Transmission electron microscopy

Transmission electron microscopy (TEM) is a high-resolution imaging technique used to visualise the internal ultrastructure of cells at the nanometer scale. By transmitting a beam of electrons through ultrathin tissue sections, TEM reveals detailed subcellular features that are not visible with light microscopy.

In our research, we use TEM to examine the ultrastructure of cells within the auditory system, including key components such as stearocilia links, synapses, mitochondria, and intracellular membranes. This technique is particularly useful for identifying subtle changes that occur during development or in response to hearing impairment. By revealing how internal cellular architecture is altered under different conditions, TEM provides critical insight into the cellular mechanisms that support normal hearing and contribute to its decline.