Professor Nigel Hoggard MD MRCP FRCR
Professor of Neuroradiology
Department of Infection, Immunity & Cardiovascular Disease
Royal Hallamshire Hospital
I joined the University of Sheffield as Clinical Senior Lecturer in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents. Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003. I have published over 70 peer reviewed articles.
My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and the cerebellum in particular. I work closely with Prof Marios Hadjivassiliou, we are part of the SIGReD group founded by Marios, a multi-disciplinary research group focussed on gluten related diseases. We have published numerous articles on gluten ataxia and brain imaging in gluten sensitivity.
The cerebellum is a small part of the brain that never the less contains over half of the neurons, the brain cells that carry out the brain’s activity. It represents a highly compact system for combining and analysing information subconsciously for the rest of the brain, it can be thought of as the brain’s own supercomputer. The cerebellum helps the brain to control many activities of which the best studied is balance and coordination of movement though its role in control of emotion and cognition is gradually being revealed. When it is damaged patients may be affected by falls and feel clumsy. They may lose the ability to walk, use utensils or dress themselves and quite frequently may have to use a wheel chair as it becomes more severe.
The cerebellum is affected by a wide range of diseases including genetic conditions, degenerative conditions and auto-immunity related diseases. There are new treatments being developed for diseases affecting the cerebellum but trials are hampered by the lack of suitable ways to measure their effectiveness. In dementia and MS many trial outcomes are based on MR imaging techniques as a well as clinical changes in the patients. But because the cerebellum’s activity is subconscious and represents feedback control beneath the surface it is difficult to measure clinically. Our group’s research is focussed on assessment of the cerebellum with advanced MR imaging based techniques. In particular, there is a need for measurements in the autoimmune cerebellar diseases and aggressive degenerative cerebellar disease such as MSA-C.
Gluten sensitivity, as well as causing ataxia, can be associated with accelerated white matter small vessel disease and imaging to assess this and the evaluation the blood brain barrier is an area of great interest to us in SIGReD.
I have been heavily involved in the UK and European response to the information coming through of the accumulation of gadolinium in the brain in patients after routine administration of gadolinium based contrast agents. This is also a research interest given its proclivity to accumulate ate high concentration in the dentate nucleus of the cerebellum.
I am the lead for the Sheffield academic clinical radiology training scheme and Deputy Lead for the Sheffield academic training programme. The Sheffield radiology training scheme continues to show strong success developing academic radiologists all the way from thesis to tenured full time academic posts. I teach on the Neurology MSc course, the Sheffield Fundamentals of Neuroradiology course and the National ENT radiology Masterclass.
- Editor-in-Chief British Journal of Radiology 2013-2016.
- Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.
- Expert Advisory Panel member, European Medicines Agency 2016.
- Cancer Peer reviewer 2012-2013.
- Member of the Royal College of Radiologists FRCR part I examination committee 2011-2014.
- NIHR doctoral research fellowship selection panel member 2011 and 2013-present.
- NIHR IAT panel for competitive bids for ACF and ACL posts 2015-present.
- Sheffield Teaching Hospitals NHS Foundation Trust, Research Lead for the Directorate of Radiology 2008-present.
- Member of the Sheffield Regional Ethics committee 2006-2012.
For key publications see below. For a full list of publications click here.
- Hadjivassiliou M, Martindale J, Shanmugarajah P, Grünewald RA, Sarrigiannis PG, Beauchamp N, Garrard K, Warburton R, Sanders DS, Friend D, Duty S, Taylor J & Hoggard N (2016) Causes of progressive cerebellar ataxia: prospective evaluation of 1500 patients.. J Neurol Neurosurg Psychiatry.
- Hoggard N & Roditi GH (2016) T1 hyperintensity on brain imaging subsequent to gadolinium-based contrast agent administration: what do we know about intracranial gadolinium deposition?. British Journal of Radiology, 90(1069).
- Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R, Sarrigiannis PG, Hoggard N, Koltzenburg M, Gandini Wheeler-Kingshott CAM, Schmierer K, Giovannoni G, Miller DH & Kapoor R (2016) Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. The Lancet Neurology, 15(3), 259-269.
- Currie S, Hadjivassiliou M, Wilkinson ID, Griffiths PD & Hoggard N (2013) Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?. Cerebellum, 12(2), 205-211.
- Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S & Sanders DS (2010) Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency.. Clin Gastroenterol Hepatol, 8(5), 433-438.
- Hoggard N, Darwent G, Capener D, Wilkinson ID & Griffiths PD (2009) The high incidence and bioethics of findings on magnetic resonance brain imaging of normal volunteers for neuroscience research.. J Med Ethics, 35(3), 194-199.