Endocrinology

The Endocrinology theme has strengths in adrenal disease and neuroendocrine tumours with new drugs in development from the bench through clinical trials to market authorisation in partnership with our spinout companies.

The pituitary gland

Diabetes research is focused on three aspects: hypoglycaemia, in particular its effects on the cardiovascular system; educating patients on self-management (for example, DAFNE project); and the effect of diabetes on the central nervous system. Our laboratories have excellent facilities for a wide range of biochemical, cell culture and molecular biological techniques and we undertake clinical trials in the state of the art clinical research facility.

Meet the team

Child Health

Professor Nick Bishop

Email: n.j.bishop@sheffield.ac.uk

Research aims to improve outcomes for children with inherited and acquired bone diseases and understand better the factors contributing to fracture in apparently healthy children.

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Dr Charlotte Elder

Charlotte Elder’s main research has been in the development of a non-invasive Short Synacthen Test for adrenal insufficiency, with a novel formulation of Synacthen for nasal administration and the measurement of the glucocorticoid response in saliva samples. She has led a team over five pharmacokinetic studies in adults and children. There is a patent application filed for the novel formulation and both commercial and research arms to the current workstream.
Her other research interests include a cross-discipline bioengineering project developing pubertal simulation tools for training purposes, which has evolved into a public engagement study of male sexual health seeking behaviours.

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Dr Nils Krone

Email: n.krone@sheffield.ac.uk

Inborn errors of steroidogenesis, congenital adrenal hyperplasia, disorders of sex development (DSD), and PCOS; his main interests are on inborn errors of steroid hormone biosynthesis and steroid hormone metabolism ini health and disease.

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Dr Amaka Offiah

Email: a.offiah@sheffield.ac.uk

Optimisation of current techniques and development of novel methods of distinguishing brittle from normal bones, in understanding the mechanisms of accidental injury in children, in developing objective imaging biomarkers and normative data for the paediatric musculoskeletal system including post-mortem imaging and in diagnosing fractures in the Emergency Department.

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Diabetes, Endocrinology and Metabolism

Dr Jackie Elliott

Email: j.elliott@sheffield.ac.uk

Research interests include complex interventions for patients with diabetes. Interventions to examine the best way in which to deliver education to different patient groups, e.g. those with hypoglycaemia unawareness, or young people,, and how best to integrate technology, e.g. the use of insulin pumps, physical activity monitors, etc.

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Professor Simon Heller

Email: s.heller@sheffield.ac.uk

Pathophysiology of hypoglycaemia in diabetes, the contribution of hypoglycaemia to the increased risk of sudden death in young people with Type 1 diabetes (the 'dead in bed' syndrome), the clinical benefits of insulin analogues and trials of complex interventions to enable more effective self-management in people with diabetes.

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Dr Catarina Henriques

Email: c.m.henriques@sheffield.ac.uk

Research focused on understanding the interplay between immune regulation and tissue homeostasis in health and with ageing, using zebrafish as a model.

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Professor John Newell-Price

Email: j.newellprice@sheffield.ac.uk

The focus of his research is glucocorticoids. His group has identified important aspects of epigenetic regulation of proopiomelanocortin, the key regulator of the hypothalamic-pituitary-adrenal axis, and now is using this information to design strategies to modify over-expression in conditions of excess hormone secretion, such as Cushing's disease.

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Professor Richard Ross

Email: r.j.ross@sheffield.ac.uk

The focus of both my clinical and basic research is on optimising pituitary hormone replacement.

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Dr Philip Watson

Email: p.f.watson@sheffield.ac.uk

My main research interests centre on the aetiology of endocrine autoimmune disease, with a particular focus on the thyroid.

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Human Nutrition

Dr Bernard Corfe

Email: b.m.corfe@sheffield.ac.uk

Work in my group examines the relationship between diet, short-chain fatty acid production and metabolism and cell fate in the normal and neoplastic colon.

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Dr Elizabeth Williams

Email: e.a.williams@sheffield.ac.uk

Long-standing research interest in diet and intestinal health and, in particular, biomarkers of colorectal cancer, and the role of butyrate and folate on colorectal carcinogenesis.

Also research interest in the nutrition, health and wellbeing of older adults. This includes an interest in the relationship between diet, immune function and ageing, and the assessment of dietary intake in older adults.

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Flagship institutes

The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.