treating familial chylomicronaemia syndrome [ID1326] (Highly Specialised Technology assessment for NICE) (2018-19; project lead)
- Velmanase alfa for treating alpha-mannosidosis [ID800] (Highly Specialised Technology Assessment for NICE) (2018-19) Trifluridine–tipiracil for treating metastatic gastric or gastro-oesophageal junction cancer after 2 or more therapies [ID1507](Single Technology Appraisal for NICE) (2019)
- Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis (Diagnostic Assessment for NICE) (2017-18; project lead)
Recent and current other work
- The impact of pruritus on health-related quality of life (HRQoL) in patients with end-stage kidney disease (ESKD) or chronic kidney disease associated with pruritus (CKD-aP) on haemodialysis: a systematic review (Commercial sponsor) (2020 – ongoing)
- A series of systematic reviews and meta-analyses of the risk of hip and non-vertebral fractures in patients with chronic kidney disease, Parkinson’s disease and diabetes (Commercial Sponsor) (2019)
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- The risk of hip and non-vertebral fractures in patients with Parkinson's disease and parkinsonism : a systematic review and meta-analysis. Bone, 132. View this article in WRRO
- Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis. Health Technology Assessment, 23(30). View this article in WRRO
- Exhaled nitric oxide in the diagnosis of asthma in adults: a systematic review. Clinical and Experimental Allergy, 47(3), 410-429. View this article in WRRO
- Olaparib for Maintenance Treatment of BRCA 1 or 2 Mutated, Relapsed, Platinum-Sensitive Ovarian, Fallopian Tube and Peritoneal Cancer in People Whose Relapsed Disease has Responded to Platinum-Based Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(1), 97-109. View this article in WRRO
- Vedolizumab for Treating Moderately to Severely Active Crohn’s Disease After Prior Therapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(12), 1241-1253. View this article in WRRO
- Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review. EBioMedicine. View this article in WRRO
- Association between Transfusion Status and Overall Survival in Patients with Myelodysplastic Syndromes: A Systematic Literature Review and Meta-Analysis. Acta Haematologica, 136(1), 23-42. View this article in WRRO
- Pruning and prioritising: a case study of a pragmatic method for managing a rapid systematic review with limited resources. Evidence & Policy: A Journal of Research, Debate and Practice, 11(4), 589-601. View this article in WRRO
- Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. British Journal of Surgery, 99(12), 1630-1638.
- A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease. Health Technology Assessment, 15(40).
- Magnetic resonance for assessment of axillary lymph node status in early breast cancer: a systematic review and meta-analysis.. Eur J Surg Oncol, 37(11), 928-936. View this article in WRRO
- Clinical decision rules for adults with minor head injury: a systematic review.. J Trauma, 71(1), 245-251.
- Positron emission tomography (PET) for assessment of axillary lymph node status in early breast cancer: A systematic review and meta-analysis.. Eur J Surg Oncol, 37(3), 187-198.
- Clinical decision rules for children with minor head injury: A systematic review. Archives of Disease in Childhood, 96(5), 414-421.
- Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and Nobreath. Health Technology Assessment, 19(82), 1-330. View this article in WRRO
Conference proceedings papers
- TOWARDS COST-EFFECTIVENESS ANALYSIS OF THE HEALTH AND WELLBEING BENEFITS OF URBAN GREEN SPACE: A MAPPING REVIEW. VALUE IN HEALTH, Vol. 14(7) (pp A343-A343)
All publications
Journal articles
- Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England. Applied Health Economics and Health Policy, 1-13.
- Association between stress, depression or anxiety and cancer: Rapid review of reviews. Comprehensive Psychoneuroendocrinology. View this article in WRRO
- Systematic review of time lag between antibiotic use and rise of resistant pathogens among hospitalized adults in Europe. JAC-Antimicrobial Resistance, 5(1). View this article in WRRO
- A cost-effectiveness analysis of remdesivir for the treatment of hospitalised patients with COVID-19 in England and Wales. Value in Health, 25(5), 761-769. View this article in WRRO
- The relationship between chronic kidney disease–associated pruritus and health-related quality of life: a systematic review. Clinical Kidney Journal, 15(3), 484-499. View this article in WRRO
- The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update. Bone, 137. View this article in WRRO
- Risks of hip and nonvertebral fractures in patients with CKD G3a-G5D: a systematic review and meta-analysis. American Journal of Kidney Diseases. View this article in WRRO
- The risk of hip and non-vertebral fractures in patients with Parkinson's disease and parkinsonism : a systematic review and meta-analysis. Bone, 132. View this article in WRRO
- Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis. Health Technology Assessment, 23(30). View this article in WRRO
- An Updated Systematic Review of Studies Mapping (or Cross-Walking) Measures of Health-Related Quality of Life to Generic Preference-Based Measures to Generate Utility Values. Applied Health Economics and Health Policy, 17(3), 295-313. View this article in WRRO
- Obinutuzumab with Bendamustine for Treating Follicular Lymphoma Refractory to Rituximab: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 36(10), 1143-1151. View this article in WRRO
- Rapid diagnostic test for antenatal syphilis screening in low-income and middle-income countries: a systematic review and meta-analysis. BMJ Open, 8(2), e018132-e018132. View this article in WRRO
- The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review. BMC Cancer, 17, 697-697. View this article in WRRO
- Mepolizumab for Treating Severe Eosinophilic Asthma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. View this article in WRRO
- Exhaled nitric oxide in the diagnosis of asthma in adults: a systematic review. Clinical and Experimental Allergy, 47(3), 410-429. View this article in WRRO
- Olaparib for Maintenance Treatment of BRCA 1 or 2 Mutated, Relapsed, Platinum-Sensitive Ovarian, Fallopian Tube and Peritoneal Cancer in People Whose Relapsed Disease has Responded to Platinum-Based Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(1), 97-109. View this article in WRRO
- Vedolizumab for Treating Moderately to Severely Active Crohn’s Disease After Prior Therapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(12), 1241-1253. View this article in WRRO
- Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review. EBioMedicine. View this article in WRRO
- Association between Transfusion Status and Overall Survival in Patients with Myelodysplastic Syndromes: A Systematic Literature Review and Meta-Analysis. Acta Haematologica, 136(1), 23-42. View this article in WRRO
- A systematic review of fractional exhaled nitric oxide in the routine management of childhood asthma. Pediatric Pulmonology, 51(3), 316-328.
- Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review. European Respiratory Society, 47(3), 751-768. View this article in WRRO
- Acute ischaemic stroke patients – direct admission to a specialist centre or initial treatment in a local hospital? A systematic review. Journal of Health Services Research & Policy, 21(1), 51-60.
- Pruning and prioritising: a case study of a pragmatic method for managing a rapid systematic review with limited resources. Evidence & Policy: A Journal of Research, Debate and Practice, 11(4), 589-601. View this article in WRRO
- Impact of prehospital transfer strategies in major trauma and head injury. Journal of Trauma and Acute Care Surgery, 78(1), 164-177. View this article in WRRO
- Effectiveness and cost-effectiveness of an awareness campaign for colorectal cancer: a mathematical modeling study.. Cancer Causes Control, 25(6), 647-658. View this article in WRRO
- Cost-effectiveness of cilostazol, naftidrofuryl oxalate, and pentoxifylline for the treatment of intermittent claudication in people with peripheral arterial disease.. Angiology, 65(3), 190-197.
- The Cost Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas aeruginosa in Patients with Cystic Fibrosis. PHARMACOECONOMICS, 32(2), 159-172.
- Colistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model.. Health Technol Assess, 17(56), v-181.
- Systematic review of the dry powder inhalers colistimethate sodium and tobramycin in cystic fibrosis.. Eur Respir Rev, 22(130), 476-486.
- Authors' reply: systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638).. Br J Surg, 100(13), 1838-1839.
- Gene expression profiling and expanded immunohistochemistry tests to guide the use of adjuvant chemotherapy in breast cancer management: a systematic review and cost-effectiveness analysis.. Health Technol Assess, 17(44), 1-302. View this article in WRRO
- Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. British Journal of Surgery, 99(12), 1630-1638.
- Diagnostic accuracy of clinical characteristics for identifying CT abnormality after minor brain injury: a systematic review and meta-analysis.. J Neurotrauma, 29(5), 707-718.
- A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease. Health Technology Assessment, 15(40).
- Magnetic resonance for assessment of axillary lymph node status in early breast cancer: a systematic review and meta-analysis.. Eur J Surg Oncol, 37(11), 928-936. View this article in WRRO
- Diagnosis and management of minor head injury in the UK. Journal of Paramedic Practice, 3(8), 418-423.
- Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation.. Health Technol Assess, 15(27), 1-202.
- Clinical decision rules for adults with minor head injury: a systematic review.. J Trauma, 71(1), 245-251.
- Positron emission tomography (PET) for assessment of axillary lymph node status in early breast cancer: A systematic review and meta-analysis.. Eur J Surg Oncol, 37(3), 187-198.
- Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation.. Health Technol Assess, 15(4), iii-134.
- Clinical decision rules for children with minor head injury: A systematic review. Archives of Disease in Childhood, 96(5), 414-421.
- Cost-effectiveness of MRI and PET imaging for the evaluation of axillary lymph node metastases in early stage breast cancer.. Eur J Surg Oncol, 37(1), 40-46.
- Faecal Immunochemical Tests For Patients With Symptoms Suggestive Of Colorectal Cancer: An Updated Systematic Review And Multiple-Threshold Meta-Analysis of Diagnostic Test Accuracy Studies. Colorectal Disease.
- Ceftazidime with avibactam for treating severe aerobic Gram-negative bacterial infections: technology evaluation to inform a novel subscription-style payment model. Health Technology Assessment, 1-230.
- Systematic Review of Presymptomatic Treatment for Spinal Muscular Atrophy. International Journal of Neonatal Screening, 10(3), 56-56.
- Systematic Review of Newborn Screening Programmes for Spinal Muscular Atrophy. International Journal of Neonatal Screening, 10(3), 49-49.
- Cefiderocol for treating severe aerobic Gram-negative bacterial infections: technology evaluation to inform a novel subscription-style payment model. Health Technology Assessment, 1-238.
- Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and Nobreath. Health Technology Assessment, 19(82), 1-330. View this article in WRRO
Conference proceedings papers
- SUN-622 The risk of hip and non-vertebral fractures in diabetes : a systematic review and meta-analysis update. Journal of the Endocrine Society, Vol. 4(Supplement_1). San Francisco, CA, USA, 28 March 2020 - 31 March 2020. View this article in WRRO
- THE RISK OF HIP AND NON-VERTEBRAL FRACTURES IN PARKINSON'S DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. OSTEOPOROSIS INTERNATIONAL, Vol. 31(SUPPL 1) (pp S55-S55)
- The Risk of Hip and Non-Vertebral Fractures in Parkinson's Disease: A Systematic Review and Meta-Analysis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 103-103)
- The Risk of Hip and Non-Vertebral Fractures in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 25-25)
- Exhaled Nitric Oxide For The Diagnosis Of Asthma In Adults And Children: A Systematic Review. Value in Health, Vol. 18(7) (pp A345-A345)
- Systematic Review and Meta-Analysis of the Association Between Transfusion Independence (TI) and Overall Survival (OS) in Patients (pts) with Myelodysplastic Syndromes (MDS). Blood, Vol. 124(21) (pp 1934-1934)
- The Cost-Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas Aeruginosa in Patients with Cystic Fibrosis. Value in Health, Vol. 16(7) (pp A372-A372)
- SYSTEMATIC REVIEW OF COLISTIMETHATE SODIUM DRY POWDER AND TOBRAMYCIN DRY POWDER ANTIBIOTICS FOR PSEUDOMONAS AERUGINOSA LUNG INFECTION IN CYSTIC FIBROSIS. VALUE IN HEALTH, Vol. 16(7) (pp A367-A367)
- COST-EFFECTIVENESS OF CILOSTAZOL, NAFTIDROFURYL OXALATE, PENTOXIFYLLINE AND INOSITOL NICOTINATE FOR THE TREATMENT OF INTERMITTENT CLAUDICATION IN PEOPLE WITH PERIPHERAL ARTERIAL DISEASE IN THE UK. VALUE IN HEALTH, Vol. 15(7) (pp A633-A633)
- DIAGNOSTIC ACCURACY OF CLINICAL CHARACTERISTICS FOLLOWING MINOR HEAD INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. VALUE IN HEALTH, Vol. 14(7) (pp A245-A245)
- CLINICAL DECISION RULES FOR ADULTS WITH MINOR HEAD INJURY: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 14(7) (pp A244-A244)
- TOWARDS COST-EFFECTIVENESS ANALYSIS OF THE HEALTH AND WELLBEING BENEFITS OF URBAN GREEN SPACE: A MAPPING REVIEW. VALUE IN HEALTH, Vol. 14(7) (pp A343-A343)
- BIOCHEMICAL MARKERS FOR THE IDENTIFICATION OF INTRACRANIAL INJURY FOLLOWING MINOR HEAD INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. VALUE IN HEALTH, Vol. 14(7) (pp A244-A244)
- alpha(1B)-adrenoceptor affinity and density differentiated and undifferentiated mouse glomerular mesangial cells.. J AM SOC NEPHROL, Vol. 8 (pp A1432-A1432)
- EFFECTS OF LY293558 AND NBQX ON GLUTAMATE-RECEPTOR RESPONSES IN RAT CEREBELLAR PURKINJE NEURONS AND HEK293 CELLS EXPRESSING THE HUMAN GLUR6 GLUTAMATE-RECEPTOR. BRIT J PHARMACOL, Vol. 115 (pp P112-P112)
Reports
- Newborn screening for congenital adrenal hyperplasia. External review against programme appraisal criteria for the UK National Screening Committee
- Final report for the technology evaluation of ceftazidime with avibactam for treating severe aerobic Gram-negative bacterial infections.
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix J - Dementia.
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix K - Cardiovascular.
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix H - Psychological Therapies
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix I - Schizophrenia
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix E - Diabetes
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix G - Head and Neck Cancer.
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix D - Epilepsy
- View this article in WRRO . Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme. Appendix F - Bowel Cancer.
- View this article in WRRO Supporting the collection patient reported outcome measures in the National Clinical Audits for assessing costeffectiveness Work Package 1. What patient reported outcome measures should be used in the 13 health conditions specified in the 2013/14 National Clinical Audit programme? APPENDIX C, INFLAMMATORY BOWEL DISEASE
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audits for assessing cost-effectiveness. Work Package 1. What patient reported outcome measures should be used in the 2013/14 National Clinical Audit Programme.
Posters
- Clinical Decision Rules for children with minor head injury: A systematic review. European Society of Emergency Medicine,(EuSEM) Stockholm.
- Diagnostic accuracy of individual characteristics following minor head injury in children: A systematic review.
- A systematic review of Clinical Decision Rules in the management of adult minor head injury.
- Surgical interventions for the primary prophylaxis of retinal detachment in Stickler Syndrome: a systematic review.
- Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review.
- Clinical decision rules for adults with minor head injury: a systematic review.
- Towards cost-effectiveness analysis of the health and wellbeing benefits of urban green space: a mapping review.
- The role of biochemical markers in the identification of intracranial pathology following minor head injury: a systematic review and meta-analysis.
- Diagnostic accuracy of clinical characteristics following minor head injury: a systematic review and meta-analysis.
- Clinical Decision Rules for children with minor head injury: A systematic review.
- Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review.
- Diagnostic accuracy of clinical characteristics following minor head injury: a systematic review and meta-analysis.
- Teaching interests
-
I am a module co-ordinator for HAR6501, Systematic Reviews and Critical Appraisal Techniques on ScHARR’s Masters in Public Health. I also teach on ScHARR’s short courses and bespoke training courses, including our Systematic Review short course, our Rapid Review short course and our short course on Reviewing for Modelling Parameters.