Dr Lisa Parker
BSc, MRes, PhD, PGCert, FHEA
School of Medicine and Population Health
Lecturer in Inflammation Biology
+44 114 215 9544
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I graduated from the University of Manchester in 1996 with a BSc (First Class Honours) in Neuroscience. I then completed an MRes in Neuroscience (University of Manchester, 1997) followed by my PhD entitled `Interleukin-1 and its receptors in the brain´ under the supervision of Professor Dame Nancy Rothwell (University of Manchester, 1997-2000).
I joined the University of Sheffield in 2001 to take up my first post-doctoral position, where I was keen to maintain and develop my interest into inflammatory mechanisms in disease, with a focus on the respiratory system. In 2010 I was appointed to a lectureship within the Inflammation Biology Research Group and in 2014 I was awarded the Postgraduate Certificate in Learning and Teaching (PG CiLT) and became a Fellow of The Higher Education Academy (FHEA).
During my lectureship my increasing involvement in teaching ignited a strong passion for learning and teaching, prompting me to actively pursue opportunities that would allow me to focus more on educational roles. In 2010 I started to teach on the MSc Molecular Medicine degree, this developed into running several modules for the course and I was appointed Deputy Programme Lead in 2023. During this time I also designed and led modules for several other courses, at both postgraduate and undergraduate level. I currently teach on multiple programmes within the School of Medicine and Population Health, and the School of Biosciences.
In the last few years I have also taken on multiple teaching-focused leadership roles. I was appointed Deputy Director of Phase 1 (MBChB) in 2021, and I also lead the MBChB Phase 2a Immunology block. My involvement with the MBChB has continued to develop, I was appointed Associate Director of Student Affairs (MBChB) in 2024 and Deputy Programme Lead of BSc in Medical Sciences Research Intercalation studies in 2025.
I am also a Faculty of Health representative for the Learning and Teaching Scholarship Network (LTSN) Steering committee, SMPH Annual Research Meeting Working Group committee member and SMPH Athena Swan Committee member.
- Qualifications
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Academic
- 2000: PhD, Division of Neuroscience, University of Manchester Professor Dame Nancy Rothwell & Dr Giamal Luheshi
- 1997: MRes, Division of Neuroscience, University of Manchester
- 1996: BSc (Hons) First Class, Neuroscience, University of Manchester
Professional
- 2014: Postgraduate Certificate in Learning and Teaching (PGCert Learning and Teaching), University of Sheffield
- 2014: Fellow of the Higher Education Academy (FHEA)
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Role of unfolded proteins in lung disease. Thorax, 76(1), 92-99. View this article in WRRO
- Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10. View this article in WRRO
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10.
- DUSP10 negatively regulates the inflammatory response to rhinovirus through IL-1β signalling. Journal of Virology, 93(2). View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.. Mucosal Immunology, 9(5), 1303-1316.
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12).
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
All publications
Journal articles
- Role of unfolded proteins in lung disease. Thorax, 76(1), 92-99. View this article in WRRO
- Pellino-1 regulates the responses of the airway to viral infection. Frontiers in Cellular and Infection Microbiology, 10. View this article in WRRO
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10.
- Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease.. International Journal of Molecular Sciences, 20(3). View this article in WRRO
- DUSP10 negatively regulates the inflammatory response to rhinovirus through IL-1β signalling. Journal of Virology, 93(2). View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10.
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.. Mucosal Immunology, 9(5), 1303-1316.
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12).
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
- The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365.
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19.
- Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107.
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921.
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063.
- Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
- Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
- Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
- The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
- Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
- Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
- Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311.
- Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
- Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
- IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.. Br J Pharmacol, 136(2), 312-320.
- Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.. J Neurochem, 83(4), 754-763.
- Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
- The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
- Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
- IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.. Brain Res Mol Brain Res, 79(1-2), 156-158.
- Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.. Proc Natl Acad Sci U S A, 97(10), 5580-5585.
- Expression of the IL-1 type I receptor and accessory protein in mouse primary glial cell cultures. EUR J NEUROSCI, 12, 359-359.
- Interleukin-1 type-1 receptor expression in the rat hypothalamus. BRIT J PHARMACOL, 123, U106-U106.
- Phasic and tonic reflexes evoked in human antagonistic wrist muscles by tendon vibration.. Electroencephalogr Clin Neurophysiol, 109(1), 24-35.
- Autogenetic and reciprocal tonic reflex actions of muscle vibration-evoked afferent input studied in human wrist muscles.. J PHYSIOL-LONDON, 504P, P119-P119.
Book chapters
- Pathogen Recognition Receptors and the Lung, Encyclopedia of Respiratory Medicine (pp. 264-270). Elsevier
Conference proceedings
- S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans (pp A60.2-A60)
- Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
- P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair (pp A112.1-A112)
- The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
- Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
- The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
- Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
- Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS (pp A5660-A5660)
- INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
- CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
- Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY (pp A4009-A4009)
- The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
- DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
- THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38)
- DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
- Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
- Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
- The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
- The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
- Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
- Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
- Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)
- Role of unfolded proteins in lung disease. Thorax, 76(1), 92-99. View this article in WRRO
- Teaching interests
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I have created, developed, led and taught modules at both undergraduate and postgraduate level within the Faculties of Health and Science for many years, with a particular focus on immunology and the impact of viral infections on respiratory disease.
I am also passionate about student support and welfare; I run an enhanced support programme for first year medical students as part of my role as Deputy Director of Phase 1, and support students in all phases of the MBChB in my role as a Associate Director of Student Affairs. I am also an academic tutor for undergraduate medical students, PGT and PGR students in the Medical school.
I am also committed to the continued improvement of teaching practice, supporting the development of others, and ultimately providing students with the very best learning experiences. My role as Faculty of Health representative for the Learning and Teaching Scholarship Network (LTSN) Steering committee allows me to support the ongoing development of colleagues across the University.
- Teaching activities
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- Deputy Director of Phase 1 (MBChB)
- Associate Director of Student Affairs (MBChB)
- Deputy Programme Lead for BSc Medical Sciences Research Intercalation Programme
- MBChB Phase 2a Immunology Block Lead
- BSc in Biomedical Sciences Level 3 Module lead (Pharmacology of Respiratory Disease)
- Teaching on the MBChB, intercalated BSc and BSc Biomedical Sciences courses
- Assessment MBChB – marking student selected components throughout the 5 year MBChB course; setting, quality assurance, standard setting and marking first and second year exams
- Assessment BSc – setting and marking assignments for different modules on the Biomedical and intercalated BSc courses
- Student support and academic tutoring
- Curriculum design
- Admissions – interviews for MBChB course
- Professional activities and memberships
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- Fellow of the Higher Education Academy (FHEA).
- Deputy Director of Phase 1 (MBChB)
- Associate Director of Student Affairs (MBChB)
- Deputy Programme Lead for BSc Medical Sciences Research Intercalation Programme
- Faculty of Health representative for the Learning and Teaching Scholarship Network (LTSN) Steering committee
- SMPH Athena Swan Committee member
- SMPH Annual Research Meeting Working Group Committee member
- SMPH HEA Fellowship Support / Mentor Scheme member
- Member of the British Society for Immunology