James Fotheringham

School of Health and Related Research

Consultant Nephrologist and Honorary Lecturer

+44 114 222 4346

Full contact details

James Fotheringham
School of Health and Related Research
Regent Court (ScHARR)
30 Regent Street
S1 4DA

I am passionate about data. During my PhD (2010-2013) funded by Kidney Research UK using data from and collaborating with the UK Renal Registry I was able for the first time to link registry data to Hospital Episode Statistics data to undertake a range of analyses. This research is used as a case study by NHS Digital, the Association of Medical Research Charities and Understanding Patient Data to highlight the value of secondary data analysis and data linkage.

I have received national junior investigator awards from the British Transplant Society and the Renal Association for analyses arising from this project. In 2015 was received an NIHR Clinician Scientist Award to fund my continued research into the excess admissions and deaths associated with the two-day break in patients receiving three times a week haemodialysis. This award allows me to continue clinical practice as a consultant nephrologist at the Sheffield Kidney Institute.

I am involved in a number of other renal studies including the UK-Catheter study (an ancillary study to the Peritoneal Dialysis Outcomes and Practice Patterns Study) and SHARE-HD, a study designed to promote and understand the impact of encouraging in-centre haemodialysis patients to perform more tasks relating to their dialysis treatment. Collaborating with others I have published on albuminuria, obesity and renal bone disease, often championing the use of existing trial and cohort study datasets.

Outside of kidney disease, was part of the group who undertook the statistical appraisal of Summary Hospital Mortality Indicator for the Department of Health/NHS Information Centre, and have supervised the analysis a range of cohorts to understand the impact of smoking on cardiovascular events the prognosis following them. I coordinate and deliver medical education for medical students and core medical trainees.

Research interests

Methods and Instruments

  • Patient reported outcome and experience measures - Symptom burden, patient activation, quality of life, experience of services
  • Observational data, secondary use of data and data linkage for epidemiology and comparative effectiveness
  • Statistical methods to reduced confounding - Instrumental variables, marginal structural models, G-methods and treatment switching
  • Discrete choice experiments
  • Predictive models and machine learning to inform decision making
  • Realist Evaluation


  • The two-day break in three times as week haemodialysis
  • The health economics surrounding renal replacement therapy - In centre haemodialysis (range of formats and settings including intensive frequency/duration and minimal care), peritoneal dialysis, home haemodialysis and transplantation
  • Patient centred care, decision making and research prioritisation

Show: Featured publications All publications

Journal articles

All publications

Journal articles


Conference proceedings papers


  • Ashby D, Bird SM, Hunt I, Grant R, King T, Atkinson AC, Riani M, Gandy A, Kvaloy JT, Caan W , Eames M et al (2012) Discussion on the paper by Spiegelhalter, Sherlaw-Johnson, Bardsley, Blunt, Wood and Grigg. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, 175, 25-47. RIS download Bibtex download
  • NIHR (C): Inter-CEPt: Intervening to eliminate the centre effect variation in home dialysis use, July 2020. £1,110,815
  • NIHR (C): A randomised controlled trial assessing the effectiveness and cost effectiveness of thrice weekly, extended, in-centre nocturnal haemodialysis versus standard care using a mixed methods approach, Jan 2020, £2,132,709
  • Kidney Research UK (C). The UK Peritoneal Dialysis Outcomes and Practice Patterns Study: UK-PDOPPS – March 2018. £260,000.
  • The Health Foundation (C). Scaling up shared care haemodialysis: SHAREHD. £500,000.
  • National Institute for Health Research (L). Individualising in centre haemodialysis therapy to reduce the harm caused by the two-day break in the three times a week treatment schedule – Dec 2015. £521,823 over 5 years.
  • British Renal Society (C).Qualitative study into intensified haemodialysis regimes – Jan 2015. £15,000.
  • Kidney Research UK (L). Travel grant for peritoneal dialysis research – Jan 2015. £2,500.
  • National Institute for Health Research (C). Peritoneal Dialysis Outcomes and Practice Patterns Study (UK) – February 2014. £349,989.
  • Department of Health (C). Statistical appraisal of Summary Hospital Mortality Indicator – Feb 2011. £66,000.
  • Kidney Research UK (L). Clinical Training Fellowship – April 2010. £180,000 over 3 years