Dr Adrienn Angyal

Ph.D

Clinical Medicine, School of Medicine and Population Health

Postdoctoral Research Associate

A.Angyal@sheffield.ac.uk
+44 114 215 9579

The Medical School

Full contact details

Dr Adrienn Angyal
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Qualifications

B.Sc. in Biology.
M.Sc. in Molecular Immunology.
Ph.D. in Molecular Immunology.

Research interests: I am interested in anti-viral T cell responses, particularly in characterising the phenotype of the antigen-specific memory T cell populations that are generated in individuals upon natural viral infection with SARS-CoV-2 and/or as a consequence of the vaccination schedule.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves. Nature Communications, 13(1). View this article in WRRO
Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. The Lancet Microbe, 3(1), e21-e31. View this article in WRRO
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24(11). View this article in WRRO
Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11. View this article in WRRO
Groves DC, Rowland-Jones SL & Angyal A (2021) The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design. Biochemical and Biophysical Research Communications, 538, 104-107.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell, 182(4), 812-827.e19. View this article in WRRO

Preprints

Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali S-E , Angyal A et al (2020) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses, Cold Spring Harbor Laboratory.

All publications

Journal articles

Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Publisher Correction: Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves. Nature Communications, 13(1).
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves. Nature Communications, 13(1). View this article in WRRO
Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. The Lancet Microbe, 3(1), e21-e31. View this article in WRRO
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24(11). View this article in WRRO
Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11. View this article in WRRO
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O’Toole Á , Amato R et al (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), 266-269. View this article in WRRO
de Silva TI, Liu G, B Lindsey B, Dong D, Shah D, J. Mentzer A, Angyal A, Brown R, D. Parker M, Ying Z , Yao X et al (2021) The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells.
Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali SE , Angyal A et al (2021) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. Nature Communications, 12(1). View this article in WRRO
Parker MD, Lindsey BB, Leary S, Gaudieri S, Chopra A, Wyles M, Angyal A, Green LR, Parsons P, Tucker RM , Brown R et al (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research, 31(4), 645-658. View this article in WRRO
Groves DC, Rowland-Jones SL & Angyal A (2021) The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design. Biochemical and Biophysical Research Communications, 538, 104-107.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell, 182(4), 812-827.e19. View this article in WRRO
The COVID-19 Genomics UK (COG-UK) consortium , Wang D, Angyal A, Brown RL, Carrilero L, de Silva TI, Green LR, Groves DC, Keeley AJ, Lindsey BB , Parker MD et al (2020) An integrated national scale SARS-CoV-2 genomic surveillance network. The Lancet Microbe, 1(3), e99-e100. View this article in WRRO
Parker MD, Lindsey BB, Leary S, Gaudieri S, Chopra A, Wyles M, Angyal A, Green LR, Parsons P, Tucker RM , Brown R et al (2020) periscope: sub-genomic RNA identification in SARS-CoV-2 Genomic Sequencing Data. View this article in WRRO
Cole J, Angyal A, Emes RD, Mitchell TJ, Dickman MJ & Dockrell DH (2020) Pneumolysin is responsible for differential gene expression and modifications in the epigenetic landscape of primary monocyte derived macrophages.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10). View this article in WRRO
Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E , Angyal A et al (2019) TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proceedings of the National Academy of Sciences. View this article in WRRO
Condliffe AM, Hoenderdos K, Lodge K, Hirst RA, Chen C, Emerenciana A, Palazzo SGC, Summers C, Angyal A, Porter L , Juss JK et al (2016) Hypoxia upregulates neutrophil degranulation and potential for tissue injury. Thorax, 71(11), 1030-1038. View this article in WRRO
Guan H, Shuaib A, De Leon D, Angyal A, Salazar M, Velasco G, Holcombe M, Dower S & Kiss-Toth E (2016) Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways. Scientific Reports, 6. View this article in WRRO
Kövesdi D, Angyal A, Huber K, Szili D & Sármay G (2014) T-bet is a new synergistic meeting point for the BCR and TLR9 signaling cascades. European Journal of Immunology, 44(3), 887-893.
Sung HY, Francis SE, Arnold ND, Holland K, Ernst V, Angyal A & Kiss-Toth E (2012) Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis.. Biology (Basel), 1(1), 43-57. View this article in WRRO
Angyal A & Kiss-Toth E (2012) The tribbles gene family and lipoprotein metabolism.. Curr Opin Lipidol, 23(2), 122-126.
Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK , Francis SE et al (2008) Tribbles-2 is a novel regulator of inflammatory activation of monocytes.. Int Immunol, 20(12), 1543-1550. View this article in WRRO
Cole J, Angyal A, Emes RD, Mitchell TJ, Dickman MJ & Dockrell DH () Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages. Frontiers in Immunology, 12.
Angyal A, Longet S, Moore S, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al () T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study. SSRN Electronic Journal.

Chapters

Angyal A & Kiss-Toth E (2018) Tribbles, Encyclopedia of Signaling Molecules (pp. 5690-5697). Springer International Publishing

Conference proceedings papers

Johnston JM, Martinez-Campesino L, Angyal A, Hadadi E, Kraus R, Wilson HL, Bauer R, Rader D, Hamby SE, Goodall AH , Francis SE et al (2019) Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
Johnston JM, Angyal A, Bauer R, Hamby SE, Suvarna SK, Baidžajevas K, Hegedus Z, Dear NT, Turner M, Wilson HL , Goodall AH et al (2018) P14 MYELOID TRIB1 PROMOTES EXPERIMENTAL ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) Myeloid Tribbles 1 Regulates Experimental Atherosclerosis. Atherosclerosis Supplements, Vol. 32 (pp 11-11)
Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S & Kiss-Toth E (2018) 123 Myeloid TRIB1 controls experimental atherosclerosis. Basic Science
Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM , Rader DJ et al (2017) 157 Myeloid expression of trib1 regulates the polarisation state of tissue resident macrophages that has consequences on plasma lipid and metabolic homeostasis. Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) Does myeloid expression of TRIB1 regulate plasma lipid levels?. Atherosclerosis, Vol. 241(1) (pp e34-e34)
Ilyas Z, Angyal A, Szili D, Johnston J & Kiss-Toth E (2015) 223 MIRNA202 is a Novel Regulator of Tribbles-1 Expression. Heart, Vol. 101(Suppl 4) (pp A121.2-A121)
Johnston J, Angyal A, Alfaidi M, Francis S & Kiss-Toth E (2015) 186 Assessment of Plaque Macrophage Phenotypein situby Multicolour Fluorescence Microscopy. Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
Daigneault M, Angyal A, Hadadi E, Baskerville J & Wilson H (2013) A NOVEL ROLE FOR THE GAS3/PMP22 FAMILY MEMBER EMP2 IN THE REGULATION OF INFLAMMATION. HEART, Vol. 99
Angyal A, Daigneault M, Hadadi E, Ariaans M, Burnett A, Wilson H, Ridger V & Kiss-Toth E (2013) TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS. HEART, Vol. 99 (pp A126-A126)
Docherty LM, Angyal A, Francis S & Kiss-Toth E (2009) THE ROLE OF TRIBBLES 2 IN PI3K CASCADE REGULATION AND AKT/PKB ANTI-APOPTOTIC SIGNALLING CASCADE. HEART, Vol. 95(22)

Preprints

Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Silva Reyes L, Meardon N, Faustini S , Al-Taei S et al (2022) Evolution of long-term hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study, Cold Spring Harbor Laboratory.
Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali S-E , Angyal A et al (2020) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses, Cold Spring Harbor Laboratory.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion, Cold Spring Harbor Laboratory.
de Silva TI, Liu G, Lindsey BB, Dong D, Shah D, Mentzer AJ, Angyal A, Brown R, Parker MD, Yin Z , Yao X et al () The Impact of Viral Mutations on Recognition by SARS-CoV-2 Specific T-Cells.
Angyal A, Longet S, Moore S, Payne RP, Harding A, Tipton T, Rongkard P, Hering LM, Meardon N, Skelly D , Gillson N et al () T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study.

Teaching interests: I am involved in teaching immunology at the Molecular medicine M.Sc. course.

Awarded greats:: COG-UK supplementary funding to 166547 (Research Project Fund)