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BMS6007: Mass spectrometry-based proteomics and metabolomics course

11-15 January 2021, Online sessions through Blackboard Collaborate

Course summary

Mass spectrometry-based proteomics and metabolomics are powerful approaches to investigate biological problems in an unbiased and quantitative manner. In recent years, rapid technological developments have allowed unprecedented insights into protein function and has made proteomics an essential tool for many areas of biological and medical research. The field of proteomics spans a wide range of molecular complexity from protein synthesis and degradation, protein interactions and protein complexes to a variety of post-translational modifications. Metabolomics, the systematic study of the diverse range of small molecule products of the proteome, is driven by a number of mass spectrometry approaches and has many applications from plants to the clinic.

This course aims to provide an introduction to mass spectrometry, proteomics and metabolomics and will explore how these technologies can be used to quantitatively dissect protein-protein interactions, characterise post-translational modifications and profile metabolomes and proteomes. Additionally, it briefly explores some applications of mass spectrometry for the general analysis of organic and inorganic compounds derived from synthetic processes or from living organisms. Two interactive sessions have been developed to reinforce concepts introduced in lectures and include spectral interpretation and experimental workflows.

Topics will include the following:
• Introduction to Mass Spectrometry
• Quantitative proteomics
• Protein-protein interactions
• Post-translational modifications
• Targeted & Non-targeted Metabolomics
• Imaging Mass Spectrometry
• Mass spectrometry for chemistry applications
• Virtual tour of the Faculty of Science Spectrometry Centre facilities

PhD students taking this DDP module must attend all lectures in order to complete the course. Attendance at the interactive sessions is also strongly recommended.

Course programme

Day 1: Monday 11th January 2021

Time

Session

Instructor

10.00 am - 11.00 am

Lecture 1: Introduction I: Mass Spectrometry

Mark Collins

11.00 am - 11.30 am

Lecture 2: Introduction II: Chromatography

Adelina E Acosta-Martin

11.30 am - 11.45 am

Short break

11.45 am - 1.00 pm

Interactive session 1: Mass spectrum interpretation

Adelina E Acosta-Martin

Day 2: Tuesday 12th January 2021

Time

Session

Instructor

10.00 am - 11.00 am

Lecture 3: Introduction to Proteomics and Proteome bioinformatics

Mark Collins

11.00 am - 11.15 am

Short break

11.15 am - 12.15 pm

Lecture 4: Targeted quantification

Adelina E Acosta-Martin

Day 3: Wednesday 13th January 2021

Time

Session

Instructor

10.00 am - 11.00 am

Lecture 5: Global quantitative proteomics

Mark Collins

11.00 am - 11.15 am

Short break

11.15 am - 12.15 pm

Lecture 6: Protein interactions

Mark Collins

Day 4: Thursday 14th January 2021

Time

Session

Instructor

10.00 am - 11.00 am

Lecture 7: Post-translational modifications

Mark Collins

11.00 am - 11.15 am

Short break

11.15 am - 12.15 pm

Lecture 8: Introduction to Metabolomics

Heather Walker

12.15 pm - 1.30 pm

Interactive session 2: The importance of experimental design

Various instructors

Day 5: Friday 15th January 2021

Time

Session

Instructor

10.00 am - 10.30 am

Lecture 9: Introduction III: ICP

Heather Walker

10.30 am - 10.50 am

Virtual tour of the Faculty of Science Spectrometry Centre facilities

Adelina E Acosta-Martin

10.50 am - 11.50 am

Lecture 10: MALDI imaging

Heather Walker

Questions?

Contact us if you have any questions about this course or any additional interest in learning about mass spectrometry.

How to register

If you want to register, please fill in the registration form through this link.

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