Dr. Janet Chamberlain BSc PhD FHEAJanet Chamberlain

University Teacher

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44 (0) 114 215 9566
Fax: +44 (0) 114 271 1863


After completing an MRC-funded PhD studentship at the University of Manchester, I spent a year working as an immunohistochemist at Zeneca Pharmaceuticals, Alderley Park. I joined the University of Sheffield in 1995, and spent 3 years as a Postdoctoral Research Associate in the Department of Cardiovascular Research (with Professor David Crossman as PI). Following this, I wrote my own funding applications, although remained as a Postdoctoral Research Associate, then an Experimental Officer; holding several Project Grants as Principal Investigator, working closely with Professors Sheila Francis and Julian Gunn. In 2016, I became a University Teacher and now concentrate mainly on teaching, although still have an interest in research.

Research Interests:

My research career has focused on the understanding and prevention of restenosis and atherosclerosis, using several different experimental models. My long-standing interest is in the role of interleukin-1 (IL-1) in these diseases. My current areas of research relate to the mechanisms by which IL-1 is released from endothelial cells, the role of IL-1 in the development of atherosclerosis, and the use of IL-1 antagonists to inhibit disease progression. In addition, I am currently involved in investigating the role of carbon monoxide as a possible therapeutic for restenosis and myocardial infarction, and in research to develop a miniature stenting device for use in small calibre vessels. These studies are being undertaken in collaboration with colleagues in the Departments of Infection, Immunity & Cardiovascular Disease and Chemistry at the University of Sheffield, as well as collaborations with industry.

Teaching Interests:

I teach on several undergraduate and postgraduate taught modules, including MBB334 Biochemical Basis of Human Disease, CDL301 Cardiovascular Pharmacology: Personalising Medicine, CDL401 & CDL402 modules within the MSc in Molecular Medicine, and several modules within the CDLT01 MRes Cardiovascular Medicine: From Molecules to Man.

I am the module administrator for CDL301/630, deputy module lead for CDL601 and CDL602, and course co-ordinator for the overall programme of CDLT01 MRes Cardiovacular Medicine:From Molecules to Man, and MOLE co-ordinator for CDL302.

Current Projects:

  • Release of IL-1 from endothelial cells (Embassy of Libya).
  • Development of a novel, small calibre, balloon expandable stent system (MRC, with Prof Gunn).
  • The use of carbon-monoxide releasing molecules in Restenosis/atherosclerosis (BHF, with Francis/Gunn/Mann).
  • The use of carbon-monoxide releasing molecules in MI (BHF with Gunn/Iqbal/Francis/Mann).
  • Cholesterol crystal formation in atherosclerosis (with Francis) .


For key publications see below. For a full list of publications click here.

Journal articles