Sheffield Hyperpolarised Imaging of Metabolism and MR Engineering Research

SHIMMER

9.4T Imaging and Spectroscopy scanner

Based in the Jessop wing maternity hospital we have a Bruker Avance III 9.4T (400MHz) scanner. This system has a wide range of capabilities. These include:

Imaging

  • Ultra-shielded magnet
  • Powerful gradients – 1500 mT/m
  • High Spatial Resolution Imaging to 15 microns
  • 1H, 13C, 31P signal detection in coil sizes of 5, 10 and 25 mm

High resolution Spectroscopy

  • Broadband 5 mm liquid spectroscopy
  • 1H and broadband nuclei detection

HR Magic Angle Spinning Spectroscopy

  • Spectroscopy of solid samples such as biopsy tissue
  • 1H, 13C and 31P nuclei detection

For further information on imaging and spectroscopy follow the links on the right hand side.

Bruker Avance III

Sensitivity enhancement

Hyperpolarised dissolution Dynamic Nuclear Polarization (dDNP) is a preclinical technique for monitoring in vivo metabolism by magnetic resonance spectroscopy and imaging (MRS/MRI) that has recently been used in a preliminary clinical trial of human prostate cancer. The sensitivity for 13C nuclei is increased by many orders of magnitude allowing real time measurement of metabolic kinetics without the interfering background signals experienced in 1H MRS.

We have a fully automated HyperSense DNP system at Sheffield for in vivo and ex vivo studies. Click here for more information of dDNP at Sheffield .




HyperSense DNP