Lisa ParkerDr Lisa Parker BSc MRes PhD

Lecturer in Inflammation Biology

Department of Infection Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Tel: +44 (0)114 215 9544
Fax: +44 (0)114 271 3892
Email: l.c.parker@sheffield.ac.uk

Secretary: Mrs Susan Clary
Tel: +44 (0) 114 215 9503
Email: s.clary@sheffield.ac.uk

Biography:

I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience. I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brainĀ“, under the supervision of Professor Dame Nancy Rothwell.

I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity. My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.

I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).

Research Interests:

My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.

Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified. A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.

Professional Activities:

Current Projects:

  • 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.
  • 2014-2017 University of Sheffield PhD studentship "Phosphatases and respiratory viral infection". Lead applicant, co-applicant Prof Ian Sabroe.
  • 2014-2017 Medical Research Council Project Grant "The role of pellino proteins in viral inflammation". Named collaborator, lead applicants Prof Ian Sabroe, Prof David Dockrell.
  • 2013-2017 Medical Research Council New Investigator Research Grant "Probing the sequence of cellular activation by rhinoviral infection in the airway and identifying how this may be dysregulated in COPD". Lead applicant.

Publications:

For key publications see below.  For a full list of publications click here.

Journal articles