Suman De

Department of Neuroscience

Research Fellow

UKRI Future Leaders Fellow

Suman De
s.de@sheffield.ac.uk
+44 114 21 59107

Full contact details

Suman De
Department of Neuroscience
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
Research interests

Identification and characterisation of protein complexes, aggregates and post-translational modifications in human is essential for understanding the underlying mechanism of a range of neurodegenerative disease including Alzheimer’s disease, Parkinson disease and Amyotrophic Lateral Sclerosis. In all these diseases, physiological form of proteins such as amyloid-β, α-synuclein, Tar DNA binding protein-43, under specific conditions, aggregate into a range of soluble complexes, and ultimately polymerising into insoluble fibrils to deposit in the specific parts of the central nervous system. These diseases associated proteins can potentially aggregate into many different forms, consisting of different numbers of peptides, with multiple possible post-translational modifications and co-aggregating species. Since the structural and compositional heterogeneities of these protein aggregate correlate with the disease type and severity, determination of specific molecular details of individual pathogenic aggregates is of vital importance. 

In our group, we develop and apply novel imaging-based biophysical methodologies to identify and characterise these disease-associated protein aggregates at the single-molecule level with the goal of identifying the structural determinants of their pathogenicity, determining the primary molecular events that trigger their formation and finally, finding the right molecular approach to prevent their formation, block their neurotoxic effects or enhance their clearance. Single-molecule characterisation of these individual aggregates is crucial, especially in a scenario where toxicity may arise from a specific type of species, conformation, or pathways. By studying aggregation and propagation of disease-relevant proteins at the highest level of sensitivity, we aim to understand molecular mechanism underpinning various neurological disorders such as Alzheimer’s disease, Parkinson disease and Amyotrophic Lateral Sclerosis.

Current ProjectS

  1. Interaction of Amyloid-β and Apolipoprotein in Alzhimer’s disease
  2. Protein-aggregate membrane interaction in health and disease
  3. Misfolded and aggregated conformational strains in Neurodegenerative Diseases
  4. Identificaton and charecterisation of protein aggregates in human biofluids and post-mortem tissue 
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Grants

2022-2026: UKRI Future Leaders Fellowship

2021-2023: AMS Springboard Award

2019: Pilot Grant funded by Dementia Research Institute UK

2019: Pilot Grant funded Alzheimer’s Research UK

2016: Marie Curie Individual Fellowship funded by European Union