Professor Stephen A Renshaw MA FRCP PhD

Sir Arthur Hall Professor of Medicine

Department of Infection, Immunity & Cardiovascular DiseaseProfessor Steve Renshaw
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Tel:  +44 (0)114 222 2334 (Firth Court)
Tel:  +44 (0) 114 215 9574 (Medical School)
Fax: +44 (0)114 271 1863
Email: s.a.renshaw@sheffield.ac.uk
Secretary:  Vanessa Hainsworth
Tel:  +44 (0)114 222 2710
Email:  v.hainsworth@sheffield.ac.uk

Biography:

I am incredibly proud of my role as the Sir Arthur Hall Professor of Medicine, appointed in 2016 after 18 years with the University of Sheffield. I studied medicine at Cambridge and then at Oxford Clinical School, qualifying in 1994. After a clinical rotation in Nottingham, I moved to Sheffield to take up a Wellcome Trust Clinical Research Training Fellowship, to work on the regulation of neutrophil lifespan with Professor Moira Whyte. I was awarded a PhD in 2001, and was appointed as the Clinical Lecturer in Respiratory Medicine. In 2004 I was awarded an MRC Clinician Scientist Fellowship to develop a zebrafish model of inflammation. I have been able to develop a unique neutrophil-specific transgenic zebrafish which has allowed several important advances in our understanding of inflammation biology and of host-pathogen interaction. In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work. I was appointed Professor of Respiratory Medicine in 2014 and continue clinical work in Respiratory Medicine.

Research Interests:

Diseases of immunity cause much illness in the developed world – on one hand we are beset by a range of antibiotic resistance bacterial infections, while on the other hand our immune systems are responsible for many the common diseases of ageing – heart disease, stroke and COPD. Understanding the regulation of innate immune cells, neutrophils and macrophages, in infection and inflammation will help us tune the immune system to the exact level needed to cope with the current level of threat. More host defence to fight antibiotic resistant organisms; less host defence to prevent lung damage in response to environmental pollutants. To improve our understanding, I have set up a model system in which the genes controlling regulation of innate immune cell function can be identified. The model I have chosen is the Zebrafish, which is both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence host-pathogen interaction and the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an infection or an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease.

Professional Activities:

  • Director, The Bateson Centre.
  • Academic Lead, MRC Doctoral Training Partnership, Discovery Medicine North.
  • Academic Lead for Respiratory Medicine Training Programme.
  • Fellow of the Royal College of Physicians of London.
  • MRC Programme Grant Holder.
  • Sponsor of 3 Wellcome Trust/Royal Society Sir Henry Dale Fellows, 1 MRC Career Development Fellow, 1 Marie Curie Fellow and 1 European Leukodystrophy Association Fellow.

Current Projects

  • Identification of key regulatory pathways in inflammation resolution.
  • Non-mammalian models of host-pathogen interaction.
  • Identification of novel compounds targeting inflammation resolution using zebrafish in vivo screens.

Publications

For key publications see below. Or go to my full list of publications.

Journal articles