Dr Mark Fenwick

BSc (Hons), PhD, PGCertHE, SFHEA

Department of Oncology and Metabolism

Senior Lecturer

Mark Fenwick
m.a.fenwick@sheffield.ac.uk
+44 114 215 9664

Full contact details

Dr Mark Fenwick
Department of Oncology and Metabolism
Level 4, JW4 57
Jessop Wing
Tree Root Walk
Sheffield
S10 2SF
Profile

I obtained my BSc (Hons) and PhD (2004) from the University of Otago in Dunedin, New Zealand. After that I came to the UK, where I undertook two Postdoctoral positions in London - firstly at the Royal Veterinary College looking at the effect of negative energy balance on reproduction in dairy cows (2005-2007), and then Imperial College London working on projects relating to early follicle development in the ovary (2007-2012).

I joined the University of Sheffield in December 2012 as a lecturer in the Academic Unit of Reproductive and Developmental Medicine.

Research interests

The ovary is an incredibly dynamic organ that is constantly producing and responding to internal molecular ‘cues’. Both environmental and genetic factors can exert influences on these internal signals, leading to dysregulation or failure of oocytes to develop. We are interested in understanding how these cues (i) coordinate the development of oocytes for ovulation and (ii) produce steroid hormones for other reproductive processes. For this, we use molecular tools and microscopic imaging to investigate these details in ovarian cells and tissue cultures (see link on right). Our research is motivated by its translational potential within the clinical context of infertility and disorders that affect follicle development such as endometriosis, premature ovarian failure and polycystic ovary syndrome.

Current projects:

  • Molecular mechanisms regulating TGFβ signalling during early follicle development
  • Modelling spatial relationships in the ovary to elucidate mechanisms of early follicle growth
  • Regulation of AMH expression and role of AMH during early development
  • Effect of endometriosis on ovarian function and fertility
  • Effects of nicotine and derivatives from e-cigarettes on the ovarian reserve
Publications

Journal articles

Conference proceedings papers

  • Idrees S, Fenwick M & Pacey A (2019) Examining the effect of nicotine on a mouse model of the ovarian reserve. HUMAN REPRODUCTION, Vol. 34 (pp 457-457) RIS download Bibtex download
Research group
  • Isam Sharum
  • Sallwa Alshehre
  • Sara Idrees
  • Sofia Aparici
Teaching interests

I am the Course Leader for the MSc in Reproductive and Developmental Medicine since its inception in 2013 (see link). Within this course I lead and provide teaching on the Gonads to gametes: fundamentals of reproduction module. I also co-lead the Research project module on this course and provide ongoing training to BSc, MBChB, MSc and PhD research students. I am also the co-PGR lead for the Department of Oncology & Metabolism.

Professional activities
  • Member Editorial Board Scientific Reports
  • Member Editorial Board (Section Editor) Reproductive Biomedicine Online
  • Member of Council Society for Reproduction and Fertility (SRF)
  • External reviewer for a number of international journals in reproductive biology
  • External reviewer for funding bodies (e.g. BBSRC, MRC etc)
  • External Examiner, Reproductive Biology Honours, University of Edinburgh