Professor Li Su

Neuroscience, School of Medicine and Population Health

Professor of Neuroimaging

l.su@sheffield.ac.uk
+44 114 21 59108

Sheffield Institute for Translational Neuroscience (SITraN)

Full contact details

Professor Li Su
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ

Profile

Professor Su was awarded a PhD in Computational Neuroscience from University of Kent in 2009. After several years of postdoctoral research in Institute of Psychiatry at King’s College London, MRC Cognition and Brain Sciences Unit and University of Cambridge, he was awarded a highly competitive Senior Research Fellowship from Alzheimer’s Research UK in 2017.

He leads the Artificial Intelligence & Computational Neuroscience Group (www.aicn-group.com), which aims to combine innovative and original computational methods with the state-of-the-art brain imaging techniques such as MEG/EEG, 7T MRI and PET in understanding, detecting and developing treatments for neurological and psychiatric conditions.

In 2020, he was appointed Professor of Neuroimaging at the University of Sheffield. He also holds a part-time PI position in Department of Psychiatry at University of Cambridge. He leads the Alzheimer’s Research UK East Network Centre and is an elected Fellow in Clare Hall, University of Cambridge. His research has been recognised through international awards including an International College of Geriatric Psychoneuropharmacology Junior Investigator Award in 2015.

Research interests

Conduct multimodal and longitudinal EEG, MRI and PET studies to discover clinically relevant biomarkers for neurodegenerative disorders (including Parkinson’s disease, Alzheimer’s disease), motor neuron disorders, stroke and other related conditions. Apply machine learning and other advanced imaging analysis to the imaging, genetic, blood and other clinical data.

Develop advanced imaging analysis methods for basic and clinical neuroscience.

Develop and validate AI models using clinical and neuroimging data. Use the model to predict therapeutic effects of potential drug targets on normalising neural network functions from computer simulations.

Early detection and prevention of dementia. In particular, apply multimodal imaging and VR to find earliest signals for functional declines and pathological abnormalities. Develop and test pharmaceutical and non-pharmaceutical interventions to slow or reverse disease progression for those with increased risk of developing dementia.

Publications

Journal articles

Mak E, Dounavi M-E, Operto G, Ziukelis ET, Jones PS, Low A, Swann P, Newton C, Muniz Terrera G, Malhotra P , Koychev I et al (2023) APOE ɛ4 exacerbates age-dependent deficits in cortical microstructure. Brain Communications, 6(1).
Mak E, Carter SF, Savulich G, Holland N, Swann P, McKiernan E, Chouliaras L, Malpetti M, Su L, Jones PS , Rowe JB et al (2023) Multi‐modal MR and synaptic PET changes in dementia with Lewy bodies. Alzheimer's & Dementia, 19(S17).
Mak E, Dounavi M, Operto G, Ziukelis ET, Jones PS, Low A, Swann P, Newton C, Muniz‐Terrera G, Malhotra PA , Koychev I et al (2023) Apoe ε4 exacerbates age‐dependent decline of cortical microstructural changes in cognitively normal midlife individuals: the PREVENT‐Dementia and ALFA studies. Alzheimer's & Dementia, 19(S16).
Dounavi M, Mak E, Low A, Williams GB, Wells K, Muniz‐Terrera G, Lawlor BA, Naci L, Malhotra PA, Koychev I , Ritchie K et al (2023) Investigating the impact of APOE4 genotype on the association between cerebral blood flow and haematological properties in mid‐life adults. Alzheimer's & Dementia, 19(S16).
Stefaniak JD, Mak E, Su L, Carter SF, Dounavi M, Muniz‐Terrera G, Wells K, Ritchie K, Lawlor B, Naci L , Koychev I et al (2023) Brain age gap, dementia risk factors and cognition in middle age. Alzheimer's & Dementia, 19(S23).
Low A, McKiernan E, Prats‐Sedano MA, Carter SF, Stefaniak JD, Su L, Dounavi M, Muniz‐Terrera G, Jenkins ND, Ritchie K , Lawlor B et al (2023) Cerebral microbleeds in traumatic brain injury associated with differential risk factors and clinical outcomes: the PREVENT‐Dementia study. Alzheimer's & Dementia, 19(S16).
Malpetti M, Swann P, Chouliaras L, Ashton NJ, Tsvetanov KA, Street D, Whiteside DJ, Cope TE, Savulich G, Rittman T , Surendranathan A et al (2023) Inflammation blood profiles across neurodegenerative diseases. Alzheimer's & Dementia, 19(S17).
Chouliaras L, Thomas AJ, Clark G, Donaghy PC, Swann P, Malpetti M, Mak E, Savulich G, Prats‐Sedano MA, Low A , Su L et al (2023) DNA methylation alterations in Lewy Body Dementia. Alzheimer's & Dementia, 19(S12).
Kucikova L, Kalabizadeh H & Su L (2023) Underlying mechanisms, clinical manifestation, and methodological considerations of functional connectivity in Dementia with Lewy Bodies. Alzheimer's & Dementia, 19(S16).
Dounavi M, Mak E, Low A, Williams GB, Wells K, Muniz‐Terrera G, Lawlor BA, Naci L, Malhotra PA, Koychev I , Ritchie K et al (2023) Investigating the impact of APOE4 genotype on the association between cerebral blood flow and haematological properties in mid‐life adults. Alzheimer's & Dementia, 19(S10).
Mak E, Dounavi M, Operto G, Ziukelis ET, Jones PS, Low A, Swann P, Newton C, Muniz‐Terrera G, Malhotra PA , Koychev I et al (2023) Apoe ε4 exacerbates age‐dependent decline of cortical microstructural changes in cognitively normal midlife individuals: the PREVENT‐Dementia and ALFA studies. Alzheimer's & Dementia, 19(S10).
Low A, McKiernan E, Prats‐Sedano MA, Carter SF, Stefaniak JD, Su L, Dounavi M, Muniz‐Terrera G, Jenkins ND, Ritchie K , Lawlor B et al (2023) Cerebral microbleeds in traumatic brain injury associated with differential risk factors and clinical outcomes: the PREVENT‐Dementia study. Alzheimer's & Dementia, 19(S10).
Kucikova L, Kalabizadeh H, Motsi KG, Rashid S, O’Brien JT, Taylor J-P & Su L (2023) A systematic literature review of fMRI and EEG resting-state functional connectivity in Dementia with Lewy Bodies: underlying mechanisms, clinical manifestation, and methodological considerations. Ageing Research Reviews, 102159-102159.
Huang W, Zeng J, Jia L, Zhu D, O’Brien J, Ritchie C, Shu N & Su L (2023) Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults. Brain Communications, 5(5).
Butters E, Srinivasan S, O’Brien JT, Su L & Bale G (2023) A promising tool to explore functional impairment in neurodegeneration: A systematic review of near-infrared spectroscopy in dementia.. Ageing Research Reviews, 90, 101992-101992.
Rajab MD, Jammeh E, Taketa T, Brayne C, Matthews FE, Su L, Ince PG, Wharton SB & Wang D (2023) Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer’s Research & Therapy, 15.
Srinivasan S, Butters E, Collins-Jones L, Su L, O’Brien J & Bale G (2023) Illuminating neurodegeneration: a future perspective on near-infrared spectroscopy in dementia research. Neurophotonics, 10(02).
Wingfield C, Zhang C, Devereux B, Fonteneau E, Thwaites A, Liu X, Woodland P, Marslen-Wilson W & Su L (2022) On the similarities of representations in artificial and brain neural networks for speech recognition. Frontiers in Computational Neuroscience, 16.
Newton C, Pope M, Dounavi M, Carter SF, Muniz‐Terrera G, Henson RN, Ritchie K, Ritchie CW, O'Brien JT, Su L & Chan D (2022) Multifactor mid‐life risk for Alzheimer’s disease associated with alterations in navigation but not episodic memory: the PREVENT‐Dementia study. Alzheimer's & Dementia, 18(S7).
Low A, Prats-Sedano MA, McKiernan E, Carter SF, Stefaniak JD, Nannoni S, Su L, Dounavi M-E, Muniz-Terrera G, Ritchie K , Lawlor B et al (2022) Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study. Alzheimer’s Research & Therapy, 14(1).
Zhou D-A, Xu K, Zhao X, Chen Q, Sang F, Fan D, Su L, Zhang Z, Ai L & Chen Y (2022) Spatial Distribution and Hierarchical Clustering of β-Amyloid and Glucose Metabolism in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 14, 788567.
Ziukelis ET, Mak E, Dounavi M-E, Su L & O'Brien J (2022) FRACTAL DIMENSION OF THE BRAIN IN NEURODEGENERATIVE DISEASE AND DEMENTIA: A SYSTEMATIC REVIEW.. Ageing Res Rev, 101651.
Kucikova L, Danso S, Jia L & Su L (2022) Computational psychiatry and computational neurology : seeking for mechanistic modeling in cognitive impairment and dementia. Frontiers in Computational Neuroscience, 16.
Dounavi M-E, Low A, Muniz-Terrera G, Ritchie K, Ritchie CW, Su L, Markus HS & O’Brien JT (2022) Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults. Brain Communications, 4(3).
Dounavi M-E, Newton C, Jenkins N, Mak E, Low A, Muniz-Terrera G, Williams GB, Lawlor B, Naci L, Malhotra P , Mackay CE et al (2022) Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia : the PREVENT-Dementia study. Journal of Neurology.
Wang X, Bi Q, Lu J, Chan P, Hu X, Su L, Jessen F, Lin H, Han C, Shu N , Liu H et al (2022) Difference in amyloid load between single memory domain and multidomain subjective cognitive decline: a study from the SILCODE. Journal of Alzheimer's Disease, 85(4), 1573-1582.
Chouliaras L, Thomas A, Malpetti M, Donaghy P, Kane J, Mak E, Savulich G, Prats-Sedano MA, Heslegrave AJ, Zetterberg H , Su L et al (2022) Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy. Journal of Neurology, Neurosurgery & Psychiatry.
Baig SS, Kamarova M, Ali A, Su L, Dawson J, Redgrave JN & Majid A (2022) Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions. Autonomic Neuroscience, 237, 102909-102909.
Malpetti M, Savulich G, Mak E, Nicastro N, Jones PS, Surendranathan A, Su L, Passamonti L, Chouliaras L, Fryer TD , Hong YT et al (2021) Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies. Alzheimer's & Dementia, 17(S4).
Low A, Prats‐Sedano M, Stefaniak JD, Dounavi M, McKiernan E, Carter SF, Mak E, Su L, Muñiz‐Terrera G, Ritchie K , Ritchie CW et al (2021) The effects of age and hypertension on cerebral small‐vessel disease differ between men and women at midlife: The PREVENT Dementia study. Alzheimer's & Dementia, 17(S10).
Kucikova L, Goerdten J, Dounavi M-E, Mak E, Su L, Waldman AD, Danso S, Muniz-Terrera G & Ritchie CW (2021) Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer’s disease. Neuroscience & Biobehavioral Reviews.
Zeng J, Xiong X, Hou X, Chen H & Su L (2021) A Genetic Determinant of the Preference Reversal Phenomenon. The American Journal of Psychology, 134(2), 167-174.
Mak E, Dounavi ME, Low A, Carter SF, McKiernan E, Williams GB, Jones PS, Carriere I, Muniz GT, Ritchie K , Ritchie C et al (2021) Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study. NeuroImage, 229.
Su L, Surendranathan A, Huang Y, Bevan-Jones WR, Passamonti L, Hong YT, Arnold R, Rodríguez PV, Wang Y, Mak E , Fryer TD et al (2021) Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD study. Information Fusion, 67, 116-124.
Cardinal RN, Meiser-Stedman CE, Christmas DM, Price AC, Denman C, Underwood BR, Chen S, Banerjee S, White SR, Su L , Ford TJ et al (2021) Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician–Clinician Encounters, Clinician–Patient–Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering. Frontiers in Psychiatry, 12, 620842.
Lin L, Sun Y, Wang X, Su L, Wang X & Han Y (2021) Resilience to Plasma and Cerebrospinal Fluid Amyloid-β in Cognitively Normal Individuals: Findings From Two Cohort Studies. Frontiers in Aging Neuroscience, 13, 610755.
Mak E, Dounavi M, Low A, McKiernan E, Carter SF, Newton C, Williams GB, Ritchie K, Wells K, Sahin Z , Carriere I et al (2020) Multifaceted pattern of longitudinal imaging changes in cognitively normal midlife adults: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S5).
Low A, Su L, Stefaniak JD, Mak E, Dounavi M, Ritchie K, Ritchie CW, Markus HS & O'Brien JT (2020) Progression of cerebral small vessel disease in healthy middle‐aged adults associated with inherited risk of Alzheimer’s disease: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
Malpetti M, Kievit RA, Passamonti L, Jones PS, Tsvetanov KA, Rittman T, Mak E, Nicastro N, Bevan‐Jones WR, Su L , Hong YT et al (2020) The prognostic role of microglia and tau PET in Alzheimer’s disease. Alzheimer's & Dementia, 16(S4).
Raymont V, O'Donoghue MC, Mak E, Dounavi M, Su L, MacKay C, O'Brien JT & Ritchie CW (2020) Impact of mild head injury on diffusion MRI brain characteristics in midlife: Data from the PREVENT Dementia Study. Alzheimer's & Dementia, 16(S5).
Huang Y, Prats‐Sedano M, O'Brien JT, Kocagoncu E, Henson R, Rowe JB & Su L (2020) Increased electromagnetic variability in Lewy body dementia: A MILOS study. Alzheimer's & Dementia, 16(S4).
Mak E, Dounavi M, Low A, McKiernan E, Carter SF, Newton C, Williams GB, Ritchie K, Wells K, Sahin Z , Terrera GM et al (2020) Multi‐faceted brain changes associated with proximity to dementia onset: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
Dounavi M, Mak E, Wells K, Ritchie K, Ritchie CW, Su L & O'Brien JT (2020) Hippocampal subfield volumetry in subjects at high risk of dementia: The PREVENT‐Dementia study. Alzheimer's & Dementia, 16(S4).
Su L (2020) Mesoscopic compensations for microscopic impairments in mid‐age individuals with family history of dementia. Alzheimer's & Dementia, 16(S5).
Wang X, Huang W, Su L, Xing Y, Jessen F, Sun Y, Shu N & Han Y (2020) Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer’s disease. Molecular Neurodegeneration, 15(1).
Low A, Su L, Stefaniak JD, Mak E, Dounavi M-E, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS & O’Brien JT (2020) Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study. Neurobiology of Aging.
Mak E, Nicastro N, Malpetti M, Savulich G, Surendranathan A, Holland N, Passamonti L, Jones SP, Carter SF, Su L , Hong YT et al (2020) Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography. Neurobiology of Aging.
Zheng B, Báez S, Su L, Xiang X, Weis S, Ibáñez A & García AM (2020) Semantic and attentional networks in bilingual processing: fMRI connectivity signatures of translation directionality. Brain and Cognition, 143, 105584-105584.
Dounavi M-E, Mak E, Wells K, Ritchie K, Ritchie CW, Su L & O’ Brien JT (2020) Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. Neurobiology of Aging, 91, 36-44.
McKiernan EF, Mak E, Dounavi M-E, Wells K, Ritchie C, Williams G, Su L & O'Brien J (2020) Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort. Journal of Neurology, Neurosurgery & Psychiatry, 91(8), 861-866.
McKeever A, Paris AF, Cullen J, Hayes L, Ritchie CW, Ritchie K, Waldman AD, Wells K, Busza A, Carriere I , O’Brien JT et al (2020) Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia. Journal of Alzheimer's Disease, 75(4), 1211-1218.
Castillo-Barnes D, Su L, Ramírez J, Salas-Gonzalez D, Martinez-Murcia FJ, Illan IA, Segovia F, Ortiz A, Cruchaga C, Farlow MR , Xiong C et al (2020) Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning. Information Fusion, 58, 153-167.
Malpetti M, Kievit RA, Passamonti L, Jones PS, Tsvetanov KA, Rittman T, Mak E, Nicastro N, Bevan-Jones WR, Su L , Hong YT et al (2020) Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease. Brain, 143(5), 1588-1602.
O'Brien JT, Firbank MJ, Ritchie K, Wells K, Williams GB, Ritchie CW & Su L (2020) Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study. Journal of Neurology, Neurosurgery & Psychiatry, 91(2), 158-161.
Huang Y, Su L & Ma Q (2020) The Stroop effect: An activation likelihood estimation meta-analysis in healthy young adults. Neuroscience Letters, 716, 134683-134683.
Nicastro N, Mak E, Williams GB, Surendranathan A, Bevan-Jones WR, Passamonti L, Vàzquez Rodrìguez P, Su L, Arnold R, Fryer TD , Hong YT et al (2020) Correlation of microglial activation with white matter changes in dementia with Lewy bodies. NeuroImage: Clinical, 25, 102200-102200.
Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Rodríguez PV, Passamonti L , Bevan‐Jones WR et al (2019) Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid‐positive mild cognitive impairment is associated with key clinical features. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11(1), 690-699.
Zeng J, Wang Y, Zeng J, Cao Z, Chen H, Liu Y, Zhang Q & Su L (2019) Predicting the behavioural tendency of loss aversion. Scientific Reports, 9(1).
Zhao W, Luo Y, Zhao L, Mok V, Su L, Yin C, Sun Y, Lu J, Shi L & Han Y (2019) Automated Brain MRI Volumetry Differentiates Early Stages of Alzheimer’s Disease From Normal Aging. Journal of Geriatric Psychiatry and Neurology, 32(6), 354-364.
Huang Y, Pan X, Su L, Sun Y, Mo Y & Ma Q (2019) The role of information sentiment in popularity on social media: a psychoinformatic and electroencephalogram study. Social Influence, 14(3-4), 133-146.
Passamonti L, Tsvetanov KA, Jones PS, Bevan-Jones WR, Arnold R, Borchert RJ, Mak E, Su L, O'Brien JT & Rowe JB (2019) Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance. The Journal of Neuroscience, 39(36), 7218-7226.
Li X, Wang X, Su L, Hu X & Han Y (2019) Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline. BMJ Open, 9(7), e028188-e028188.
Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Rodríguez PV, Passamonti L , Bevan-Jones WR et al (2019) P2-373: ASYMMETRICAL THALAMIC SUBNUCLEI IN ALZHEIMER'S DISEASE ASSOCIATED WITH GREATER DISEASE SEVERITY. Alzheimer's & Dementia, 15, P744-P745.
Hou X, Zeng J, Chen H & Su L (2019) The endowment effect in the genes: An exploratory study. Judgment and Decision Making, 14(3), 293-298.
Leming M, Su L, Chattopadhyay S & Suckling J (2019) Normative pathways in the functional connectome. NeuroImage, 184, 317-334.
Su L, Li Z, Ritchie CW, Ritchie K, Waldman A, Wells K & O'Brien JT (2018) P3-362: HYPERFUNCTIONAL CONNECTIVITY ASSOCIATED WITH GENETIC RISKS OF DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_23), P1226-P1226.
Su L, Li Z, Ritchie CW, Ritchie K, Waldman A, Wells K & O'Brien JT (2018) IC-P-169: HYPERFUNCTIONAL CONNECTIVITY ASSOCIATED WITH GENETIC RISKS OF DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_2), P141-P142.
Minett T, Su L, Mak E, Williams G, Firbank M, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK , Brooks DJ et al (2018) Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study. Journal of Neurology, 265(7), 1528-1539.
Passamonti L, Rodríguez PV, Hong YT, Allinson KSJ, Bevan-Jones WR, Williamson D, Jones PS, Arnold R, Borchert RJ, Surendranathan A , Mak E et al (2018) [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy. Neurology, 90(22), e1989-e1996.
Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW & O'Brien JT (2018) Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease. Alzheimer's & Dementia, 14(2), 253-258.
Mak E, Bethlehem RAI, Romero‐Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan‐Jones RW, Passamonti L, Vázquez Rodríguez P , Su L et al (2018) In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10(1), 678-687.
Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, Vázquez Rodríguez P, Bevan-Jones WR, Brain SAE, Fryer TD , Aigbirhio FI et al (2018) Early microglial activation and peripheral inflammation in dementia with Lewy bodies. Brain, 141(12), 3415-3427.
Ritchie K, Carrière I, Howett D, Su L, Hornberger M, O’Brien JT, Ritchie CW & Chan D (2018) Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer’s Disease: The PREVENT Dementia Study. Journal of Alzheimer's Disease, 65(3), 885-896.
Su L, Hayes L, Soteriades S, Williams G, Brain SAE, Firbank MJ, Longoni G, Arnold RJ, Rowe JB & O’Brien JT (2017) Hippocampal Stratum Radiatum, Lacunosum, and Moleculare Sparing in Mild Cognitive Impairment. Journal of Alzheimer's Disease, 61(1), 415-424.
Ritchie K, Carrière I, Su L, O'Brien JT, Lovestone S, Wells K & Ritchie CW (2017) The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study. Alzheimer's & Dementia, 13(10), 1089-1097.
Su L, Wang Y, Surendranathan A, Bevan-Jones WR, Passamonti L, Hong YT, Arnold R, Rodriguez PV, Mak E, Fryer TD , Aigbirhio FI et al (2017) INVESTIGATION OF THE RELATIONSHIP BETWEEN TAU AND NEUROINFLAMMATION IN ALZHEIMER’S DISEASE USING PET AND REACTION MODELLING. Alzheimer's & Dementia, 13(7), P921-P922.
Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Mollenhauer B, Owen AM, Khoo TK , Brooks DJ et al (2017) Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease. Neurobiology of Aging, 55, 78-90.
Habib M, Mak E, Gabel S, Su L, Williams G, Waldman A, Wells K, Ritchie K, Ritchie C & O’Brien JT (2017) Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer’s disease. Ageing Research Reviews, 36, 88-104.
Mak E, Gabel S, Mirette H, Su L, Williams GB, Waldman A, Wells K, Ritchie K, Ritchie C & O’Brien J (2017) Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes. Ageing Research Reviews, 35, 250-264.
Mak E, Gabel S, Su L, Williams GB, Arnold R, Passamonti L, Vazquez Rodríguez P, Surendranathan A, Bevan-Jones WR, Rowe JB & O'Brien JT (2017) Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies. International Psychogeriatrics, 29(4), 545-555.
Bevan-Jones WR, Surendranathan A, Passamonti L, Vázquez Rodríguez P, Arnold R, Mak E, Su L, Coles JP, Fryer TD, Hong YT , Williams G et al (2017) Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. BMJ Open, 7(1), e013187-e013187.
Su L, Faluyi YO, Hong YT, Fryer TD, Mak E, Gabel S, Hayes L, Soteriades S, Williams GB, Arnold R , Passamonti L et al (2016) Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. British Journal of Psychiatry, 209(6), 525-526.
Yan C, Wang Y, Su L, Xu T, Yin D-Z, Fan M-X, Deng C-P, Wang Z-X, Lui SSY, Cheung EFC & Chan RCK (2016) Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy. Psychiatry Research: Neuroimaging, 254, 127-136.
Su L, Blamire AM, Watson R, He J, Hayes L & O'Brien JT (2016) Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. Translational Psychiatry, 6(8), e877-e877.
Yan C, Su L, Wang Y, Xu T, Yin D-Z, Fan M-X, Deng C-P, Hu Y, Wang Z-X, Cheung EFC , Lim KO et al (2016) Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex. Scientific Reports, 6(1).
Su L, M. Blamire A, Watson R, He J, Aribisala B & T. O'Brien J (2016) Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study. Current Alzheimer Research, 13(5), 534-544.
Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire A & O’Brien J (2016) Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and Alzheimer Disease. The American Journal of Geriatric Psychiatry, 24(2), 136-143.
Zhang J & Su L (2015) Temporal Autocorrelation-Based Beamforming With MEG Neuroimaging Data. Journal of the American Statistical Association, 110(512), 1375-1388.
Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ , Rowe JB et al (2015) Baseline and longitudinal grey matter changes in newly diagnosed Parkinson’s disease: ICICLE-PD study. Brain, 138(10), 2974-2986.
Su L, Wyble B, Zhou L-Q, Wang K, Wang Y-N, Cheung EFC, Bowman H & Chan RCK (2015) Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions. Scientific Reports, 5(1).
Mak E, Su L, Williams GB & O'Brien JT (2015) Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease. Parkinsonism & Related Disorders, 21(8), 862-870.
Su L, Blamire AM, Watson R, He J, Aribisala B & O'Brien JT (2015) P3-003: A longitudinal and quantitative MRI study of Alzheimer's disease. Alzheimer's & Dementia, 11(7S_Part_13), P620-P620.
Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire AM & O'Brien JT (2015) P3-151: Comparing trajectories of grey matter changes in Alzheimer's disease and dementia with lewy bodies: A longitudinal study. Alzheimer's & Dementia, 11(7S_Part_15), P685-P685.
Su L, Blamire AM, Watson R, He J, Aribisala B & O'Brien JT (2015) IC-P-075: A longitudinal and quantitative MRI study of Alzheimer's disease. Alzheimer's & Dementia, 11(7S_Part_1), P54-P55.
Mak E, Su L, Williams GB, Watson R, Firbank MJ, Blamire AM & O'Brien JT (2015) Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of Aging, 36(4), 1743-1750.
Su L, Blamire AM, Watson R, He J, Aribisala B & O’Brien JT (2015) Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI. Journal of Neurology, 262(1), 165-172.
Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire AM & O'Brien JT (2015) Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. NeuroImage: Clinical, 7, 456-462.
Bozic M, Fonteneau E, Su L & Marslen-Wilson WD (2015) Grammatical analysis as a distributed neurobiological function. Human Brain Mapping, 36(3), 1190-1201.
Su L, Gomez R & Bowman H (2014) Analysing neurobiological models using communicating automata. Formal Aspects of Computing, 26(6), 1169-1204.
Mak E, Su L, Williams GB & O’Brien JT (2014) Neuroimaging characteristics of dementia with Lewy bodies. Alzheimer's Research & Therapy, 6(2), 18-18.
Lawrence EJ, Su L, Barker GJ, Medford N, Dalton J, Williams SCR, Birbaumer N, Veit R, Ranganatha S, Bodurka J , Brammer M et al (2014) Self-regulation of the anterior insula: Reinforcement learning using real-time fMRI neurofeedback. NeuroImage, 88, 113-124.
Bozic M, Tyler LK, Su L, Wingfield C & Marslen-Wilson WD (2013) Neurobiological Systems for Lexical Representation and Analysis in English. Journal of Cognitive Neuroscience, 25(10), 1678-1691.
Hu H, Su L, Xu YQ, Zhang H & Wang LW (2010) Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression. Neuroscience, 169(1), 171-181.
Su L, Bowman H, Barnard P & Wyble B (2009) Process algebraic modelling of attentional capture and human electrophysiology in interactive systems. Formal Aspects of Computing, 21(6), 513-539.
Su L, Bowman H & Barnard P (2008) Performance of Reactive Interfaces in Stimulus Rich Environments, Applying Formal Methods and Cognitive Frameworks. Electronic Notes in Theoretical Computer Science, 208, 95-111.
Bowman H, Gomez R & Su L (2005) A Tool for the Syntactic Detection of Zeno-timelocks in Timed Automata. Electronic Notes in Theoretical Computer Science, 139(1), 25-47.
Newton C, Pope M, Rua C, Henson R, Ji Z, Burgess N, Rodgers CT, Stangl M, Dounavi M, Castegnaro A , Koychev I et al () Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease. Alzheimer's & Dementia.
Payne T, Burgess T, Bradley S, Roscoe S, Sassani M, Dunning MJ, Hernandez D, Scholz S, McNeill A, Taylor R , Su L et al () Multimodal assessment of mitochondrial function in Parkinson's disease. Brain.
Baig SS, Kamarova M, Bell SM, Ali AN, Su L, Dimairo M, Dawson J, Redgrave JN & Majid A () tVNS in Stroke: A Narrative Review on the Current State and the Future. Stroke.
Kucikova L, Zeng J, Muñoz-Neira C, Muniz-Terrera G, Huang W, Gregory S, Ritchie C, O’Brien J & Su L () Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals. Journal of Neurology.
Payne T, Appleby M, Buckley E, van Gelder LMA, Mullish BH, Sassani M, Dunning MJ, Hernandez D, Scholz SW, McNeill A , Libri V et al () A double‐blind, randomized, placebo‐controlled trial of ursodeoxycholic acid (UDCA) in Parkinson's disease. Movement Disorders.
Dounavi M-E, Mak E, Swann P, Low A, Muniz-Terrera G, McKeever A, Pope M, Williams GB, Wells K, Lawlor B , Naci L et al () Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife. Journal of Cerebral Blood Flow & Metabolism, 0271678X2311735-0271678X2311735.
McKiernan E, Su L & O’Brien J () Magnetic Resonance Spectroscopy in neurodegenerative dementias, prodromal syndromes and at‐risk states: a systematic review of the literature. NMR in Biomedicine.
Mehraram R, Peraza LR, Murphy NRE, Cromarty RA, Graziadio S, O’Brien JT, Killen A, Colloby SJ, Firbank M, Su L , Collerton D et al () Functional and structural brain network correlates of visual hallucinations in Lewy body dementia. Brain.
Low A, Prats-Sedano MA, Stefaniak JD, McKiernan EF, Carter SF, Douvani M-E, Mak E, Su L, Stupart O, Muniz G , Ritchie K et al () CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study. Journal of Neurology, Neurosurgery & Psychiatry.
Liu X, Dounavi M-E, Ritchie K, Wells K, Ritchie CW, Su L, Muniz-Terrera G & O’Brien JT () Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals. Journal of Neurology.
Dounavi M-E, Low A, McKiernan EF, Mak E, Muniz-Terrera G, Ritchie K, Ritchie CW, Su L & O’Brien JT () Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study. Journal of Cerebral Blood Flow & Metabolism, 0271678X2110208-0271678X2110208.
Prats‐Sedano MA, Savulich G, Surendranathan A, Donaghy PC, Thomas AJ, Rowe JB, Su L & O'Brien JT () The revised Addenbrooke's Cognitive Examination can facilitate differentiation of dementia with Lewy bodies from Alzheimer's disease. International Journal of Geriatric Psychiatry.
Ritchie K, Carrière I, Gregory S, Watermeyer T, Danso S, Su L, Ritchie CW & O'Brien JT () Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study. Journal of Neurology, Neurosurgery & Psychiatry.
Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB , Markus HS et al () In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry.
Firbank MJ, O’Brien JT, Ritchie K, Wells K, Williams G, Su L & Ritchie CW () Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study. Journal of Neurology.
Zeng J, Liu M, Hou X, Zhang Q, Chen H & Su L () Can genes modulate anchoring effect?. International Journal of Psychology.
Qin H, Zeng J, Chen H, Deng L & Su L () Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks. Frontiers in Human Neuroscience, 12.
Su L, Huang Y, Wang Y, Rowe J & O’Brien J () Predict Disease Progression With Reaction Rate Equation Modeling of Multimodal MRI and PET. Frontiers in Aging Neuroscience, 10.
Li Z, Zhang C-Y, Huang J, Wang Y, Yan C, Li K, Zeng Y-W, Jin Z, Cheung EFC, Su L & Chan RCK () Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens.. Neuropsychology, 32(6), 764-776.
Wingfield C, Su L, Liu X, Zhang C, Woodland P, Thwaites A, Fonteneau E & Marslen-Wilson WD () Relating dynamic brain states to dynamic machine states: Human and machine solutions to the speech recognition problem. PLOS Computational Biology, 13(9), e1005617-e1005617.
Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KSJ, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS , Arnold R et al () 18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy. Brain, aww340-aww340.
Alahmadi HH, Shen Y, Fouad S, Luft CDB, Bentham P, Kourtzi Z & Tino P () Classifying Cognitive Profiles Using Machine Learning with Privileged Information in Mild Cognitive Impairment. Frontiers in Computational Neuroscience, 10.
Wang Y, Yang T-X, Su L, Yan C, Wang Y, Huang J, Fan M-X, Yin D-Z, Jin Z, Zeng Y-W , Shum DHK et al () Neural correlates of prospective memory in individuals with schizotypal personality features.. Neuropsychology, 28(3), 373-381.
Bowman H, Filetti M, Alsufyani A, Janssen D & Su L () Countering Countermeasures: Detecting Identity Lies by Detecting Conscious Breakthrough. PLoS ONE, 9(3), e90595-e90595.
Su L, Zulfiqar I, Jamshed F, Fonteneau E & Marslen-Wilson W () Mapping tonotopic organization in human temporal cortex: representational similarity analysis in EMEG source space. Frontiers in Neuroscience, 8.
Nili H, Wingfield C, Walther A, Su L, Marslen-Wilson W & Kriegeskorte N () A Toolbox for Representational Similarity Analysis. PLoS Computational Biology, 10(4), e1003553-e1003553.
Bowman H, Filetti M, Janssen D, Su L, Alsufyani A & Wyble B () Subliminal Salience Search Illustrated: EEG Identity and Deception Detection on the Fringe of Awareness. PLoS ONE, 8(1), e54258-e54258.
Su L, Bowman H & Barnard P () Glancing and Then Looking: On the Role of Body, Affect, and Meaning in Cognitive Control. Frontiers in Psychology, 2.
Suckling J, Simas T, Chattopadhyay S, Tait R, Su L, Williams G, Rowe JB & O’Brien JT () A Winding Road: Alzheimer’s Disease Increases Circuitous Functional Connectivity Pathways. Frontiers in Computational Neuroscience, 9.

Chapters

Malpetti M, Rowe JB, Su L & O'Brien JT (2023) Dementia, Advances in Magnetic Resonance Technology and Applications (pp. 321-336). Elsevier
Mavritsaki E, Bowman H & Su L (2019) Attentional Deficits in Alzheimer’s Disease: Investigating the Role of Acetylcholine with Computational Modelling, Springer Series in Cognitive and Neural Systems (pp. 113-126). Springer International Publishing
Su L, Barnard P & Bowman H (2010) On the Fringe of Awareness: The Glance-Look Model of Attention-Emotion Interactions, Artificial Neural Networks – ICANN 2010 (pp. 504-509). Springer Berlin Heidelberg
Bowman H, Su L, Wyble B & Barnard PJ () Salience sensitive control, temporal attention and stimulus-rich reactive interfaces, Human Attention in Digital Environments (pp. 114-144). Cambridge University Press

Conference proceedings papers

Su L, Fonteneau E, Marslen-Wilson W & Kriegeskorte N (2012) Spatiotemporal Searchlight Representational Similarity Analysis in EMEG Source Space. 2012 Second International Workshop on Pattern Recognition in NeuroImaging, 2 July 2012 - 4 July 2012.

Preprints

Booi L, Gregory S, Bridgeman K, Willingham K, Davies M, Agyapong N, Amfo-Antiri A, Caipa MP, Jenkins N, Eyre HA , Su L et al (2023) Protocol for the Next Generation brain health survey: an international survey of attitudes, understanding and exposure to brain health risk factors in young adults, Research Square Platform LLC.
Booi L, Gregory S, Bridgeman K, Willingham K, Davies M, Agyapong N, Amfo-Antiri A, Caipa MP, Jenkins N, Eyre H , Su L et al (2023) Protocol for the Next Generation brain health survey: an international survey of attitudes, understanding and exposure to brain health risk factors in young adults, Center for Open Science.
Ritchie CW, Wells K, Gregory S, Carriere I, Danso SO, Driscoll D, Dounavi M-E, Hillary R, Koychev I, Lawlor B , Li S et al (2023) The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia, Cold Spring Harbor Laboratory.
Chen H, Huang W, Dong X, Feng G, Wang Y, Liu Z, Ma S, Peng J, Su L & Shu N (2023) Vascular risk factors modulate gender-specific aging of brain white matter structural network, Cold Spring Harbor Laboratory.
Newton C, Pope M, Rua C, Henson R, Ji Z, Burgess N, Rodgers CT, Stangl M, Dounavi M-E, Castegnaro A , Koychev I et al (2023) Path integration selectively predicts midlife risk of Alzheimer’s disease, Cold Spring Harbor Laboratory.
Huang W, Chen H, Liu Z, Feng G, Dong X, Su L, Ma G, Zhang Z & Shu N (2023) Individual Variability in Structural Connectivity Architecture of the Human Brain across the Middle-aged and Old Adult, Cold Spring Harbor Laboratory.
Butters E, Srinivasan S, O’Brien JT, Su L & Bale G (2022) A systematic review of near-infrared spectroscopy in dementia, Cold Spring Harbor Laboratory.
Rajab MD, Jammeh E, Taketa T, Brayne C, Matthews FE, Su L, Ince PG, Wharton SB & Wang D (2022) Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, Research Square.
Rajab M, Jammeh E, Taketa T, Brayne C, Matthews F, Su L, Ince P, Wharton S & Wang D (2022) Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, medRxiv.
Wingfield C, Zhang C, Devereux B, Fonteneau E, Thwaites A, Liu X, Woodland P, Marslen-Wilson W & Su L () On the similarities of representations in artificial and brain neural networks for speech recognition, Cold Spring Harbor Laboratory.
Nicastro N, Mak E, Williams GB, Surendranathan A, Bevan-Jones WR, Passamonti L, Rodriguez PV, Su L, Arnold R, Aigbirhio FI , Rowe JB et al () Correlation of Microglial Activation with White Matter Changes in Dementia with Lewy Bodies, Cold Spring Harbor Laboratory.
Passamonti L, Tsvetanov KA, Jones PS, Bevan-Jones WR, Arnold R, Borchert RJ, Mak E, Su L, O’Brien JT & Rowe JB () Neuroinflammation and functional connectivity in Alzheimer’s disease: interactive influences on cognitive performance, Cold Spring Harbor Laboratory.
Wingfield C, Su L, Liu X, Zhang C, Woodland P, Thwaites A, Fonteneau E & Marslen-Wilson WD () Relating dynamic brain states to dynamic machine states: human and machine solutions to the speech recognition problem, Cold Spring Harbor Laboratory.

Grants

Principal funding sources:

Alzheimer’s Research UK
Alzheimer’s Society
The Lewy Body Society
Addenbrooke’s Charitable Trust
Isaac Newton Trust

School of Medicine and Population Health