Dr Lisa Parker BSc MRes PhD
Lecturer in Inflammation Biology
Department of Infection Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience. I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.
I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity. My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.
I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).
My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.
Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified. A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.
- Member of the Society for Leukocyte Biology
- Science and Engineering Ambassador (STEMNET programme)
- Early Career Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
- Research Meeting Working Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
- Member of Centre for Membrane Interactions and Dynamics (CMIAD)
- Member of the British Society for Immunology
- 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.
- 2014-2017 University of Sheffield PhD studentship "Phosphatases and respiratory viral infection". Lead applicant, co-applicant Prof Ian Sabroe.
- 2014-2017 Medical Research Council Project Grant "The role of pellino proteins in viral inflammation". Named collaborator, lead applicants Prof Ian Sabroe, Prof David Dockrell.
- 2013-2017 Medical Research Council New Investigator Research Grant "Probing the sequence of cellular activation by rhinoviral infection in the airway and identifying how this may be dysregulated in COPD". Lead applicant.
For key publications see below. For a full list of publications click here.
- Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I & Parker LC (2016) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1316. View this article in WRRO
- Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Parker LC, Stokes CA & Sabroe I (2014) Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
- Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC & Sabroe I (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19.
- Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P & Whyte MKB (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
- Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2008) Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- Sabroe I, Parker LC, Dower SK & Whyte MKB (2008) The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2007) Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Parker LC, Whyte MKB, Dower SK & Sabroe I (2005) The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G & Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.