Lisa ParkerDr Lisa Parker BSc MRes PhD

Lecturer in Inflammation Biology

Department of Infection Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
S10 2RX

Tel: +44 (0)114 215 9544
Fax: +44 (0)114 271 1863


I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience. I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.

I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity. My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.

I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).

Research Interests:

My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.

Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified. A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.

Teaching Interests:

I currently teach on the MSc in Molecular Medicine. I am coordinator of the “Research Literature Review” and “Project Presentation” modules, and I teach on the Microbes and Infection Pathway, as well as regularly supervising laboratory projects. I am also module coordinator of “CDL302 Pharmacology of Respiratory Disease” a level 3 undergraduate taught module for Biomedical Sciences.

Professional Activities:

Current Projects:

  • 2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
  • 2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Lead applicant Dr Lisa Parker, co-applicant Prof I Sabroe.
  • 2018-2019 BLF pump-priming research grant. “Treating RSV infection by targeting membrane microdomains” Lead applicant LC Parker, co-applicants Dr Clare Stokes, Dr Fiona Culley (Imperial College London), I Sabroe.
  • 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.


For key publications see below.  For a full list of publications click here.

Journal articles