Professor Stephen A Renshaw MA FRCP PhD
Sir Arthur Hall Professor of Medicine
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0)114 222 2334 (Firth Court)
Tel: +44 (0) 114 215 9574 (Medical School)
Fax: +44 (0)114 271 3892
Secretary: Vanessa Hainsworth
Tel: +44 (0)114 222 2710
I am incredibly proud of my role as the Sir Arthur Hall Professor of Medicine, appointed in 2016 after 18 years with the University of Sheffield. I studied medicine at Cambridge and then at Oxford Clinical School, qualifying in 1994. After a clinical rotation in Nottingham, I moved to Sheffield to take up a Wellcome Trust Clinical Research Training Fellowship, to work on the regulation of neutrophil lifespan with Professor Moira Whyte. I was awarded a PhD in 2001, and was appointed as the Clinical Lecturer in Respiratory Medicine. In 2004 I was awarded an MRC Clinician Scientist Fellowship to develop a zebrafish model of inflammation. I have been able to develop a unique neutrophil-specific transgenic zebrafish which has allowed several important advances in our understanding of inflammation biology and of host-pathogen interaction. In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work. I was appointed Professor of Respiratory Medicine in 2014 and continue clinical work in Respiratory Medicine.
Diseases of immunity cause much illness in the developed world – on one hand we are beset by a range of antibiotic resistance bacterial infections, while on the other hand our immune systems are responsible for many the common diseases of ageing – heart disease, stroke and COPD. Understanding the regulation of innate immune cells, neutrophils and macrophages, in infection and inflammation will help us tune the immune system to the exact level needed to cope with the current level of threat. More host defence to fight antibiotic resistant organisms; less host defence to prevent lung damage in response to environmental pollutants. To improve our understanding, I have set up a model system in which the genes controlling regulation of innate immune cell function can be identified. The model I have chosen is the Zebrafish, which is both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence host-pathogen interaction and the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an infection or an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease.
- Director, The Bateson Centre.
- Academic Lead, MRC Doctoral Training Partnership, Discovery Medicine North.
- Academic Lead for Respiratory Medicine Training Programme.
- Fellow of the Royal College of Physicians of London.
- MRC Programme Grant Holder.
- Sponsor of 2 Wellcome Trust/Royal Society Sir Henry Dale Fellows and 1 MRC Career Development Fellow.
- Identification of key regulatory pathways in neutrophil apoptosis and inflammation resolution.
- Non-mammalian models of host-pathogen interaction.
- Identification of novel compounds targeting inflammation resolution using zebrafish in vivo screens.
For key publications see below. Or go to my full list of publications.
- Renshaw SA, robertson A, ogryzko N, Henry K, Loynes C, foulkes M, meloni M, Wang X, Ford C, Jackson M, Ingham P, Wilson H, Farrow S, Solari R, Flower R, Jones S & Whyte M (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. DMM Disease Models and Mechanisms, 9, 621-632. View this article in WRRO
- Nourshargh S, Renshaw SA & Imhof BA (2016) Reverse Migration of Neutrophils: Where, When, How, and Why?. Trends in Immunology, 37(5), 273-286.
- Ellett F, Elks PM, Robertson AL, Ogryzko NV & Renshaw SA (2015) Defining the phenotype of neutrophils following reverse migration in zebrafish. Journal of Leukocyte Biology, 98(6), 975-981.
- Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Torok ME, Peacock SJ, Holden M, Blundell T, Wang L, Ligoxygakis P, Minichiello L, Woods CG, Foster SJ, Renshaw SA & Floto RA (2014) A Spaetzle-like role for nerve growth factor in vertebrate immunity to Staphylococcus aureus. Science, 346(6209), 641-646. View this article in WRRO
- Candel S, de Oliveira S, López-Muñoz A, García-Moreno D, Espín-Palazón R, Tyrkalska SD, Cayuela ML, Renshaw SA, Corbalán-Vélez R, Vidal-Abarca I, Tsai H-J, Meseguer J, Sepulcre MP & Mulero V (2014) Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation.. PLoS Biol, 12(5), e1001855. View this article in WRRO
- Ogryzko NV, Renshaw SA & Wilson HL (2014) The IL-1 family in fish: swimming through the muddy waters of inflammasome evolution.. Dev Comp Immunol, 46(1), 53-62.
- McVicker G, Prajsnar TK, Williams A, Wagner NL, Boots M, Renshaw SA & Foster SJ (2014) Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention.. PLoS Pathog, 10(2), e1003959. View this article in WRRO
- Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MKB & Renshaw SA (2014) A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.. Sci Transl Med, 6(225), 225ra29. View this article in WRRO
- Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
- Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MKB & Renshaw SA (2014) Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.. J Immunol, 192(4), 1796-1805.
- Elks PM, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, Renshaw SA & Meijer AH (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.. PLoS Pathog, 9(12), e1003789. View this article in WRRO
- Henry KM, Loynes CA, Whyte MKB & Renshaw SA (2013) Zebrafish as a model for the study of neutrophil biology.. J Leukoc Biol, 94(4), 633-642.
- Pase L, Layton JE, Wittmann C, Ellett F, Nowell CJ, Reyes-Aldasoro CC, Varma S, Rogers KL, Hall CJ, Keightley MC, Crosier PS, Grabher C, Heath JK, Renshaw SA & Lieschke GJ (2012) Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish. Current Biology, 22(19), 1818-1824.
- Holmes GR, Anderson SR, Dixon G, Robertson AL, Reyes-Aldasoro CC, Billings SA, Renshaw SA & Kadirkamanathan V (2012) Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling.. J R Soc Interface, 9(77), 3229-3239. View this article in WRRO
- Prajsnar TK, Hamilton R, Garcia-Lara J, McVicker G, Williams A, Boots M, Foster SJ & Renshaw SA (2012) A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model.. Cell Microbiol, 14(10), 1600-1619. View this article in WRRO
- Feng Y, Renshaw S & Martin P (2012) Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE 2. Current Biology.
- McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH & Whyte MKB (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.. Thorax, 67(9), 796-803. View this article in WRRO
- Renshaw SA & Trede NS (2012) A model 450 million years in the making: zebrafish and vertebrate immunity.. Dis Model Mech, 5(1), 38-47.
- Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MKB, Walmsley SR & Renshaw SA (2011) Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.. Blood, 118(3), 712-722.
- Gray C, Loynes CA, Whyte MKB, Crossman DC, Renshaw SA & Chico TJA (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.. Thromb Haemost, 105(5), 811-819. View this article in WRRO
- Loynes CA, Martin JS, Robertson A, Trushell DMI, Ingham PW, Whyte MKB & Renshaw SA (2010) Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.. J Leukoc Biol, 87(2), 203-212.
- Prajsnar TK, Cunliffe VT, Foster SJ & Renshaw SA (2008) A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.. Cell Microbiol, 10(11), 2312-2325.
- Sabroe I, Dockrell DH, Vogel SN, Renshaw SA, Whyte MKB & Dower SK (2007) Identifying and hurdling obstacles to translational research.. Nat Rev Immunol, 7(1), 77-82. View this article in WRRO
- Renshaw SA, Loynes CA, Trushell DMI, Elworthy S, Ingham PW & Whyte MKB (2006) A transgenic zebrafish model of neutrophilic inflammation.. Blood, 108(13), 3976-3978.
- Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER & Whyte MKB (2003) Acceleration of human neutrophil apoptosis by TRAIL.. J Immunol, 170(2), 1027-1033. View this article in WRRO