Dr Mark Fenwick
BSc (Hons), PhD, PGCertHE, SFHEA
Department of Oncology and Metabolism
+44 114 215 9664
Full contact details
Department of Oncology and Metabolism
Level 4, JW4 57
Tree Root Walk
I obtained my BSc (Hons) and PhD (2004) from the University of Otago in Dunedin, New Zealand. After that I came to the UK, where I undertook two Postdoctoral positions in London - firstly at the Royal Veterinary College looking at the effect of negative energy balance on reproduction in dairy cows (2005-2007), and then Imperial College London working on projects relating to early follicle development in the ovary (2007-2012).
I joined the University of Sheffield in December 2012 as a lecturer in the Academic Unit of Reproductive and Developmental Medicine.
- Research interests
The ovary is an incredibly dynamic organ that is constantly producing and responding to internal molecular ‘cues’. Both environmental and genetic factors can exert influences on these internal signals, leading to dysregulation or failure of oocytes to develop. We are interested in understanding how these cues (i) coordinate the development of oocytes for ovulation and (ii) produce steroid hormones for other reproductive processes. For this, we use molecular tools and microscopic imaging to investigate these details in ovarian cells and tissue cultures (see link on right). Our research is motivated by its translational potential within the clinical context of infertility and disorders that affect follicle development such as endometriosis, premature ovarian failure and polycystic ovary syndrome.
- Molecular mechanisms regulating TGFβ signalling during early follicle development
- Modelling spatial relationships in the ovary to elucidate mechanisms of early follicle growth
- Regulation of AMH expression and role of AMH during early development
- Effect of endometriosis on ovarian function and fertility
- Effects of nicotine and derivatives from e-cigarettes on the ovarian reserve
- SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles. Scientific Reports, 9. View this article in WRRO
- Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary. Journal of Cell Science, 131(17). View this article in WRRO
- Androgen stimulates growth of mouse preantral follicles in vitro: Interaction with follicle-stimulating hormone and with growth factors of the TGFβ super family. Endocrinology, 158(4), 920-935. View this article in WRRO
- Serine threonine kinase receptor associated protein regulates early follicle development in the mouse ovary.. Reproduction, 153(2), 221-231. View this article in WRRO
- Onset and Heterogeneity of Responsiveness to FSH in Mouse Preantral Follicles in Culture. Endocrinology, 158(1), 134-147. View this article in WRRO
- Investigations of TGF-β signaling in preantral follicles of female mice reveal differential roles for bone morphogenetic protein 15. Endocrinology, 154(9), 3423-3436.
- Influence of energy balance on the antimicrobial peptides S100A8 and S100A9 in the endometrium of the post-partum dairy cow.. Reproduction, 145(5), 527-539. View this article in WRRO
- Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.. Genes Dev, 26(13), 1445-1458.
- Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles.. Biol Reprod, 86(5), 153-14.
- Identification and regulation of bone morphogenetic protein antagonists associated with preantral follicle development in the ovary.. Endocrinology, 152(9), 3515-3526.
- Moderate Inhibition of Bone Morphogenetic Protein (BMP) Signaling Induces Rapid Growth of Cultured Preantral Follicles.. Biology of Reproduction, 85(Suppl_1), 659-659.
- Influence of energy balance on the somatotrophic axis and matrix metalloproteinase expression in the endometrium of the postpartum dairy cow.. Reproduction, 141(2), 269-281. View this article in WRRO
- Expression and Regulation of Bone Morphogenetic Protein (BMP) Antagonists in Mouse Preantral Follicles.. Biology of Reproduction, 83(Suppl_1), 62-62.
- IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells.. Reproduction, 139(1), 139-151.
- Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows.. Physiol Genomics, 39(1), 1-13.
- Object recognition in the ovary: Quantification of oocytes from microscopic images. DSP 2009: 16th International Conference on Digital Signal Processing, Proceedings.
- Interrelationships between negative energy balance (NEB) and IGF regulation in liver of lactating dairy cows.. Domest Anim Endocrinol, 34(1), 31-44.
- Negative energy balance in dairy cows is associated with specific changes in IGF-binding protein expression in the oviduct.. Reproduction, 135(1), 63-75.
- Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow.. Theriogenology, 68 Suppl 1, S232-S241.
- Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells.. Reproduction, 133(1), 11-19.
- Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation.. Endocrinology, 147(10), 4996-5005.
- Caspase-3, TUNEL and ultrastructural studies of small follicles in adult human ovarian biopsies.. Hum Reprod, 21(8), 1974-1980.
- Otago glaucoma surgery outcome study: cytology and immunohistochemical staining of bleb capsules around Molteno implants.. Invest Ophthalmol Vis Sci, 47(5), 1975-1981.
- Immunohistochemical localization of active caspase-3 in the mouse ovary: growth and atresia of small follicles.. Reproduction, 124(5), 659-665.
Conference proceedings papers
- Research group
- Isam Sharum
- Sallwa Alshehre
- Sara Idrees
- Sofia Aparici
- Teaching interests
I am the Course Leader for the MSc in Reproductive and Developmental Medicine since its inception in 2013 (see link). Within this course I lead and provide teaching on the Gonads to gametes: fundamentals of reproduction module. I also co-lead the Research project module on this course and provide ongoing training to BSc, MBChB, MSc and PhD research students. I am also the co-PGR lead for the Department of Oncology & Metabolism.
- Professional activities
- Member Editorial Board Scientific Reports
- Member Editorial Board (Section Editor) Reproductive Biomedicine Online
- Member of Council Society for Reproduction and Fertility (SRF)
- External reviewer for a number of international journals in reproductive biology
- External reviewer for funding bodies (e.g. BBSRC, MRC etc)
- External Examiner, Reproductive Biology Honours, University of Edinburgh