Professor David James

Department of Chemical and Biological Engineering

Professor of Systems Biology

Research Centre Director Advanced Biomanufacturing Centre

Professor David James
d.c.james@sheffield.ac.uk
+44 114 222 7505

Full contact details

Professor David James
Department of Chemical and Biological Engineering
Room D62
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

I graduated in 1989 from King´s College London with a Ph.D. in Biochemistry, followed by postdoctoral research in Wye College (University of London), then the University of Kent; the latter a joint project with the Advanced Centre for Biochemical Engineering at University College London.

Following appointment to Lecturer, then Senior Lecturer at Kent, I moved to the University of Queensland in 2001 as an Associate Professor of Bioengineering, then Professorial Research Fellow in the Australian Institute of Bioengineering and Nanotechnology.

I was appointed to a Chair in Bioprocess Engineering at Sheffield in 2006 with a Royal Society Wolfson Research Merit Award, Research and Training in Biopharmaceutical Bioprocessing for UK Bioindustry.

Research interests
  • Production of high-value therapeutic recombinant protein biopharmaceuticals
  • Systems Biotechnology for Rational Bioprocess Engineering
  • Cell Factory and Gene Vector Engineering
  • Process Analytical Technology
Publications

Books

Journal articles

Chapters

Conference proceedings papers

Patents

  • Brown AJ, James DC, Gibson SJ & Hatton D (2018) In silico design of mammalian promoters with user-defined functionality. WO 2018/193072 A1 Appl. 25 Oct 2018. RIS download Bibtex download
  • James DC & Brown AJ (2015) Synthetic promoters for CHO cells, methods of producing synthetic promoters using transcription factor binding site modules. WO2015079053-A2; WO2015079053-A3 Appl. 08 Oct 2015. RIS download Bibtex download
  • James DC & Brown AJ (2014) Regulating recombinant gene expression in vitro comprises providing a host cell encoding recombinant genes for expression, and contacting the cell with an exonuclease resistant block decoy. WO2014202640-A1 Appl. 24 Dec 2014. RIS download Bibtex download
  • Davies SL, James D & Thompson B () Method for determining e.g. cell identity of mammalian producer of user, involves comparing query cell-specific growth response fingerprint with reference cell-specific growth response fingerprints corresponding to cells. WO2014207166-A1 Appl. 01 Jan 1970. RIS download Bibtex download
  • Clifford J, James D & Thompson B () Predicting relative production titer of a panel of clonal producer cells in fed batch culture by simultaneously incubating each producer cell with a chemical cell stressor and determining the production titer response of each cell. EP2902493-A1; WO2015113704-A1 Appl. 01 Jan 1970. RIS download Bibtex download

Theses / Dissertations

  • Toronjo Urquiza L (2020) Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture. RIS download Bibtex download
Teaching activities

CPE412 – Molecular Biotechnology