Professor Julian Gunn MA MB BChir MD MRCP
Professor of Interventional Cardiology, Honorary Consultant Cardiologist & Insigneo Fellow.
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
Tel NHS Secretary - Northern General Hospital: +44 (0) 114 271 4953
Fax: +44 (0)114 271 1863
Email: j.gunn@sheffield.ac.uk
Biography:
I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994. I was trained in Cardiology in Sheffield, and in coronary intervention by Professor David Cumberland. I won the BCS Young Investigator of the Year in 1995. I was appointed Senior Lecturer in 2000 and became Reader in Interventional Cardiology in 2014 and Professor in 2016. I lead the Mathematical Modelling in Medicine group within the Department of Infection, Immunity & Cardiovascular Disease, and Chair the Cardio-Respiratory Workgroup of the Insigneo Institute for in silico medicine.
Research Activities:
My higher degree was in the field of local coronary artery injury and healing, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, and how we can improve upon the results of PCI. This research has spanned basic research, in vivo experimentation, translation into clinical studies and clinical decision making. Increasingly I am focusing on the application of computer models of coronary artery disease to develop ‘virtual’ coronary physiology based upon the coronary angiogram. I supervise Academic Clinical Fellows and students at BMedSci, MD and PhD level and welcome applications from students interested in undertaking projects in the field of computational modelling of coronary artery blood flow.
Teaching Interests:
I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally. I also teach on the Molecular Medicine MSc course. I have taught 21 BMedSci, 7 MD and 8 PhD students.
Professional Activities:
I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust and Lead for Acute Coronary Syndrome Pathways, Sheffield Teaching Hospitals Foundation Trust. I am Chairman of the Insigneo Cardiovascular Working Group. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society and its R&D committee. I am a Supervisor for the Wellcome 4Ward North Clinical PhD Programme, and Member of the EPSRC Image-guided therapies UK Network. I am reviewer for six Cardiology journals and for the BHF, MRC and NIHR.
Current Projects:
- Computer modelling of coronary artery disease and blood flow.
- Clinical decision making in coronary artery disease.
- Complex percutaneous coronary interventions.
- Translational clinical trials in these areas.
I currently hold NIHR, BHF and MRC-DPFS grants.
Publications:
For key publications see below. For a full list of publications click here.
Journal articles
- Virtual Coronary Intervention. A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Eurointervention. View this article in WRRO
- Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. Journal of American College Cardiology Basic to Translational Science, 2(4), 434-446. View this article in WRRO
- Simulation training for the trainee cardiologist: the evidence mounts. EuroIntervention, 11(13), 1454-1455. View this article in WRRO
- When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
- Computational fluid dynamics modelling in cardiovascular medicine. Heart, 102(1), 18-28. View this article in WRRO
- “Virtual” (Computed) Fractional Flow Reserve. JACC: Cardiovascular Interventions, 8(8), 1009-1017.
- Simulation in cardiology: state of the art. European Heart Journal, 36(13), 777-783.
- From Histology and Imaging Data to Models for In-Stent Restenosis. The International Journal of Artificial Organs, 37(10), 786-800.
- Contribution of Mechanical and Fluid Stresses to the Magnitude of In-stent Restenosis at the Level of Individual Stent Struts. Cardiovascular Engineering and Technology, 5(2), 164-175.
- The effects of stenting on shear stress: relevance to endothelial injury and repair.. Cardiovasc Res, 99(2), 269-275.
- Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
- Simulation of oxygen transfer in stented arteries and correlation with in-stent restenosis. International Journal for Numerical Methods in Biomedical Engineering, 29(12), 1373-1387.
- Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design. INTERFACE FOCUS, 1(3), 365-373.
- A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations. Journal of Computational Science.
Conference proceedings papers
- Reconstruction of Coronary Trees from 3DRA Using a 3D+t Statistical Cardiac Prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)