Dr Paul Morris MBChB MRCP BMedSci
NIHR Clinical Lecturer in Cardiology
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0) 114 215 9548
Fax: +44 (0) 114 271 1863
I joined the University of Sheffield in 1998 when I came to study Medicine. During this time, I developed an interest in cardiology and research. I intercalated a BMedSci degree and investigated the role of testosterone in men with heart disease. I qualified as a medical doctor in 2004 and became a member of the Royal College of Physicians in 2007. I am currently a British Heart Foundation Research Training Fellow within the Department of Cardiovascular Science. I am also a member of the Insigneo Institute for in silico Medicine and am an Honorary Specialist Training Registrar in Cardiology at Sheffield Teaching Hospitals NHS Foundation Trust.
My research interests are in computational modelling of cardiac physiology and heart disease. I am interested in the construction, development and validation of computational workflows which predict cardiac physiology. My current work is focused on the development of a model of intra-coronary physiology. Our VIRTUheart™ model computes virtual fractional flow reserve (vFFR) a marker of coronary artery disease significance and a guide to treatment.
I enjoy lecturing clinical cardiology to undergraduates and post-graduates. I also teach clinical skills to medical students and doctors on the wards and in the clinic. A textbook of the cardiovascular system and clinical cardiology is currently in preparation.
Other professional activities and interests include public engagement with science and the development of assessments for clinical knowledge and skills.
- Virtual coronary physiology: an angiogram is all you need. Wellcome Trust and Department of Health. Health Innovation Challenge Fund (£671,856).
- Modelling the significance of coronary artery disease (British Heart Foundation Personal Fellowship; £166,125)
- NIHR Cardiovascular Biomedical Research Unit Entry level Fellowship 2011 (£60 000)
Images from the VIRTUheartTM workflow. VIRTUheartTM predicts pressure changes within coronary arteries. A and B are angiogram images from a patient with coronary heart disease. The arrows point to an area of disease (narrowing). Image C shows the reconstructed or virtual artery. The colours indicate the computed blood pressure within the artery. A drop in pressure can be seen beyond the diseased segment. D and E show the artery after percutaneous coronary intervention (stent insertion). F shows the virtual artery, this time with no significant pressure changes. Doctors can use these computed pressure measurements to help guide treatment decisions.
For key publications see below. For a full list of publications click here.
- Morris PD, Taylor J, Boutong S, Brett S, Louis A, Heppenstall J, Morton AC & Gunn JP (2016) When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?. Catheterization and Cardiovascular Interventions, 87(4), E104-E112. View this article in WRRO
- Morris PD, Ryan D, Morton AC, Lycett R, Lawford PV, Hose DR & Gunn JP (2013) Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.. JACC Cardiovasc Interv, 6(2), 149-157.
- Warriner DR, Morris PD, Saraf K & Al-Mohammad A (2013) Heart failure with a preserved ejection fraction.. Br J Hosp Med (Lond), 74(2), C26-C30.
- Morris PD, Robinson T & Channer KS (2012) Reversible heart failure: toxins, tachycardiomyopathy and mitochondrial abnormalities.. Postgrad Med J, 88(1046), 706-712.
- Morris PD & Channer KS (2012) Testosterone and cardiovascular disease in men. Asian Journal of Andrology, 14(3), 428-435.
- Malkin CJ, Pugh PJ, Morris PD, Asif S, Jones TH & Channer KS (2010) Low serum testosterone and increased mortality in men with coronary heart disease. Heart, 96(22), 1821-1825.
- Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH & Channer KS (2004) Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart, 90(8), 871-876.
- Morris PD, Malkin CJ, Channer KS & Jones TH (2004) A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men. European Journal of Endocrinology, 151(2), 241-249.
Conference proceedings papers
- Çimen S, Hoogendoorn C, Morris PD, Gunn J & Frangi AF (2014) Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 8674 LNCS(PART 2) (pp 619-626)