Dr Jon Wood
Department of Neuroscience
Senior University Teacher
+44 114 222 2243
Full contact details
Department of Neuroscience
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Jon joined the department in 2001 after postdoctoral work on Huntington disease and other polyglutamine disorders at the University of Wales College of Medicine in Cardiff (1994-96) and the Laboratory of Molecular Neurobiology at the Johns Hopkins Medical Institutions in Baltimore (1996-2001).
His research focused on molecular mechanisms underlying neurodegenerative disorders and neurodevelopmental pathways conferring susceptibility to psychiatric disease, prior to focusing on teaching.
- Research interests
No current research projects
- Zebrafish as a model to investigate the CRH axis and interactions with DISC1. Current Opinion in Endocrine and Metabolic Research, 100383-100383.
- Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis. The Journal of Pathology. View this article in WRRO
- Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human Molecular Genetics, 26(11), 1992-2005. View this article in WRRO
- Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate‐length CAG repeat expansions in Ataxin‐2 does not have 1C2‐positive polyglutamine inclusions. Neuropathology and Applied Neurobiology, 42(4), 377-389. View this article in WRRO
- Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience, 322, 287-297. View this article in WRRO
- Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open. View this article in WRRO
- Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based Approach. Scientific Reports, 5(1). View this article in WRRO
- Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.. Dis Model Mech, 3(11-12), 743-751.
- Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.. Hum Mol Genet, 18(3), 391-404.
- Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Human Molecular Genetics, 18(4), 723-736.
- Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.. J Neurochem, 110(1), 34-44.
- The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.. Hum Mol Genet, 15(18), 2763-2771.
- Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease, 21(2), 381-391.
- Protein aggregation in motor neurone disorders.. Neuropathol Appl Neurobiol, 29(6), 529-545.
- Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.. Ann Neurol, 54(6), 748-759.
- The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.. J Neuropathol Exp Neurol, 62(11), 1166-1177.
- Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. J BIOL CHEM, 278(15), 13047-13055.
- Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation.. Neuroreport, 14(4), 565-568.
- SOD1 aggregation in familial amyotrophic lateral sclerosis (FALS). Biochemical Society Transactions, 30(3), A85-A85.
- Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry, 41(48), 14299-14305.
- Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.. Neurobiol Dis, 8(3), 405-418.
- Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy.. Ann Neurol, 49(1), 14-23.
1-Adrenergic Receptor Association with the Synaptic Scaffolding Protein Membrane-associated Guanylate Kinase Inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 AND PSD-95. Journal of Biological Chemistry, 276(44), 41310-41317.
- Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.. J Cell Biol, 150(5), 939-948.
- Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci U S A, 97(8), 4233-4238.
- Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.. Neuron, 24(1), 275-286.
- Polyglutamine pathogenesis.. Philos Trans R Soc Lond B Biol Sci, 354(1386), 1005-1011.
- Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem, 274, 8730-8736.
- Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.. Mol Cell Neurosci, 11(3), 149-160.
- Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases.. Exp Neurol, 150(2), 213-222.
- Huntingtin interacts with cystathionine beta-synthase.. Hum Mol Genet, 7(3), 371-378.
- Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions.. Prog Brain Res, 117, 397-419.
- Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology.. Brain Pathol, 7(3), 1003-1016.
- Huntington disease: advances in molecular and cell biology.. J Inherit Metab Dis, 20(2), 125-138.
- Expression of phagocyte NADPH oxidase components in human endothelial cells.. Am J Physiol, 271(4 Pt 2), H1626-H1634.
- Oxidant Production by Human B Lymphocytes: Detection of Activity and Identification of Components Involved. Methods, 9(3), 619-627.
- Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain.. Hum Mol Genet, 5(4), 481-487.
- The functional expression of p47-phox and p67-phox may contribute to the generation of superoxide by an NADPH oxidase-like system in human fibroblasts.. FEBS Lett, 355(2), 178-182.
- Homology between cellobiose oxidase from Phanerochaete chrysosporium and other proteins.. Biochem Soc Trans, 20(2), 109S.
- Evidence that cellobiose:quinone oxidoreductase from Phanerochaete chrysosporium is a breakdown product of cellobiose oxidase.. Biochim Biophys Acta, 1119(1), 90-96.
- Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntingdon's disease and other polyglutamine diseases In Beal MF, Lang AE & Ludolph AC (Ed.), Neurodegenerative Diseases (pp. 861-870). Cambridge University Press
- Pathogenesis of Polyglutamine Neurodegenerative Diseases:Towards a Unifying Mechanism In Wells RD, Warren ST & Sarmiento M (Ed.), Genetic instabilities and hereditary neurological diseases (pp. 761-776). Academic Press
Conference proceedings papers
- Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016. The Journal of Pathology, Vol. 240 (pp S1-S48) View this article in WRRO
- Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42(S1) (pp 28-28), 2 March 2016 - 4 March 2016. View this article in WRRO
- Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 26-27)
- The mRNA exporter GLE1 is essential for embryonic development. FEBS Journal, Vol. 281(Suppl 1) (pp 644-645)
- Deficiency in Gle1, an mRNA export mediator, inhibits Schwann cell development in the zebrafish embryo. FEBS JOURNAL, Vol. 281 (pp 771-771)
- Research group
- Teaching activities
Course lead for MSc Clinical Neurology and MSc Neuroscience and Neurodegeneration.
Also teaches on the MBChB programme, MSc Translational Neuropathology, MSc Clinical Neurology, MSc Genomic Medicine and MSc Molecular Medicine.
Jon is a Senior Fellow of the Higher Education Academy and a Senate Fellow for his work in development of a video resource for neuroanatomy teaching.