Sheffield Hyperpolarised Imaging of Metabolism and MR Engineering Research
9.4T Imaging and Spectroscopy scanner
Based in the Jessop wing maternity hospital we have a Bruker Avance III 9.4T (400MHz) scanner. This system has a wide range of capabilities. These include:
High resolution Spectroscopy
HR Magic Angle Spinning Spectroscopy
For further information on imaging and spectroscopy follow the links on the right hand side.
Hyperpolarised dissolution Dynamic Nuclear Polarization (dDNP) is a preclinical technique for monitoring in vivo metabolism by magnetic resonance spectroscopy and imaging (MRS/MRI) that has recently been used in a preliminary clinical trial of human prostate cancer. The sensitivity for 13C nuclei is increased by many orders of magnitude allowing real time measurement of metabolic kinetics without the interfering background signals experienced in 1H MRS.
We have a fully automated HyperSense DNP system at Sheffield for in vivo and ex vivo studies. Click here for more information of dDNP at Sheffield .