Our Publications



Jeng JY, Carlton AJ, Goodyear R, Chinowsky C, Ceriani F, Johnson SL, Sung T-C, Dayn Y, Richardson GP, Bowl MR, Brown SDM, Manor U, Marcotti W (2022) AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness. Molecular Therapy, Methods & Clinical Development, 26, 355-370.

Murtha KE, Yang Y, Ceriani F, Jeng JY, Climer LK, Jones F, Charles J, Devana SK, Hornak AJ, Marcotti W, Simmons DD (2022). Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells. Cell Calcium 105,102613.

Lorente-Cánovas B, Eckrich S, Lewis MA, Johnson SL, Marcotti W, Steel KP (2022) Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells. PLoS ONE

Newton S, Kong F, Carlton AJ, Aguilar C, Parker A, Codner GF, Teboul L, Wells S, Brown SDM, Marcotti W, Michael R Bowl (2022) Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. PLoS Genetics.


Manca M, Yen P, Spaiardi P, Russo G, Giunta R, Johnson SL, Marcotti W, Masetto S (2021) Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells. Front in Neuro.

Hardy K, Amariutei AE, Faveri FD, Hendry A, Marcotti W, Ceriani F (2021) Functional development and regeneration of hair cells in the zebrafish lateral line. J Physiol.

Faveri FD, Marcotti W, Ceriani F (2021) Sensory adaptation at ribbon synapses in the zebrafish lateral line. J Physiol.

Jeng JY, Harasztosi C, Carlton AJ, Corns LF, Marchetta P, Johnson SL, Goodyear RJ, Legan KP, Rüttiger L, Richardson GP, Marcotti W (2021) MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia. J Physiol.

Carlton AJ, Halford J, Underhill A, Jeng JY, Avenarius MR, Gilbert ML, Ceriani F, Ebisine K, Brown SDM, Bowl MR, Barr‐Gillespie PG, Marcotti W (2021) Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. J Physiol.

Jeng JY, Carlton AJ, Johnson SL, Brown SDM, Holley MC, Bowl MR, Marcotti W (2021) Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea. J Physiol.


Jeng JY, Ceriani F, Olt J, Brown SDM, Holley MC, Bowl MR, Johnson SL, Marcotti W (2020) Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea. J Physiol.

Jeng JY, Johnson SL, Carlton AJ, Tomasi LD, Goodyear RJ, Faveri FD, Furness DN, Wells S,  Brown SDM, Holley MC, Richardson GP, Mustapha M, Bowl MR, Marcotti W (2020) Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. J Physiol.

Spaiardi P, Marcotti W, Masetto S, Johnson SL (2020) Exocytosis in mouse vestibular Type II hair cells shows a high-order Ca2+ dependence that is independent of synaptotagmin-4. Physiol Reports.

Boddy SL, Romero-Guevara R, Ji A, Unger C, Corns LF, Marcotti W, Rivolta MN (2020) Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs. Stem Cells Inter.

Spaiardi P, Tavazzani E, Manca M, Russo G, Prigioni I, Biella G, Giunta R, Johnson SL, Marcotti W, Masetto S (2020) K+ Accumulation and Clearance in the Calyx Synaptic Cleft of Type I Mouse Vestibular Hair Cells. Neuroscience.

Martelletti E, Ingham NJ, Houston O, Pass JC, Chen J, Marcotti W, Steel KP (2020) Synaptojanin2 Mutation Causes Progressive High-frequency Hearing Loss in Mice. Front Cell Neuro.

Jeng JY, Ceriani F, Hendry A, Johnson SL, Yen P, Simmons DD, Kros CJ, Marcotti W (2020) Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea. J Physiol.


Ceriani F, Hendry A, Jeng JY, Johnson S, Olt J, Holley MC, Mammano F, Kros CJ, Simmons DD, Marcotti W (2019) Coordinated Ca2+ activity of cochlear sensory and non-sensory cells refines OHC afferent innervation”. EMBO J, e99839.

Johnson SL, Safieddine S, Mustapha M, Marcotti W (2019) Hair Cell Afferent Synapses: Function and Dysfunction. Cold Spring Harb Perspect Med. pii: a033175.

Groot SC, Sliedregt K, Benthem PPG, Rivolta MN, Huisman MA (2019) Building an Artificial Stem Cell Niche: Prerequisites for Future 3D‐Formation of Inner Ear Structures ‐ Towards 3D Inner Ear Biotechnology –. The Anatomical Record.

Abbas L & Rivolta MN (2019) The use of animal models to study cell transplantation in neuropathic hearing loss. Hear Res. 377, 72-87

Smeriglio P, Leu R and Mustapha M (2019) TSP1 and TSP2 have unique and overlapping roles in protecting against noise-induced auditory synaptopathy. Neuroscience;408:68-80.


Corns LF, Johnson S, Roberts T, Ranatunga K, Hendry A, Ceriani F, Safieddine S, Steel K, Forge A, Petit C, Furness D, Kros C, Marcotti W (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature Comm, 9:4015.

Chessum et al (17 authors) Marcotti W, Brown SDM, Elkon R, Bowl MR, Hertzano R (2018) Ikzf2/helios is a key transcriptional regulator of outer hair cell maturation. Nature, 563:696-700.

Razlivanov I, Liew T, Moore EW, Al-Kathiri A, Bartram T, Kuvshinov D & Nikolaev A (2018) Long-term imaging of calcium dynamics using genetically encoded calcium indicators and automatic tracking of cultured cells. BioTechniques, 65, 37-39.

Bergmann K, Meza Santoscoy P, Lygdas K, Nikolaeva Y, MacDonald R, Cunliffe V & Nikolaev A (2018) Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. J Dev Biol, 6(1).

Iannitti T, Scarrott J, Likhite S, Coldicott IRP, Lewis KE, Heath PR, Higginbottom A, Myszczynska MA, Milo M, Hautbergue GM, Meyer K et al (2018) Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS. Mol Ther: Nucleic Acids, 12, 75-88.

García-Alcántara F, Murillo-Costa S, Pulido S, Bermúdez-Muñoz JM, Martínez-Vega R, Milo M, Varela-Nieto I, Rivera T (2018) The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. Hear Res, 358, 10-21.

Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P , Crouch S et al (2018) Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. Reg Med 13, 935-944.


Johnson SL, Olt J, Cho S, von Gersdorff H, Marcotti W (2017) The coupling between Ca2+ channels and the exocytotic Ca2+ sensor at hair cell ribbon synapses varies tonotopically along the mature cochlea. J Neurosci. 37:258-268.

Johnson SL, Ceriani F, Houston O, Polishchuk R, Polishchuk E, Crispino G, Zorzi V, Mammano F, Marcotti W (2017) Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea. J Neurosci 37: 258-268.

Corns LF, Jeng JY, Richardson GP, Kros CJ, Marcotti W (2017) TMC2 modifies permeation properties of the mechanoelectrical transducer channel in early postnatal mouse cochlear outer hair cells. Front Mol Neurosci. 10:326.

Erickson T, Morgan CP, Olt J, Hardy K, Busch-Nentwich E, Maeda R, Clemens R, Krey JF, Nechiporuk A, Barr-Gillespie PG, Marcotti W, Nicolson T (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife 6: e28474.

Sheets L, He XJ, Olt J, Schreck M, Petralia RS, Wang YX, Zhang Q, Beirl A, Nicolson T, Marcotti W, Trapani JG, Kindt KS (2017) Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset. J Neurosci 37: 6299-6313.

Waller R, Goodall EF, Milo M, Cooper-Knock J, Da Costa M, Hobson E, Kazoka M, Wollff H, Heath PR, Shaw P & Kirby J (2017) Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). Neurobiol of Aging, 55, 123-131.

Schomann T, Mezzanotte L, De Groot JCMJ, Rivolta MN, Hendriks SH, Frijns JHM, Huisman MA (2017) Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants. PLoS ONE, 12(10).

Heimsath, EG Jr., Yim YI, Mustapha M, Hammer JA, and Cheney RE (2017) Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation. Scientific Reports, 7:17354.

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Sheffield is a research university with a global reputation for excellence. We're a member of the Russell Group: one of the 24 leading UK universities for research and teaching.