Dr Claire Garwood, PhDClaire Garwood

Alzheimer’s Society Junior Research Fellow

Department of Neuroscience
Sheffield Institute for Translational Neuroscience
University of Sheffield
385a Glossop Road
Sheffield
S10 2HQ

Telephone: +44 (0)114 22 22272
Fax: +44 (0)114 22 22290
Email: c.garwood@sheffield.ac.uk

Biography

2015-present: Alzheimer Society Junior Research Fellow
2011-2015: Post-doctoral Research Associate
2007-2010: PhD (Neuroscience), Institute of Psychiatry, Kings College London.
2009-2010: Research Assistant, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, Kings College London.

I obtained my PhD in Neuroscience from Kings College London in 2010 where I determined that astrocytes mediate many of the toxic effects of beta-amyloid, one of the pathological proteins implicated in Alzheimer’s disease pathogenesis, and that minocycline was able to reduce the inflammatory response of astrocytes in Alzheimer’s disease models (Garwood et al., Cell Death Dis 2.e167; Garwood et al., Front. Psychiatry 1:136; Noble et al., FASEB J. 23(3): 739-750.)

After completing my PhD I moved to the Sheffield Institute for Translational Neuroscience to continue investigating the role of astrocytes in Alzheimer’s disease pathogenesis as a post-doctoral research associate with Prof. Stephen Wharton.
I have recently been awarded an Alzheimer’s Society Junior Research Fellowship based within the Sheffield Institute for Translational Neuroscience (SITraN) to continue working on the role astrocytes in Alzheimer’s disease and to develop a 3D astrocyte-neuron co-culture system in collaboration with Prof. John Haycock in the Department of Bioengineering.

Research

My research is focused on understanding the role of astrocytes in neurodegeneration, particularly their contribution to Alzheimer’s disease development and progression. In particular I am investigating how alterations in specific astrocytic signalling pathways compromises their function and their ability to support neurons.

Teaching

I teach on the MSc courses in Translational Neuroscience, Translational Pathology and Molecular Medicine focussing on molecular neuroscience including experimental design to study protein expression and critical review of the literature teaching. I also supervise MSc and BMedSci students during their research projects.

Research Team

  • Laura Ratcliffe (2nd Year PhD Student)
  • Research Technician (to be appointed)

Current Projects

  • Consequences of impaired insulin signalling in Alzheimer’s disease.
  • Development of a 3D neural co-culture system.

Funding

Dr Garwood’s research is funded by the Alzheimer’s Society and the University of Sheffield.

Collaborations

Prof. John Haycock, Department of Bioengineering, University of Sheffield

Awards

Faculty of Medicine Early Career Researcher Award 2015: Outstanding contributions to excellence in enhancing the research environment within the faculty

Journal articles

Conference proceedings papers

  • Seehra RS, Wharton S, Heath P, Ince P, Muthana M, Garwood C & Simpson J (2018) Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood CJ, Ince PG, Heath PR & Wharton SB (2017) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43) RIS download Bibtex download
  • Ratcliffe L, Garwood CJ, Heath P, Villasenor I, Simpson J, Ince PG & Wharton SB (2016) Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2016) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2015) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32) RIS download Bibtex download
  • Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB & Ageing MRCCF (2015) A reduced astrocyte response to beta-amyloid plaques in the ageing brain associates with dementia and cognitive impairment. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 30-31) View this article in WRRO RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32) RIS download Bibtex download
  • Simpson J, Ince P, Heath P, Raman R, Shaw P, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G, Brayne C, Wharton S & MRC Cognitive Function Ageing (2010) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46) RIS download Bibtex download