Professor Jim Wild, PhD
Professor of Magnetic Resonance Physics
NIHR Research Professor in Pulmonary Imaging
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Royal Hallamshire Hospital
Telephone: +44 (0) 114 215 9141
Fax: +44 (0) 114 271 1714
I joined the University of Sheffield in 2000 to set up the technology for Hyperpolarised gas lung Magnetic Resonance Imaging (MRI).
Postdoctoral researcher at the NMR group University of Alberta (1998-2000) -high field strength imaging and spectroscopy methods.
PhD was in 1H MR spectroscopy at the University of Edinburgh (1995-1998).
My research is the physics and engineering and clinical applications of hyperpolarised gas (3He and 129Xe) and proton MRI in the lungs and pulmonary vasculature.
Physics and engineering projects include:
- rapid acquisition methods for imaging of inhaled hyperpolarised gases using compressed sensing, steady state free precession and parallel imaging.
- Techniques for simultaneous imaging of 1H, 3He and 129Xe in the lungs.
- RF coil hardware engineering for 3He and 129Xe lung MRI.
- 3He and 129Xe MRI at different magnetic field strengths.
- Spin exchange optical pumping physics for polarisation of 3He and 129Xe.
- Measuring and modelling gas flow and diffusion in the lungs; physiological models of alveolar geometry and gas exchange.
These technical developments have made a clinical impact, we have performed the first clinical studies in the UK with hyperpolarised 3He and 129Xe gas MRI. Our research has demonstrated the role of these pulmonary MRI methods in Asthma, COPD, Cystic Fibrosis, Interstitial Lung Disease, Lung cancer and Pulmonary Hypertension. Using hyperpolarised gas and proton lung MRI as markers we are evaluating novel pulmonary therapies in collaboration with pharmaceutical companies. Our lung imaging methods and models are the basis of patient specific in-silico models of lung disease – insigneo. Our pulmonary imaging methods have made a clinical impact on NHS radiological practice in the diagnosis and management of patients from the Sheffield Pulmonary Vascular Disease Unit. We are now a national and international referral centre for Clinical Pulmonary Imaging.
Current Research Projects and Grants:
- NIHR Research Professorship 2013-2018.
- MRC - POLARIS Hyperpolarised lung Imaging infrastructure award.
- MRC – LIFT – fluorinated gas MRI.
- RHiNO: Respiratory Health In Preterm Neonatal Outcomes.
- IMI – TRISTAN - Imaging biomarkers (IBs) for safer drugs
Teaching & Supervision:
I currently supervise 5 PhD students
Graduated PhD students: Anderson Mon (2004), Kevin Teh (2006), Hoonsin Cheong (2008), Neil Woodhouse (2007), Martin Deppe (2010), Salma Ajraoui (2010), Andrew Swift (2012), Smitha Rajaram (2013), Xiaoxun Xu (2015), Felix Horn (2015), Graham Norquay (2015) , Madhwesha Rao (2016), Angela Lungu (2016), Neil Stewart (2016), Bilal Tahir (2016), Paul Hughes (2017), Ho Fung Chan (2018), Chris Johns (2018), Nick Weatherley (2018).
I am involved in international teaching in MR physics and pulmonary imaging:
- Deputy Editor Journal of Magnetic Resonance Imaging.
- Member of the Fleischner Society.
- Director of Research Insigneo.
- NIHR Research Professor 2013-2018.
- EPSRC Advanced Research Fellow 2006-2011.
- EPSRC peer review college member.
- Medical Futures Award for Translational Respiratory Innovation 2011.
- Chairman (2008-2011) and Secretary (2005-2008) of the BRSG the Magnetic Resonance Group of the Institute of Physics.
- 2008-2009 Chairman ISMRM study group of hyperpolarised MRI.
- 2011-2014 Chair of the European Society of Thoracic Imaging Research Committee.
- Member of European Respiratory Society Imaging workgroup.
- MHRA QP licence holder for manufacture of hyperpolarised contrast agents (3He and 129Xe).
- Honorary Chair in MR Physics at the University of Oxford.
For key publications see below. For a full list of publications click here.
- Swift AJ, Rajaram S, Campbell MJ, Hurdman J, Thomas S, Capener D, Elliot C, Condliffe R, Wild JM & Kiely DG (2014) Prognostic value of cardiovascular magnetic resonance imaging measurements corrected for age and sex in idiopathic pulmonary arterial hypertension.. Circ Cardiovasc Imaging, 7(1), 100-106.
- Marshall H, Parra-Robles J, Deppe MH, Lipson DA, Lawson R & Wild JM (2014) (3)He pO2 mapping is limited by delayed-ventilation and diffusion in chronic obstructive pulmonary disease.. Magn Reson Med, 71(3), 1172-1178. View this article in WRRO
- (2013) Optimized production of hyperpolarized129Xe at 2 bars for in vivo lung magnetic resonance imaging. Journal of Applied Physics, 113(4).
- Rajaram S, Swift AJ, Telfer A, Hurdman J, Marshall H, Lorenz E, Capener D, Davies C, Hill C, Elliot C, Condliffe R, Wild JM & Kiely DG (2013) 3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry.. Thorax, 68(7), 677-678.
- Wild JM, Marshall H, Xu X, Norquay G, Parnell SR, Clemence M, Griffiths PD & Parra-Robles J (2013) Simultaneous imaging of lung structure and function with triple-nuclear hybrid MR imaging.. Radiology, 267(1), 251-255.
- Ajraoui S, Parra-Robles J & Wild JM (2013) Incorporation of prior knowledge in compressed sensing for faster acquisition of hyperpolarized gas images.. Magn Reson Med, 69(2), 360-369.
- Parra-Robles J & Wild JM (2012) The influence of lung airways branching structure and diffusion time on measurements and models of short-range 3He gas MR diffusion.. J Magn Reson, 225, 102-113.
- Swift AJ, Rajaram S, Condliffe R, Capener D, Hurdman J, Elliot C, Kiely DG & Wild JM (2012) Pulmonary artery relative area change detects mild elevations in pulmonary vascular resistance and predicts adverse outcome in pulmonary hypertension.. Invest Radiol, 47(10), 571-577.
- Marshall H, Deppe MH, Parra-Robles J, Hillis S, Billings CG, Rajaram S, Swift A, Miller SR, Watson JH, Wolber J, Lipson DA, Lawson R & Wild JM (2012) Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI.. Thorax, 67(7), 613-617. View this article in WRRO
- Rajaram S, Swift AJ, Capener D, Telfer A, Davies C, Hill C, Condliffe R, Elliot C, Hurdman J, Kiely DG & Wild JM (2012) Lung morphology assessment with balanced steady-state free precession MR imaging compared with CT.. Radiology, 263(2), 569-577.
- Xu X, Norquay G, Parnell SR, Deppe MH, Ajraoui S, Hashoian R, Marshall H, Griffiths PD, Parra-Robles J & Wild JM (2012) Hyperpolarized 129Xe gas lung MRI-SNR and T2* comparisons at 1.5 T and 3 T.. Magn Reson Med, 68(6), 1900-1904.
- (2010) Enhancement of 129Xe polarization by off-resonant spin exchange optical pumping. Journal of Applied Physics, 108(6). View this article in WRRO