Professor Sheila Francis

BSc PhD SFHEA FRSB

Department of Infection, Immunity and Cardiovascular Disease

Professor of Cardiovascular Biology

Professor Sheila Francis
s.francis@sheffield.ac.uk
+44 114 215 9501

Full contact details

Professor Sheila Francis
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – iicd-operational@sheffield.ac.uk

I joined the University of Sheffield in 1990 after a BBSRC CASE PhD studentship at the University of Manchester. After 4 years as a Postdoctoral Research Associate in Cardiac Surgery (with Angelini) and Molecular Medicine (with Duff), I held an Independent Open Competition Fellowship from the Lloyd´s Tercentenary Foundation on the molecular and inflammatory basis of coronary artery disease.

After being appointed Lecturer in 1994, I spent a sabbatical period in the Hynes Lab at MIT as a Fulbright Scholar. I am currently Professor of Cardiovascular Biology at the University of Sheffield.

Research interests

I have a long-standing interest in the role of interleukin-1 (IL-1) and its naturally occurring antagonist, IL-1ra in modulating vascular cell function in experimental models and in human disease. Over the past 10-15 years, I have shown that IL-1 and IL-1ra are increased in diseased human arteries and in other experimental cardiovascular systems. I described the association of a genetic variant of IL-1ra with coronary artery disease and showed that this variant alters protein levels and the biology of endothelial cells.

Programme funding from the British Heart Foundation (with Professor David Crossman) allowed the use of strategies to inhibit IL-1 in several experimental models including atherosclerosis in mice. The impact of this early work alongside that of others has now been translated to man through the ILA-HEART and CANTOS trials.

My current research areas of interest relate to the mechanisms by which IL-1 is released from vascular cells especially endothelial cells, IL-1 related molecules and their antagonists, and the role of IL-1 in complex vascular phenotypes such as inflammatory vascular plaques in the brain and the mixed models of atherosclerosis after chronic infection and also episodes of hypoglycaemia. More recently, I have become interested in the control of endothelial senescence and impacts upon age-related diseases working with colleague in HELSI.

I collaborate with colleagues in Infection, Immunity and Cardiovascular Disease, Metabolism, Psychology and Neuroscience at the University of Sheffield and with colleagues at the Universities of Manchester (Pinteaux, Allan), the University of Virginia (Owens, Abbate) and others.

Current projects

  1. Release of IL-1 from vascular cells especially endothelial cells.
  2. Tribbles and Atherosclerosis (with Kiss-Toth).
  3. S.pneumoniae infection and atherosclerosis (with Bazaz and Dockrell (Edinburgh)).
  4. Carbon monoxide releasing molecules (with Gunn/Iqbal, Motterlini and Mann)).
  5. Hypoglycaemia and risk of atherosclerosis (with Iqbal and Heller).
  6. Interleukin-1 alpha versus interleukin-1 beta in atherosclerosis, hypertension and stroke (with Pinteaux and Allan, Manchester)).
  7. Macrophage phenotypes in human carotid atherosclerosis (with Kiss-Toth and Redgrave).
  8. Neurovascular function in atherosclerosis (with Wharton, Berwick and Howarth).
  9. Approaches to alter endothelial senescence and ageing (with Bellantuono).
  10. PKC alpha/TGF beta axis in atherosclerosis and medical calcification (with Brennan, Canfield and Borland, Manchester)
Publications

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Journal articles

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Journal articles

Chapters

Conference proceedings papers

Research group
  • Dr Osman Shabir
  • Dr Aya Elwazir
  • Klaudia Kocsy
  • Monica Rebollar Guagnelli
  • David Drew
Teaching interests

I am a Senior Fellow of the Higher Education Academy. I teach on the MSc in Molecular Medicine where I lead Molecular Genetics of Human Diseases (MED6003) and on the  MRes in Cardiovascular Medicine – From Molecules to Man (lead for the literature review module, CDL601. I also teach on phase 2a (Cardiology) MBChB. I co-founded an undergraduate BMS 3rd year module ‘Cardiovascular Pharmacology – personalising medicine’ now led by Dr Janet Chamberlain and Dr Nigel Wheeldon.

Professional activities
  • Translational Research Projects Panel Member, Heart Research UK (HRUK) current.
  • Training Awards Committee (TAC), BBSRC (2006-2010).
  • Project Grants Committee, British Heart Foundation (2007-2010).
  • Secretary of the British Atherosclerosis Society (September 2018 - ).
  • Fellowships Committee, British Heart Foundation (July 2020 - ).
  • External Examiner, MRes (BHF 4 year PhD), University of Cambridge (December 2019 - ).