Professor Sheila Francis

BSc PhD SFHEA FRSB

Clinical Medicine, School of Medicine and Population Health

Professor of Cardiovascular Biology

Faculty Director of One University Strategy Delivery (FDOU)

s.francis@sheffield.ac.uk
+44 114 215 9501

+44 114 271 1863 (fax)

The Medical School

Full contact details

Professor Sheila Francis
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

For One University Strategy enquiries in the Faculty of Health, please contact Isabel Andrews.

I joined the University of Sheffield in 1990 after a BBSRC CASE PhD studentship at the University of Manchester. After four years as a Postdoctoral Research Associate in Cardiac Surgery (with Angelini) and Molecular Medicine (with Duff), I held an Independent Open Competition Fellowship from the Lloyd´s Tercentenary Foundation on the molecular and inflammatory basis of coronary artery disease.

After being appointed Lecturer in 1994, I spent a sabbatical period in the Hynes Lab at MIT as a Fulbright Scholar. I am currently a Professor of Cardiovascular Biology at the University of Sheffield.

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Research interests

I have a long-standing interest in the role of interleukin-1 (IL-1) and its naturally occurring antagonist, IL-1ra in modulating vascular cell function in experimental models and in human disease. Over the past 10-15 years, I have shown that IL-1 and IL-1ra are increased in diseased human arteries and in other experimental cardiovascular systems. I described the association of a genetic variant of IL-1ra with coronary artery disease and showed that this variant alters protein levels and the biology of endothelial cells.

Programme funding from the British Heart Foundation (with Professor David Crossman) allowed the use of strategies to inhibit IL-1 in several experimental models including atherosclerosis in mice. The impact of this early work alongside that of others has now been translated to man through the ILA-HEART and CANTOS trials.

My current research areas of interest relate to the mechanisms by which IL-1 is released from vascular cells especially endothelial cells, IL-1 related molecules and their antagonists, and the role of IL-1 in complex vascular phenotypes such as inflammatory vascular plaques in the brain and the mixed models of atherosclerosis after chronic infection and also episodes of hypoglycaemia. More recently, I have become interested in the control of endothelial senescence and impacts upon age-related diseases working with colleague in HELSI.

I collaborate with colleagues in Infection, Immunity and Cardiovascular Disease, Metabolism, Psychology and Neuroscience at the University of Sheffield and with colleagues at the Universities of Manchester (Pinteaux, Allan), the University of Virginia (Owens, Abbate) and others.

Current projects

Release of IL-1 from vascular cells especially endothelial cells.
S.pneumoniae infection and atherosclerosis (with Bazaz and Dockrell (Edinburgh)).
Hypoglycaemia and risk of atherosclerosis (with Iqbal and Heller).
Interleukin-1 alpha versus interleukin-1 beta in atherosclerosis, hypertension and stroke (with Pinteaux and Allan, Manchester)).
Macrophage phenotypes in human carotid atherosclerosis (with Kiss-Toth and Redgrave).
Neurovascular function in atherosclerosis (with Wharton, Berwick and Howarth).
Approaches to alter endothelial senescence and ageing (with Bellantuono).
PKC alpha/TGF beta axis in atherosclerosis and medical calcification (with Brennan, Canfield and Borland, Manchester)
Vascular Brain pathology (with Simpson and Wharton)
Inflammation, atherosclerosis and molecular manipulation of the microbiome (with Jon Shaw)

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Kidder E, Gangopadhyay S, Francis S & Alfaidi M (2024) “How to Release or Not Release, That Is the Question.” A Review of Interleukin‐1 Cellular Release Mechanisms in Vascular Inflammation. Journal of the American Heart Association, e032987.
Prince LR & Francis SE (2023) Barriers to equality, diversity and inclusion in research and academia stubbornly persist. So, what are we doing about it?. Disease Models & Mechanisms, 16(7). View this article in WRRO
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH (2023) Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice. Frontiers in Cellular and Infection Microbiology, 13.
Eyre B, Shabir O, Lee L, Francis S, Howarth C & Berwick J (2022) How does alzheimer’s disease, atherosclerosis and comorbid alzheimer’s disease and atherosclerosis impact neurovascular function?. Alzheimer's & Dementia, 18(S6).
Al Mansouri M, Patel PA, Chamberlain J & Francis S (2022) OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms. Vascular Biology, 4(1), 11-18.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, 8(35).
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling. Frontiers in Cardiovascular Medicine, 9.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al (2022) Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease. eLife, 2022(11). View this article in WRRO
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W & Waisman A (2020) Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors : a new toolbox to study the role of IL-1 in health and disease. Journal of Molecular Medicine, 98(7), 923-930. View this article in WRRO
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10). View this article in WRRO
Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE , Ainscough JFX et al (2019) Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight, 4(17). View this article in WRRO
Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N , Ábrahám H et al (2019) Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms. Proceedings of the National Academy of Sciences, 116(26), 13067-13076. View this article in WRRO
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A , Müller W et al (2019) Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behavior and Immunity, 76, 126-138. View this article in WRRO
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St. Hilaire C, Müller W, Waisman A, Francis SE , Pinteaux E et al (2018) Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Nature Medicine, 24(9), 1418-1429. View this article in WRRO
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol MC, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism. Journal of the American Heart Association, 7(13). View this article in WRRO
Pickworth JA, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey P, Gladson S, Shay S, Morrell N, Francis S , West JD et al (2017) Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. Pulmonary Circulation. View this article in WRRO
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. JACC - Journal of the American College of Cardiology bts, 2(4), 398-414. View this article in WRRO
Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) IL-1 drives breast cancer growth and bone metastasis in vivo.. Oncotarget, 7, 75571-75584. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Rothman AM, Arnold N, Pickworth J, Iremonger J, Ciuclan L, Allan R, Guth-Gundel S, Southwood M, Morrell N, Thomas M , Francis S et al (2016) MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. Journal of Clinical Investigation, 126(7), 2495-2508. View this article in WRRO
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Annals of Neurology, 75(5), 670-683. View this article in WRRO

All publications

Journal articles

Kidder E, Gangopadhyay S, Francis S & Alfaidi M (2024) “How to Release or Not Release, That Is the Question.” A Review of Interleukin‐1 Cellular Release Mechanisms in Vascular Inflammation. Journal of the American Heart Association, e032987.
Prince LR & Francis SE (2023) Barriers to equality, diversity and inclusion in research and academia stubbornly persist. So, what are we doing about it?. Disease Models & Mechanisms, 16(7). View this article in WRRO
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH (2023) Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice. Frontiers in Cellular and Infection Microbiology, 13.
Eyre B, Shabir O, Lee L, Francis S, Howarth C & Berwick J (2022) How does alzheimer’s disease, atherosclerosis and comorbid alzheimer’s disease and atherosclerosis impact neurovascular function?. Alzheimer's & Dementia, 18(S6).
Al Mansouri M, Patel PA, Chamberlain J & Francis S (2022) OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms. Vascular Biology, 4(1), 11-18.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, 8(35).
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling. Frontiers in Cardiovascular Medicine, 9.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al (2022) Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease. eLife, 2022(11). View this article in WRRO
Gustschin A, Riedel M, Taphorn K, Petrich C, Gottwald W, Noichl W, Busse M, Francis SE, Beckmann F, Hammel JU , Moosmann J et al (2021) High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators. Optica, 8(12), 1588-1595.
Tulotta C, Lefley DV, Moore CK, Amariutei AE, Spicer-Hadlington AR, Quayle LA, Hughes RO, Ahmed K, Cookson V, Evans CA , Vadakekolathu J et al (2021) IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer. npj Breast Cancer, 7(1).
Lawrie A & Francis SE (2021) Frataxin and endothelial cell senescence in pulmonary hypertension. Journal of Clinical Investigation, 131(11).
Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B, Motterlini R, Francis S & Gunn J (2021) Carbon monoxide releasing molecule A1 reduces myocardial damage after acute myocardial infarction in a porcine model. Journal of Cardiovascular Pharmacology, Publish Ahead of Print.
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W & Waisman A (2020) Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors : a new toolbox to study the role of IL-1 in health and disease. Journal of Molecular Medicine, 98(7), 923-930. View this article in WRRO
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 10(1).
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V , McCourt M et al (2019) A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nature Communications, 10(1). View this article in WRRO
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10). View this article in WRRO
Bazaz R, Francis S & Dockrell D (2019) 407. The Effect of Streptococcus pneumoniae Pneumonia on Atherosclerosis. Open Forum Infectious Diseases, 6(Supplement_2), S207-S207.
Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE , Ainscough JFX et al (2019) Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight, 4(17). View this article in WRRO
(2019) Correction for Helyes et al., Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms. Proceedings of the National Academy of Sciences, 116(29), 14782-14782.
Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N , Ábrahám H et al (2019) Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms. Proceedings of the National Academy of Sciences, 116(26), 13067-13076. View this article in WRRO
Borland S, Behnsen J, Akerele A, Sherratt MJ, Brennan K, Holt C, Francis S & Canfield A (2019) BS61 PKCαα knock-down enhances intimal calcification in a murine model of atherosclerosis. Basic Science.
Borland S, Facchi C, Behnsen J, Adamson A, Humphrey N, Sherratt MJ, Brennan K, Francis S, Ashton N & Canfield A (2019) BS50 PKCα knock-down increases medial calcification in a murine model of chronic kidney disease. Basic Science.
Kocsy K, Francis S, Kiss-Toth E, Lonsdale R, Majid A & Redgrave J (2019) BS22 Double positive (CD86+ MRC1+) inflammatory macrophages in the pathogenesis of carotid atherosclerosis. Basic Science.
Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA , Jacques RM et al (2019) Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A , Müller W et al (2019) Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behavior and Immunity, 76, 126-138. View this article in WRRO
Shabir O, Berwick J & Francis S (2018) Neurovascular Dysfunction in Vascular Dementia, Alzheimer’s and Atherosclerosis. BMC Neuroscience, 19. View this article in WRRO
Johnston JM, Francis SE & Kiss-Toth E (2018) Experimental models of murine atherosclerosis: does perception match reality?. Cardiovascular Research, 114(14), 1845-1847. View this article in WRRO
Martinez Campesino L, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) P4 CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. Cardiovascular Research, 114(suppl_2), S2-S2.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St. Hilaire C, Müller W, Waisman A, Francis SE , Pinteaux E et al (2018) Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Nature Medicine, 24(9), 1418-1429. View this article in WRRO
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol MC, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism. Journal of the American Heart Association, 7(13). View this article in WRRO
Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DFJ , Lutgens E et al (2018) Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice. European Journal of Preventive Cardiology, 25(9), 948-955. View this article in WRRO
Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2018) Selective improvement of pulmonary arterial hypertension with a dual ET A /ET B receptors antagonist in the apolipoprotein E −/− model of PAH and atherosclerosis. Pulmonary Circulation, 8(1), 1-11. View this article in WRRO
Borland SJ, Morris TG, Borland SC, Morgan MR, Francis SE, Merry CLR & Canfield AE (2017) Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ. Cardiovascular Research, 113(13), 1639-1652. View this article in WRRO
Pickworth JA, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey P, Gladson S, Shay S, Morrell N, Francis S , West JD et al (2017) Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. Pulmonary Circulation. View this article in WRRO
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. JACC - Journal of the American College of Cardiology bts, 2(4), 398-414. View this article in WRRO
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) IL-1 drives breast cancer growth and bone metastasis in vivo.. Oncotarget, 7, 75571-75584. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Rothman AM, Arnold N, Pickworth J, Iremonger J, Ciuclan L, Allan R, Guth-Gundel S, Southwood M, Morrell N, Thomas M , Francis S et al (2016) MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. Journal of Clinical Investigation, 126(7), 2495-2508. View this article in WRRO
Iqbal J, Chamberlain J, Francis SE & Gunn J (2016) Role of Animal Models in Coronary Stenting. Annals of Biomedical Engineering, 44(2), 453-465.
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Johnston J, Basatvat S, Ilyas Z, Francis S & Kiss-Toth E (2015) Tribbles in inflammation. Biochemical Society Transactions, 43(5), 1069-1074. View this article in WRRO
Salazar M, Lorente M, García-Taboada E, Gómez EP, Dávila D, Zúñiga-García P, Flores JM, Rodríguez A, Hegedus Z, Mosén-Ansorena D , Aransay AM et al (2015) TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.. Molecular & Cellular Oncology, 2(3). View this article in WRRO
Salazar M, Lorente M, García-Taboada E, Pérez Gómez E, Dávila D, Zúñiga-García P, María Flores J, Rodríguez A, Hegedus Z, Mosén-Ansorena D , Aransay AM et al (2015) Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death & Differentiation, 22(1), 131-144. View this article in WRRO
Raina T, Iqbal J, Arnold N, Moore H, Aflatoonian B, Walsh J, Whitehouse S, Al-Lamee K, Francis S & Gunn J (2014) Coronary stents seeded with human trophoblastic endovascular progenitor cells show accelerated strut coverage without excessive neointimal proliferation in a porcine model. EuroIntervention, 10(6), 709-716.
Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO & Evans PC (2014) Requirement of JNK1 for endothelial cell injury in atherogenesis.. Atherosclerosis, 235(2), 613-618.
Raina T, Arnold N, Moore H, Aflatoonian B, Walsh J, Whitehouse S, Al-Lamee K, Francis S, Gunn J & Iqbal J (2014) 152 Stem Cell Coated Metallic Coronary Stents Show Accelerated Strut Coverage without Excessive Neointimal Proliferation in a Porcine Model. Heart, 100(Suppl 3), A88.2-A89.
Alfaidi M, Chamberlain J & Francis S (2014) 212 Docosahexaenoic Acid but not Alpha-linolenic Acid Ameliorates High Fat Diet Induced Atherosclerosis and Hypertension in APOE-/- MICE Via IL-1 Mechanism.. Heart, 100 Suppl 3, A116-A117.
Samokhin AO, Francis SE & Qwarnstrom EE (2014) Blocking the IL-1RI Co-receptor TILRR Reduces Vascular Inflammation – in vivo Analysis Using TILRR Knockout Mice. Heart, 100.
Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Annals of Neurology, 75(5), 670-683. View this article in WRRO
Steiner T, Francescut L, Byrne S, Hughes T, Jayanthi A, Guschina I, Harwood J, Cianflone K, Stover C & Francis S (2014) Protective Role for Properdin in Progression of Experimental Murine Atherosclerosis. PLoS ONE, 9(3). View this article in WRRO
Ellam T, Hameed A, ul Haque R, Muthana M, Wilkie M, Francis SE & Chico TJA (2014) Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.. PLoS One, 9(2), e88767. View this article in WRRO
West LE, Steiner T, Judge HM, Francis SE & Storey RF (2014) Vessel wall, not platelet, P2Y12 potentiates early atherogenesis.. Cardiovasc Res, 102(3), 429-435.
Ellam T, Fotheringham J, Wilkie ME, Francis SE & Chico TJA (2014) Bone mineral metabolism parameters and urinary albumin excretion in a representative US population sample.. PLoS One, 9(2), e88388. View this article in WRRO
Francis SE (2014) Genetic experimental preparations for studying atherosclerosis.. Prog Mol Biol Transl Sci, 124, 1-18.
Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) 2 IL-1B Secretion in Coronary Vascular Endothelium is Mediated by Neutrophil Serine Protease and is Independent of caspase-1.. Heart, 100 Suppl 1, A2.
West LE, Steiner T, Francis SE & Storey RF (2013) The role of vessel wall P2Y12 in early atherogenesis is not blocked by ticagrelor or clopidogrel. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 156-156.
McDonald RA, White KM, Wu J, Cooley BC, Robertson KE, Halliday CA, McClure JD, Francis S, Lu R, Kennedy S , George SJ et al (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), 1636-1643. View this article in WRRO
Salazar M, Lorente M, García-Taboada E, Hernández-Tiedra S, Davila D, Francis SE, Guzmán M, Kiss-Toth E & Velasco G (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action.. Biochim Biophys Acta, 1831(10), 1573-1578.
Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) No evidence for cardiac dysfunction in Kif6 mutant mice.. PLoS One, 8(1), e54636. View this article in WRRO
Bazaz R, Marriott HM, Francis SE & Dockrell DH (2013) Mechanistic links between acute respiratory tract infections and acute coronary syndromes.. J Infect, 66(1), 1-17.
Sung HY, Francis SE, Arnold ND, Holland K, Ernst V, Angyal A & Kiss-Toth E (2012) Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis.. Biology (Basel), 1(1), 43-57. View this article in WRRO
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.. J Exp Med, 209(11), 1919-1935. View this article in WRRO
Denes A, Drake C, Stordy J, Chamberlain J, McColl BW, Gram H, Crossman D, Francis S, Allan SM & Rothwell NJ (2012) Interleukin-1 Mediates Neuroinflammatory Changes Associated With Diet-Induced Atherosclerosis. Journal of the American Heart Association, 1(3). View this article in WRRO
Neilan M, Zhang X, Steiner T, Boyle J, Francis S, Haskard D & Qwarnstrom E (2012) 18 TILRR Functional Mutants Selectively Inhibit Inflammatory and Anti-Apoptotic Responses. Heart, 98(Suppl 3), A6.1-A6.
Francescut L, Steiner T, Byrne S, Cianflone K, Francis S & Stover C (2012) The Role of Complement in the Development and Manifestation of Murine Atherogenic Inflammation: Novel Avenues. Journal of Innate Immunity, 4(3), 260-272.
Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE , Crossman DC et al (2012) Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.. Pulm Circ, 2(1), 21-27. View this article in WRRO
Steiner T, Francescut L, Stover C & Francis S (2011) 26 The role of properdin in murine atherosclerosis. Heart, 97(20), e7-e7.
Francescut L, Byrne S, Steiner T, Francis S & Stover C (2011) 28 LDLR and properdin cooperate in LPS-mediated cell signalling. Heart, 97(20), e7-e7.
Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJ (2011) Dietary Phosphate Modulates Atherogenesis and Insulin Resistance in Apolipoprotein E Knockout Mice. Arteriosclerosis Thrombosis and Vascular Biology, 31, 1988-1990.
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in WRRO
Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis.
Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC & Francis SE (2011) Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.. Am J Pathol, 179(4), 1693-1705. View this article in WRRO
Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A , Vail A et al (2011) Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity, 25(6), 1113-1122.
Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis, 215(2), 348-354.
Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A , Vail A et al (2011) Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity.
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.. PLoS Pathog, 7(1), e1001262. View this article in WRRO
Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) Sustained P2Y12 Receptor Inhibition is Required to Effectively Inhibit Neointima Formation in a Murine Vascular Injury Model. CIRCULATION, 122(21).
Patil SB, Jackman LE, Francis SE, Judge HM, Nylander S & Storey RF (2010) Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima.. Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
Neilan M, Zhang X, Francis S & Qwarnstrom EE (2010) BAS/BSCR51 Control of vascular cell inflammatory responses through TILRR, an interleukin 1 co-receptor. Heart, 96(17), e27-e27.
Docherty LM, Angyal A, Francis S & Kiss-Toth E (2010) BAS/BSCR20 The role of a Gab1-Tribbles 2 interaction in phosphoinositide-3-kinase, AKT/PKB cascade regulation and cellular morphology. Heart, 96(17), e18-e18.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
Al-Malki A, Newton S, Francis SE & El-Ghariani K (2010) Circulating endothelial cells in whole blood donations and the effect of leucodepletion. TRANSFUS APHER SCI, 42(1), 97-99.
Ward JR, Francis SE, Marsden L, Suddason T, Lord GM, Dower SK, Crossman DC & Sabroe I (2009) A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.. Immunology, 128(1), 58-68.
Chamberlain J, Wheatcroft M, Arnold N, Lupton H, Crossman DC, Gunn J & Francis S (2009) A novel mouse model of in situ stenting. Cardiovasc Res, 85, 38-44. View this article in WRRO
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) Abstract: 1509 IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. Atherosclerosis Supplements, 10(2), e463-e463.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.. Clin Exp Immunol, 156(3), 386-394.
Evans DJW, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K, Norman KE, Francis SE & Storey RF (2009) Platelet P2Y(12) receptor influences the vessel wall response to arterial injury and thrombosis.. Circulation, 119(1), 116-122.
Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK , Francis SE et al (2008) Tribbles-2 is a novel regulator of inflammatory activation of monocytes.. Int Immunol, 20(12), 1543-1550. View this article in WRRO
Dewberry RM, King AR, Crossman DC & Francis SE (2008) Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation.. FEBS Lett, 582(6), 886-890.
Eder K, Guan H, Sung HY, Francis SE, Crossman DC & Kiss-Toth E (2008) LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression.. Immunol Lett, 116(2), 178-183.
Lawrie A, Waterman E, Southwood M, Evans D, Suntharalingam J, Francis S, Crossman D, Croucher P, Morrell N & Newman C (2008) Evidence of a Role for Osteoprotegerin in the Pathogenesis of Pulmonary Arterial Hypertension. The American Journal of Pathology, 172(1), 256-264.
Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CM (2007) Abstract 376: A Potential Role for TRAIL in the Pathogenesis of Pulmonary Arterial Hypertension. Circulation, 116(suppl_16).
Watt V, Francis S & Crossman D (2007) Deletion of tumour necrosis factor-related apoptosis-inducing ligand attenuates development of atherosclerosis in ApoE null mice. EUROPEAN HEART JOURNAL, 28, 110-110.
Patil SBG, Norman KE, Robins SJ, Crosdale DJ, Nylander S, Francis SE & Storey RF (2007) INHIBITION OF THROMBOSIS BY AZD6140 VIA SELECTIVE BLOCKADE OF THE P2Y12 RECEPTOR IN A MURINE LASER-INJURY MODEL. Journal of Thrombosis and Haemostasis, 5.
Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE , Crossman DC et al (2007) Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.. J Biol Chem, 282(25), 18379-18387. View this article in WRRO
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.. Br J Pharmacol, 151(1), 115-127.
Dewberry R, Jetha K, Shaw G, Crossman D & Francis S (2006) Interleukin-1 receptor antagonist modulates circulating endothelial progenitor cells in mice. Vascular Pharmacology, 45(3), e28-e28.
Sung HY, Francis SE, Crossman DC & Kiss-Toth E (2006) Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific.. Immunol Lett, 104(1-2), 171-177.
Chamberlain J, Evans D, King A, Dewberry R, Dower S, Crossman D & Francis S (2006) Interleukin-1β and Signaling of Interleukin-1 in Vascular Wall and Circulating Cells Modulates the Extent of Neointima Formation in Mice. The American Journal of Pathology, 168(4), 1396-1403.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.. Cytokine, 33(5), 274-280.
Morton AC, Arnold ND, Gunn J, Varcoe R, Francis SE, Dower SK & Crossman DC (2005) Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.. Cardiovasc Res, 68(3), 493-501.
Satterthwaite G, Francis SE, Suvarna K, Blakemore S, Ward C, Wallace D, Braddock M & Crossman D (2005) Differential gene expression in coronary arteries from patients presenting with ischemic heart disease: further evidence for the inflammatory basis of atherosclerosis.. Am Heart J, 150(3), 488-499.
Akowuah EF, Gray C, Lawrie A, Sheridan PJ, Su C-H, Bettinger T, Brisken AF, Gunn J, Crossman DC, Francis SE , Baker AH et al (2005) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.. Gene Ther, 12(14), 1154-1157.
RAY KK, FRANCIS S & CROSSMAN DC (2005) A potential pharmacogenomic strategy for anticoagulant treatment in non-ST elevation acute coronary syndromes: the role of interleukin-1 receptor antagonist genotype. Journal of Thrombosis and Haemostasis, 3(2), 287-291.
Ray KK, Francis S & Crossman DC (2004) Measurement of plasma von Willebrand factor in acute coronary syndromes and the influence of ABO blood group status. Journal of Thrombosis and Haemostasis, 2(11), 2053-2054.
Hauser ER, Crossman DC, Granger CB, Haines JL, Jones CJH, Mooser V, McAdam B, Winkelmann BR, Wiseman AH, Muhlestein JB , Bartel AG et al (2004) A Genomewide Scan for Early-Onset Coronary Artery Disease in 438 Families: The GENECARD Study. The American Journal of Human Genetics, 75(3), 436-447.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.. J Immunol, 173(2), 1202-1208.
Francis S (2004) Endothelial progenitor cells and coronary artery disease. Heart, 90(6), 591-592.
Morton AC, Varcoe R, Francis S, Dower S, Arnold N, Gunn J & Crossman D (2004) INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1RA) MODULATES THE RESPONSE TO OVERSIZED BALLOON ANGIOPLASTY AND STENTING IN A PORCINE CORONARY ARTERY MODEL. Cardiovascular Pathology, 13(3), 93-93.
Evans D, Crossman D, Francis S & Chamberlain J (2004) TGF-BETA ACTIVATION AND NEOINTIMAL FORMATION IN A MURINE MODEL OF VASCULAR INJURY. Cardiovascular Pathology, 13(3), 117-117.
Dewberry R, Crossman D & Francis S (2004) INTRACELLULAR INTERLEUKIN-1 RECEPTOR ANTAGONIST TYPE I (ICIL-1RA1) MODULATES THE REPLICATIVE CAPACITY OF HUMAN ENDOTHELIAL CELLS. Cardiovascular Pathology, 13(3), 95-95.
Chamberlain J, Dower S, Crossman D & Francis S (2004) INHIBITION OF INTERLEUKIN-1 SIGNALLING REDUCES THE NEOINTIMAL RESPONSE TO ARTERIAL INJURY AND PROMOTES VESSEL REMODELLING. Cardiovascular Pathology, 13(3), 116-117.
King AR, Rowe SJ, Francis SE, Whyte MKB & Crossman DC (2004) HUMAN UMBILICAL VEIN ENDOTHELIAL CELL (HUVEC) RESISTANCE TO APOPTOSIS IS MEDIATED BY ACTIVATION OF NF-KAPPAB. Cardiovascular Pathology, 13(3), 127-127.
Morton AC, Francis SE, Dower S, Arnold ND, Gunn J & Grossman DC (2004) Interleukin-1 Receptor Antagonist (IL-1ra) Modulates the Porcine Coronary Arterial Response to Oversized Balloon Angioplasty and Stenting. Clinical Science, 106(s50), 2P-2P.
Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
King AR, Francis SE, Bridgeman CJ, Bird H, Whyte MKB & Crossman DC (2003) A role for caspase-1 in serum withdrawal-induced apoptosis of endothelial cells.. Lab Invest, 83(10), 1497-1508.
Dewberry RM, Crossman DC & Francis SE (2003) Interleukin-1 receptor antagonist (IL-1RN) genotype modulates the replicative capacity of human endothelial cells.. Circ Res, 92(12), 1285-1287.
Satterthwaite G, Francis SE, Blakemore SJ, Ward CL, Wallace DM, Braddock M & Crossman DC (2002) Differential gene expression in atherosclerotic human coronary arteries:strong evidence for the inflammatory basis of atherosclerosis. Biochemical Society Transactions, 30(5), A130-A130.
Ray KK, Camp NJ, Bennett CE, Francis SE & Crossman DC (2002) Genetic variation at the interleukin-1 locus is a determinant of changes in soluble endothelial factors in patients with acute coronary syndromes.. Clin Sci (Lond), 103(3), 303-310.
Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D & Hynes RO (2002) Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies.. Arterioscler Thromb Vasc Biol, 22(6), 927-933.
Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K & Xiao Q (2002) The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symposia on Quantitative Biology, 67, 143-153.
Lambert DL, Malik N, Shepherd L, Gunn J, Francis SE, King A, Crossman DC, Cumberland DC & Holt CM (2001) Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries.. Arterioscler Thromb Vasc Biol, 21(11), 1727-1732.
Ray KK, Camp NJ, Bennett CE, Francis SE & Crossman DC (2001) Differential regulation of endothelial function and systemic inflammation by gene variation at the IL-1 locus during acute coronary syndromes. CIRCULATION, 104(17), 390-391.
Ray KK, Bennett CE, Francis SE, Crossman DC & Camp NJ (2001) Polymorphism at the IL-1 locus determines the endothelial but not the systemic response in acute coronary syndromes. EUR HEART J, 22, 373-373.
Francis SE, Camp NJ, Burton AJ, Dewberry RM, Gunn J, Stephens-Lloyd A, Cumberland DC, Gershlick A & Crossman DC (2001) Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty.. Heart, 86(3), 336-340.
Chamberlain J, Gunn J, Francis SE, Holt CM, Arnold ND, Cumberland DC, Ferguson MW & Crossman DC (2001) TGFbeta is active, and correlates with activators of TGFbeta, following porcine coronary angioplasty.. Cardiovasc Res, 50(1), 125-136.
Chico TJ, Chamberlain J, Gunn J, Arnold N, Bullens SL, Gadek TR, Francis SE, Bunting S, Horton M, Shepherd L , Lipari MT et al (2001) Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.. Circulation, 103(8), 1135-1141.
Kalashnik L, Bridgeman CJ, King AR, Francis SE, Mikhalovsky S, Wallis C, Denyer SP, Crossman D & Faragher RGA (2000) A cell kinetic analysis of human umbilical vein endothelial cells. MECH AGEING DEV, 120(1-3), 23-32.
Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC & Newman CM (2000) Microbubble-enhanced ultrasound for vascular gene delivery.. Gene Ther, 7(23), 2023-2027.
Dewberry R, Holden H, Crossman D & Francis S (2000) Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(11), 2394-2400.
Crossman DC, Francis SE, Camp NJ, Dewberry RM, Gunn J, Cumberland DC, Duff GW, Syrris P, Carter ND, Jeffery S & Kaski JC (2000) Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction - Response. CIRCULATION, 101(18), E193-E193.
Townsend CF, Francis SE & Newman CM (2000) Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
Owens PE, Watson CJ, Canfield AE, Francis SE, Crossman DC & Brenchley PE (2000) VEGF promoter polymorphisms and the risk of ischaemic heart disease. J AM COLL CARDIOL, 35(2), 306A-306A.
Lambert DL, Gunn J, Francis SE, Malik N, King A, Cumberland DC, Crossman DC & Holt CM (2000) Antisense oligonucleotide to c-myb induces apoptosis in vascular smooth muscle cells in vitro and in vivo. Heart, 83(SUPPL. 1).
Galea J, Armstrong J, Francis SE, Cooper G, Crossman DC & Holt CM (1999) Alterations in c-fos expression, cell proliferation and apoptosis in pressure distended human saphenous vein.. Cardiovasc Res, 44(2), 436-448.
Chamberlain J (1999) Temporal and spatial distribution of interleukin-1β in balloon injured porcine coronary arteries. Cardiovascular Research, 44(1), 156-165.
Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC & Newman CM (1999) Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro.. Circulation, 99(20), 2617-2620.
Francis SE, Camp NJ, Dewberry RM, Gunn J, Syrris P, Carter ND, Jeffery S, Kaski JC, Cumberland DC, Duff GW & Crossman DC (1999) Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.. Circulation, 99(7), 861-866.
Townsend CF, Newman CM & Francis SE (1999) Efficient extraction of RNA from vascular tissue.. Methods Mol Med, 30, 39-46.
Dewberry RM, Holden H, Crossman DC & Francis SE (1999) Interleukin-1 receptor antagonist (IL-1RA) in human diseased arteries: Association of allele 2 of IL-1RN (+2016) human gene polymorphism with reduced expression in endothelial cells. Heart, 81(SUPPL. 1).
(1998) . Clinical Science, 95(6), 659-659.
Syrris P, Carter ND, Metcalfe JC, Kemp PR, Grainger DJ, Kaski JC, Crossman DC, Francis SE, Gunn J, Jeffrey S & Heathcote K (1998) Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLIN SCI, 95(6), 659-667.
Malik N, Gunn J, Holt CM, Shepherd L, Francis SE, Newman CM, Crossman DC & Cumberland DC (1998) Intravascular stents: a new technique for tissue processing for histology, immunohistochemistry, and transmission electron microscopy.. Heart, 80(5), 509-516.
John AE, Galea J, Francis SE, Holt CM & Finn A (1998) Interleukin-8 mRNA expression in circulating leucocytes during cardiopulmonary bypass.. Perfusion, 13(6), 409-417.
Malik N, Francis SE, Holt CM, Gunn J, Thomas GL, Shepherd L, Chamberlain J, Newman CM, Cumberland DC & Crossman DC (1998) Apoptosis and cell proliferation after porcine coronary angioplasty.. Circulation, 98(16), 1657-1665.
Lawrie A, Brisken AF, Chamberlain JC, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
Malik N, Gunn J, Holt CM, Francis SE, Arnold N, Newman CMH, Crossman DC & Cumberland DC (1998) Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AM J CARDIOL, 82(7A), 68S-68S.
MALIK NM, SYRRIS P, SCHWARTZMAN R, KASKI JC, CROSSMAN DC, FRANCIS SE, CARTER ND & JEFFERY S (1998) Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. Clinical Science, 95(3), 311-315.
Malik NM, Syrris P, Schwartzman R, Kaski JC, Crossman DC, Francis SE, Carter ND & Jeffery S (1998) Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. CLIN SCI, 95(3), 311-315.
Malik N, Francis SE, Holt CM, Gunn J, Shepherd L, Newman CMH, Cumberland DC & Crossman DC (1998) Apoptosis and cell proliferation following porcine angioplasty. J AM COLL CARDIOL, 31(2), 22A-22A.
Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
Francis SE, Holden H, Holt CM & Duff GW (1998) Interleukin-1 in myocardium and coronary arteries of patients with dilated cardiomyopathy.. J Mol Cell Cardiol, 30(2), 215-223.
Dewberry RM, Camp NJ, Gunn J, Burton AJ, Carter ND, Jeffery S, Syrris P, Schwartzmann RA, Kaski JC, Cumberland DC , Duff GW et al (1998) Interleukin-1 (IL-1) gene polymorphisms: Risk of coronary arterial disease. Heart, 79(SUPPL. 1).
Gunn J, Malik N, Holt C, Francis S, Shepherd L, Newman C, Crossman D & Cumberland D (1997) The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
Gunn J, Holt CM, Francis SE, Shepherd L, Grohmann M, Newman CM, Crossman DC & Cumberland DC (1997) The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty.. Circ Res, 80(4), 520-531.
Bridgeman CJ, King A, Francis SE & Crossman D (1997) Modulation of Bcl-2 and the related proteins Bak and Bax during in vitro ageing of HUVEC. Heart, 77(SUPPL. 1).
Gunn J, Malik N, Shepherd L, Holt CM, Francis SE, Newman CMH, Crossman DC & Cumberland DC (1997) In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
Bridgeman CJ, Francis SE & Crossman D (1997) Z-VAD but not Z-DEVD inhibits serum withdrawal induced apoptosis of HUVEC in vitro. Heart, 77(SUPPL. 1).
Galea J, Armstrong J, Gadsdon P, Holden H, Francis SE & Holt CM (1996) Interleukin-1 beta in coronary arteries of patients with ischemic heart disease.. Arterioscler Thromb Vasc Biol, 16(8), 1000-1006.
John AE, Galea J, Francis SE, Holt CM, Crossman DC & Finn A (1996) Neutrophils are a source of interleukin-6 in human cardiopulmonary bypass surgery. HEART, 75(5), 100-100.
Francis SE, Duff GW & Crossman DC (1996) c-fms proto-oncogene expression is increased in endothelial and smooth muscle cells following vascular grafting. HEART, 75(5), 161-161.
Galea J, Armstrong J, Francis SE, Crossman DC & Holt CM (1996) Early response gene expression and vascular cell proliferation in human saphenous vein prepared for coronary bypass grafting. HEART, 75(5), 279-279.
Bridgeman CJ, King AR, Francis SE & Crossman DC (1996) Apoptosis of human umbilical vein endothelial cells (HUVEC) - Role of interleukin-1 beta converting enzyme (ICE) and associated proteases. HEART, 75(5), 11-11.
Gunn J, Holt GM, Francis SE, Shepherd L, Malik N, Grohmann M, Crossman DC & Cumberland DC (1996) Restenosis after balloon angioplasty: Intimal hyperplasia or vessel remodelling?. HEART, 75(5), 88-88.
GALEA J, FRANCIS SE, CROSSMAN DC & HOLT CM (1995) UP-REGULATION OF THE EARLY RESPONSE GENES C-FOS, C-JUN AND C-MYC IN SURGICALLY PREPARED HUMAN SAPHENOUS-VEIN. CIRCULATION, 92(8), 3080-3080.
GUNN J, HOLT CM, SHEPHERD L, GROHMANN M, FRANCIS SE, CROSSMAN DC & CUMBERLAND DC (1995) INTRA-CORONARY DRUG-DELIVERY VIA POROUS BALLOON - LOCAL OR REGIONAL. CIRCULATION, 92(8), 3220-3220.
Gunn J, Holt CM, Shepherd L, Francis SE, Smith GH & Cumberland DC (1995) 793-4 Local Delivery of C-myb Antisense attenuates Neo-Intimal Thickening in a Porcine Model of Coronary Angioplasty. Journal of the American College of Cardiology, 25(2), 376A-377A.
Cooper GJ, Gillot T, Francis SE & Angelini GD (1995) Distension produces medial but not endothelial damage in porcine internal mammary artery.. Cardiovasc Surg, 3(2), 171-174.
Francis SE, Hunter S, Holt CM, Gadsdon PA, Rogers S, Duff GW, Newby AC & Angelini GD (1994) Release of platelet-derived growth factor activity from pig venous arterial grafts.. J Thorac Cardiovasc Surg, 108(3), 540-548.
Holt CM, Francis SE, Gadsdon PA, Violaris A, Izzat MB & Angelini GD (1994) Release of platelet derived growth factor in serum-free organ culture of human coronary artery.. Cardiovasc Res, 28(8), 1170-1175.
HOLT CM, ARMSTRONG J, GADSDON P, FRANCIS SE & SMITH GH (1994) DETECTION OF IL-1 IN HUMAN ATHEROSCLEROSIS. J CELL BIOCHEM, 285-285.
FRANCIS SE, HOLDEN H, HOLT CM, SMITH GH & DUFF GW (1994) INTERLEUKIN-10 IN HUMAN ARTERIES AND VEINS. J CELL BIOCHEM, 284-284.
Francis SE & Duff GW (1993) 7B6, a ubiquitous mRNA: with significant homology to L41 human ribosomal protein RNA.. Nucleic Acids Res, 21(12), 2944.
Holt CM, Francis SE, Newby AC, Rogers S, Gadsdon PA, Taylor T & Angelini GD (1993) Comparison of response to injury in organ culture of human saphenous vein and internal mammary artery.. Ann Thorac Surg, 55(6), 1522-1528.
Jones MN, Francis SE, Hutchinson FJ, Handley PS & Lyle IG (1993) Targeting and delivery of bactericide to adsorbed oral bacteria by use of proteoliposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1147(2), 251-261.
Violaris A, Francis S, Holt C, Clelland C, Gadsdon P & Angelini G (1993) Organ culture of human coronary artery following balloon angioplasty. International Journal of Angiology, 2(03), 105-111.
Holt CM, Francis SE, Rogers S, Gadsdon PA, Taylor T, Clelland C, Soyombo A, Newby AC & Angelini GD (1992) Intimal proliferation in an organ culture of human internal mammary artery.. Cardiovasc Res, 26(12), 1189-1194.
FRANCIS SE, HOLT CM, GADSDON PA, TAYLOR T & ANGELINI GD (1992) SERUM-FREE ORGAN-CULTURE OF VASCULAR TISSUES. IN VITRO CELL DEV-AN, 28A(11-12), 693-694.
FRANCIS SE, HOLT CM, GADSDON PA, TAYLOR T & ANGELINI GD (1992) ANOTHER CAUTIONARY NOTE ON THE USE OF PCNA. J PATHOL, 166(4), 418-418.
FRANCIS SE, HOLT CM, TAYLOR T, GADSDON P & ANGELINI GD (1992) HEPARIN AND NEOINTIMAL THICKENING IN AN ORGAN-CULTURE OF HUMAN SAPHENOUS-VEIN. ATHEROSCLEROSIS, 93(1-2), 155-156.
Francis SE, Hutchinson FJ, Lyle IG & Jones MN (1992) The control of protein surface concentration on proteoliposomes. Colloids and Surfaces, 62(1-2), 177-184.
Imrie F, Karim SN, Goudie RB, Francis SE, Holt CM, Gadsdon PA, Taylor T, Angelini GD, Friedmann I, Laing RW & Carter N (1992) Letters to the editor. The Journal of Pathology, 166(4), 417-420.
Francis SE, Lyle IG & Jones MN (1991) The effect of surface-bound protein on the permeability of proteoliposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1062(2), 117-122.
Hutchinson FJ, Francis SE, Lyle IG & Jones MN (1989) The integrity of proteoliposomes adsorbed on a biosurface. Biochimica et Biophysica Acta (BBA) - Biomembranes, 987(2), 212-216.
HUTCHINSON FJ, FRANCIS SE & JONES MN (1989) The integrity of proteoliposomes targeted to a model biosurface. Biochemical Society Transactions, 17(3), 558-559.
Hutchinson FJ, Francis SE, Lyle IG & Jones MN (1989) The characterisation of liposomes with covalently attached proteins. Biochimica et Biophysica Acta (BBA) - Biomembranes, 978(1), 17-24.
Borland SJ, Behnsen J, Ashton N, Francis SE, Brennan K, Sherratt MJ, Withers PJ & Canfield AE () X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models. International Journal of Molecular Sciences, 21(12), 4538-4538.
Shabir O, Pendry B, Heath PR, Rebollar MA, Howarth C, Wharton SB, Berwick J & Francis SE () Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
() Correction: Bone Mineral Metabolism Parameters and Urinary Albumin Excretion in a Representative US Population Sample. PLoS ONE, 9(5), e97392-e97392.
Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S & Crossman DC () Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073-e5073. View this article in WRRO
Violaris A, Francis S, Holt C, Clelland C, Gadsdon P & Angelini G () Organ culture of human coronary artery following balloon angioplasty. International Journal of Angiology, 2(03), 105-111.
Borland SJ, Facchi C, Behnsen J, Adamson A, Humphreys NE, Withers PJ, Sherratt MJ, Francis SE, Brennan K, Ashton N & Canfield AE () Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease.
Gomez D, Baylis R, Durgin B, Newman A, Alencar G, Mahan S, St Hilaire C, Mueller W, Waisman A, Pinteaux E , Randolph G et al () Interleukin-1β promotes an atheroprotective distribution of smooth muscle cells and macrophages in late stage murine atherosclerotic lesions. Nature Medicine.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar MA, Howarth C, Heath PR, Wharton SB, Francis SE & Berwick J () Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.

Chapters

Francis SE (2006) Integrins and vascular development in differentiated embryonic stem cells in vitro. (pp. 331-340).

Conference proceedings papers

Turton H, West L, Arnold N, Wright C, Francis S, Marriott H, Lawrie A & Thompson R (2023) Prior lung inflammation induced by intranasal double-stranded RNA does not exacerbate pulmonary hypertension in a mouse model. 13.01 - Pulmonary hypertension
Lawrie A, Zawia A, West L, Arnold N, Pickworth J, Turton H, Thompson AAR & Francis SE (2023) Osteoprotegerin Has Distinct Roles in Pulmonary Vascular and Cardiac Remodelling in a Mouse Model of Pulmonary Arterial Hypertension. A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION
Zhou Z, Van-Hateren N, Francis S, Fragiadaki M & Evans P (2021) BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques. Heart, Vol. 107(Suppl 1) (pp a172-a173)
Kocsy K, Kiss-Toth E, Redgrave J, Majid A & Francis S (2021) BS1 Reprogramming human macrophages with drug X: potential mechanisms for stabilisation of atherosclerotic plaques. Heart, Vol. 107(Suppl 1) (pp a156-a156)
Guagnelli MAR, Wharton S, Francis S & Simpson J (2021) The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
Lawrie A, Arnold ND, Pickworth JA, West LE, Papworth J, Germaschewski V, Thompson AAR & Francis SE (2020) The Anti-Osteoprotegerin (OPG) Antibody Ky3 Attenuates OPG-Fas Mediated Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Pro-Inflammatory Signalling In Vitro and In Vivo. A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
Johnston JM, Martinez-Campesino L, Angyal A, Hadadi E, Kraus R, Wilson HL, Bauer R, Rader D, Hamby SE, Goodall AH , Francis SE et al (2019) Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
Rebollar MA, Wharton S, Francis S & Simpson J (2019) The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
Iqbal A, Prince L, Novodvorsky P, Bernjak A, Thomas M, Birch L, Lambert D, Kay L, Wright F, Jacques R , Storey R et al (2018) Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
Kocsy K, Alqurashi R, Johnston JM, Baidzajevas K, Majid A, Wilson HL, Kiss-Toth E, Redgrave J & Francis SE (2018) P16 HUMAN MACROPHAGE SUBSETS IN THE PATHOGENESIS OF CAROTID ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
Johnston JM, Angyal A, Bauer R, Hamby SE, Suvarna SK, Baidžajevas K, Hegedus Z, Dear NT, Turner M, Wilson HL , Goodall AH et al (2018) P14 MYELOID TRIB1 PROMOTES EXPERIMENTAL ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
Campesino LM, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. CARDIOVASCULAR RESEARCH, Vol. 114 (pp S2-S2)
Almansouri M, Francis S & Chamberlain J (2018) 140 Acetylated ldl induces IL-1β release from human coronary endothelial cells. Heart, Vol. 104(Suppl 6) (pp A102-A103), 4 June 2018 - 6 June 2018. View this article in WRRO
Wright K, Haycock J & Francis S (2018) 95 Investigating fibroblast involvement in vascular inflammation using co-culture models. Basic Science
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) 123 Myeloid TRIB1 controls experimental atherosclerosis. Basic Science
Kocsy K, Wadanamby S, Tang K, Majid A, Redgrave J, Johnston J, Francis S & Kiss-Toth E (2018) 116 Semi-quantitative imaging of macrophages in human carotid atherosclerotic plaques. Basic Science
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) Myeloid Tribbles 1 Regulates Experimental Atherosclerosis. Atherosclerosis Supplements, Vol. 32 (pp 11-11)
Rothman AM, West L, Srivastava S, Quigley C, Southwood M, Lawrie A, Francis S, Morrell N & Rowlands D (2018) Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation. CIRCULATION, Vol. 138
Arnold ND, Pickworth JA, Carvalho JA, Braithwaite AT, Iremonger J, West L, Casbolt HL, Renshall LJ, Germaschewski V, McCourt M , Evans HR et al (2017) Development of a Novel Human Anti-OPG Antibody That Attenuates Experimental Pulmonary Arterial Hypertension. CIRCULATION, Vol. 136
Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM , Rader DJ et al (2017) 157 Myeloid expression of trib1 regulates the polarisation state of tissue resident macrophages that has consequences on plasma lipid and metabolic homeostasis. Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
Borland S, Borland S, Morgan M, Francis S, Merry C & Canfield A (2017) 210 Syndecan-4/fgf-2/pkca signalling regulates vascular smooth muscle cell calcification via cross-talk with tgfb. Heart, Vol. 103(Suppl 5) (pp A139.2-A140)
Wong L, Sharp P, Howarth C, Hoggard N, Berwick J & Francis S (2016) 179 Neurovascular Function in Atherosclerosis. Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
Bowden N, Feng S, Francis S & Evans P (2016) 211 Non-Canonical NF-Îšb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress. Heart, Vol. 102(Suppl 6) (pp A140.1-A140), 6 June 2016 - 8 June 2016.
Johnston J, Kiss-Toth E & Francis SE (2016) 165 In situExamination of Plaque Macrophage Populations Using Multicolour Florescence Microscopy Reveals Critical Differences between Murine Models of Experimental Atherosclerosis. Heart, Vol. 102(Suppl 6) (pp A116.2-A117)
Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Thomas M , Francis SE et al (2016) E microRNA-140-5p and SMURF1 Regulate Pulmonary Arterial Hypertension. Heart, Vol. 102(Suppl 6) (pp A147-A147)
Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Chamberlain J, Mann BE, Francis SE, Iqbal J & Gunn J (2016) 160 Modulation of Myocardial Ischaemic Injury by Carbon Monoxide Releasing Molecule-A1 in a Porcine Model of Acute Reperfusion Infarction. Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
Pickworth J, Shay S, Gladson S, Iremonger J, Rothman AMK, Francis S, West J & Lawrie A (2015) S3 Reduced BMPR2 expression potentiates a pulmonary artery smooth muscle cell specific IL-1ß response. Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
Rothman AMK, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen R, Guth-Gundel S, Southwood M, Morrell NW, Francis SE , Rowlands DJ et al (2015) T5 MicroRNA-140–5p Regulates Disease Phenotype in Experimental Pulmonary Arterial Hypertension via SMURF1. Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) Does myeloid expression of TRIB1 regulate plasma lipid levels?. Atherosclerosis, Vol. 241(1) (pp e34-e34)
Alfaidi M, Schenkel T, Evans P, Chamberlain J & Francis S (2015) 192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions. Heart, Vol. 101(Suppl 4) (pp A107.2-A107)
Smith S, Samokhin A, Murphy E, Francis S & Qwarnstrom E (2015) 217 Altered Regulation of the Inhibitor IÎºBÎ± Contributes to Changes in NF-ÎºB Regulated Genes in the TILRR ko Mouse. Heart, Vol. 101(Suppl 4) (pp A118.2-A119)
Johnston J, Angyal A, Alfaidi M, Francis S & Kiss-Toth E (2015) 186 Assessment of Plaque Macrophage Phenotypein situby Multicolour Fluorescence Microscopy. Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
Bazaz R, Francis S & Dockrell D (2015) 215 Increased Atherosclerotic Plaque Macrophage Content following Streptococcus Pneumoniae Pneumonia. Heart, Vol. 101(Suppl 4) (pp A117.2-A118)
Dawson S, Pickworth J, Rothman A, Iremonger J, Arnold N, Francis S & Lawrie A (2014) T5 Opg Regulates Pulmonary Arterial Smooth Muscle Cell Proliferation And The Expression Of Pah-associated Genes Via Fas. Thorax, Vol. 69(Suppl 2) (pp A2-A3)
Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE & Evans PC (2014) Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne. Atherosclerosis, Vol. 237(2) (pp e2-e2)
Murphy E, Samokhin A, Francis S, Bowskill S & Qwarnstrom E (2014) 187 The Inflammatory Phenotype of the Tilrr Knockout Mouse - Mechanisms Undelying Reduced Responses to Vascular Injury. Heart, Vol. 100(Suppl 3) (pp A104.2-A105)
Arnold N, Dawson S, Pickworth J, Rothman AMK, Iremonger J, Francis S & Lawrie A (2014) Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
West L, Francis S & Storey R (2013) YIA6: VESSEL WALL, BUT NOT PLATELET, P2Y12 CONTRIBUTES TO EARLY ATHEROGENESIS. Heart, Vol. 99(suppl 2) (pp A7-A7)
Alfaidi M, Wilson H, Burnett A, Chamberlain J & Francis S (2013) 172 IL-1 BETA SECRETION IN CORONARY VASCULAR ENDOTHELIUM IS MEDIATED BY NEUTROPHIL SERINE PROTEASE AND IS INDEPENDENT OF CASPASE-1.. Heart, Vol. 99(suppl 2) (pp A99.2-A99)
Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2013) Tumour necrosis factor-related apoptosis-inducing ligand is a novel therapeutic target in pulmonary arterial hypertension. The Lancet, Vol. 381, Supplement 1 (pp S47 --S47 -)
Hameed AG, Arnold ND, Chamberlain J, Pickworth J, Newman CMH, Crossman DC, Francis SE & Lawrie A (2012) TISSUE TRAIL DRIVES PULMONARY VASCULAR REMODELING AND ITS INHIBITION REVERSES EXPERIMENTAL PULMONARY ARTERIAL HYPERTENSION. HEART, Vol. 98 (pp A1-A1)
Pickworth J, Hopkinson K, Francis SE, Kiss-Toth E & Lawrie A (2012) Interplay Between Interleukin-1 And Dysfunctional BMP Signalling May Play A Role In The Pathogenesis Of Pulmonary Arterial Hypertension. B26. PULMONARY VASCULAR SIGNALING IN PULMONARY HYPERTENSION
Lawrie A, Hameed AG, Arnold N, Chamberlain J, Pickworth J, Dawson S, Newman CMH & Francis SE (2012) Osteoprotegerin Blockade Prevents And Reverses Experimental Pulmonary Arterial Hypertension. D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
Hameed AG, Arnold ND, Pickworth J, Chamberlain JC, Newman CMH, Crossman DC, Francis SE & Lawrie A (2011) TRAIL IS A POTENTIAL NOVEL THERAPEUTIC TARGET IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 66 (pp A3-A3)
Condliffe R, Pickworth J, Hopkinson K, Hameed A, Walker S, Elliot C, Francis S, Newman C, Crossman D, Morton A , Kiely D et al (2011) S69 Serum osteoprotegerin predicts mortality in a prospective study on incident cases of pulmonary arterial hypertension. Thorax, Vol. 66(Suppl 4) (pp A34-A34)
Ellam T, Wilkie M, Crossman D, Francis S & Chico T (2011) YIA 2 The effects of dietary phosphate intake on atherogenesis and insulin resistance in Apolipoprotein E knockout mice. Heart, Vol. 97(20) (pp e7-e7)
Lawrie A, Hameed AG, Chamberlain J, Arnold N, Crossman DC & Francis SE (2011) PAIGEN DIET-FED APOLIPOPROTEIN E KNOCK-OUT MICE DEVELOP SEVERE PULMONARY HYPERTENSION IN AN INTERLEUKIN-1 DEPENDENT MANNER. HEART, Vol. 97(20) (pp 10-10)
Hameed AG, Chamberlain J, Arnold N, Newman C, Francis S, Crossman D & Lawrie A (2011) Beneficial Effects Of Inhibiting Trail In Monocrotaline-Induced Experimental Pulmonary Hypertension. B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
Hameed AG, Chamberlain J, Arnold ND, Francis SE, Newman CMH, Crossman DC & Lawrie A (2010) TRAIL DEFICIENCY IS PROTECTIVE IN EXPERIMENTAL PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 65 (pp A68-A68)
Hameed AG, Francis SE, Crossman DC & Lawrie A (2010) TRAIL Deficiency Protects Fat-fed ApoE-/- Mice From Pulmonary Arterial Hypertension. A96. INFLAMMATION AND BONE MARROW DERIVED CELLS IN PULMONARY ARTERIAL HYPERTENSION
Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) FAT-FED APOE/IL-1R1 DOUBLE-DEFICIENT MICE ARE PROTECTED FROM ATHEROSCLEROSIS BUT DEVELOP SEVERE PULMONARY HYPERTENSION. THORAX, Vol. 64 (pp A9-A10)
Condliffe R, Hameed AG, Paiva C, Suntharalingam J, Francis SE, Newman CMH, Crossman DC, Morrell NW & Lawrie A (2009) OSTEOPROTEGERIN/TUMOUR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND PATHWAY: A POTENTIAL BIOMARKER FOR PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A58-A59)
Hameed AG, Vinogradova T, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) TRAIL EXPRESSION IS INCREASED IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A8-A8)
Vinogradova T, Hameed AG, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) OSTEOPROTEGERIN EXPRESSION IS INCREASED PRIOR TO HAEMODYNAMIC ALTERATIONS IN THE RAT MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 64 (pp A9-A9)
Paiva C, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) REGULATION OF EXPRESSION AND FUNCTION OF OSTEOPROTEGERIN IN PULMONARY ARTERY SMOOTH MUSCLE CELLS IN VITRO. THORAX, Vol. 64 (pp A9-A9)
Docherty LM, Angyal A, Francis S & Kiss-Toth E (2009) THE ROLE OF TRIBBLES 2 IN PI3K CASCADE REGULATION AND AKT/PKB ANTI-APOPTOTIC SIGNALLING CASCADE. HEART, Vol. 95(22)
Hameed AG, Francis SE, Neilan M, Parmar S, Crossman DC & Lawrie A (2009) Fat Fed ApoE/IL-1R1 Double Deficient Mice Are Protected From Atherosclerosis but Develop Severe Pulmonary Hypertension. CIRCULATION, Vol. 120(18) (pp S751-S751)
Watt V, Soon E, Suntharalingam J, Paiva C, Hameed AG, Francis SE, Newman CM, Crossman DC, Morrell NW & Lawrie A (2009) OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2)
Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2). Boston, MA, 14 June 2009 - 18 June 2009.
Chamberlain J, Wheatcroft M, Arnold N, Francis S, Lupton H & Gunn J (2009) A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
Lawrie A, Paiva C, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CMH (2008) THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
Guan H, Eder K, Sung HY, Sheridan PJ, Ward J, Morton A, Angyal A, Sarmay G, Duda E, Turner M , Dower SK et al (2008) Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44)
Al-Malki A, Francis S & El-Ghariani K (2008) Leucodepletion filters do not eliminate circulating endothelial cells (CECs) in human whole blood donations. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 141 (pp 113-113)
Evans DJW, Crosdale DJ, Judge HM, Chamberlain J, Jetha K, Norman KE, Francis SE & Storey RF (2008) The platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp A291-A291)
Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW, Morrell NW & Newman CM (2007) A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
Watt V, Francis S & Crossman DC (2007) Deletion of tumour necrosis factor-related apoptosis-inducing ligand attenuates development of atherosclerosis in ApoE−/− mice. Atherosclerosis, Vol. 193(2) (pp S5-S5)
Lawrie A, Suntharalingham J, Southwood M, Francis S, Crossman D, Morrell N & Newman C (2007) A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
Ward JR, Francis SE, Marsden LL, Dower SK, Crossman DC & Sabroe I (2007) Bidirectional signalling between monocytes and endothelial cells regulate responses to TLR4 agonists in coculture models of vascular inflammation. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
Lawrie A, Evans DJW, Waterman EA, Francis SE, Crossman DC & Newman CMH (2006) Osteoprotegerin is up-regulated by BMP-R2 RNA-interference and induces proliferation and migration of human pulmonary artery smooth cells in vitro. Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
Watt V, Ray KK, Francis SE & Crossman DC (2006) Interaction between tumour necrosis factor-related apoptosis inducing ligand & osteoprotegerin in acute coronary syndromes. EUROPEAN HEART JOURNAL, Vol. 27 (pp 229-229)
Morton AC, Francis SE, Arnold ND, Gunn J, Dower S & Crossman D (2006) The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231)
Evans D, Crosdale DJ, Norman KE, Francis SE & Storey RF (2006) The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. EUROPEAN HEART JOURNAL, Vol. 27 (pp 753-753)
Evans D, Crosdale D, Norman K, Francis S & Storey R (2006) The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. HEART, Vol. 92 (pp A111-A111)
Watt V, Ray KK, Francis SE, Whyte MK & Crossman DC (2006) Soluble tumour necrosis factor-related apoptosis inducing ligand is low early in the presentation of acute coronary syndromes and is inversely correlated with C-reactive protein and troponin T. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 194A-194A)
Wheatcroft M, Lupton H, Arnold N, Francis S & Gunn J (2005) A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51)
Sung HY, Francis S, Crossman DC & Kiss-Toth E (2005) Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15)
Varcoe RW, Stokes L, Francis SE, Dower S, Surprenant A & Crossman DC (2005) Investigation of P2X7 dependent mechanisms of interleukin-1 beta (IL-1 beta) release from human endothelial cells. HEART, Vol. 91 (pp A13-A13)
Akowuah E, Gray C, Sheridon P, Bettinger T, Res B, Brisken A, Gunn J, Crossman D, Francis S, Baker A & Newman C (2004) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4)
Morton AC, Varcoe R, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2004) Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2)
Morton AC, Francis SE, Dower S, Arnold ND, Gunn J & Crossman DC (2003) Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195)
Akowuah E, Gray C, Francis S, Gunn J, Bettinger T, Brisken A, Crossman D & Newman C (2003) Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
Ray KK, Francis SE & Crossman DC (2003) IL-1 RN (VNTR) gene polymorphism predicts clinical events up to 1 year after a non-ST-elevation acute coronary syndrome: An association independent of troponin T and C-reactive protein. EUROPEAN HEART JOURNAL, Vol. 24 (pp 70-70)
Ray KK, Francis SE & Crossman DC (2002) IL-1RN (VNTR) gene polymorphism predicts a proinflammatory endothelial cell phenotype in HUVEC-Implications for atherogenesis and plaque rupture. EUROPEAN HEART JOURNAL, Vol. 23 (pp 594-594)
Townsend CF, Francis SE, Chamberlain J, Gunn J, Crossman DC & Newman CMH (2001) Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
Lawrie A, Brisken AF, Francis SE, Crossman DC, Cumberland D & Newman CM (1999) Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
Chamberlain J, Gunn J, Francis SE, Holt CM, Cumberland DC & Crossman DC (1998) IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) High frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
Gunn J, Francis S, Holt C, Chamberlain J, Lambert D, Newman C, Crossman D & Cumberland D (1997) Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
FRANCIS SE & JONES MN (1990) Effect of surface-bound lectin on the release of encapsulated sugar from vesicle delivery systems. Biochemical Society Transactions, Vol. 18(5) (pp 876-877)
Dawson S, Arnold N, Pickworth J, Francis S & Lawrie A () TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension. Diseases, Vol. 2(3) (pp 260-273) View this article in WRRO
Alfaidi MAA, Wilson H, Ridger, V, Chamberlain J & Francis S () Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.

Preprints

Gustschin A, Riedel M, Taphorn K, Petrich C, Gottwald W, Noichl W, Busse M, Francis SE, Beckmann F, Hammel JU , Moosmann J et al (2021) High resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators, arXiv.
Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D () Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice, Research Square Platform LLC.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis, Cold Spring Harbor Laboratory.
Low EL, Schwartze JT, Kurkiewicz A, Pek M, Kelly DJ, Shaw AS, Thorikay M, McClure J, McBride M, Arias-Rivas S , Francis SE et al () Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia, Cold Spring Harbor Laboratory.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J () Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al () Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion, Cold Spring Harbor Laboratory.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al () Neutrophil microvesicles drive atherosclerosis by deliveringmiR-155to atheroprone endothelium.

Research group

Dr Osman Shabir
Dr Aya Elwazir
Mr Kieran Bowden
Miss Pooja Atul Patel
Dr Janet Chamberlain
Mr David Reid (with the Paul Evans group)
Ms Priscila Hirschfield (with the Paul Evans group)
Mr Oliver Heaney ( with the Shaw group)
Mr Rahul Sidhu ( with the Howarth/Berwick group)

Teaching interests

I am a Senior Fellow of the Higher Education Academy. I teach the MSc in Molecular Medicine, where I lead Molecular Genetics of Human Diseases (MED6003). I also teach phase 2a (Cardiology) MBChB.

I co-founded an undergraduate BMS 3rd year module ‘Cardiovascular Pharmacology – personalising medicine’ now led by Dr Janet Chamberlain and Dr Nigel Wheeldon.

Professional activities and memberships

Secretary of the British Atherosclerosis Society (September 2018 - September 2023)
European Atherosclerosis Society Distinguished Awards and Prizes Committee (2022 - present)
Fellowships Committee, British Heart Foundation (July 2020 - present)
Academy of Medical Sciences, Springboard Awards Committee (November 2022 - present)