Dr Steven Reynolds

Department of Infection, Immunity and Cardiovascular Disease

Preclinical MRI Facility Manager

Dr Steven Reynolds
Steven.Reynolds@sheffield.ac.uk
+44 114 215 9596

Full contact details

Dr Steven Reynolds
Department of Infection, Immunity and Cardiovascular Disease
C Floor
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
Profile

For enquiries, please contact – iicd-operational@sheffield.ac.uk

In 2009, I joined the University of Sheffield as a Senior Research fellow on a CRUK funded programme grant. Here I set up the lab to study cancer metabolism by Hyperpolarised Magnetic Resonance Imaging and Spectroscopy (MRI/S). Previously, I held positions in industry both as part of GE Healthcare (2001-2006), developing scientific instruments, and Oxford Instruments (2006 – 2009), where I led the MRS facility and was responsible for project delivery using the HyperSense hyperpolarisation instrument. It was from these roles that I developed an interest in hyperpolarised magnetic resonance experiments and metabolism.

I have a degree in chemistry from Aston University, where I also received my PhD. I have held research positions at the University of Surrey and the University of Cambridge. 

Research interests

My main research interest is in the use of Magnetic Resonance Spectroscopy (MRS) to study cellular metabolism and metabolomics. This is augmented by the use of hyperpolarisation technology that allows in vivo and in vitro cellular metabolism to be studied in real time.

The spermNMR group studies the metabolism of these unique cells to learn more about male factor infertility.  Sperm undergo a lot of changes before fertilising an egg. These changes require energy and our research examines how sperm metabolise at different stages of their journey through the female reproductive tract. We use MRS to track the conversion of substrates by different metabolic pathways to understand how sperm produce this energy. Alongside this, I have a longstanding collaboration with Prof Dilly Anumba in studying the metabolic triggers of preterm birth. We examine how the bacteria present in the vagina can influence pregnancy outcomes. These bacteria produce metabolites that can be quantified by MRS and could be used to predict the likelihood of preterm birth.

I also manage the 7T and 9.4T magnetic resonance spectroscopy and imaging facility at the University of Sheffield. Here I have a number of collaborations to develop the use of high resolution MRI, including live zebrafish imaging.

Publications

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Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Amabebe E, Reynolds S & Anumba DO (2019) Discriminative Capacity of H-1-MRS Spectrum Binning for Preterm Delivery-Associated Lactobacilli-Dominated Vaginal Microbiota.. REPRODUCTIVE SCIENCES, Vol. 26 (pp 212A-212A) RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba D (2017) Decreased cervicovaginal fluid glutamate improves the predictive value of acetate for risk of preterm delivery within two weeks of presentation with threatened preterm labour. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 124 (pp 127-127) RIS download Bibtex download
  • Parker J, Stafford GP, Stern V, Amabebe E, Reynolds S, Paley M & Anumba DOC (2016) Prognostic Microbiomial and Metabolite Markers of Preterm Birth in Second Trimester Cervicovaginal Fluid from Women at Risk.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 128A-128A) RIS download Bibtex download
  • Stern V, Amabebe E, Reynolds S, Stafford G, Paley M & Anumba D (2016) The Association of Cervicovaginal Fluid Metabolites at 20-22 Weeks Gestation with Quantitative Fetal Fibronectin, Ultrasound Cervical Length and Gestational Age at Delivery in Asymptomatic Pregnant Women.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 190A-191A) RIS download Bibtex download
  • Amabebe E, Stern V, Parker J, Reynolds S, Stafford G, Paley M & Anumba D (2015) Elucidating Potential Metabolite Markers of Preterm Birth in Cervicovaginal Secretions By Nuclear Magnetic Resonance Spectroscopy. REPRODUCTIVE SCIENCES, Vol. 22 (pp 130A-130A) RIS download Bibtex download
Research group

PhD students

  • Evie Gruszyk
Teaching interests

I deliver the MRI component of the FRCR (Radiology) programme to the Medical school Undergraduate course. I also contribute to the Student Selected Components on Phase 1b (Research Methods). I supervise Master students on the Reproductive and Developmental medicine course. Outside of the Medical school I provide research experiences for the University’s SURE scheme and Nuffield foundation.

Professional activities
  • Member of the Royal Society of Chemistry.
  • Member of the Institute for Physics.