Professor David James

School of Chemical, Materials and Biological Engineering

Professor of Bioprocess Engineering

Research Centre Director Advanced Biomanufacturing Centre

Professor David James stands in the Engineering Heartspace
Profile picture of Professor David James stands in the Engineering Heartspace
d.c.james@sheffield.ac.uk
+44 114 222 7505

Full contact details

Professor David James
School of Chemical, Materials and Biological Engineering
Room D62
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

I graduated in 1989 from King´s College London with a Ph.D. in Biochemistry, followed by postdoctoral research in Wye College (University of London), then the University of Kent; the latter a joint project with the Advanced Centre for Biochemical Engineering at University College London.

Following appointment to Lecturer, then Senior Lecturer at Kent, I moved to the University of Queensland in 2001 as an Associate Professor of Bioengineering, then Professorial Research Fellow in the Australian Institute of Bioengineering and Nanotechnology.

I was appointed to a Chair in Bioprocess Engineering at Sheffield in 2006 with a Royal Society Wolfson Research Merit Award, Research and Training in Biopharmaceutical Bioprocessing for UK Bioindustry.

Research interests
  • Production of high-value therapeutic recombinant protein biopharmaceuticals
  • Systems Biotechnology for Rational Bioprocess Engineering
  • Cell Factory and Gene Vector Engineering
  • Process Analytical Technology
Publications

Books

Journal articles

Chapters

Conference proceedings papers

Patents

  • Brown AJ, James DC, Gibson SJ & Hatton D (2018) In silico design of mammalian promoters with user-defined functionality. WO 2018/193072 A1 Appl. 25 Oct 2018. RIS download Bibtex download
  • James DC & Brown AJ (2015) Synthetic promoters for CHO cells, methods of producing synthetic promoters using transcription factor binding site modules. WO2015079053-A2; WO2015079053-A3 Appl. 08 Oct 2015. RIS download Bibtex download
  • James DC & Brown AJ (2014) Regulating recombinant gene expression in vitro comprises providing a host cell encoding recombinant genes for expression, and contacting the cell with an exonuclease resistant block decoy. WO2014202640-A1 Appl. 24 Dec 2014. RIS download Bibtex download
  • Clifford J, James D & Thompson B () Predicting relative production titer of a panel of clonal producer cells in fed batch culture by simultaneously incubating each producer cell with a chemical cell stressor and determining the production titer response of each cell. EP2902493-A1; WO2015113704-A1 Appl. 01 Jan 1970. RIS download Bibtex download
  • Davies SL, James D & Thompson B () Method for determining e.g. cell identity of mammalian producer of user, involves comparing query cell-specific growth response fingerprint with reference cell-specific growth response fingerprints corresponding to cells. WO2014207166-A1 Appl. 01 Jan 1970. RIS download Bibtex download

Theses / Dissertations

  • Toronjo Urquiza L (2020) Screening and development of natural compounds as tools to improve IgG production and quality in recombinant CHO cell culture. RIS download Bibtex download

Preprints

Teaching activities

CPE412 – Molecular Biotechnology