Ellen Lee
School of Health and Related Research
Statistician - Research Fellow
Clinical Trials Research Unit, ScHARR
e.lee@sheffield.ac.uk
+44 114 222 0805
+44 114 222 0805
3.10, The Innovation Centre
Full contact details
Ellen Lee
School of Health and Related Research
3.10
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
School of Health and Related Research
3.10
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
- Profile
-
I joined CTRU as a Medical Statistician in October 2011. Before that I graduated with a BSc degree in Economics and Mathematics and an MSc in Statistics with Medical Applications from The University of Sheffield. I have also worked for the NIHR Research Design Service Yorkshire and the Humber (RDS-YH) and in the Cancer Clinical Trials Centre, Sheffield.
Current projects
I am involved in the following projects:
- ASPECT - Alleviating Specific Phobias Experienced by Children Trial
- The PRIEST Study: Pandemic Respiratory Infection Emergency System Triage
- The PITSTOP Study - Pllonidal sinus Treatment: STudying the OPtions
- ASTIClite - Autologgous Stem cell Transplantation IN refractory Crohn's disease - Low Intensity Therapy Evaluation
Section
I am based in Design, Trials and Statistics.
- Research interests
-
- Clinical trials methodology
- Cluster randomised controlled trials and clustering in individually randomised controlled trials
- Multiple imputation for dealing with missing data
- Design and analysis of pilot trials
- Complex interventions
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- A preventative lifestyle intervention for older adults (lifestyle matters): a randomised controlled trial. Age And Ageing, 46, 627-634. View this article in WRRO
- A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study. Health Technology Assessment, 20(90). View this article in WRRO
- Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- The statistical interpretation of pilot trials: should significance thresholds be reconsidered?. BMC Med Res Methodol, 14, 41. View this article in WRRO
All publications
Journal articles
- Post-exertion oxygen saturation as a prognostic factor for adverse outcome in patients attending the emergency department with suspected COVID-19: a substudy of the PRIEST observational cohort study. Emergency Medicine Journal. View this article in WRRO
- Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection : observational cohort study. PLoS ONE, 15(11). View this article in WRRO
- Treatment effects may remain the same even when trial participants differed from the target population. Journal of Clinical Epidemiology. View this article in WRRO
- Early variation of ultrasound halo sign with treatment and relation with clinical features in patients with giant cell arteritis. Rheumatology. View this article in WRRO
- Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19(1). View this article in WRRO
- Healthcare access for asylum seekers and refugees in England : a mixed methods study exploring service users’ and health care professionals’ awareness. European Journal of Public Health. View this article in WRRO
- Study protocol for a randomised controlled trial assessing the clinical and cost-effectiveness of the Journeying through Dementia (JtD) intervention compared to usual care. BMJ Open, 9(9). View this article in WRRO
- Clinical and cost-effectiveness of one-session treatment (OST) versus multisession cognitive-behavioural therapy (CBT) for specific phobias in children: Protocol for a non-inferiority randomised controlled trial. BMJ Open, 8(8). View this article in WRRO
- Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes: a health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. BMJ Open, 8(4). View this article in WRRO
- Recruitment of older adults to three preventative lifestyle improvement studies. Trials, 19. View this article in WRRO
- A preventative lifestyle intervention for older adults (lifestyle matters): a randomised controlled trial. Age And Ageing, 46, 627-634. View this article in WRRO
- Aquatic therapy for children with Duchenne muscular dystrophy: a pilot feasibility randomised controlled trial and mixed-methods process evaluation. HEALTH TECHNOLOGY ASSESSMENT, 21(27). View this article in WRRO
- A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Aquatic therapy for boys with Duchenne muscular dystrophy (DMD): an external pilot randomised controlled trial. Pilot and Feasibility Studies, 3, 16-16. View this article in WRRO
- The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study. Health Technology Assessment, 20(90). View this article in WRRO
- Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- The assessment of depression in people with multiple sclerosis: a systematic review of psychometric validation studies. BMC Psychiatry, 16. View this article in WRRO
- Creatine kinase enzyme level correlates positively with serum creatinine and lean body mass, and is a prognostic factor for survival in amyotrophic lateral sclerosis. European Journal of Neurology, 23(6), 1071-1078.
- Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
- Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 478-484. View this article in WRRO
- View this article in WRRO
- A rapid review indicated higher recruitment rates in treatment trials than in prevention trials. Journal of Clinical Epidemiology, 68(3), 347-354. View this article in WRRO
- The statistical interpretation of pilot trials: should significance thresholds be reconsidered?. BMC Med Res Methodol, 14, 41. View this article in WRRO
- The impact on the family carer of motor neurone disease and intervention with noninvasive ventilation.. J Palliat Med, 16(12), 1602-1609.
- Use of non-invasive ventilation at end of life.. Palliat Med, 27(9), 878.
- The use of non-invasive ventilation at end of life in patients with motor neurone disease: a qualitative exploration of family carer and health professional experiences.. Palliat Med, 27(6), 516-523. View this article in WRRO
- The initiation of non-invasive ventilation for patients with motor neuron disease: patient and carer perceptions of obstacles and outcomes.. Amyotroph Lateral Scler Frontotemporal Degener, 14(2), 105-110.
- The PITSTOP Study: PIlonidal sinus Treatment: STudying the OPtions - Protocol.
Conference proceedings papers
- Do RCTs reflect patient populations and does it matter? Considerations and a case study. Trials, Vol. 20(Supplement 1) (pp 124-124). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
- An exploratory study of the limitations of outcome measures used in a randomised controlled trial of a complex intervention in dementia. Trials, Vol. 20(Supplement 1) (pp 118-118). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
- Analysis and reporting of trials which randomise couples to therapy based interventions: how should we do it?. Trials, Vol. 16(S2)
- View this article in WRRO
- Elevated creatine kinase suggests better prognosis in patients with amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
- Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
Posters
- A preventative lifestyle intervention for older adults (lifestyle matters): a randomised controlled trial. Age And Ageing, 46, 627-634. View this article in WRRO