Professor Endre Kiss-Toth

Department of Infection, Immunity and Cardiovascular Disease

Professor of Cell Signalling

e.kiss-toth@sheffield.ac.uk
+44 114 215 9534

Full contact details

Professor Endre Kiss-Toth
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – iicd-operationalteam@sheffield.ac.uk

I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach.

This is based on detecting the bioactivity of proteins, which are transiently over expressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.

In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.

In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.

I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.

Research interests

My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.

Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease.

We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.


Current projects

  • Discovery of novel regulators of inflammatory signalling.
  • Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
  • Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes
  • Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

  • (2018) T, Encyclopedia of Signaling Molecules (pp. 5299-5299). Springer International Publishing RIS download Bibtex download

Conference proceedings papers

  • Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) Does myeloid expression of TRIB1 regulate plasma lipid levels?. Atherosclerosis, Vol. 241(1) (pp e34-e34) RIS download Bibtex download
  • Ilyas Z, Angyal A, Szili D, Johnston J & Kiss-Toth E (2015) 223 MIRNA202 is a Novel Regulator of Tribbles-1 Expression. Heart, Vol. 101(Suppl 4) (pp A121.2-A121) RIS download Bibtex download
  • Hadadi E, Kiss-Toth E, Wilson HL & Wong SC (2015) 179 Investigation of human monocyte derived macrophage phenotypes for their functional role in atherosclerosis:. Heart, Vol. 101(Suppl 4) (pp A101.2-A102) RIS download Bibtex download
  • Johnston J, Angyal A, Alfaidi M, Francis S & Kiss-Toth E (2015) 186 Assessment of Plaque Macrophage Phenotypein situby Multicolour Fluorescence Microscopy. Heart, Vol. 101(Suppl 4) (pp A104.2-A105) RIS download Bibtex download
  • Angyal A, Daigneault M, Hadadi E, Ariaans M, Burnett A, Wilson H, Ridger V & Kiss-Toth E (2013) TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS. HEART, Vol. 99 (pp A126-A126) RIS download Bibtex download
  • Dugast E, Docherty L, Kiss-Toth E, Danger R, Soulillou JP, Brouard S & Ashton-Chess J (2012) Tribbles-1 is expressed by regulatory T cells and interacts with FOXP3. IMMUNOLOGY, Vol. 137 (pp 418-418) RIS download Bibtex download
  • Dugast E, Docherty L, Kiss-Toth E, Danger R, Soulillou J-P, Brouard S & Ashton-Chess J (2012) Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with Foxp3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 12 (pp 445-445) RIS download Bibtex download
  • Dugast E, Docherty L, Kiss-Toth E, Pettre S, Danger R, Soulillou JP, Brouard S & Ashton-Chess J (2010) Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with FOXP3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 10 (pp 363-363) RIS download Bibtex download
  • Docherty LM, Angyal A, Francis S & Kiss-Toth E (2009) THE ROLE OF TRIBBLES 2 IN PI3K CASCADE REGULATION AND AKT/PKB ANTI-APOPTOTIC SIGNALLING CASCADE. HEART, Vol. 95(22) RIS download Bibtex download
  • Guan H, Eder K, Sung HY, Sheridan PJ, Ward J, Morton A, Angyal A, Sarmay G, Duda E, Turner M , Dower SK et al (2008) Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44) RIS download Bibtex download
  • Guan H, Sung HY, Eder K, Dower S & Kiss-Toth E (2007) TRB proteins are competitive inhibitors of MAPK activation via interaction of MAPKKS. CYTOKINE, Vol. 39(1) (pp 13-13) RIS download Bibtex download
  • Sung HY, Francis S, Crossman DC & Kiss-Toth E (2005) Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15) RIS download Bibtex download
  • Wilkinson JM, Wilson AG, Eastell R & Kiss-Toth E (2002) A single nucleotide polymorphism at-238 in the TNF gene influences promoter activity in-vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S237-S237) RIS download Bibtex download
  • Kolber M, Nemeth M, Krizbai L, Szemes M & Kiss-Toth E (1998) Detectability of prunus necrotic ringspot and plum pox viruses by RT-PCR, multiplex RT-PCR, ELISA and indexing on woody indicators. 17TH INTERNATIONAL SYMPOSIUM ON VIRUS AND VIRUS-LIKE DISEASES OF TEMPERATE FRUIT CROPS: FRUIT TREE DISEASES, VOLS 1 AND 2(472) (pp 243-247) RIS download Bibtex download
  • Kolber M, Nemeth M, Krizbai L, Kiss-Toth E & Kalman M (1997) Detection of plum pox virus by different methods. DIAGNOSIS AND IDENTIFICATION OF PLANT PATHOGENS, Vol. 11 (pp 317-319) RIS download Bibtex download
  • KISSTOTH E, UNK I, BACHRATI C & CZIBULA A (1994) REGULATION OF THE BOVINE LEUKEMIA-VIRUS BASAL TRANSCRIPTION. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 48-48) RIS download Bibtex download
  • KISSTOTH E, UNK I & BOROS I (1993) THE INVIVO ROLE OF CREB-ALPHA ON HTLV-I AND BLV PROMOTERS. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 24-24) RIS download Bibtex download
  • UNK I, PACAUCCARALERTKUN S, KISSTOTH E & BOROS I (1993) PROTEIN AND DNA ELEMENTS INVOLVED IN THE TRANSCRIPTIONAL TRANSACTIVATION OF BLV. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 131-131) RIS download Bibtex download
Research group
  • Kajus Baidzajevas
  • Eva Hadadi
  • Zabran Ilyas
  • Jessica Johnston
  • Li Yang
Teaching interests

I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.