Professor Stephen A Renshaw MA FRCP PhD
Sir Arthur Hall Professor of Medicine
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0)114 222 2334 (Firth Court)
Tel: +44 (0) 114 215 9574 (Medical School)
Fax: +44 (0)114 271 1863
Secretary: Vanessa Hainsworth
Tel: +44 (0)114 222 2710
I have worked for the University of Sheffield since 1998. I am the Sir Arthur Hall Professor of Medicine and Director of the Bateson Centre - a large cross-faculty research centre (former MRC Centre, 41PIs, over 130 members and active grant funding of over £30m). I have important leadership roles in large cross-institution partnerships, including directing an MRC Doctoral Training Partnership across 4 major civic universities of the North of England – highly regarded as a model for student-led, cross-institutional, innovative postgraduate research training. I also have national and International leadership roles through membership of REF 2021 sub-panel 1, and through being a board member of Zebrafish Disease Models Society and principal organiser of Neutrophil 2020 – the foremost international neutrophil biology meeting. I studied medicine at Cambridge and then at Oxford Clinical School. After a clinical rotation in Nottingham, I moved to Sheffield to take up a Wellcome Trust Clinical Research Training Fellowship, to work on the regulation of neutrophil lifespan with Professor Moira Whyte. After 3 years as Clinical Lecturer in Respiratory Medicine, I was awarded an MRC Clinician Scientist Fellowship to develop an innovative model of neutrophil biology in the transparent, genetically tractable larval zebrafish. I have been able to develop a number of unique transgenic zebrafish which have allowed several important advances in our understanding of inflammation biology and of host-pathogen interaction. In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work. I continue clinical work in Respiratory Medicine with a special interest in Interstitial Lung Disease associated with a range of multisystem diseases.
Diseases of immunity cause much illness in the developed world – on one hand we are beset by a range of antibiotic resistance bacterial infections, while on the other hand our immune systems are responsible for many the common diseases of ageing – heart disease, stroke and COPD. Understanding the regulation of innate immune cells, neutrophils and macrophages, in infection and inflammation will help us tune the immune system to the exact level needed to cope with the current level of threat. More host defence to fight antibiotic resistant organisms; less host defence to prevent lung damage in response to environmental pollutants. To improve our understanding, I have set up a model system in which the genes controlling regulation of innate immune cell function can be identified. The model I have chosen is the Zebrafish, which is both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence host-pathogen interaction and the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an infection or an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease.
- Director, The Bateson Centre.
- Director, MRC Doctoral Training Partnership, Discovery Medicine North.
- Deputy Director and Sheffield Lead, MRC SHIELD Antimicrobial Research Consortium.
- MRC Programme Grant Holder.
- Sponsor of 3 Wellcome Trust/Royal Society Sir Henry Dale Fellows, 1 Marie Curie Fellow, 2 Wellcome Trust Clinical Training Fellows and 1 European Leukodystrophy Association Fellow.
- Board Member and co-chair of the Trainee Programme, Zebrafish Disease Models Society.
- Principal Organiser, Neutrophil in Immunity Meeting 2020.
- Research Excellence Framework, Subpanel Member.
- Identification of key regulatory pathways in inflammation resolution.
- Non-mammalian models of host-pathogen interaction.
- Identification of novel compounds targeting inflammation resolution using zebrafish in vivo screens.
For key publications see below. Or go to my full list of publications.
- 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens, 15(3). View this article in WRRO
- CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses. Cell Reports, 26(7), 1828-1840.e4. View this article in WRRO
- PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Science Advances, 4(9). View this article in WRRO
- Human skin commensals augment Staphylococcus aureus pathogenesis. Nature Microbiology, 3(8), 881-890. View this article in WRRO
- Reverse Migration of Neutrophils: Where, When, How, and Why?. Trends in Immunology, 37(5), 273-286.
- A Spaetzle-like role for nerve growth factor in vertebrate immunity to Staphylococcus aureus. Science, 346(6209), 641-646. View this article in WRRO
- Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation.. PLoS Biol, 12(5), e1001855. View this article in WRRO
- The IL-1 family in fish: swimming through the muddy waters of inflammasome evolution.. Dev Comp Immunol, 46(1), 53-62.
- Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention.. PLoS Pathog, 10(2), e1003959. View this article in WRRO
- A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.. Sci Transl Med, 6(225), 225ra29. View this article in WRRO
- Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.. J Immunol, 192(4), 1796-1805.
- Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
- Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.. PLoS Pathog, 9(12), e1003789. View this article in WRRO
- Zebrafish as a model for the study of neutrophil biology.. J Leukoc Biol, 94(4), 633-642.
- Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish. Current Biology, 22(19), 1818-1824.
- Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling.. J R Soc Interface, 9(77), 3229-3239. View this article in WRRO
- A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model.. Cell Microbiol, 14(10), 1600-1619. View this article in WRRO
- Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE 2. Current Biology.
- Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
- A model 450 million years in the making: zebrafish and vertebrate immunity.. Dis Model Mech, 5(1), 38-47.
- Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.. Blood, 118(3), 712-722.
- Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.. Thromb Haemost, 105(5), 811-819. View this article in WRRO
- Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.. J Leukoc Biol, 87(2), 203-212.
- A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.. Cell Microbiol, 10(11), 2312-2325.
- Identifying and hurdling obstacles to translational research.. Nat Rev Immunol, 7(1), 77-82. View this article in WRRO
- A transgenic zebrafish model of neutrophilic inflammation.. Blood, 108(13), 3976-3978.
- Acceleration of human neutrophil apoptosis by TRAIL.. J Immunol, 170(2), 1027-1033. View this article in WRRO