Dr Julie Simpson

Journal articles

• Floare M-L, Wharton SB, Simpson JE, Aeschlimann D, Hoggard N & Hadjivassiliou M (2024) Cerebellar degeneration in gluten ataxia is linked to microglial activation. Brain Communications, 6(2). View this article in WRRO
• Mistry H, Richardson CD, Higginbottom A, Ashford B, Ahamed SU, Moore Z, Matthews FE, Brayne C, Simpson JE & Wharton SB (2024) Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort. Neuroscience Research.
• Waller R, Hase Y, Simpson JE, Heath PR, Wyles M, Kalaria RN & Wharton SB (2022) Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures.. Transl Stroke Res.
• Matuszyk MM, Garwood CJ, Ferraiuolo L, Simpson JE, Staniforth RA & Wharton SB (2021) Biological and methodological complexities of beta‐amyloid peptide; implications for Alzheimer’s disease research. Journal of Neurochemistry. View this article in WRRO
• Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes J, Haris H, Henderson FE, Matthews FE , Richardson CD et al (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer’s and small vessel disease pathologies. Brain Pathology, 31(3). View this article in WRRO
• Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB (2021) Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1).
• Almasnouri TS, Hamilton N, Heath P, van Eeden Van Eeden F & Simpson JE (2020) Hypoxia‐induced changes in microglia in the vhl ‐/‐ zebrafish. Alzheimer's & Dementia, 16(S3).
• MacGregor Sharp M, Saito S, Keable A, Gatherer M, Aldea R, Agarwal N, Simpson JE, Wharton SB, Weller RO & Carare RO (2020) Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia. Acta Neuropathologica Communications, 8(1). View this article in WRRO
• Ashford BA, Boche D, Cooper‐Knock J, Heath PR, Simpson JE & Highley JR (2020) Review: Microglia in motor neuron disease. Neuropathology and Applied Neurobiology. View this article in WRRO
• Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C (2020) Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function.. Brain, Behavior, & Immunity - Health, 5. View this article in WRRO
• Waller R, Mandeya M, Viney E, Simpson JE & Wharton SB (2020) Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex. Neuropathology. View this article in WRRO
• Fadul MM, Garwood CJ, Waller R, Garrett N, Heath PR, Matthews FE, Brayne C, Wharton SB & Simpson JE (2020) NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21(1). View this article in WRRO
• Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC & Simpson JE (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20(20). View this article in WRRO
• Goodall EF, Leach V, Wang C, Cooper-Knock J, Heath PR, Baker D, Drew DR, Saffrey MJ, Simpson JE, Romero IA & Wharton SB (2019) Age-associated mRNA and miRNA expression changes in the blood-brain barrier. International Journal of Molecular Sciences, 20(12). View this article in WRRO
• Vazquez‐Villaseñor I, Garwood CJ, Heath PR, Simpson JE, Ince PG & Wharton SB (2019) Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease. Neuropathology and Applied Neurobiology. View this article in WRRO
• Mozumder M, Pozo JM, Coelho S, Constantini M, Simpson J, Highley JR, Ince PG & Frangi AF (2019) Quantitative histomorphometry of capillary microstructure in deep white matter. NeuroImage Clinical, 23. View this article in WRRO
• Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG & Frangi AF (2019) Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations. Data in Brief, 23. View this article in WRRO
• López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O & Highley JR (2019) TIGAR inclusion pathology is specific for Lewy body diseases. Brain Research, 1706, 218-223. View this article in WRRO
• Ameen-Ali K, Simpson J, Wharton S, Heath P, Sharp P, Brezzo G & Berwick J (2019) The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
• Waller R, Baxter L, Fillingham DJ, Coelho S, Pozo JM, Mozumder M, Frangi AF, Ince PG, Simpson JE & Highley JR (2019) Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions. PLoS ONE, 14(1). View this article in WRRO
• Waller R, Murphy M, Garwood C, Jennings L, Heath P, Chambers A, Matthews F, Brayne C, Ince P, Wharton S & Simpson J (2018) Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain. Glia, 66(11), 2316-2323. View this article in WRRO
• Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ & Wharton SB (2018) Loss of IGF1R in human astrocytes alters complex I activity and support for neurons.. Neuroscience, 390, 46-59. View this article in WRRO
• Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG & Frangi AF (2018) Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter. NeuroImage, 179, 275-287. View this article in WRRO
• Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaquéz-Villaseñor I, Minshull TC, Ince PG , Dickman MJ et al (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47(12), 1444-1456. View this article in WRRO
• Simpson JE, Wharton S, Brayne C, Matthews F, Heath P & Ince P (2018) S5-01-01: AGEING AND NEUROIMMUNOLOGY: WHITE MATTER PATHOLOGY. Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624.
• Ajikumar A, Ridger V, Heath P, Wharton S, Ince P & Simpson JE (2018) P4-059: NEUTROPHIL-DERIVED MICROVESICLE-INDUCED BLOOD BRAIN BARRIER DYSFUNCTION: A POTENTIAL MECHANISM LINKING SYSTEMIC INFLAMMATION AND DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
• Goodall EF, Wang C, Simpson JE, Baker DJ, Drew DR, Heath PR, Saffrey MJ, Romero IA & Wharton SB (2018) Age‐associated changes in the blood‐brain barrier: comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44(3), 328-340. View this article in WRRO
• Simpson JE, Wharton SB & Heath PR (2018) Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain, 273-284.
• Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P & Berwick J (2017) Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
• Garwood CJ, Ratcliffe LE, Simpson JE, Heath PR, Ince PG & Wharton SB (2017) Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and Applied Neurobiology, 43(4), 281-298. View this article in WRRO
• Tu WY, Simpson JE, Robin Highley J & Heath PR (2017) Spinal muscular atrophy: Factors that modulate motor neurone vulnerability.. Neurobiology of Disease. View this article in WRRO
• Simpson JE, Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas R, Rounding N & Sharrack B (2016) Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299, 139-146. View this article in WRRO
• Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG & Heath PR (2016) Expression microdissection isolation of enriched cell populations from archival brain tissue. Journal of Neuroscience Methods, 268, 125-130. View this article in WRRO
• Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C , Rattray M et al (2016) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology, 42(2), 167-179. View this article in WRRO
• Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG & Wharton SB (2015) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8(1). View this article in WRRO
• Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ , Wharton SB et al (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609, 11-17. View this article in WRRO
• Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG & Wharton SB (2015) Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathology, 25(5), 565-574. View this article in WRRO
• Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A & Wharton SB (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41(4), 483-496. View this article in WRRO
• Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SMA, Hirst MC, de Vries HE, Sharrack B , Baker D et al (2015) Brain Endothelial miR-146a Negatively Modulates T-Cell Adhesion through Repressing Multiple Targets to Inhibit NF-κB Activation. Journal of Cerebral Blood Flow & Metabolism, 35(3), 412-423.
• Wharton SB, Simpson JE, Brayne C & Ince PG (2015) Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study. Brain Pathology, 25(1), 35-43.
• Asi YT, Lees AJ, Revesz T, Holton JL, Simpson JE, Heath PR, Wharton SB & Houlden H (2014) Alpha-synuclein mRNA expression in oligodendrocytes in MSA. GLIA. View this article in WRRO
• Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B , Baker D et al (2014) MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.. FASEB J, 28(6), 2551-2565.
• Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG , Wharton SB et al (2014) DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.. Neuropathol Appl Neurobiol, 40(7), 802-814.
• Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, O'Brien JT, Barber R, Kalaria RN, Brayne C, Lewis CE , Shaw PJ et al (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Journal of Aging Science, 2(1). View this article in WRRO
• Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB , Ince PG et al (2014) Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.. Neuropathol Appl Neurobiol, 40(3), 258-269. View this article in WRRO
• Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE , Brayne C et al (2013) Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.. Neuropathol Appl Neurobiol, 39(7), 788-799.
• Stephan BCM, Wharton SB, Simpson J, Matthews FE, Ince P & Brayne C (2012) The epidemiological neuropathology of dementia and the implications for drug development. Neurodegenerative Disease Management, 2(5), 471-482.
• Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE & Wharton SB (2012) Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.. Dement Geriatr Cogn Disord, 34(1), 15-24.
• Waller R, Woodroofe MN, Francese S, Heath PR, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection.. J Neurosci Methods, 208(2), 108-113.
• Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. NEUROBIOL AGING, 32(10), 1795-1807.
• Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.. Neurosci Lett, 505(1), 25-30.
• Simpson J, Ince P, Heath P, Raman R, Garwood C, Shaw P, Gelstorpe C, Baxter L, Forster G, Fiona M , Savva G et al (2011) P3-156: Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype. Alzheimer's & Dementia, 7, S566-S566.
• Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG & Medical Research Council Cognitive Function and Aging Study (2011) Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.. J Alzheimers Dis, 25(2), 359-372.
• Gebril OH, Simpson JE, Kirby J, Brayne C & Ince PG (2011) Brain iron dysregulation and the risk of ageing white matter lesions. NeuroMolecular Medicine, 13(4), 289-299.
• Gebril OH, Simpson JE, Kirby J, Brayne C & Ince PG (2011) Brain Iron Dysregulation and the Risk of Ageing White Matter Lesions. NeuroMolecular Medicine, 1-11.
• Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Neuroscience Letters, 505(1), 25-30.
• Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.. Neurosci Lett, 486(3), 246-251.
• Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function and Ageing Neuropathology Study Group (2010) Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain.. Neurobiol Aging, 31(4), 578-590.
• Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE , Savva GM et al (2010) Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.. Neuropathol Appl Neurobiol, 36(1), 25-40.
• Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neuroscience Letters, 486(3), 246-251.
• Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.. Stroke, 40(2), 369-375.
• Wharton SB, O'Callaghan JP, Savva GM, Nicoll JAR, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG & MRC Cognitive Function and Ageing Neuropathology Study Group (2009) Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia.. Dement Geriatr Cogn Disord, 27(5), 465-473.
• Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) Microglial activation in white matter lesions and nonlesional white matter of ageing brains.. Neuropathol Appl Neurobiol, 33(6), 670-683.
• Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.. Neuropathol Appl Neurobiol, 33(4), 410-419.
• Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.. Stroke, 37(6), 1391-1398.
• Hadjivassiliou M, Boscolo S, Davies-Jones GAB, Grünewald RA, Not T, Sanders DS, Simpson JE, Tongiorgi E, Williamson CA & Woodroofe NM (2002) The humoral response in the pathogenesis of gluten ataxia.. Neurology, 58(8), 1221-1226.
• Hadjivassiliou M, Grunewald RA, Davies-Jones GAB, Simpson JE, Williamson CA, Woodroofe MN, Boscolo S, Tongiorgi E & Not T (2001) Humoral response in the pathogenesis of gluten ataxia. ANNALS OF NEUROLOGY, 50(3), S37-S37.
• John GR, Simpson JE, Woodroofe MN, Lee SC & Brosnan CF (2001) Extracellular nucleotides differentially regulate interleukin-1 beta signaling in primary human astrocytes: Implications for inflammatory gene expression. J NEUROSCI, 21(12), 4134-4142.
• Simpson JE & Woodroofe MN (2001) Inflammation in the central nervous system in multiple sclerosis: The role of chemokines and their receptors. Inflammopharmacology, 9(1-2), 23-33.
• Simpson J, Rezaie P, Newcombe J, Cuzner ML, Male D & Woodroofe MN (2000) Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue.. J Neuroimmunol, 108(1-2), 192-200.
• Simpson JE, Newcombe J, Cuzner ML & Woodroofe MN (2000) Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions.. Neuropathol Appl Neurobiol, 26(2), 133-142.
• Woodroofe N, Cross AK, Harkness K & Simpson JE (1999) The role of chemokines in the pathogenesis of multiple sclerosis.. Adv Exp Med Biol, 468, 135-150.
• Simpson JE, Hadjivassiliou M, Grunewald R, Smith C, Davies-Jones GAB & Woodroofe MN (1998) Investigation of the mechanism of neural damage in patients with gluten sensitivity and neurological dysfunction. Journal of Neuroimmunology, 90(1), 32-32.
• Simpson JE, Newcombe J, Cuzner ML & Woodroofe MN (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions.. J Neuroimmunol, 84(2), 238-249.
• Almansouri T, Waller R, Wharton SB, Heath PR, Matthews FE, Brayne C, van Eeden F & Simpson JE () The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), 4445-4445.
• Wharton SB, Simpson JE, Ince PG, Richardson CD, Merrick R, Matthews FE & Brayne C () Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies. Neuropathology and Applied Neurobiology.
• Simpson JE () Potential Mechanisms Underlying the Dysfunction of the Blood–Brain Barrier. International Journal of Molecular Sciences, 24(9), 8184-8184.
• Hase Y, Ameen‐Ali KE, Waller R, Simpson JE, Stafford C, Mahesh A, Ryan L, Pickering L, Bodman C, Hase M , Boche D et al () Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke. Brain Pathology.
• Vázquez-Villaseñor I, Smith CI, Thang YJR, Heath PR, Wharton SB, Blackburn DJ, Ridger VC & Simpson JE () RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity. International Journal of Molecular Sciences, 23(11), 5913-5913.
• Vazquez‐Villasenor I, Garwood CJ, Simpson JE, Heath PR, Mortiboys H & Wharton SB () Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience.
• Allen SP, Seehra RS, Heath PR, Hall BPC, Bates J, Garwood CJ, Matuszyk MM, Wharton SB & Simpson JE () Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response. International Journal of Molecular Sciences, 21(21), 8028-8028.
• Chambers A, Bury JJ, Minett T, Richardson CD, Brayne C, Ince PG, Shaw PJ, Garwood CJ, Heath PR, Simpson JE , Matthews FE et al () Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort. Journal of Neuropathology & Experimental Neurology.
• Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C () Acute effects of systemic inflammation upon neurovascular unit and cerebrovascular function..
• Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P, Brezzo G & Berwick J () The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease..
• Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB () A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLoS ONE, 10(2). View this article in WRRO
• Fadul MM, Heath PR, Cooper-Knock J, Kurz JM, Al-Azzawi HA, Ali Z, Smith T, Matthews FE, Brayne C, Wharton SB & Simpson JE () Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response. International Journal of Molecular Sciences, 21(21), 7924-7924.

Conference proceedings papers

• Ashford BA, Appleby-Mallinder CS, Dawson C, Matuszyk MM, Heath PR, Wei W, Dunning MJ, Boche D, Simpson JE & Highley JR (2023) Inflammatory pathology in human motor neuron disease. JOURNAL OF PATHOLOGY, Vol. 261 (pp S5-S5)
• Matuszyk M, Ferraiuolo L, Taylor A, Davis P, Staniforth R, Garwood C, Simpson J & Wharton S (2022) Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
• Thang Y, Vazquez-Villasenor I, Smith C, Blackburn D, Wharton S, Heath P, Ridger V & Simpson J (2022) The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
• Floare M, Simpson J, Wharton S, Aeschlimann D & Hadjivassiliou M (2022) Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
• Ashford B, Dunning M, Wei W, Heath P, Boche D, Simpson J & Highley R (2022) Exploring the neuroinflammatory response of the motor cortex and spinal cord in human motor neurone disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
• Almansouri T, Heath P, Wharton S, Van Eeden F & Simpson J (2022) Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
• Waller R, Heath PR, Simpson JE, Hase Y, Kalaria RN & Wharton SB (2021) What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
• Ashford B, Appleby-Mallinder C, Boche D, Wei W, Heath P, Simpson J & Highley R (2021) Exploring the Neuroinflammatory Response of the Motor Regions in Human Motor Neurone Disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 11-11)
• Guagnelli MAR, Wharton S, Francis S & Simpson J (2021) The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
• (2020) General Information. Neuropathology and Applied Neurobiology, Vol. 46 (pp 5-6)
• Jennings O, Ajikumar A, Heath PR, Wharton SB & Simpson JE (2020) Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46)
• Hase Y, Foster V, Waller R, Simpson JE, Heath P, Wharton SB & Kalaria RN (2020) 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15)
• Leach V, Goodall E, Cooper-Knock J, Wang C, Simpson J, Baker D, Drew D, Saffrey MJ, Romero I, Heath P & Wharton S (2019) Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
• Vazquez-Villasenor I, Garwood CJ, Heath PR, Simpson JE & Wharton SB (2019) Investigating senescence activation in response to oxidative DNA damage in neurones in vitro. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 39-39)
• Mistry H, Simpson J, Chambers A, Garwood C, Ince P, Heath P & Wharton S (2019) Cholesterol dysregulation in the neurone-astrocyte unit as an early contributor to neuronal dysfunction in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 15-16)
• Rebollar MA, Wharton S, Francis S & Simpson J (2019) The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
• Waller S, Baxter L, Fillingham D, Coelho S, Pozo JM, Mozumder M, Frangi A, Ince PG, Simpson JE & Highley JR (2019) Iba-1-/CD68+microglia are a prominent feature of age-associated deep subcortical white matter lesions. Neuropathology and Applied Neurobiology, Vol. 45(S1) (pp 33-33), 6 March 2019 - 8 March 2019. View this article in WRRO
• Ashford BA, Appleby-Mallinder CS, Heath P, Simpson JE & Highley R (2019) The role of immunity in human motor neuron disease (MND). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 24-24)
• Fadul MM, Heath P, Cooper-Knock J, Brayne C, Matthews F, Wharton S & Simpson J (2019) A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300)
• Seehra RS, Wharton S, Heath P, Ince P, Muthana M, Garwood C & Simpson J (2018) Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18)
• Chambers A, Minett T, Matthews F, Brayne C, Ince P, Shaw P, Heath P, Simpson J & Wharton S (2018) Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12)
• Leach V, Goodall E, Cooper-Knock J, Wang J, Simpson J, Baker D, Drew D, Saffrey J, Romero I, Heath P & Wharton S (2018) Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36)
• Coelho S, Highley R, Pozo J, Costantini M, Mozumder M, Simpson J, Ince P & Frangi A (2018) Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter lesions and normal white matter in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 26-26)
• Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P & Berwick J (2017) Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43)
• Vazquez-Villasenor I, Simpson JE, Garwood CJ, Ince PG, Heath PR & Wharton SB (2017) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43)
• Ratcliffe L, Garwood CJ, Heath P, Villasenor I, Simpson J, Ince PG & Wharton SB (2016) Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52)
• Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2016) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28)
• Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB & Ageing MRCCF (2015) A reduced astrocyte response to beta-amyloid plaques in the ageing brain associates with dementia and cognitive impairment. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 30-31) View this article in WRRO
• Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2015) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32)
• Ramos I, Walter R, Simpson J, Woodroofe N & Lyng F (2014) Probing the biochemical composition of normal appearance white matter, active and chronic lesions from multiple sclerosis cases using vibrational spectroscopy. Journal of Neuroimmunology, Vol. 275(1-2) (pp 128-128)
• Alsomali KY, Simpson J & Heath PR (2014) Investigating RNA editing in the pathogenesis of amyotrophic lateral sclerosis. FEBS JOURNAL, Vol. 281 (pp 685-686)
• Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
• Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2014) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
• Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2013) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
• Ince PG, Janaway B, Wharton SB, Simpson JE, Highley JR, Matthews FE, Forster G & Brayne C (2013) Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42)
• Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, de Vries HE, Hirst MC, Sharrack B, Baker D , Michael GJ et al (2012) Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 3-4)
• Waller R, Heath PR, Woodroofe MN, Francese S, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54)
• Simpson J, Richardson K, Heath P & Wharton S (2011) Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36)
• Simpson JE, Ince PG, Heath PR, Raman R, Shaw PJ, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33)
• Simpson J, Ince P, Heath P, Raman R, Shaw P, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2010) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46)
• Simpson JE, Ince PG, Theaker R, Haynes L, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function & Ageing Ne (2009) Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19)
• Simpson J, Ince P, Theaker R, Haynes L, Forster G, Shaw P, Matthews F, Savva G, Brayne C & Wharton S (2008) DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727)
• Hosny O, Kirby J, Simpson J & Ince P (2008) Iron metabolism pathways in white matter lesions in the elderly. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1717-1718)
• Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Brayne C, Wharton SB & MRC Cognitive Function Ageing (2008) Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31)
• Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2008) Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31)
• Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2007) Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255)
• Simpson JE, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255)
• Hosny O, Highley JR, Simpson JE, Forster G, Wharton SB & Ince PG (2007) Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267)
• Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
• Simpson JE, Fernando MS, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224)
• Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2006) Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225)
• Owasil R, O’Neill R, Keable A, Nimmo J, MacGregor Sharp M, Kelly L, Saito S, Simpson JE, Weller RO, Smith C , Attems J et al () The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy. International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225)

Preprints

• Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C () Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function., Research Square Platform LLC.