Dr Spencer Collis

Department of Oncology and Metabolism

Reader in Genome Stability

Head of the Genome Stability Group

Staff Spencer Collis
s.collis@sheffield.ac.uk
+44 114 215 9043

Full contact details

Dr Spencer Collis
Department of Oncology and Metabolism
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

1994 - 1997
BSc (Hons): Biochemistry, UMIST

1997 - 2000
PhD: Oncology, CRUK Paterson Institute for Cancer Research

2001 - 2004
Post-Doc: Prof. Theodore DeWeese laboratory, Johns Hopkins University

2004 - 2009
Post-Doc: Dr Simon Boulton laboratory, Clare Hall Laboratories, CRUK London Research Institute

2009 - 2013
Group leader: Institute for Cancer Studies, University of Sheffield

2013 - 2015
Senior Lecturer: Academic unit of Molecular Oncology, Department of Oncology, University of Sheffield

2016 -
Reader:  Academic unit of Molecular Oncology, Department of Oncology, University of Sheffield

Research interests

The overarching research goals of the Collis laboratory is to identify and functionally characterise novel factors that are important for the maintenance of genome integrity in human cells. This research also aims to establish if such factors are novel drug targets and/or biomarkers that can be exploited to improve the treatment of diseases such as cancer, either alone, or in combination with existing chemo- and/or radio-therapeutic regimes. To achieve this, the Collis group collaborate with a range of national and international scientists and clinicians to maximise the potential therapeutic impact of their basic biological discoveries.

Funding Sources

Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

  • Marples B, Krueger SA, Collis SJ & Joiner MC (2008) Low dose hyper-radiosensitivity; an historical perspective In Stigbrand T, Carlsson J & Adams GP (Ed.), Targeted Radionuclide Tumor Therapy: Biological Aspects (pp. 329-348). Springer RIS download Bibtex download
  • Collis SJ (2007) Molecular targeting of DNA repair; A means to improve therapeutic index. In Landseer BR (Ed.), New Research on DNA Repair Nova Biomedical RIS download Bibtex download

Conference proceedings papers

  • Rominiyi MO, Gomez-Roman DN, Al-Tamimi MY, Jellinek MDA, Chalmers PAJ, Carroll MTA, Chen PB & Collis DS (2018) FA-based combinations to target the DNA damage response in glioblastoma. Neuro-Oncology, Vol. 20(suppl_5) (pp v358-v358). Winchester, UK, 4 July 2018 - 6 July 2018. View this article in WRRO RIS download Bibtex download
  • Rominiyi O, Gomez-Roman N, Lad N, Al-Tamimi Y, Jellinek DA, Chalmers AJ, Carroll TA, Chen B & Collis SJ (2018) PRECLINICAL EVALUATION OF COMBINATIONS TARGETING THE DNA DAMAGE RESPONSE IN 2D AND 3D MODELS OF GLIOBLASTOMA STEM CELLS. NEURO-ONCOLOGY, Vol. 20 (pp 297-297) RIS download Bibtex download
  • Marples B, Krueger SA, Wilson TG, Dabjan MB, Lee KC, Hymas RV, Wilson GD & Collis SJ (2016) Improving the Efficacy of Pulsed Radiation Therapy Using DNA Repair Inhibitors: A Preclinical Study. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 96(2) (pp E566-E567) View this article in WRRO RIS download Bibtex download
  • Patil AA, Hua P, Sellwood MA, Jellinek DA, Carroll TA, Chen B & Collis SJ (2015) IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF THE FANCONI ANAEMIA DNA REPAIR PATHWAY AS A MEANS TO SENSITISES GLIOBLASTOMAS TO CHEMOTHERAPEUTIC AGENTS. NEURO-ONCOLOGY, Vol. 17 (pp 20-20) RIS download Bibtex download
  • DeWeese TL, Collis SJ, Lupold SE, Chowdury W, Kudrolli T, Swartz M & Rodriguez R (2007) Optimization of siRNA-transgene expression in adenoviral vector systems for radiation sensitizing strategies. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 69(3) (pp S595-S596) RIS download Bibtex download
  • Collis SJ, Barber LJ, Martin JS, Ward JD & Boulton SJ (2006) HCLK2 couples FANCD2 to stalled replication forks and functions in the mammalian S-phase checkpoint. BREAST CANCER RESEARCH, Vol. 8 (pp S6-S6) RIS download Bibtex download
Research group

Research Group

  • Dr. Katie Myers (Research Assistant/Lab Manager)
  • Mr. Ola Rominiyi (Clinical PhD student)
  • Abhijit Patil (PhD student)
  • Aurelie Vanderlinden Dibekeme (PhD student)
  • Connor McGarrity-Cottrell (PhD student)
  • Hannah Gagg (PhD student with Thomas Helleday)
  • Iris Bierith (PhD student with Stephen Brown)
  • Rebecca Livesey (PhD student with Fred Claeyssens)
  • George Duffield (MRes student)
Teaching interests

M.Sc. Molecular Medicine
M.Sc. Translational Oncology
MSc Genomic Medicine