Dr Robin Highley

DPhil, FRCPath

Department of Neuroscience

Senior Clinical Lecturer in Neuropathology

robin.highley@sheffield.ac.uk
+44 114 222 2244

Full contact details

Dr Robin Highley
Department of Neuroscience
Room B28
385a Glossop Road
Sheffield
S10 2HQ
Profile

I graduated in Experimental Psychology from the University of Oxford in 1993 and subsequently completed a DPhil in Oxford studying the neuropathology of Schizophrenia from which I completed in 1997.

I then trained in medicine at the University of Birmingham from 1997-2002. Following this, I moved to Sheffield, to train in neuropathology, gaining the European Fellowship of Neuropathology in 2008 and FRCPath in 2009.

On completing this training in 2009, I took up an MRC/Motor Neurone Disease Association Lady Edith Wolfson Fellowship to study Motor neurone disease. I became a Senior Clinical Lecturer in Neuropathology in 2012.

I also work as a Consultant Neuropathologist for the South and East Yorkshire Neuropathology Network, which provides diagnostic neuropathology services to the Sheffield Teaching Hospitals NHS Foundation Trust and the Hull and East Yorkshire NHS Trust.

Research interests

I am interested in the neuropathology and pathophysiology of neurodegeneration, in particular motor neurone disease (MND), Parkinson’s disease and dementia.

I use standard neuropathological techniques to characterise post mortem tissue kindly donated by individuals with these diseases and to highlight contrasts with tissue from people who were free from disease. These methods are used to study genes, proteins and molecular pathways of interest and the pathological effects of gene mutations known to neurodegeneration.

I study mouse, zebrafish and cellular models of disease and the comparison of these with human tissue based pathology.

Current projects

  1. The pathobiology and neuropathology of C9ORF72-mediated MND
  2. Oligodendrocyte disease and function in MND
  3. TIGAR-related pathology in Parkinson’s disease
  4. Zebrafish models of Parkinson’s disease
  5. The relationship between pathological and radiological measures of white matter in vascular dementia.
Publications

Journal articles

Chapters

  • Highley JR & Sullivan N (2019) Neuropathology and muscle biopsy techniques, Bancroft's Theory and Practice of Histological Techniques (pp. 306-336). Elsevier RIS download Bibtex download
  • Ince PG, Highley JR & Wharton SB (2015) Motor neuron disorders In Love S, Budka H, Ironside JW & Perry A (Ed.), Greenfield's Neuropathology (pp. 817-848). Boca Raton: CRC Press. RIS download Bibtex download
  • Highley JR & Sullivan N (2013) Techniques in neuropathology, Bancroft's Theory and Practice of Histological Techniques (pp. 353-380). Elsevier RIS download Bibtex download
  • Astbury C, Bancroft JD, Bartlett JH, Blythe D, Dunk L, Floyd AD, Gilbertson JA, Hand NM, Highley JR, Horobin RW , Hunt T et al (2013) List of contributors, Bancroft's Theory and Practice of Histological Techniques (pp. xiii-xiv). Elsevier RIS download Bibtex download
  • Highley JR & Sullivan N (2012) Techniques in neuropathology In Suvarna KS, Layton C & Bancroft JD (Ed.), Theory and Practice of Histological Techniques (pp. 352-380). Churchill Livingstone RIS download Bibtex download
  • Highley JR & Ince PG (2012) The neuropathology of the motor neurone diseases In Strong MJ (Ed.), Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias OUP Oxford RIS download Bibtex download
  • Highley JR (2012) Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias In Strong MJ (Ed.), Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias OUP Oxford RIS download Bibtex download

Conference proceedings papers

  • Appleby-Mallinder CS, Heath PR & Highley JR (2019) DNA Methylation in Amyotrophic Lateral Sclerosis. JOURNAL OF PATHOLOGY, Vol. 249 (pp S15-S15) RIS download Bibtex download
  • Waller S, Baxter L, Fillingham D, Coelho S, Pozo JM, Mozumder M, Frangi A, Ince PG, Simpson JE & Highley JR (2019) Iba-1-/CD68+microglia are a prominent feature of age-associated deep subcortical white matter lesions. Neuropathology and Applied Neurobiology, Vol. 45(S1) (pp 33-33), 6 March 2019 - 8 March 2019. View this article in WRRO RIS download Bibtex download
  • (2016) Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016. The Journal of Pathology, Vol. 240 (pp S1-S48) View this article in WRRO RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2016) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42(S1) (pp 28-28), 2 March 2016 - 4 March 2016. View this article in WRRO RIS download Bibtex download
  • Robles-Lopez KL, Bandmann O & Highley JR (2016) The role of TIGAR in Parkinson's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 34-35) RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2015) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 26-27) RIS download Bibtex download
  • Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATED WITH AN INTERMEDIATE LENGTH GGGGCC REPEAT EXPANSION HAS DISTINCT NEUROPATHOLOGY COMPARED TO PATIENTS WITH LARGER EXPANSIONS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4) RIS download Bibtex download
  • Highley JR, Cooper-Knock J, Frolov A, Charlesworth G, Kirby J, Wharton SB, Ince PG, Shaw PJ, Wood N & Bandman O (2013) A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51) RIS download Bibtex download
  • Cooper-Knock J, Highley JR, Hartley J, Milano A, Sawcer S, Compston A, Frolov A, Charlesworth G, Wood N, Bandmann O , McDermott CJ et al (2013) Neurodegeneration caused by intronic expansions of C9ORF72 is a clinically heterogeneous but pathologically distinct disease. LANCET, Vol. 381 (pp 32-32) RIS download Bibtex download
  • Ince PG, Janaway B, Wharton SB, Simpson JE, Highley JR, Matthews FE, Forster G & Brayne C (2013) Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42) RIS download Bibtex download
  • Green NH, Nicholls Z, Heath PR, Highley JR, Cooper-Knock J, Corfe BM, Wilson JH, Rattray M, Liu X, MacNeil S & Bury JP (2012) Barrett's Metaplasia: Exploiting a Tissue-engineered Model to Understand the Response of the Oesophageal Squamous Mucosa to Bile and Acid Exposure. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3) RIS download Bibtex download
  • Highley JR, Smith O, Brockington A, Kirby J, Wharton SB, Spillantini M, Lowe JS, Layfield R, Shaw PJ & Ince PG (2007) Extra-motor manifestations of motor neurone disease and the role of TDP43 in ALS variants. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 264-265) RIS download Bibtex download
  • Hosny O, Highley JR, Simpson JE, Forster G, Wharton SB & Ince PG (2007) Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267) RIS download Bibtex download
  • Crow TJ, Highley R, McDonald B, Walker M & Esiri MM (1998) Deviations in brain structure as pointers to the role of asymmetry and sex in the genetics of schizophrenia.. AMERICAN JOURNAL OF MEDICAL GENETICS, Vol. 81(6) (pp 533-533) RIS download Bibtex download
Teaching activities

I teach neuropathology and neuroanatomy to medical students as well as orthoptics students and postgraduate psychiatry trainees.