Professor Claire Lewis

Department of Oncology and Metabolism

Professor of Molecular & Cellular Pathology

Research Director, Weston Park Cancer Centre

Visiting Professor, Leiden University, The Netherlands

claire.lewis@sheffield.ac.uk
+44 114 215 9012

Full contact details

Professor Claire Lewis
Department of Oncology and Metabolism
Floor E
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

After completing my DPhil (PhD) in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, I held two postdoctoral positions and a Lectureship in the Medical School there before moving to join the Medical School in Sheffield in 1996.

I currently hold a Personal Chair in Molecular & Cellular Pathology and head a team of pre and postdoctoral scientists in the Academic Unit of Inflammation and Tumour Targeting.

I was awarded a DSc by Oxford University in 2006 for my contribution to the field of tumour inflammation research.

Research interests

Our research is focused mainly on the role of inflammatory cells called macrophages in tumour progression and responses to conventional anti-cancer treatments like chemotherapy and irradiation.

We have also developed ways of using these cells to target therapeutic genes and viruses to tumours. Our work was reported in the national press (http://www.bbc.co.uk/news/health-20795977,) and is mainly funded by grants from Breast Cancer Now, Prostate Cancer UK, The European Union, Cancer Research UK and Team Verrico.

Publications

Books

  • Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell. RIS download Bibtex download

Journal articles

Chapters

  • Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell RIS download Bibtex download

Conference proceedings papers

Research group

Members of the AUITT

  • Professor Claire Lewis
  • Dr Munitta Muthana (Senior Lecturer)
  • Dr Mohammed Ridha (Postdoc)
  • Dr Haider Al-Janabi (Postdoc)
  • Dr Jenny Down (Postdoc)
  • Dr Xuan Pu (Postdoc)
  • Dr Faith Howard (Postdoc)
  • Dr Amy Kwan (Clinical Research Fellow & PhD Student)
  • Christine Hospach (ECR & PhD Student)
  • Richard Allen (PhD Student)
  • Areej Alghamdi (PhD Student)
  • Natalie Winder (PhD Student)
  • Rita Dey (SHU Placement Student)
Teaching interests
  • Acute and chronic inflammation
  • Angiogenesis in human diseases
  • Cancer
Professional activities

Journals

  • Member of the Editorial Board, Cancer Research.
  • Member of the Editorial Board, Journal of Clinical Investigation Insight.
  • Member of the Editorial Board, OncoImmunology.
  • Member of the Editorial Board, International Journal of Cancer.
  • Associate Editor, International Journal of Experimental Pathology.

Grant Awarding Bodies

  • Member, MRC Molecular & Cellular Medicines Board (April 2018 onwards).
  • Member, PCUK Research Advisory Committee (October 2019 onwards).
  • Member, Quinquennial Review Panel, MRC Human Immunology Unit, Oxford, Nov. 2016.
  • Member, Quinquennial Review Panel, Breast Cancer Now Manchester Research Unit, Feb. 2016.
  • Member, Senior Investigator Awards Committee, The Wellcome Trust, (2013).
  • Member of 3 Scientific Advisory Boards: ‘Cancer Immunotherapy’, Tumour Inflammation’ and ‘Metastasis’ for the Cancer Section of EU Framework 7 (2007- present).
  • Member, International Science Evaluation Panel (for biology, medicine and health), The Research Council, Norway (2011).
  • Member, AACR Basic Cancer Research Grants Scientific Review Committee (2010).
  • Chair, BBSRC Review Panel in Interdisciplinary Research (2005).
  • MRC College of Experts - Molecular and Cellular Medicine Board, (2004-current).
  • EPSRC Peer Review College (2006-2009).
  • Member, Scientific Advisory Board, Breast Cancer Campaign (1999-2002)