Professor Albert CM Ong

MA, DM, FRCP, FAoP, FERA

Department of Infection, Immunity and Cardiovascular Disease

Professor of Renal Medicine

Professor Albert Ong
Professor Albert Ong
a.ong@sheffield.ac.uk
+44 114 215 9542

Full contact details

Professor Albert CM Ong
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – iicd-om-operational@sheffield.ac.uk

Albert Ong is Professor of Renal Medicine and Head of Academic Nephrology at the University of Sheffield, UK. A graduate of the University of Oxford, he studied physiological sciences and clinical medicine at Exeter College, later completing a doctorate in cell biology. A practicing nephrologist, university teacher and clinician-scientist, he held academic positions at University College London and Oxford before moving to Sheffield. An expert in renal genetics, he is widely regarded as a leading authority on autosomal dominant polycystic kidney disease (ADPKD). He has trained and mentored over 30 postgraduate students and fellows, some of whom have gone on to independent academic careers. In 2022, he received the Lilian Jean Kaplan International Prize from the International Society of Nephrology (ISN) and the PKD Foundation.

Research interests

Our major research goals have been to define the molecular basis of autosomal dominant polycystic kidney disease (ADPKD), discover, develop and test new treatments and to improve the patient care pathway.


Current projects:

  • Understanding the molecular basis of polycystic kidney disease.
  • Identifying new therapeutic targets for ADPKD in experimental models.
  • Improving diagnosis, prognosis and clinical outcomes in ADPKD.
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Winterbottorn J, Simms R & Ong A (2020) REDUCED QUALITY OF LIFE IN ADPKD PATIENTS WITH CKD STAGE 1-3: THE CYSTIC I QUALITY OF LIFE STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 35 (pp 98-98) RIS download Bibtex download
  • Magayr T, Streets A & Ong A (2020) SAT-442 Identification of exosome microRNAs as novel biomarkers for rapid disease progression in autosomal dominant polycystic kidney disease. Kidney International Reports, Vol. 5(3) (pp S185-S185). Abu Dhabi, United Arab Emirates, 26 March 2020 - 29 March 2020. View this article in WRRO RIS download Bibtex download
  • Magayr T, Streets A & Ong A (2019) GLOBAL MICRORNA PROFILING IN HUMAN URINARY EXOSOMES REVEALS NEW DISEASE BIOMARKERS AND CELLULAR PATHWAYS FOR AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34 RIS download Bibtex download
  • Huynh VT, Audrezet M-P, Domenger C, Bridoux F, Seret G, Longuet H, Halimi J-M, Senum S, Pajot A, Albaret J , Ponlot E et al (2019) CLINICAL PRESENTATION AND PROGNOSIS OF DNAJB11-ASSOCIATED NEPHROPATHY: AN INTERNATIONAL COLLABORATIVE STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34 RIS download Bibtex download
  • Gimpel C, Avni EF, Breysem L, Burgmaier K, Caroli A, Cetiner M, Haffner D, Hartung EA, Franke D, König J , Liebau MC et al (2018) Imaging of kidney cysts and cystic kidney diseases in children. Consensus paper by an ad hoc committee. Ultraschall in der Medizin, 14 November 2018 - 16 November 2018. View this article in WRRO RIS download Bibtex download
  • Logeman C, Cho Y, Sautenet B, Rangan G, Gutman T, Craig J, Ong ACM, Chapman A, Ahn C, Coolican H , Kao JT-W et al (2018) PATIENT AND CAREGIVER BELIEFS, ATTITUDES AND PERSPECTIVES ON GENETIC SCREENING AND TESTING FOR AUTOSOMAL POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY, Vol. 23 (pp 88-88) RIS download Bibtex download
  • Chong J, Durkie M, Dalton A & Ong A (2017) VERY EARLY-ONSET AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE DUE TO BI-ALLELIC MUTATIONS IN PKD1 AND PKD2. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 32 (pp 94-94) RIS download Bibtex download
  • Simms RJ, Ryan D, Metherall P, Wright P, Gruel N, Tindale W & Ong ACM (2016) SO052DEVELOPMENT OF A RAPID SEMI-AUTOMATED TOOL TO MEASURE TOTAL KIDNEY VOLUME IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. Nephrology Dialysis Transplantation, Vol. 31(suppl_1) (pp i22-i22) View this article in WRRO RIS download Bibtex download
  • Lannoy M, Abdela-ali F, Streets AJ & Ong ACM (2016) SELECTIVE PROSTAGLANDIN E2 RECEPTOR BLOCKADE FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 31 (pp 22-23) RIS download Bibtex download
  • Rocío Cantero MD, Velázquez IF, Streets AJ, Ong ACM & Cantiello HF (2016) The Cyclic AMP Signaling Pathway and Direct PKA Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function. Biophysical Journal, Vol. 110(3) (pp 611a-612a) RIS download Bibtex download
  • Robinson P, McEwan P, Ong ACM, Ørskov B, Sandford R, Scolari F, Walz G, Bennet-Wilton H & O'Reilly K (2015) FP064ASSESSING THE LONG TERM OUTCOMES OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USING THE ADPKD OUTCOMES MODEL: A UK CASE STUDY. Nephrology Dialysis Transplantation, Vol. 30(suppl_3) (pp iii85-iii86) RIS download Bibtex download
  • Simms RJ, Thong KM, Dworschak GC & Ong ACM (2015) INCREASED PSYCHOSOCIAL BURDEN AND ADVERSE QUALITY OF LIFE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30 RIS download Bibtex download
  • Streets AJ, Xu Y & Ong ACM (2015) POLYCYSTIN-1 TRAFFICKING IS REGULATED BY CAMP DEPENDENT PHOSPHORYLATION OF THE PLAT DOMAIN. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30 RIS download Bibtex download
  • Robinson P, McEwan P, Hadimeri H, Ong ACM, Orskov B, Peces R, Sandford R, Scolari F, Walz G, Cooke C & O'Reilly K (2014) DEVELOPMENT OF A MODEL TO PREDICT DISEASE PROGRESSION IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 29 (pp 75-75) RIS download Bibtex download
  • Holden BJ, van Eeden FJ, Ong ACM & Chico TJ (2011) PKD2 MUTANT ZEBRAFISH DISPLAY EXCESSIVE DEVELOPMENTAL ANGIOGENESIS. HEART, Vol. 97(20) (pp 12-12) RIS download Bibtex download
  • Streets AJ, Ibraghimov-Beskrovnaya O & Ong ACM (2003) Regulation of polycystin-1 mediated intercellular adhesion by phosphorylation in renal epithelia cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 575A-575A) RIS download Bibtex download
  • Robson L, Laycock SK, Brier T, Ong ACM & Haigh C (2003) A Ca2+-activated conductance in cultured mouse collecting duct cells.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 80A-80A) RIS download Bibtex download
  • Zhao Y, Haylor JL & Ong ACM (2002) Upregulation of polycystin-2 expression following experimental ischaemic renal injury.. J AM SOC NEPHROL, Vol. 13 (pp 113A-113A) RIS download Bibtex download
Research group
  • Dr Andrew Streets
  • Dr Manoj Kumar Valluru
  • Dr Matthew Gittus
  • Ms Lisa Chang
  • Dr Jean Winterbottom
  • Dr Joshua Griffiths

PhD Students

  • Elliot Brooks (with Iwan Evans)
  • Jiehan Chong (with David Beech)
Teaching activities

I am committed to postgraduate nephrology training especially in developing clinical and non-clinical academics in renal science and in enhancing nephrology training for young nephrologists in the developing ‘two-thirds’ world. I am Deputy Director for Clinical Academic Training at Sheffield, having served as Academic Programme Director for Nephrology for many years. I am a member of the ISN Fellowship Committee and was previously Chair of the UK Kidney Association (Renal Association) International Committee (2009-2013).

Professional activities

National and International Committees

  • European Renal Association – Council member and Trustee.
  • CYSTic Consortium – Chief investigator.
  • ADPKD in Europe Consortium - Co-chair.
  • European ADPKD Forum – Faculty member.
  • ISN Fellowship committee – Committee member.
  • UK Kidney Association (formerly Renal Association) International Committee - Committee member, Chair (2009-2013).

Editorial Boards

  • Faculty of 1000 Medicine, Nephrology faculty.
  • Theme Editor, Nephrology Dialysis Transplantation.
  • Editor, Nature Scientific Reports.
  • Review Editor, Frontiers in Pharmacology.
  • Subject Editor, Nephrology.

Advisory Boards

  • Mayo Translational PKD Centre, Mayo Clinic, Rochester - External Faculty.
  • Renal Genomic England Clinical Interpretation Partnership (GeCIP) – Co-chair for Cystic Diseases.
  • National Institute for Clinical Excellence (NICE) Technology Appraisal of Tolvaptan for ADPKD - Nominated Clinical Expert (2013-2015).
  • Federation of European Associations of Patients Affected by Genetic Diseases (FEDERG) - Scientific Council.

National and International Guidelines

  • Kidney Diseases Improving Global Outcomes (KDIGO) ADPKD Guideline Initiative – Working group and Theme Lead.
  • Standardised Outcomes in Nephrology–PKD (SONG-PKD) – Steering committee.
  • PKD Outcomes Consortium (PKDOC) – Committee.
  • UK Kidney Association (formerly Renal Association) Working Group for Tolvaptan in ADPKD – Chair.