Dr Jovana Serbanovic-Canic

Department of Infection, Immunity and Cardiovascular Disease

BHF Intermediate Basic Science Research Fellow

j.serbanovic-canic@sheffield.ac.uk
+44 114 215 9502

Full contact details

Dr Jovana Serbanovic-Canic
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis.

Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of Sheffield. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish.

I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.

Research interests

I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally.

My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells.

Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.

Current projects

Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Serbanovic-Canic J, Feng S, Souilhol C & Evans PC (2019) The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273) RIS download Bibtex download
  • Souilhol C, Feng S, Gauci I, Serbanovic-Canic J, Canham L & Evans PC (2019) Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272) RIS download Bibtex download
  • Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL. Heart, Vol. 99(suppl 2) (pp A6.1-A6) RIS download Bibtex download
  • Freson K, Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple D & Ouwehand W (2011) Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its role in thrombopoiesis and iron uptake. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 33-33) RIS download Bibtex download
  • Cvejic A, Serbanovic-Canic J, Stemple D & Ouwehand W (2010) THE ROLE OF MEIS1 IN PRIMITIVE AND DEFINITIVE HAEMATOPOIESIS AND VASCULAR PATTERNING DURING ZEBRAFISH DEVELOPMENT. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 95 (pp 247-247) RIS download Bibtex download
  • Brieu N, Serbanovic-Canic J, Cvejic A, Stemple D, Ouwehand W, Navab N & Groher M (2010) Thrombus segmentation by texture dynamics from microscopic image sequences. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7623(PART 1) RIS download Bibtex download
Research group
  • Mr George Bowley (NC3R PhD Studentship)
  • Mr Neil Patel (MSc student)

Professional activities

Member of British Atherosclerosis Society (since 2013)